Research Topics
| John W WrightSummaryAffiliation: Washington State University Country: USA Publications
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Publications
The brain renin-angiotensin system: a diversity of functions and implications for CNS diseasesJohn W Wright
Programs in Neuroscience and Biotechnology, Washington State University, P O Box 646520, Pullman, WA, 99164 6520, USA
Pflugers Arch 465:133-51. 2013....
Differences in spatial learning comparing transgenic p75 knockout, New Zealand Black, C57BL/6, and Swiss Webster miceJohn W Wright
Department of Psychology, Washington State University, Pullman, WA 99164 4820, USA
Behav Brain Res 153:453-8. 2004..On the other hand, these results do not support the use of the NZB mouse as an animal model of human learning disability and dementia...- Influence of hippocampectomy on habituation, exploratory behavior, and spatial memory in ratsJohn W Wright
Department of Psychology, Washington State University, Pullman, WA 99164 4820, USA
Brain Res 1023:1-14. 2004..These results question the hypothesis that habituation is solely mediated by the hippocampus in favor of a process that utilizes different brain structures and degrees of neural plasticity dependent upon task requirements... 
Contributions of matrix metalloproteinases to neural plasticity, habituation, associative learning and drug addictionJohn W Wright
Department of Psychology, Washington State University, Pullman, WA 99164 4820, USA
Neural Plast 2009:579382. 2009....- The brain RAS and Alzheimer's diseaseJohn W Wright
Departments of Psychology, Veterinary and Comparative, Anatomy, Pharmacology and Physiology, and Programs in Neuroscience and Biotechnology, Washington State University, Pullman, Pullman, WA 99164 4820, USA
Exp Neurol 223:326-33. 2010..These efforts have resulted in a small molecule with desirable hydrophobicity characteristics that shows promise with respect to memory facilitation when peripherally administered... - Habituation of the head-shake response induces changes in brain matrix metalloproteinases-3 (MMP-3) and -9John W Wright
Department of Psychology, Washington State University, Pullman, WA 99164 4820, USA
Behav Brain Res 174:78-85. 2006..However, cues present in the test environment appear to have provoked elevations in MMP-3 and -9 independent of those accompanying habituation... - Habituation-induced neural plasticity in the hippocampus and prefrontal cortex mediated by MMP-3John W Wright
Department of Psychology, Washington State University, Pullman, WA 99164 4820, United States
Behav Brain Res 203:27-34. 2009..These results suggest that elevations in hippocampus and prefrontal cortex MMP-3 expression contribute to this simplest form of learning and may be a mechanism underlying spontaneous recovery... - Pathways involved in the transition from hypertension to hypertrophy to heart failure. Treatment strategiesJohn W Wright
Department of Psychology, Washington State University, Pullman, WA 99164 4820, USA
Heart Fail Rev 13:367-75. 2008..In addition, treatment strategies are discussed, focusing on middle aged and elderly hypertensive and heart failure patients... - The angiotensin AT4 receptor subtype as a target for the treatment of memory dysfunction associated with Alzheimer's diseaseJohn W Wright
Department of Psychology, Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, P O Box 644820, Pullman, WA 99164 4820, USA
J Renin Angiotensin Aldosterone Syst 9:226-37. 2008..We conclude with a working hypothesis concerning the importance of the AT4 receptor subtype as a new potential drug target for the treatment of Alzheimer's disease-associated memory loss... - Brain renin-angiotensin--a new look at an old systemJohn W Wright
Department of Psychology, Washington State University, P O Box 644820, Pullman, WA 99164 4820, USA
Prog Neurobiol 95:49-67. 2011..The development of blood-brain barrier penetrant AT(4) receptor agonists and antagonists is of major importance regarding the continuing evaluation of the efficacy of new treatment approaches... - The brain angiotensin system and extracellular matrix molecules in neural plasticity, learning, and memoryJohn W Wright
Department of Psychology, Washington State University, P O Box 644820, Pullman, WA 99164 4820, USA
