Michael Wong

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Rapamycin attenuates the development of posttraumatic epilepsy in a mouse model of traumatic brain injury
    Dongjun Guo
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS ONE 8:e64078. 2013
  2. pmc Profile of ezogabine (retigabine) and its potential as an adjunctive treatment for patients with partial-onset seizures
    Judith Lz Weisenberg
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Neuropsychiatr Dis Treat 7:409-14. 2011
  3. pmc Clinical utility, safety, and tolerability of ezogabine (retigabine) in the treatment of epilepsy
    Michael A Ciliberto
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Drug Healthc Patient Saf 4:81-6. 2012
  4. doi request reprint Dendritic spine pathology in epilepsy: cause or consequence?
    M Wong
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, Box 8111, 660 South Euclid Avenue, St Louis, MO 63110, United States Electronic address
    Neuroscience 251:141-50. 2013
  5. pmc A critical review of mTOR inhibitors and epilepsy: from basic science to clinical trials
    Michael Wong
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO 63110, USA
    Expert Rev Neurother 13:657-69. 2013
  6. pmc Mammalian target of rapamycin (mTOR) pathways in neurological diseases
    Michael Wong
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO 63110, USA
    Biomed J 36:40-50. 2013
  7. pmc Mammalian target of rapamycin (mTOR) activation in focal cortical dysplasia and related focal cortical malformations
    Michael Wong
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO 63110, USA
    Exp Neurol 244:22-6. 2013
  8. ncbi request reprint Stabilizing dendritic structure as a novel therapeutic approach for epilepsy
    Michael Wong
    Department of Neurology, Box 8111, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Expert Rev Neurother 8:907-15. 2008
  9. ncbi request reprint Animal models of focal cortical dysplasia and tuberous sclerosis complex: recent progress toward clinical applications
    Michael Wong
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Epilepsia 50:34-44. 2009
  10. pmc Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: From tuberous sclerosis to common acquired epilepsies
    Michael Wong
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Epilepsia 51:27-36. 2010

