Michael Welch

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc STAT1-deficient mice spontaneously develop estrogen receptor α-positive luminal mammary carcinomas
    Szeman Ruby Chan
    Department of Pathology and Immunology, Washington University School of Medicine, 425 S, Euclid Avenue, St, Louis, MO 63110, USA
    Breast Cancer Res 14:R16. 2012
  2. ncbi request reprint [Tc(CO)(3)](+) chemistry: a promising new concept for SPECT? Against
    Michael J Welch
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Eur J Nucl Med Mol Imaging 30:1302-4. 2003
  3. ncbi request reprint Potential and pitfalls of therapy with alpha-particles
    Michael J Welch
    Washington University School of Medicine, St Louis, MO 63110, USA
    J Nucl Med 46:1254-5. 2005
  4. pmc Autoradiographic and small-animal PET comparisons between (18)F-FMISO, (18)F-FDG, (18)F-FLT and the hypoxic selective (64)Cu-ATSM in a rodent model of cancer
    Carmen S Dence
    Mallinckrodt Institute of Radiology, The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 35:713-20. 2008
  5. ncbi request reprint Delineation of hypoxia in canine myocardium using PET and copper(II)-diacetyl-bis(N(4)-methylthiosemicarbazone)
    Jason S Lewis
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 43:1557-69. 2002
  6. ncbi request reprint Investigation into 64Cu-labeled Bis(selenosemicarbazone) and Bis(thiosemicarbazone) complexes as hypoxia imaging agents
    Paul McQuade
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 32:147-56. 2005
  7. ncbi request reprint MicroPET assessment of androgenic control of glucose and acetate uptake in the rat prostate and a prostate cancer tumor model
    Nobuyuki Oyama
    Division of Radiological Sciences and the Alvin J Siteman Cancer Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, Missouri, USA
    Nucl Med Biol 29:783-90. 2002
  8. ncbi request reprint Assessment of myocardial metabolism in diabetic rats using small-animal PET: a feasibility study
    Michael J Welch
    The Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 47:689-97. 2006
  9. ncbi request reprint Minimally invasive method of determining blood input function from PET images in rodents
    Joonyoung Kim
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 47:330-6. 2006
  10. ncbi request reprint 11C-acetate PET imaging of prostate cancer: detection of recurrent disease at PSA relapse
    Nobuyuki Oyama
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Boulevard, St Louis, MO 63110, USA
    J Nucl Med 44:549-55. 2003

Research Grants

Detail Information

Publications79

  1. pmc STAT1-deficient mice spontaneously develop estrogen receptor α-positive luminal mammary carcinomas
    Szeman Ruby Chan
    Department of Pathology and Immunology, Washington University School of Medicine, 425 S, Euclid Avenue, St, Louis, MO 63110, USA
    Breast Cancer Res 14:R16. 2012
    ..Herein, we show that a subset of human breast cancers display reduced STAT1 expression and that mice lacking STAT1 surprisingly develop ERα+/PR+ mammary tumors...
  2. ncbi request reprint [Tc(CO)(3)](+) chemistry: a promising new concept for SPECT? Against
    Michael J Welch
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Eur J Nucl Med Mol Imaging 30:1302-4. 2003
  3. ncbi request reprint Potential and pitfalls of therapy with alpha-particles
    Michael J Welch
    Washington University School of Medicine, St Louis, MO 63110, USA
    J Nucl Med 46:1254-5. 2005
  4. pmc Autoradiographic and small-animal PET comparisons between (18)F-FMISO, (18)F-FDG, (18)F-FLT and the hypoxic selective (64)Cu-ATSM in a rodent model of cancer
    Carmen S Dence
    Mallinckrodt Institute of Radiology, The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 35:713-20. 2008
    ....
  5. ncbi request reprint Delineation of hypoxia in canine myocardium using PET and copper(II)-diacetyl-bis(N(4)-methylthiosemicarbazone)
    Jason S Lewis
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 43:1557-69. 2002
    ..Using canine models of hypoxic myocardium, we report our findings on *Cu-ATSM PET (*Cu is defined as either (60)Cu, (61)Cu, or (64)Cu) for the delineation of ischemic and hypoxic myocardium...
  6. ncbi request reprint Investigation into 64Cu-labeled Bis(selenosemicarbazone) and Bis(thiosemicarbazone) complexes as hypoxia imaging agents
    Paul McQuade
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 32:147-56. 2005
    ..Two approaches are to increase alkylation or to replace the sulfur atoms with selenium, resulting in the formation of selenosemicarbazones...