Prog Neurobiol 72:263-93. 2004.... - Neural plasticity and the brain renin-angiotensin systemJohn W Wright
Department of Psychology and Program in Neuroscience, Washington State University, PO Box 644820, Pullman, WA 99164 4820, USA
Neurosci Biobehav Rev 26:529-52. 2002..These findings generally support an important contribution by angiotensin peptides to neural plasticity and memory consolidation... - Conversion of brain angiotensin II to angiotensin III is critical for pressor response in ratsJohn W Wright
Department of Psychology, Washington State University, Pullman, Washington 99164 4820, USA
Am J Physiol Regul Integr Comp Physiol 284:R725-33. 2003..These results suggest that the brain AT(1) receptor may be designed to preferentially respond to ANG III, and ANG III's importance as a centrally active ligand has been underestimated... - Ethanol-induced impairment of spatial memory and brain matrix metalloproteinasesJohn W Wright
Department of Psychology, Washington State University, Pullman, WA 99164 4820, USA
Brain Res 963:252-61. 2003..Thus, ethanol-induced impairment in the acquisition of spatial memory tasks may, in part, be due to disruption of brain MMP activity... - Ethanol-induced suppression of LTP can be attenuated with an angiotensin IV analogJohn W Wright
Department of Psychology, Washington State University, Pullman, WA 99164 4820, USA
Regul Pept 113:49-56. 2003..These results suggest that an AT(4) receptor agonist is effective in overcoming ethanol's suppressing influence on LTP, and encourage further investigation of the cognitive enhancing properties of such compounds... - Introduction: aminopeptidases and hypertension-mechanisms of action and therapeutic strategiesJohn W Wright
Stadium Way, Pullman, 99164-4820, USA
Heart Fail Rev 13:271-2. 2008 - Effects of extracellular matrix-degrading proteases matrix metalloproteinases 3 and 9 on spatial learning and synaptic plasticityStarla E Meighan
Department of Veterinary Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Washington 99164, USA
J Neurochem 96:1227-41. 2006..Together these results indicate that changes in MMP function are critical to synaptic plasticity and hippocampal-dependent learning... - Influence of dorsal hippocampal lesions and MMP inhibitors on spontaneous recovery following a habituation/classical conditioning head-shake taskRoberta V Wiediger
Department of Psychology, Lincoln Land Community College, Springfield, IL 62794, USA
Neurobiol Learn Mem 92:504-11. 2009..Thus, it appears that the dorsal hippocampus influences habituation by conserving responses and reducing spontaneous recovery when a temporally contingent signaling cue is present... - The role of the AT4 and cholinergic systems in the Nucleus Basalis Magnocellularis (NBM): effects on spatial memoryWendy L Wilson
Department of Psychology, Washington State University, Pullman, WA 99164 4820, USA
Brain Res 1272:25-31. 2009..These findings suggest a functional role for both the cholinergic and AT(4) receptor systems in spatial learning, and indicate for the first time a functional role for the AngIV/AT(4) receptor system in the NBM... - Effects of matrix metalloproteinase inhibition on short- and long-term plasticity of schaffer collateral/CA1 synapsesPeter C Meighan
Department of Veterinary Comparative Anatomy, Washington State University, Pullman, Washington 99164, USA
J Neurochem 102:2085-96. 2007..Together, these data support a generalized role for MMPs in short-term and long-term hippocampal plasticity and indicate that MMPs are a necessary facet of integrin-mediated cell adhesion supporting LTP stabilization... - Roles of brain angiotensins II and III in thirst and sodium appetiteWendy L Wilson
Department of Psychology, Washington State University, Pullman, WA 99164 4820, USA
Brain Res 1060:108-17. 2005..However, these results do not resolve the primary question of whether conversion of AngII to AngIII is a prerequisite to dipsogenic and salt appetite responses in the brain... - Extracellular matrix molecules, long-term potentiation, memory consolidation and the brain angiotensin systemJohn W Wright
Department of Psychology, Washington State University, PO Box 644820, Pullman, WA 99164 4820, USA
