Jonathan P Wisor

Summary

Affiliation: Washington State University
Country: USA

Publications

  1. pmc Sleep slow-wave activity regulates cerebral glycolytic metabolism
    Jonathan P Wisor
    WWAMI Medical Education Program, Department of Veterinary Comparative Anatomy, Pharmacology and Physiology, Washington State University, Spokane, WA 99210 1945, USA
    Cereb Cortex 23:1978-87. 2013
  2. ncbi request reprint Sleep-active neuronal nitric oxide synthase-positive cells of the cerebral cortex: a local regulator of sleep?
    Jonathan P Wisor
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Spokane, WA 99202, USA
    Curr Top Med Chem 11:2483-9. 2011
  3. doi request reprint Cerebral microglia mediate sleep/wake and neuroinflammatory effects of methamphetamine
    Jonathan P Wisor
    Department of Veterinary Comparative Anatomy, Pharmacology and Physiology, WWAMI Medical Education Program, Washington State University, Spokane, WA 99202, USA
    Brain Behav Immun 25:767-76. 2011
  4. doi request reprint Quantification of short-term slow wave sleep homeostasis and its disruption by minocycline in the laboratory mouse
    Jonathan P Wisor
    Department of Veterinary Comparative Anatomy, Pharmacology and Physiology and WWAMI Medical Education Program, Washington State University, Spokane, WA 99210 1945, United States
    Neurosci Lett 490:165-9. 2011
  5. doi request reprint Effects of ramelteon and triazolam in a mouse genetic model of early morning awakenings
    Jonathan P Wisor
    Center for Neuroscience, SRI International, Menlo Park, CA 94025, USA
    Brain Res 1296:46-55. 2009
  6. pmc Evidence for neuroinflammatory and microglial changes in the cerebral response to sleep loss
    Jonathan P Wisor
    WWAMI Medical Education Program and Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Spokane, WA, USA
    Sleep 34:261-72. 2011
  7. doi request reprint A metabolic-transcriptional network links sleep and cellular energetics in the brain
    Jonathan P Wisor
    WWAMI Medical Education Program and Department Of Veterinary Comparative Anatomy, Pharmacology and Physiology, Washington State University, Spokane, WA, USA
    Pflugers Arch 463:15-22. 2012
  8. pmc Toll-like receptor 4 is a regulator of monocyte and electroencephalographic responses to sleep loss
    Jonathan P Wisor
    Department of Veterinary Comparative Anatomy, Pharmacology and Physiology, Sleep and Performance Research Center, Washington State University, Spokane, WA 99210 1945, USA
    Sleep 34:1335-45. 2011
  9. pmc Identification of a population of sleep-active cerebral cortex neurons
    Dmitry Gerashchenko
    Biosciences Division, SRI International, Menlo Park, CA 94025, USA
    Proc Natl Acad Sci U S A 105:10227-32. 2008
  10. pmc Thyrotropin-releasing hormone increases behavioral arousal through modulation of hypocretin/orexin neurons
    Junko Hara
    Biosciences Division, SRI International, Menlo Park, California 94025, USA
    J Neurosci 29:3705-14. 2009