  7. ncbi request reprint MicroPET assessment of androgenic control of glucose and acetate uptake in the rat prostate and a prostate cancer tumor model
    Nobuyuki Oyama
    Division of Radiological Sciences and the Alvin J Siteman Cancer Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, Missouri, USA
    Nucl Med Biol 29:783-90. 2002
    ..Further studies are needed to clarify the reason for the insensitivity of 11C-acetate for measuring metabolic change in prostate tumor...
  8. ncbi request reprint Assessment of myocardial metabolism in diabetic rats using small-animal PET: a feasibility study
    Michael J Welch
    The Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 47:689-97. 2006
    ..This feasibility study was undertaken to determine whether kinetic modeling in conjunction with small-animal PET could noninvasively quantify alterations in myocardial perfusion and substrate metabolism in rats...
  9. ncbi request reprint Minimally invasive method of determining blood input function from PET images in rodents
    Joonyoung Kim
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 47:330-6. 2006
    ..A factor analysis (FA) technique for extracting the blood input function and myocardial time-activity curve from dynamic small-animal PET images of the rodent heart has been implemented to overcome these limitations...
  10. ncbi request reprint 11C-acetate PET imaging of prostate cancer: detection of recurrent disease at PSA relapse
    Nobuyuki Oyama
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Boulevard, St Louis, MO 63110, USA
    J Nucl Med 44:549-55. 2003
    ..We also compared the reliability of AC PET in detecting recurrent prostate cancer with that of PET with (18)F-FDG...
  11. ncbi request reprint Monitoring of therapy in androgen-dependent prostate tumor model by measuring tumor proliferation
    Nobuyuki Oyama
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Nucl Med 45:519-25. 2004
    ..This study was undertaken to determine whether (18)F-FLT is useful in the detection of prostate cancer as well as monitoring therapeutic effects in a human tumor model...
  12. ncbi request reprint Preparation, biodistribution, and small animal PET of 45Ti-transferrin
    Amy L Vavere
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 46:683-90. 2005
    ..Investigation of 45Ti-transferrin was pursued to provide insight into the mechanism of action of titanocene dichloride, a chemotherapeutic agent currently in clinical trials...
  13. ncbi request reprint Imaging of melanoma using 64Cu- and 86Y-DOTA-ReCCMSH(Arg11), a cyclized peptide analogue of alpha-MSH
    Paul McQuade
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology and the Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Med Chem 48:2985-92. 2005
    ..The data obtained suggests that DOTA-ReCCMSH(Arg(11)), when labeled with beta(+)-emitting radionuclides, has the potential for early detection of malignant melanoma by exploiting the sensitivity and high resolution of PET...
  14. pmc [18F]- and [11C]-labeled N-benzyl-isatin sulfonamide analogues as PET tracers for apoptosis: synthesis, radiolabeling mechanism, and in vivo imaging study of apoptosis in Fas-treated mice using [11C]WC-98
    Dong Zhou
    Division of Radiological Sciences, Washington University School of Medicine, Campus Box 8225 510 S Kingshighway Blvd St Louis, Missouri 63110, USA
    Org Biomol Chem 7:1337-48. 2009
    ..Therefore, this study provides a useful method for radio-synthesis of isatin derivative radiotracers for PET and SPECT studies, and [11C] 4 is a potential PET radiotracer for noninvasive imaging of apoptosis...
  15. pmc (64)Cu-labeled CB-TE2A and diamsar-conjugated RGD peptide analogs for targeting angiogenesis: comparison of their biological activity
    Lihui Wei
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 36:277-85. 2009
    ..In this study, the chelators CB-TE2A and diamsar were conjugated to cyclic RGDyK and RGDfD and the biological properties of (64)Cu-labeled peptides were compared...
  16. ncbi request reprint In vivo evaluation of pretargeted 64Cu for tumor imaging and therapy
    Michael R Lewis
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Road, St Louis, MO 63110, USA
    J Nucl Med 44:1284-92. 2003
    ..The aim of this study was to compare pretargeting to a conventionally labeled antibody for tumor targeting of the intermediate-lived radionuclide (64)Cu, which has shown promise for PET imaging and radioimmunotherapy of cancer...