Research Grants

Collaborators

Detail Information

Publications49

  1. pmc Rapamycin attenuates the development of posttraumatic epilepsy in a mouse model of traumatic brain injury
    Dongjun Guo
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS ONE 8:e64078. 2013
    ..These results suggest that rapamycin may represent a rational treatment for preventing posttraumatic epilepsy in patients with TBI...
  2. pmc Profile of ezogabine (retigabine) and its potential as an adjunctive treatment for patients with partial-onset seizures
    Judith Lz Weisenberg
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Neuropsychiatr Dis Treat 7:409-14. 2011
    ..Ezogabine has potential for clinical applications in other medical conditions beyond epilepsy, such as neuropathic pain, neuromyotonia, and bipolar disease, but these are based primarily on experimental models...
  3. pmc Clinical utility, safety, and tolerability of ezogabine (retigabine) in the treatment of epilepsy
    Michael A Ciliberto
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Drug Healthc Patient Saf 4:81-6. 2012
    ..Overall, ezogabine appears to be well tolerated and represents a reasonable new option for treating patients with intractable epilepsy...
  4. doi request reprint Dendritic spine pathology in epilepsy: cause or consequence?
    M Wong
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, Box 8111, 660 South Euclid Avenue, St Louis, MO 63110, United States Electronic address
    Neuroscience 251:141-50. 2013
    ..The mechanistic basis of dendritic spine abnormalities in epilepsy has begun to be elucidated and suggests novel therapeutic strategies for treating epilepsy and its complications. ..
  5. pmc A critical review of mTOR inhibitors and epilepsy: from basic science to clinical trials
    Michael Wong
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO 63110, USA
    Expert Rev Neurother 13:657-69. 2013
    ..Future clinical and basic research is needed to establish whether mTOR inhibitors are an effective treatment for epilepsy...
  6. pmc Mammalian target of rapamycin (mTOR) pathways in neurological diseases
    Michael Wong
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO 63110, USA
    Biomed J 36:40-50. 2013
    ..mTOR inhibitors, such as rapamycin and its analogs, may represent novel, rational therapies for a variety of neurological disorders...
  7. pmc Mammalian target of rapamycin (mTOR) activation in focal cortical dysplasia and related focal cortical malformations
    Michael Wong
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO 63110, USA
    Exp Neurol 244:22-6. 2013
    ..The use of mTOR inhibitors may represent a rational therapeutic strategy for treating or even preventing epilepsy due to FCD and TSC...
  8. ncbi request reprint Stabilizing dendritic structure as a novel therapeutic approach for epilepsy
    Michael Wong
    Department of Neurology, Box 8111, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Expert Rev Neurother 8:907-15. 2008
    ..Mechanistically targeted approaches to limit seizure-related structural changes in dendrites may represent a novel therapeutic strategy for treating epilepsy and its complications...
  9. ncbi request reprint Animal models of focal cortical dysplasia and tuberous sclerosis complex: recent progress toward clinical applications
    Michael Wong
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Epilepsia 50:34-44. 2009
    ....
  10. pmc Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: From tuberous sclerosis to common acquired epilepsies
    Michael Wong
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Epilepsia 51:27-36. 2010
    ..Therefore, mTOR inhibition may represent a potential antiepileptogenic therapy for diverse types of epilepsy, including both genetic and acquired epilepsies...
  11. ncbi request reprint Mechanisms of epileptogenesis in tuberous sclerosis complex and related malformations of cortical development with abnormal glioneuronal proliferation
    Michael Wong
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Epilepsia 49:8-21. 2008
    ..An improved understanding of these various factors involved in epileptogenesis has direct clinical implications for optimizing current treatments or developing novel therapeutic approaches for epilepsy in these disorders...
  12. ncbi request reprint Modulation of dendritic spines in epilepsy: cellular mechanisms and functional implications
    Michael Wong
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Epilepsy Behav 7:569-77. 2005
    ..Novel therapeutic strategies directed at modulation of spine motility may prevent the detrimental effects of seizures on cognitive function in epilepsy...
  13. ncbi request reprint Advances in the pathophysiology of developmental epilepsies
    Michael Wong
    Department of Neurology, Box 8111, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Semin Pediatr Neurol 12:72-87. 2005
    ....
  14. pmc Abnormal glutamate homeostasis and impaired synaptic plasticity and learning in a mouse model of tuberous sclerosis complex
    Ling Hui Zeng
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurobiol Dis 28:184-96. 2007
    ..These results suggest that abnormal glutamate homeostasis predisposes to excitotoxic cell death, impaired synaptic plasticity and learning deficits in Tsc1 GFAP CKO mice...
  15. pmc Hippocampal seizures cause depolymerization of filamentous actin in neurons independent of acute morphological changes
    Yannan Ouyang
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO 63110, USA
    Brain Res 1143:238-46. 2007
    ..In addition to affecting non-structural functions of spines, the degree to which overt structural changes occur with actin depolymerization is dependent on the severity and type of the pathophysiological stimulus...
  16. pmc Leptin inhibits 4-aminopyridine- and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents
    Lin Xu
    Department of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 118:272-80. 2008
    ..Intranasal leptin administration may have potential as an acute abortive treatment for convulsive seizures in emergency situations...
  17. pmc Impaired astrocytic gap junction coupling and potassium buffering in a mouse model of tuberous sclerosis complex
    Lin Xu
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurobiol Dis 34:291-9. 2009
    ..These findings suggest that Tsc1 inactivation in astrocytes causes defects in astrocytic gap junction coupling and potassium clearance, which may contribute to epilepsy in Tsc1(GFAP)CKO mice...
