Research Topics
| Michael WelchSummaryAffiliation: Washington University School of Medicine Country: USA Publications
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Publications
[Tc(CO)(3)](+) chemistry: a promising new concept for SPECT? AgainstMichael J Welch
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Eur J Nucl Med Mol Imaging 30:1302-4. 2003- Potential and pitfalls of therapy with alpha-particlesMichael J Welch
Washington University School of Medicine, St. Louis, MO 63110, USA
J Nucl Med 46:1254-5. 2005 
Autoradiographic and small-animal PET comparisons between (18)F-FMISO, (18)F-FDG, (18)F-FLT and the hypoxic selective (64)Cu-ATSM in a rodent model of cancerCarmen S Dence
Mallinckrodt Institute of Radiology, The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
Nucl Med Biol 35:713-20. 2008....- Delineation of hypoxia in canine myocardium using PET and copper(II)-diacetyl-bis(N(4)-methylthiosemicarbazone)Jason S Lewis
Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
J Nucl Med 43:1557-69. 2002..CONCLUSION: *Cu-ATSM PET has shown quantitative selective uptake in hypoxic myocardium within 20 min of tracer administration in 3 canine models of hypoxia... - Investigation into 64Cu-labeled Bis(selenosemicarbazone) and Bis(thiosemicarbazone) complexes as hypoxia imaging agentsPaul McQuade
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA
Nucl Med Biol 32:147-56. 2005..However, the additional alkylation present in Cu-ATSE modifies the hypoxia selectivity and in vivo properties when compared with Cu-ATSM... - MicroPET assessment of androgenic control of glucose and acetate uptake in the rat prostate and a prostate cancer tumor modelNobuyuki Oyama
Division of Radiological Sciences and the Alvin J. Siteman Cancer Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, Missouri, USA
Nucl Med Biol 29:783-90. 2002..Further studies are needed to clarify the reason for the insensitivity of 11C-acetate for measuring metabolic change in prostate tumor... - Assessment of myocardial metabolism in diabetic rats using small-animal PET: a feasibility studyMichael J Welch
The Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
J Nucl Med 47:689-97. 2006..Thus, small-animal PET demonstrates significant promise in providing a means to link the myocardial metabolic abnormalities that occur in rat of disease with the human condition... - Minimally invasive method of determining blood input function from PET images in rodentsJoonyoung Kim
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
J Nucl Med 47:330-6. 2006.... - 11C-acetate PET imaging of prostate cancer: detection of recurrent disease at PSA relapseNobuyuki Oyama
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S. Kingshighway Boulevard, St. Louis, MO 63110, USA
J Nucl Med 44:549-55. 2003..CONCLUSION: AC PET demonstrates marked uptake in prostate cancer and has higher sensitivity than (18)F-FDG PET. These preliminary data show that (11)C-acetate is a promising tracer for detection of recurrent prostate cancer... - Monitoring of therapy in androgen-dependent prostate tumor model by measuring tumor proliferationNobuyuki Oyama
Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
J Nucl Med 45:519-25. 2004..CONCLUSION: These results indicate that (18)F-FLT is a useful tracer for detection of prostate cancer in an animal model. (18)F-FLT has the potential for monitoring the therapeutic effect of androgen ablation therapy in prostate cancer... - Preparation, biodistribution, and small animal PET of 45Ti-transferrinAmy L Vavere
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
J Nucl Med 46:683-90. 2005..Comparison of the data suggests that tissue uptake is similar whether injecting 45Ti-transferrin directly or as 45Ti-citrate, which transchelates to transferrin before the time of imaging... - In vivo evaluation of pretargeted 64Cu for tumor imaging and therapyMichael R Lewis
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S. Kingshighway Road, St. Louis, MO 63110, USA
J Nucl Med 44:1284-92. 2003..Further comparison of the therapeutic efficacy, toxicity, and dosimetry of these 2 agents is warranted... - [18F]- and [11C]-labeled N-benzyl-isatin sulfonamide analogues as PET tracers for apoptosis: synthesis, radiolabeling mechanism, and in vivo imaging study of apoptosis in Fas-treated mice using [11C]WC-98Dong Zhou
Division of Radiological Sciences, Washington University School of Medicine, Campus Box 8225 510 S Kingshighway Blvd St Louis, Missouri 63110, USA
Org Biomol Chem 7:1337-48. 2009..Therefore, this study provides a useful method for radio-synthesis of isatin derivative radiotracers for PET and SPECT studies, and [11C] 4 is a potential PET radiotracer for noninvasive imaging of apoptosis... - (64)Cu-labeled CB-TE2A and diamsar-conjugated RGD peptide analogs for targeting angiogenesis: comparison of their biological activityLihui Wei
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Nucl Med Biol 36:277-85. 2009..In this study, the chelators CB-TE2A and diamsar were conjugated to cyclic RGDyK and RGDfD and the biological properties of (64)Cu-labeled peptides were compared... - Imaging of melanoma using 64Cu- and 86Y-DOTA-ReCCMSH(Arg11), a cyclized peptide analogue of alpha-MSHPaul McQuade
Division of Radiological Sciences, Mallinckrodt Institute of Radiology and the Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri 63110, USA
J Med Chem 48:2985-92. 2005..The data obtained suggests that DOTA-ReCCMSH(Arg(11)), when labeled with beta(+)-emitting radionuclides, has the potential for early detection of malignant melanoma by exploiting the sensitivity and high resolution of PET... - Synthesis and evaluation of a bromine-76-labeled PPARgamma antagonist 2-bromo-5-nitro-N-phenylbenzamideHsiaoju Lee