  17. ncbi request reprint Synthesis and evaluation of a bromine-76-labeled PPARgamma antagonist 2-bromo-5-nitro-N-phenylbenzamide
    Hsiaoju Lee
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 33:847-54. 2006
    ..We are currently exploring second generation analogs of these lead compounds for the development of radiolabeled antagonists of the PPARgamma receptor...
  18. pmc Gallium-68-labeled DOTA-rhenium-cyclized alpha-melanocyte-stimulating hormone analog for imaging of malignant melanoma
    Lihui Wei
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 34:945-53. 2007
    ..This encouraged us to investigate DOTA-ReCCMSH(Arg11) labeled with another beta+-emitting radionuclide, 68Ga...
  19. pmc The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus
    Brian N Finck
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 109:121-30. 2002
    ....
  20. ncbi request reprint Small-animal PET of tumor angiogenesis using a (76)Br-labeled human recombinant antibody fragment to the ED-B domain of fibronectin
    Raffaella Rossin
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 48:1172-9. 2007
    ..Biodistribution and imaging studies were performed in human teratoma-bearing mice for up to 48 h after injection...
  21. ncbi request reprint Investigations into tumor accumulation and peroxisome proliferator activated receptor binding by F-18 and C-11 fatty acids
    Stephanie D Jonson
    Division of Radiological Sciences, Washington University School of Medicine, 510 South Kingshighway, St Louis, MO 63110, USA
    Nucl Med Biol 29:211-6. 2002
    ..11C]Acetate showed better tumor accumulation than PAA or FPAA. The aromatic fatty acids did not directly bind PPARalpha as confirmed by a biodistribution study of PAA in PPARalpha -/- mice...
  22. ncbi request reprint Production, processing and small animal PET imaging of titanium-45
    Amy L Vavere
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 32:117-22. 2005
    ..Titanium-45 was prepared as a tool for elucidation of the mechanism of action of titanium anticancer drugs in vivo using microPET imaging...
  23. doi request reprint An imaging comparison of 64Cu-ATSM and 60Cu-ATSM in cancer of the uterine cervix
    Jason S Lewis
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology, St Louis, Missouri, USA
    J Nucl Med 49:1177-82. 2008
    ....
  24. ncbi request reprint In vivo evaluation of copper-64-labeled monooxo-tetraazamacrocyclic ligands
    Xiankai Sun
    Mallinckrodt Institute of Radiology, School of Medicine, Washington University, St Louis, MO 63110, USA
    Nucl Med Biol 31:1051-9. 2004
    ..However, the data presented here suggest that neutral or negatively charged Cu(II) complexes of tetraazamacrocyclic ligands with a cyclam backbone (tetradecane) are optimal for copper radiopharmaceutical applications...
  25. ncbi request reprint Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol
    Jeongsoo Yoo
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, Campus Box 8225, 510 South Kingshighway Boulevard, St Louis, Missouri 63110, USA
    J Med Chem 48:6366-78. 2005
    ..Based on our results, imaging of ERalpha can be done effectively with [18F]FES, but imaging of ERbeta will likely require agents with more optimized ERbeta binding affinity and selectivity than [18F]FEDNP...
  26. pmc Evaluation of a bromine-76-labeled progestin 16alpha,17alpha-dioxolane for breast tumor imaging and radiotherapy: in vivo biodistribution and metabolic stability studies
    Dong Zhou
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 35:655-63. 2008
    ..Progesterone receptors (PRs) are present in many breast tumors, and their levels are increased by certain endocrine therapies. They can be used as targets for diagnostic imaging and radiotherapy...
  27. ncbi request reprint Copper-64-pyruvaldehyde-bis(N(4)-methylthiosemicarbazone) for the prevention of tumor growth at wound sites following laparoscopic surgery: monitoring therapy response with microPET and magnetic resonance imaging
    Jason S Lewis
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 62:445-9. 2002
    ..001). This study demonstrates the therapeutic potential of (64)Cu-PTSM in inhibiting cancer cell implantation and growth at doses well below the maximum tolerated dose, with no signs of toxicity to the hamsters...
  28. ncbi request reprint Comparison of molecular markers of hypoxia and imaging with (60)Cu-ATSM in cancer of the uterine cervix
    Perry W Grigsby
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Imaging Biol 9:278-83. 2007
    ..To determine if hypoxia-related molecular markers are associated with (60)Cu labeled diacetyl-bis (N4 -methylthiosemicarbazone); ((60)Cu-ATSM) imaging of tumor hypoxia in cervical cancer...