  18. pmc Modulation of astrocyte glutamate transporters decreases seizures in a mouse model of Tuberous Sclerosis Complex
    Ling Hui Zeng
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurobiol Dis 37:764-71. 2010
    ..These results indicate that astrocyte glutamate transporters contribute to epileptogenesis in Tsc1(GFAP)CKO mice and suggest novel therapeutic strategies for epilepsy in TSC directed at astrocytes...
  19. ncbi request reprint The natural history and treatment of epilepsy in a murine model of tuberous sclerosis
    Ebru Erbayat-Altay
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, U S A
    Epilepsia 48:1470-6. 2007
    ..Here, we characterize the natural history of the epilepsy in Tsc1(GFAP)CKO mice in more detail and report acute effects of treatment with standard antiepileptic drugs on seizures in these mice...
  20. ncbi request reprint Epileptogenesis and reduced inward rectifier potassium current in tuberous sclerosis complex-1-deficient astrocytes
    Laura A Jansen
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Epilepsia 46:1871-80. 2005
    ..Here, we investigated the hypothesis that impairment of potassium uptake through astrocyte inward rectifier potassium (Kir) channels may contribute to epileptogenesis in Tsc1(GFAP)CKO mice...
  21. pmc Vigabatrin inhibits seizures and mTOR pathway activation in a mouse model of tuberous sclerosis complex
    Bo Zhang
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 8:e57445. 2013
    ..This study identifies a potential novel mechanism of action of an antiseizure medication involving the mTOR pathway, which may account for the unique efficacy of this drug for a genetic epilepsy...
  22. ncbi request reprint Impaired glial glutamate transport in a mouse tuberous sclerosis epilepsy model
    Michael Wong
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Ann Neurol 54:251-6. 2003
    ..These findings suggest that Tsc1 inactivation in astrocytes causes dysfunctional glutamate homeostasis, leading to seizure development in TSC...
  23. pmc Transient decrease in F-actin may be necessary for translocation of proteins into dendritic spines
    Yannan Ouyang
    Department of Neurology 8111, Washington University School of Medicine, 660 South Euclid, St Louis, MO 63110, USA
    Eur J Neurosci 22:2995-3005. 2005
    ....
  24. doi request reprint Increased severity of pentylenetetrazol induced seizures in leptin deficient ob/ob mice
    Ebru Erbayat-Altay
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, United States
    Neurosci Lett 433:82-6. 2008
    ..These findings suggest that chronic leptin deficiency in vivo increases seizure susceptibility...
  25. pmc The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy
    Ling Hui Zeng
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 29:6964-72. 2009
    ..These findings indicate that mTOR signaling mediates mechanisms of epileptogenesis in the kainate rat model and that mTOR inhibitors have potential antiepileptogenic effects in this model...
  26. ncbi request reprint Kainate seizures cause acute dendritic injury and actin depolymerization in vivo
    Ling Hui Zeng
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 27:11604-13. 2007
    ....
  27. ncbi request reprint Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex
    Ling Hui Zeng
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Neurol 63:444-53. 2008
    ..Here, we tested whether rapamycin could prevent or reverse epilepsy, as well as other cellular and molecular brain abnormalities in Tsc1(GFAP)CKO mice...
  28. pmc Brief seizures cause dendritic injury
    Dongjun Guo
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurobiol Dis 45:348-55. 2012
    ..These studies demonstrate that seizures of all durations may trigger at least transient neuronal injury...
  29. pmc The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway
    Sharon S McDaniel
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Epilepsia 52:e7-11. 2011
    ..Because mTOR signaling has been implicated in epileptogenesis, these results suggest that the KD may have anticonvulsant or antiepileptogenic actions via mTOR pathway inhibition...
  30. doi request reprint Video-EEG monitoring methods for characterizing rodent models of tuberous sclerosis and epilepsy
    Nicholas R Rensing
    Department of Neurology, The Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA
    Methods Mol Biol 821:373-91. 2012
    ..These methodological approaches should be helpful in characterizing seizures and background EEG abnormalities not only in animal models of TSC but also in many rodent epilepsy models in general...
  31. pmc Pentylenetetrazole-induced seizures cause acute, but not chronic, mTOR pathway activation in rat
    Bo Zhang
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA
    Epilepsia 53:506-11. 2012
    ..To isolate the direct effects of seizures on the mTOR pathway, the time course and mechanisms of mTOR activation were investigated with acute seizures induced by pentylenetetrazole (PTZ), which does not lead to chronic epilepsy...
  32. pmc FGF14 regulates the intrinsic excitability of cerebellar Purkinje neurons
    Vikram G Shakkottai
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurobiol Dis 33:81-8. 2009
    ..6 expression in Purkinje neurons, and that the loss of FGF14 impairs spontaneous and repetitive firing in Purkinje neurons by altering the expression of Nav1.6 channels...
  33. ncbi request reprint Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures
    Erik J Uhlmann
    Department of Neurology, Washington University School of Medicine, St Louis Children s Hospital, St Louis, MO 63110, USA
    Ann Neurol 52:285-96. 2002
    ..Collectively, our results demonstrate that astrocyte-specific disruption of Tsc1 in mice provides a context-dependent growth advantage for astrocytes that results in abnormalities in neuronal organization and epilepsy...
  34. doi request reprint Tuberous sclerosis and epilepsy: role of astrocytes
    Michael Wong
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA
    Glia 60:1244-50. 2012
    ..Targeting these defects in astrocytes may represent a novel therapeutic strategy for epilepsy in patients with TSC...
  35. pmc Rapamycin has paradoxical effects on S6 phosphorylation in rats with and without seizures
    Linglin Chen