Peptides 23:221-46. 2002..These enzymatic pathways appear to be very important to an understanding of dysfunctional memory diseases such as Alzheimer's disease, multiple sclerosis, brain tumors, and infections... - Facilitation of hippocampal synaptogenesis and spatial memory by C-terminal truncated Nle1-angiotensin IV analogsCaroline C Benoist
Department of Veterinary and Comparative, Washington State University, Pullman, Washington 99164 6520, USA
J Pharmacol Exp Ther 339:35-44. 2011..These data suggest that the procognitive activity of these molecules is attributable to their ability to augment synaptic connectivity... - Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agentsAlene T McCoy
Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, P O Box 6520, Washington State University, Pullman, WA 99164 6520, USA
J Pharmacol Exp Ther 344:141-54. 2013..These data suggest that dihexa may have therapeutic potential as a treatment of disorders, such as Alzheimer's disease, where augmented synaptic connectivity may be beneficial... - Development of angiotensin IV analogs as hepatocyte growth factor/Met modifiersLeen H Kawas
Department of Veterinary and Comparative, Anatomy, Pharmacology, and Physiology, PO Box 6520, Washington State University, Pullman, WA 99164 6520, USA
J Pharmacol Exp Ther 340:539-48. 2012.... - Norleucine1-Angiotensin IV alleviates mecamylamine-induced spatial memory deficitsMikel L Olson
Department of Psychology, Washington State University, Pullman, WA 99164-4820, USA
Peptides 25:233-41. 2004..These findings support the importance of the AT4 receptor in cognitive processing and suggest that the ability of Nle1-Ang IV to improve spatial memory deficiencies may be dependant upon the brain cholinergic system... - Role of mitogen-activated protein kinases during recovery from head-shake response habituation in ratsEric S Murphy
Department of Psychology, University of Alaska Anchorage, 3211 Providence Drive, Anchorage, AK 99508, USA
Brain Res 1050:170-9. 2005.... - REM sleep deprivation attenuates actin-binding protein cortactin: a link between sleep and hippocampal plasticityChristopher J Davis
Department of Psychology, Washington State University, Pullman, WA 99164 6520, USA
Neurosci Lett 400:191-6. 2006..Thus, these data support a functional link between REMS and cytoskeletal reorganization in the hippocampus, a process that is essential for synaptic plasticity... 
Inhibition of hippocampal matrix metalloproteinase-3 and -9 disrupts spatial memoryJohn W Wright
Department of Psychology, Washington State University, Pullman, WA 99164 4820, USA
Neural Plast 2007:73813. 2007....- Effects of suprachiasmatic nucleus lesions on habituation of the head-shake responseKelby L Holtfreter
Department of Psychology, Washington State University, Pullman, WA 99164 4820, USA
Neurosci Lett 439:203-7. 2008..The present findings suggest that the SCN may mediate temporal patterning of spontaneous recovery from habituation and is necessary in order to appropriately reset the animal to its pre-habituation level of responsiveness... - Hippocampal MMP-3 elevation is associated with passive avoidance conditioningMikel L Olson
Department of Psychology, Washington State University, Pullman, WA 99164 4820, USA
Regul Pept 146:19-25. 2008..These findings suggest that increased hippocampal MMP-3 expression is an event that may play an important role in synaptic plasticity and memory consolidation... - Brain angiotensinergic activity: the state of our current knowledgeRobert C Speth
Program in Neuroscience, Dept Veterinary and Comparative Anatomy, Physiology and Pharmacology, Washington State University, P.O. Box 646520, Pullman, WA 99164-6520, USA
Proc West Pharmacol Soc 46:11-5. 2003 - Mimics of the dimerization domain of hepatocyte growth factor exhibit anti-Met and anticancer activityLeen H Kawas
Department of Veterinary and Comparative, Anatomy, Pharmacology, and Physiology, Washington State University, Pullman, WA 99164 6520, USA
J Pharmacol Exp Ther 339:509-18. 2011.... - Increase in matrix metalloproteinase-9 levels in the rat medial prefrontal cortex after cocaine reinstatement of conditioned place preferenceTravis E Brown