  29. ncbi request reprint The application of maximum likelihood factor analysis (MLFA) with uniqueness constraints on dynamic cardiac microPET data
    Yi Su
    Division of Radiological Science, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Phys Med Biol 52:2313-34. 2007
    ..The MLFA algorithm with an accompanying graphical user interface (GUI) is available at http://www.chempet.wustl.edu/faculty/shoghik...
  30. ncbi request reprint Fluorine-18-labeled benzamide analogues for imaging the sigma2 receptor status of solid tumors with positron emission tomography
    Zhude Tu
    Division of Radiological Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Med Chem 50:3194-204. 2007
    ....
  31. ncbi request reprint 18F-fluoroacetate: a potential acetate analog for prostate tumor imaging--in vivo evaluation of 18F-fluoroacetate versus 11C-acetate
    Datta E Ponde
    Mallinckrodt Institute of Radiology and 2Alvin J Siteman Cancer Center, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Nucl Med 48:420-8. 2007
    ..18)F-Fluoroacetate ((18)F-FAC) is an analog of acetate with a longer radioactive half-life ((18)F = 110 min). This study was undertaken to assess the potential usefulness of (18)F-FAC as a prostate tumor imaging agent...
  32. ncbi request reprint Synthesis and biologic evaluation of 64Cu-labeled rhenium-cyclized alpha-MSH peptide analog using a cross-bridged cyclam chelator
    Lihui Wei
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology and the Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 48:64-72. 2007
    ..The goal of this study was to conjugate CBTE2A to the alpha-MSH targeting ReCCMSH(Arg(11)) peptide for labeling to (64)Cu and to investigate whether the increased metal-chelate stability with CBTE2A would improve imaging quality...
  33. doi request reprint Radiochemical synthesis, rodent biodistribution and tumor uptake, and dosimetry calculations of [¹¹C] methylated LY2181308
    Carmen S Dence
    Department of Radiology, Division of Radiological Sciences, Washington University School of Medicine, 510 S Kingshighway Blvd, Saint Louis, MO 63110, USA
    Mol Imaging Biol 12:608-15. 2010
    ....
  34. pmc Hybrid image and blood sampling input function for quantification of small animal dynamic PET data
    Kooresh I Shoghi
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 34:989-94. 2007
    ..The results highlight limitations in using bsPTAC. The HIBS method, however, yields consistent results, and thus, is a substitute for bsPTAC...
  35. doi request reprint Molecular imaging of atherosclerotic plaque with (64)Cu-labeled natriuretic peptide and PET
    Yongjian Liu
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 51:85-91. 2010
    ....
  36. doi request reprint The advantages of nanoparticles for PET
    Michael J Welch
    Department of Radiology, Washington University, Saint Louis, Missouri 63110, USA
    J Nucl Med 50:1743-6. 2009
    ..Organic and inorganic nanostructures are included. Nanoprobes for PET of angiogenesis and cancer are highlighted...
  37. pmc In vivo metabolic phenotyping of myocardial substrate metabolism in rodents: differential efficacy of metformin and rosiglitazone monotherapy
    Kooresh I Shoghi
    Mallinckrodt Institute of Radiology, Division of Radiological Sciences, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Cardiovasc Imaging 2:373-81. 2009
    ..We aimed to assess noninvasively the efficacy of metformin and rosiglitazone monotherapy in normalizing myocardial substrate metabolism in an animal model of type 2 diabetes mellitus...
  38. pmc Bromination from the macroscopic level to the tracer radiochemical level: (76)Br radiolabeling of aromatic compounds via electrophilic substitution
    Dong Zhou
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Bioconjug Chem 20:808-16. 2009
    ....
  39. pmc Nuclear receptors PPARbeta/delta and PPARalpha direct distinct metabolic regulatory programs in the mouse heart
    Eileen M Burkart
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 117:3930-9. 2007
    ....
  40. ncbi request reprint Enhancing targeted radiotherapy by copper(II)diacetyl- bis(N4-methylthiosemicarbazone) using 2-deoxy-D-glucose
    Rebecca L Aft
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 63:5496-504. 2003
    ..Our data indicate that the strategy of combining tumor-specific cytotoxic agents that function by differing mechanisms can result in an effective, selective, tumor-specific cell death with minimal effect on the host...