    School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang, China
    Epilepsia 53:2026-33. 2012
    ..In the present study, we examined this paradoxical effect of rapamycin in more detail, both in normal rats and KA-injected animals...
  36. ncbi request reprint In vivo imaging of dendritic spines during electrographic seizures
    Nicholas Rensing
    Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Ann Neurol 58:888-98. 2005
    ..Overall, our results suggest that most neocortical seizures have minimal acute effects on dendrites over several hours, but may predispose to dendritic injury under extreme conditions...
  37. ncbi request reprint Analysis of cerebrospinal fluid glial fibrillary acidic protein after seizures in children
    Christina A Gurnett
    Department of Neurology, Washington University School of Medicine, St Louis Children s Hospital, Missouri 63110 1093, USA
    Epilepsia 44:1455-8. 2003
    ....
  38. ncbi request reprint Cerebrospinal fluid neuron-specific enolase following seizures in children: role of etiology
    Michael Wong
    Department of Neurology, Washington University School of Medicine and St Louis Children s Hospital, MO 63110 1093, USA
    J Child Neurol 17:261-4. 2002
    ..Children with cryptogenic, idiopathic, or febrile seizures, including status epilepticus, are at relatively low risk for neuronal damage following seizures...
  39. pmc Mammalian target of rapamycin (mTOR) inhibition: potential for antiseizure, antiepileptogenic, and epileptostatic therapy
    Robin C C Ryther
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, Box 8111, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Curr Neurol Neurosci Rep 12:410-8. 2012
    ..Further studies are needed to assess the full potential of mTOR inhibitors for epilepsy treatment...
  40. pmc Therapeutic role of mammalian target of rapamycin (mTOR) inhibition in preventing epileptogenesis
    Sharon S McDaniel
    Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurosci Lett 497:231-9. 2011
    ....
  41. ncbi request reprint An animal model of generalized nonconvulsive status epilepticus: immediate characteristics and long-term effects
    Michael Wong
    Department of Neurology and the Center for the Study of Nervous System Injury, Washington University School of Medicine, St Louis, MO 63110, USA
    Exp Neurol 183:87-99. 2003
    ..These results indicate that an animal model of GNCSE can be generated and that even in the absence of overt neuronal damage, GNCSE may produce functional changes in neurons that alter electrical excitability of neural circuits...
  42. ncbi request reprint CNS-directed AAV2-mediated gene therapy ameliorates functional deficits in a murine model of infantile neuronal ceroid lipofuscinosis
    Megan A Griffey
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Ther 13:538-47. 2006
    ..However, higher levels or a broader distribution of PPT1 expression, or both, will be required for more complete correction of this neurodegenerative disease...
  43. doi request reprint Acute intermittent porphyria: a diagnostic challenge
    Elizabeth Anyaegbu
    Department of Pediatrics, Division of Pediatric Nephrology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Child Neurol 27:917-21. 2012
    ....
  44. ncbi request reprint Clinical neurogenetics: recent advances in the genetics of epilepsy
    Rohini Coorg
    Department of Neurology, Washington University School of Medicine, Box 8111, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Neurol Clin 31:891-913. 2013
    ..As a standardized protocol for genetic testing has not been established, individualized diagnostic approaches to epilepsy patients should be used. ..
  45. ncbi request reprint Ataxia and paroxysmal dyskinesia in mice lacking axonally transported FGF14
    Qing Wang
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis 63110, USA
    Neuron 35:25-38. 2002
    ..Together, these studies identify a novel function for FGF14 in neuronal signaling and implicate FGF14 in axonal trafficking and synaptosomal function...
  46. pmc Successive neuron loss in the thalamus and cortex in a mouse model of infantile neuronal ceroid lipofuscinosis
    Catherine Kielar
    Pediatric Storage Disorders Laboratory, Box P040, MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, King s College London, London, SE5 8AF, UK
    Neurobiol Dis 25:150-62. 2007
    ..These findings provide novel evidence for successive neuron loss within the thalamus and cortex in Ppt1-/- mice, revealing the thalamus as an important early focus of INCL pathogenesis...
  47. ncbi request reprint The utility of tuberless models of tuberous sclerosis
    Michael Wong
    Epilepsia 48:1629-30; author reply 1632-4. 2007
  48. ncbi request reprint The therapeutic efficacy of angiostatin against weakly- and highly-immunogenic 3LL tumors
    Mengfeng Li
    Department of Pathology, University of Pittsburgh, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15123, USA
    In Vivo 16:577-82. 2002
    ..Our current study evaluated whether anti-tumor immune response could also potentiate the therapuetic efficacy of another antiangiogenic drug, angiostatin...
  49. ncbi request reprint Fetal alcohol exposure impairs alveolar macrophage function via decreased glutathione availability
    Theresa W Gauthier
    Department of Pediatrics, Emory University School of Medicine, 2040 Ridgewood Atlanta, GA 30322, USA
    Pediatr Res 57:76-81. 2005
    ..These results add a new dimension to the detrimental effects of fetal alcohol exposure on the developing alveolar macrophage, raising the possibility of GSH therapy to augment premature alveolar macrophage function...

Research Grants4

  1. Mechanisms of Brain Dysfunction in Tuberous Sclerosis
    Michael Wong; Fiscal Year: 2007
    ..Since epilepsy affects approximately 1% of all people, this research has the potential to have significant impact on public health. ..
  2. Mechanisms of Brain Dysfunction in Tuberous Sclerosis
    Michael Wong; Fiscal Year: 2006
    ..Since epilepsy affects approximately 1% of all people, this research has the potential to have significant impact on public health. ..
  3. Mechanisms of Brain Dysfunction in Tuberous Sclerosis
    Michael Wong; Fiscal Year: 2010
    ..Thus, given the high prevalence of epilepsy in the general population, this research has strong relevance to public health and has the potential to have a significant positive impact in improving public health. ..