Collaborators

Detail Information

Publications17

  1. pmc Sleep slow-wave activity regulates cerebral glycolytic metabolism
    Jonathan P Wisor
    WWAMI Medical Education Program, Department of Veterinary Comparative Anatomy, Pharmacology and Physiology, Washington State University, Spokane, WA 99210 1945, USA
    Cereb Cortex 23:1978-87. 2013
    ..We conclude that cerebral SWA promotes a decline in the rate of glycolysis in the cerebral cortex. These results demonstrate a cellular energetic function for sleep SWA, which may contribute to its restorative effects on brain function. ..
  2. ncbi request reprint Sleep-active neuronal nitric oxide synthase-positive cells of the cerebral cortex: a local regulator of sleep?
    Jonathan P Wisor
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Spokane, WA 99202, USA
    Curr Top Med Chem 11:2483-9. 2011
    ..Finally, we raise some critical unanswered questions about the role of this population in local sleep regulation within the cerebral cortex and describe some experimental approaches that might be used to address those questions...
  3. doi request reprint Cerebral microglia mediate sleep/wake and neuroinflammatory effects of methamphetamine
    Jonathan P Wisor
    Department of Veterinary Comparative Anatomy, Pharmacology and Physiology, WWAMI Medical Education Program, Washington State University, Spokane, WA 99202, USA
    Brain Behav Immun 25:767-76. 2011
    ..We propose that the effects of D-METH on sleep/wake cycles are mediated in part by actions on microglia, including possibly nNOS activity and cytokine synthesis...
  4. doi request reprint Quantification of short-term slow wave sleep homeostasis and its disruption by minocycline in the laboratory mouse
    Jonathan P Wisor
    Department of Veterinary Comparative Anatomy, Pharmacology and Physiology and WWAMI Medical Education Program, Washington State University, Spokane, WA 99210 1945, United States
    Neurosci Lett 490:165-9. 2011
    ..These data demonstrate that minocycline attenuates SWA dynamics in spontaneous sleep. Inflammatory events in the brain may underlie, in part, wakefulness-induced changes in the sleep electroencephalogram...
  5. doi request reprint Effects of ramelteon and triazolam in a mouse genetic model of early morning awakenings
    Jonathan P Wisor
    Center for Neuroscience, SRI International, Menlo Park, CA 94025, USA
    Brain Res 1296:46-55. 2009
    ..Thus, ramelteon and triazolam caused a shift in the timing of wheel-running rhythms in an LD cycle but did so without long-term effects on the functioning of the circadian clock...
  6. pmc Evidence for neuroinflammatory and microglial changes in the cerebral response to sleep loss
    Jonathan P Wisor
    WWAMI Medical Education Program and Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Spokane, WA, USA
    Sleep 34:261-72. 2011
    ..We assessed the modulation of the electroencephalographic and molecular responses to sleep deprivation (S-DEP) by minocycline, a compound that attenuates microglial activation occurring in association with neuroinflammatory events...
  7. doi request reprint A metabolic-transcriptional network links sleep and cellular energetics in the brain
    Jonathan P Wisor
    WWAMI Medical Education Program and Department Of Veterinary Comparative Anatomy, Pharmacology and Physiology, Washington State University, Spokane, WA, USA
    Pflugers Arch 463:15-22. 2012
    ..Studies of this regulatory relationship may offer insights into the function of sleep at the cellular level...
  8. pmc Toll-like receptor 4 is a regulator of monocyte and electroencephalographic responses to sleep loss
    Jonathan P Wisor
    Department of Veterinary Comparative Anatomy, Pharmacology and Physiology, Sleep and Performance Research Center, Washington State University, Spokane, WA 99210 1945, USA
    Sleep 34:1335-45. 2011
    ..Here we describe the baseline electroencephalographic sleep phenotype and the biochemical and electroencephalographic responses to sleep loss in TLR4-deficient mice...
  9. pmc Identification of a population of sleep-active cerebral cortex neurons
    Dmitry Gerashchenko
    Biosciences Division, SRI International, Menlo Park, CA 94025, USA
    Proc Natl Acad Sci U S A 105:10227-32. 2008
    ....
  10. pmc Thyrotropin-releasing hormone increases behavioral arousal through modulation of hypocretin/orexin neurons
    Junko Hara
    Biosciences Division, SRI International, Menlo Park, California 94025, USA
    J Neurosci 29:3705-14. 2009
    ..Together, these results are consistent with the hypothesis that TRH modulates behavioral arousal, in part, through the Hcrt system...
  11. pmc Sleep deprivation effects on circadian clock gene expression in the cerebral cortex parallel electroencephalographic differences among mouse strains
    Jonathan P Wisor
    Biosciences Division, SRI International, Menlo Park, California 94025, USA
    J Neurosci 28:7193-201. 2008
    ....
  12. doi request reprint Interleukin 1 receptor contributes to methamphetamine- and sleep deprivation-induced hypersomnolence
    Michelle A Schmidt
    WWAMI Medical Education Program and Department Of Veterinary Comparative Anatomy, Pharmacology and Physiology, Washington State University, Spokane, WA 99202, United States
    Neurosci Lett 513:209-13. 2012
    ..These data demonstrate that IL1R activation contributes to hypersomnolence that occurs after sleep loss, whether that sleep loss is triggered pharmacologically by methamphetamine or through behavioral sleep deprivation...
  13. ncbi request reprint Molecular genetic advances in sleep research and their relevance to sleep medicine
    Jonathan P Wisor
    Molecular Neurobiology Laboratory, Biosciences Division, SRI International, Menlo Park, CA 94025, USA
    Sleep 28:357-67. 2005
    ....
  14. pmc Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia
    Xinmin Xie
    Biosciences Division, SRI International, Menlo Park, California 94025, USA
    J Clin Invest 118:2471-81. 2008
    ..These results establish what is, to our knowledge, a novel interaction between the N/OFQ and Hcrt systems in which the corticotropin-releasing factor and N/OFQ systems coordinately modulate the Hcrt neurons to regulate SIA...
  15. pmc Gene expression in the rat brain during prostaglandin D2 and adenosinergically-induced sleep
    Akira Terao
    Biosciences Division, SRI International, Menlo Park, California 94025, USA
    J Neurochem 105:1480-98. 2008
    ..However, gene expression induced in the brain after PGD2 or CGS21680 treatment was distinct from that described during RS after SD and apparently involves glial cell gene activation and signaling pathways in neural-immune interactions...
  16. pmc A novel quantitative trait locus on mouse chromosome 18, "era1," modifies the entrainment of circadian rhythms
    Jonathan P Wisor
    Molecular Neurobiology Laboratory, SRI International, Menlo Park, CA 94025, USA
    Sleep 30:1255-63. 2007
    ..We now describe a novel circadian rhythm phenotype, and a locus influencing that phenotype, in a segregating population of mice...
  17. pmc Molecular and anatomical signatures of sleep deprivation in the mouse brain
    Carol L Thompson
    Allen Institute for Brain Science Seattle, WA, USA
    Front Neurosci 4:165. 2010
    ..These data provide a characterization of the anatomical and cell type-specific signatures of SD on neuronal activity and gene expression that may account for the associated cognitive and behavioral effects...