  41. pmc Time course of alterations in myocardial glucose utilization in the Zucker diabetic fatty rat with correlation to gene expression of glucose transporters: a small-animal PET investigation
    Kooresh I Shoghi
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 49:1320-7. 2008
    ....
  42. doi request reprint PET-based estradiol challenge as a predictive biomarker of response to endocrine therapy in women with estrogen-receptor-positive breast cancer
    Farrokh Dehdashti
    Division of Nuclear Medicine, Edward Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
    Breast Cancer Res Treat 113:509-17. 2009
    ....
  43. doi request reprint Assessing tumor hypoxia in cervical cancer by PET with 60Cu-labeled diacetyl-bis(N4-methylthiosemicarbazone)
    Farrokh Dehdashti
    Division of Nuclear Medicine, Edward Mallinckrodt Institute of Radiology, St Louis, Missouri 63110, USA
    J Nucl Med 49:201-5. 2008
    ..9). Pretherapy (60)Cu-ATSM PET provides clinically relevant information about tumor oxygenation that is predictive of outcome in patients with cervical cancer...
  44. ncbi request reprint In vivo imaging of 64Cu-labeled polymer nanoparticles targeted to the lung endothelium
    Raffaella Rossin
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    J Nucl Med 49:103-11. 2008
    ..We have evaluated the use of (64)Cu and PET to noninvasively image the lung uptake and distribution of NPs coated with an anti-ICAM antibody...
  45. ncbi request reprint Monitoring the effect of mild hyperthermia on tumour hypoxia by Cu-ATSM PET scanning
    Robert J Myerson
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Hyperthermia 22:93-115. 2006
    ..The purpose of the present report is to establish methodology that will allow one to use Cu-ATSM PET scanning to detect the impact of hyperthermia on tumour physiology in as little time as possible...
  46. ncbi request reprint Radiolabeling and in vivo behavior of copper-64-labeled cross-bridged cyclam ligands
    Xiankai Sun
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Med Chem 45:469-77. 2002
    ..A bifunctional chelator of 2 is a significant candidate for labeling copper radionuclides to biological molecules for diagnostic imaging and targeted radiotherapy...
  47. ncbi request reprint Robotic preparation of Sodium Acetate C 11 Injection for use in clinical PET
    Stephen M Moerlein
    The Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, Saint Louis, MO 63110, USA
    Nucl Med Biol 29:613-21. 2002
    ..Moreover, its design flexibility permits synthesis of additional (11)C- or (18)F-labeled PET tracers within the same shielded hot cell...
  48. ncbi request reprint In vivo behavior of copper-64-labeled methanephosphonate tetraaza macrocyclic ligands
    Xiankai Sun
    The Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Biol Inorg Chem 8:217-25. 2003
    ..Metabolism studies of (64)Cu-DO2P in rat liver suggest that the DO2P ligand may be used as a bifunctional chelator for copper radionuclides in radiodiagnostic or radiotherapeutic studies...
  49. ncbi request reprint Positron tomographic assessment of androgen receptors in prostatic carcinoma
    Farrokh Dehdashti
    The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO, 63110, USA
    Eur J Nucl Med Mol Imaging 32:344-50. 2005
    ....
  50. ncbi request reprint Measurement of input functions in rodents: challenges and solutions
    Richard Laforest
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 32:679-85. 2005
    ..To be able to implement these approaches in rodent models of disease using small-animal PET (microPET), it is imperative that the input function is measured accurately...
  51. ncbi request reprint Assessment of myocardial blood flow using 15O-water and 1-11C-acetate in rats with small-animal PET
    Pilar Herrero
    Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 47:477-85. 2006
    ..This feasibility study was undertaken to determine whether myocardial blood flow (MBF, mL/g/min) could be quantified noninvasively in small rodents using microPET and 15O-water or 1-11C-acetate...
  52. ncbi request reprint Assessing tumor hypoxia in cervical cancer by positron emission tomography with 60Cu-ATSM: relationship to therapeutic response-a preliminary report
    Farrokh Dehdashti
    Division of Nuclear Medicine, Edward Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 55:1233-8. 2003
    ..We have investigated whether pretreatment tumor hypoxia assessed by positron emission tomography (PET) with Cu-60 diacetyl-bis(N(4)-methylthiosemicarbazone) ((60)Cu-ATSM) predicts responsiveness to subsequent therapy in cervical cancer...