Department of Veterinary and Comparative Anatomy, Physiology and Pharmacology, Washington State University, Pullman, Washington 99164, USA
Synapse 62:886-9. 2008.... - REM sleep deprivation-induced deficits in the latency-to-peak induction and maintenance of long-term potentiation within the CA1 region of the hippocampusChristopher J Davis
Department of Psychology, Washington State University, Pullman, WA 99164-4820, USA
Brain Res 973:293-7. 2003..This delay in maximal induction, and the degradation of the maintenance phase of LTP, may represent sleep deprivation-induced impairment of the underlying neurochemical mechanisms normally responsible for memory acquisition... - Phospholipase C inhibitor U73122 attenuates the dipsogenic response induced by angiotensin IITravis E Brown
Program in Neuroscience, Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA, USA
Proc West Pharmacol Soc 46:61-3. 2003 - Angiotensin receptor subtype mediated physiologies and behaviors: new discoveries and clinical targetsJohn W Wright
Department of Psychology, Washington State University, P O Box 644820, Pullman, WA 99164 4820, USA
Prog Neurobiol 84:157-81. 2008..This review concludes with a consideration of the emerging therapeutic applications suggested by these newly discovered functions of the RAS... - Plasticity associated with escalated operant ethanol self-administration during acute withdrawal in ethanol-dependent rats requires intact matrix metalloproteinase systemsAlexander W Smith
Department of Psychology, Washington State University, Pullman, WA 99164 4820, USA
Neurobiol Learn Mem 96:199-206. 2011..Thus, the present data identified that an intact MMP system is required for the escalated responding that occurs during acute withdrawal in dependent animals and implicate such escalation as a learned response... - Focus on Brain Angiotensin III and Aminopeptidase A in the Control of HypertensionJohn W Wright
Departments of Psychology and Veterinary and Comparative Anatomy, Pharmacology, and Physiology and Programs in Neuroscience and Biotechnology, Washington State University, P O Box 644820, Pullman, WA 99164 4820, USA
Int J Hypertens 2012:124758. 2012..We conclude with thoughts concerning future treatment approaches to controlling hypertension and hypotension... - Importance of the brain Angiotensin system in Parkinson's diseaseJohn W Wright
Departments of Psychology, Veterinary and Comparative Anatomy, Pharmacology, and Physiology and Programs in Neuroscience and Biotechnology, Washington State University, P O Box 644820, Pullman, WA 99164 4820, USA
Parkinsons Dis 2012:860923. 2012..Recently, small angiotensin-based blood-brain barrier penetrant mimetics have been developed that activate this HGF/c-Met system. These compounds may offer a new and novel approach to the treatment of Parkinson's disease... - Attenuation of scopolamine-induced learning deficits by LVV-hemorphin-7 in rats in the passive avoidance and water maze paradigmsAnthony L Albiston
Howard Florey Institute of Experimental Physiology and Medicine, The University of Melbourne, Parkville, Vic. 3010, Australia
Behav Brain Res 154:239-43. 2004..These studies clearly demonstrate that LVV-H7, like Ang IV, is a pharmacologically active AT(4) ligand that attenuates the deleterious effects of scopolamine on learning performance in two different behavioral paradigms... - Central pressor actions of aminopeptidase-resistant angiotensin II analogs: challenging the angiotensin III hypothesisRanjita J Kokje
Department of Pharmacology, School of Pharmacy, University of Mississippi, University, MS 38677, USA
Hypertension 49:1328-35. 2007..These data do not support The Angiotensin III Hypothesis and suggest that conversion of exogenously applied angiotensin II to angiotensin III is not necessary to cause brain-mediated pressor or dipsogenic responses... - New insights into the importance of aminopeptidase A in hypertensionShigehiko Mizutani
Department of Medical Science of Proteases, Nagoya University, Graduate School of Medicine, Nagoya, Japan
Heart Fail Rev 13:273-84. 2008..Thus, it appears important to consider the relationship among activation of the RAS, circulating levels of AngII, and the availability of APA in hypertensive disorders...