  53. ncbi request reprint In vivo skeletal imaging of 18F-fluoride with positron emission tomography reveals damage- and time-dependent responses to fatigue loading in the rat ulna
    Matthew J Silva
    Department of Orthopaedic Surgery, Washington University School of Medicine, 1 Barnes Jewish Hospital Plaza, Suite 11300 WP, St Louis, MO 63110, USA
    Bone 39:229-36. 2006
    ....
  54. ncbi request reprint Three-dimensional maximum a posteriori (MAP) imaging with radiopharmaceuticals labeled with three Cu radionuclides
    Ananya Ruangma
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 33:217-26. 2006
    ....
  55. ncbi request reprint MicroPET imaging of a gastrin-releasing peptide receptor-positive tumor in a mouse model of human prostate cancer using a 64Cu-labeled bombesin analogue
    Buck E Rogers
    Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Bioconjug Chem 14:756-63. 2003
    ..This study demonstrates that (64)Cu-DOTA-Aoc-BN(7-14) can be used to detect GRPR-positive tumors by PET imaging...
  56. ncbi request reprint Evaluation of 64Cu- and 125I-radiolabeled bitistatin as potential agents for targeting alpha v beta 3 integrins in tumor angiogenesis
    Paul McQuade
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Bioconjug Chem 15:988-96. 2004
    ..Radiolabeled ligands of this type may be useful in the targeting of tumor angiogenesis, but the choice of radiolabeling approach has a significant impact on the in vivo properties of the radioligand...
  57. ncbi request reprint Impact of reversible trapping of tracer and the presence of blood metabolites on measurements of myocardial glucose utilization performed by PET and 18F-fluorodeoxyglucose using the Patlak method
    Pilar Herrero
    Division of Radiological Sciences, Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucl Med Biol 31:883-92. 2004
    ..Although further studies will be required to elucidate the reason for the egress of tracer from myocardium, not accounting for it will result in erroneous estimates of MGU...
  58. ncbi request reprint In vivo assessment of tumor hypoxia in lung cancer with 60Cu-ATSM
    Farrokh Dehdashti
    Division of Nuclear Medicine, Edward Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
    Eur J Nucl Med Mol Imaging 30:844-50. 2003
    ..04; P=0.9). (60)Cu-ATSM-PET can be readily performed in patients with NSCLC and the tumor uptake of (60)Cu-ATSM reveals clinically unique information about tumor oxygenation that is predictive of tumor response to therapy...
  59. ncbi request reprint 64Cu-labeled folate-conjugated shell cross-linked nanoparticles for tumor imaging and radiotherapy: synthesis, radiolabeling, and biologic evaluation
    Raffaella Rossin
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 46:1210-8. 2005
    ..The purpose of this study was to evaluate 64Cu-radiolabeled folate-conjugated shell cross-linked nanoparticles (SCKs) as candidate agents to shuttle radionuclides and drugs into tumors overexpressing the folate receptor (FR)...
  60. ncbi request reprint A potential Dubin-Johnson syndrome imaging agent: synthesis, biodistribution, and microPET imaging
    Jeongsoo Yoo
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St Louis, MO 63110, USA
    Mol Imaging 4:18-29. 2005
    ..The significant difference between the biodistribution data and microPET images of the normal and TR(-) rats demonstrates that this new (64)Cu complex may allow noninvasive diagnosis of DJS in humans...
  61. ncbi request reprint Comparative in vivo behavior studies of cyclen-based copper-64 complexes: regioselective synthesis, X-ray structure, radiochemistry, log P, and biodistribution
    Jeongsoo Yoo
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, Campus Box 8225, 510 South Kingshighway Boulevard, St Louis, Missouri 63110, USA
    J Med Chem 47:6625-37. 2004
    ..Trans-substituted complexes structure isomers Cu-3 and Cu-4 showed better clearance and lower retention from all organs than their cis-counterparts Cu-5 and Cu-6...
  62. ncbi request reprint Synthesis, radiolabeling, and in vivo evaluation of an 18F-labeled isatin analog for imaging caspase-3 activation in apoptosis
    Dong Zhou
    Division of Radiological Sciences, Washington University School of Medicine, 510 South Kingshighway Boulevard, St Louis, MO 63110, USA
    Bioorg Med Chem Lett 16:5041-6. 2006
    ..These data suggest that [(18)F]WC-II-89 is a potential radiotracer for imaging caspase-3 activation in tissues undergoing apoptosis...
  63. ncbi request reprint Design and synthesis of functionalized cyclopentadienyl tricarbonylmetal complexes for technetium-94m PET imaging of estrogen receptors
    Heather M Bigott
    Division of Radiological Sciences, Washington University School of Medicine, 510 S Kingshighway, Campus Box 8225, St Louis, Missouri 63110, USA
    Bioconjug Chem 16:255-64. 2005
    ..This further demonstrates the versatility of the double ligand transfer reaction and indicates that the synthesis of technetium and rhenium radiolabeled agents for breast tumor imaging and therapy is also likely to be successful...
  64. ncbi request reprint Update on PET radiopharmaceuticals: life beyond fluorodeoxyglucose
    Chyng Yann Shiue
    Department of Radiology, University of Pennsylvania School of Medicine, 1 Silverstein, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Radiol Clin North Am 42:1033-53, viii. 2004
    ..This article lists some of the radiotracers that are available for PET studies in neuroscience and oncology. The prospects for developing other new radiotracers for imaging other organ diseases also seem to be promising...
  65. ncbi request reprint Molecular (functional) imaging for radiotherapy applications: an RTOG symposium
    J D Chapman
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Radiat Oncol Biol Phys 55:294-301. 2003
  66. ncbi request reprint Preparation of 66Ga- and 68Ga-labeled Ga(III)-deferoxamine-folate as potential folate-receptor-targeted PET radiopharmaceuticals
    Carla J Mathias
    Department of Industrial and Physical Pharmacy, Purdue University, West, Lafayette, IN, USA
    Nucl Med Biol 30:725-31. 2003
    ..The autoradiographic images of 1 mm tumor sections demonstrate the gross heterogeneity of the KB cell tumor xenograft, as well as subtle disparity in the regional accumulation of the two radiotracers...
  67. ncbi request reprint Intra-tumoral distribution of (64)Cu-ATSM: a comparison study with FDG
    Atsushi Obata
    Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo, 606 8151 Kyoto, Japan
    Nucl Med Biol 30:529-34. 2003
    ..18)F]FDG was distributed more widely with highest levels in the inner regions where pre-necrotic cells were mainly observed. (64)Cu-ATSM appears to be useful for the detection of hypoxic but active tumor cell regions in vivo...
  68. ncbi request reprint Synthesis and in vivo evaluation of 2 high-affinity 76Br-labeled sigma2-receptor ligands
    Douglas J Rowland
    Department of Radiology, Washington University in St Louis, Saint Louis, Missouri, USA
    J Nucl Med 47:1041-8. 2006
    ..These are 5-bromo-N-(4-(3,4-dihydro-6,7-dimethoxyisoquinolin-2(1H)-yl)butyl)-2,3-dimethoxybenzamide (compound (1)) and 5-bromo-N-(2-(3,4-dihydro-6,7-dimethoxyisoquinolin-2(1H)-yl)ethyl)-2-methoxybenzamide (compound (2))...
  69. ncbi request reprint Basic characterization of 64Cu-ATSM as a radiotherapy agent
    Atsushi Obata
    Biomedical Imaging Research Center, University of Fukui, Matsuoka, Fukui 910 1193, Japan
    Nucl Med Biol 32:21-8. 2005
    ..These data allow us to postulate that 64Cu-ATSM will be able to attack the hypoxic tumor cells directly, as well as potentially affecting the peripheral nonhypoxic regions indirectly by the beta- particle decay of 64Cu...
  70. ncbi request reprint Automatic synthesis of 16 alpha-[(18)F]fluoro-17beta-estradiol using a cassette-type [(18)F]fluorodeoxyglucose synthesizer
    Tetsuya Mori
    Biomedical Imaging Research Center, University of Fukui, Matsuoka, Fukui 910 1193, Japan
    Nucl Med Biol 33:281-6. 2006
    ..The final product was stable for more than 6 h in saline containing sodium ascorbate. This new preparation system enables us to produce [(18)F]FES safe for clinical use with high and reproducible yield...
  71. ncbi request reprint Synthesis and biological evaluation of a fluorine-18-labeled nonsteroidal androgen receptor antagonist, N-(3-[18F]fluoro-4-nitronaphthyl)-cis-5-norbornene-endo-2,3-dicarboxylic imide
    Ephraim E Parent
    Department of Chemistry, University of Illinois, Urbana, IL 61801, USA
    Nucl Med Biol 33:615-24. 2006
    ....
  72. ncbi request reprint Synthesis and biological evaluation of a nonsteroidal bromine-76-labeled androgen receptor ligand 3-[76Br]bromo-hydroxyflutamide
    Ephraim E Parent
    Department of Chemistry, University of Illinois, Urbana, IL 61801, USA
    Nucl Med Biol 33:705-13. 2006
    ..In our efforts to develop a nonsteroidal AR-specific imaging agent, we synthesized (+/-)-3-[(76)Br]bromo-hydroxyflutamide ((76)Br-), an analog of hydroxyflutamide, the active metabolite of the AR antagonist ligand flutamide...
  73. ncbi request reprint Synthesis and biological evaluation of [18F]bicalutamide, 4-[76Br]bromobicalutamide, and 4-[76Br]bromo-thiobicalutamide as non-steroidal androgens for prostate cancer imaging
    Ephraim E Parent
    Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, Illinois 61801, USA
    J Med Chem 50:1028-40. 2007
    ..Androgen target tissue uptake was evident in castrated adult male rats; however, in DES-treated, AR-positive, tumor-bearing male mice, tumor uptake was low...
  74. ncbi request reprint New approach to fully automated synthesis of sodium [18F]fluoroacetate -- a simple and fast method using a commercial synthesizer
    Li Quan Sun
    Biomedical Imaging Research Center, University of Fukui, Yoshida, Japan
    Nucl Med Biol 33:153-8. 2006
    ..2 +/- 4.8%, decay corrected). The radiochemical purity of sodium [(18)F]fluoroacetate was greater than 99%...
  75. pmc Synthesis and biodistribution of fluorine-18-labeled fluorocyclofenils for imaging the estrogen receptor
    Jai Woong Seo
    Department of Chemistry, Inha University, Inchon 402 751, Korea
    Nucl Med Biol 34:383-90. 2007
    ....
  76. ncbi request reprint Cell line-dependent differences in uptake and retention of the hypoxia-selective nuclear imaging agent Cu-ATSM
    Paul Burgman
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Nucl Med Biol 32:623-30. 2005
    ..In this study, we examined the mechanisms underlying the uptake of (64)Cu in cells incubated with (64)Cu-ATSM...
  77. ncbi request reprint Assessment of regional tumor hypoxia using 18F-fluoromisonidazole and 64Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone) positron emission tomography: Comparative study featuring microPET imaging, Po2 probe measurement, autoradiography, and fluorescent mic
    Joseph A O'Donoghue
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Int J Radiat Oncol Biol Phys 61:1493-502. 2005
    ..To compare two potential positron emission tomography (PET) tracers of tumor hypoxia in an animal model...
  78. ncbi request reprint Copper bis(thiosemicarbazone) complexes as hypoxia imaging agents: structure-activity relationships
    Jason L J Dearling
    Biosciences Department, University of Kent, Canterbury CT2 7NJ, UK
    J Biol Inorg Chem 7:249-59. 2002
    ..The radioactivity uptake/release behaviour in the cells provides insight into possible mechanisms, and a model for hypoxia-selective intracellular trapping is discussed...
  79. doi request reprint Tumor hypoxia detected by positron emission tomography with 60Cu-ATSM as a predictor of response and survival in patients undergoing Neoadjuvant chemoradiotherapy for rectal carcinoma: a pilot study
    David W Dietz
    Department of Colorectal Surgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Dis Colon Rectum 51:1641-8. 2008
    ....

Research Grants23

  1. TARGETED METAL CHELATORS FOR DIAGNOSTIC IMAGING
    Michael Welch; Fiscal Year: 1993
    ....
  2. TARGETED METAL CHELATORS FOR DIAGNOSTIC IMAGING
    Michael Welch; Fiscal Year: 2001
    ..The synthesis characterization and physicochemical studies will be carried out at Texas A&M University while the in vitro and in vivo evaluation of the pharmaceutical preparations will be undertaken at Washington University. ..
  3. PET RADIOPHARMACEUTICALS FOR CARDIAC AND OTHER STUDIES
    Michael Welch; Fiscal Year: 2002
    ..The overall goal of this application is to develop and evaluate new PET radiopharmaceuticals that have potential for evaluating diseases of th heart, lung, and vasculature. ..
  4. Radionuclide Resource for Cancer Applications
    Michael Welch; Fiscal Year: 2007
    ..A training program is proposed and dissemination of information is an important part of this resource. ..