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Nucl Med Biol 33:847-54. 2006..We are currently exploring second generation analogs of these lead compounds for the development of radiolabeled antagonists of the PPARgamma receptor... - Evaluation of a bromine-76-labeled progestin 16alpha,17alpha-dioxolane for breast tumor imaging and radiotherapy: in vivo biodistribution and metabolic stability studiesDong Zhou
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Nucl Med Biol 35:655-63. 2008..Progesterone receptors (PRs) are present in many breast tumors, and their levels are increased by certain endocrine therapies. They can be used as targets for diagnostic imaging and radiotherapy... - Small-animal PET of tumor angiogenesis using a (76)Br-labeled human recombinant antibody fragment to the ED-B domain of fibronectinRaffaella Rossin
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Nucl Med 48:1172-9. 2007..Biodistribution and imaging studies were performed in human teratoma-bearing mice for up to 48 h after injection... - The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitusBrian N Finck
Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA
J Clin Invest 109:121-30. 2002.... - Gallium-68-labeled DOTA-rhenium-cyclized alpha-melanocyte-stimulating hormone analog for imaging of malignant melanomaLihui Wei
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Nucl Med Biol 34:945-53. 2007..This encouraged us to investigate DOTA-ReCCMSH(Arg11) labeled with another beta+-emitting radionuclide, 68Ga... - Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiolJeongsoo Yoo
Mallinckrodt Institute of Radiology, Washington University School of Medicine, Campus Box 8225, 510 South Kingshighway Boulevard, St. Louis, Missouri 63110, USA
J Med Chem 48:6366-78. 2005..Based on our results, imaging of ERalpha can be done effectively with [18F]FES, but imaging of ERbeta will likely require agents with more optimized ERbeta binding affinity and selectivity than [18F]FEDNP... - In vivo evaluation of copper-64-labeled monooxo-tetraazamacrocyclic ligandsXiankai Sun
Mallinckrodt Institute of Radiology, School of Medicine, Washington University, St. Louis, MO 63110, USA
Nucl Med Biol 31:1051-9. 2004..However, the data presented here suggest that neutral or negatively charged Cu(II) complexes of tetraazamacrocyclic ligands with a cyclam backbone (tetradecane) are optimal for copper radiopharmaceutical applications... 
An imaging comparison of 64Cu-ATSM and 60Cu-ATSM in cancer of the uterine cervixJason S Lewis
Division of Radiological Sciences, Mallinckrodt Institute of Radiology, St Louis, Missouri, USA
J Nucl Med 49:1177-82. 2008....- Production, processing and small animal PET imaging of titanium-45Amy L Vavere
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Nucl Med Biol 32:117-22. 2005..Titanium-45 was prepared as a tool for elucidation of the mechanism of action of titanium anticancer drugs in vivo using microPET imaging... - Copper-64-pyruvaldehyde-bis(N(4)-methylthiosemicarbazone) for the prevention of tumor growth at wound sites following laparoscopic surgery: monitoring therapy response with microPET and magnetic resonance imagingJason S Lewis
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
Cancer Res 62:445-9. 2002..001). This study demonstrates the therapeutic potential of (64)Cu-PTSM in inhibiting cancer cell implantation and growth at doses well below the maximum tolerated dose, with no signs of toxicity to the hamsters... - Investigations into tumor accumulation and peroxisome proliferator activated receptor binding by F-18 and C-11 fatty acidsStephanie D Jonson
Division of Radiological Sciences, Washington University School of Medicine, 510 South Kingshighway, St. Louis, MO 63110, USA
Nucl Med Biol 29:211-6. 2002..11C]Acetate showed better tumor accumulation than PAA or FPAA. The aromatic fatty acids did not directly bind PPARalpha as confirmed by a biodistribution study of PAA in PPARalpha -/- mice... - The application of maximum likelihood factor analysis (MLFA) with uniqueness constraints on dynamic cardiac microPET dataYi Su
Division of Radiological Science, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Phys Med Biol 52:2313-34. 2007..The MLFA algorithm with an accompanying graphical user interface (GUI) is available at http://www.chempet.wustl.edu/faculty/shoghik... - Molecular imaging of atherosclerotic plaque with (64)Cu-labeled natriuretic peptide and PETYongjian Liu
Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Nucl Med 51:85-91. 2010.... - 18F-fluoroacetate: a potential acetate analog for prostate tumor imaging--in vivo evaluation of 18F-fluoroacetate versus 11C-acetateDatta E Ponde
Mallinckrodt Institute of Radiology and 2Alvin J Siteman Cancer Center, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
J Nucl Med 48:420-8. 2007..18)F-Fluoroacetate ((18)F-FAC) is an analog of acetate with a longer radioactive half-life ((18)F = 110 min). This study was undertaken to assess the potential usefulness of (18)F-FAC as a prostate tumor imaging agent... - Assessing tumor hypoxia in cervical cancer by PET with 60Cu-labeled diacetyl-bis(N4-methylthiosemicarbazone)Farrokh Dehdashti
Division of Nuclear Medicine, Edward Mallinckrodt Institute of Radiology, St Louis, Missouri 63110, USA
J Nucl Med 49:201-5. 2008..9). Pretherapy (60)Cu-ATSM PET provides clinically relevant information about tumor oxygenation that is predictive of outcome in patients with cervical cancer... - Synthesis and biologic evaluation of 64Cu-labeled rhenium-cyclized alpha-MSH peptide analog using a cross-bridged cyclam chelatorLihui Wei
Division of Radiological Sciences, Mallinckrodt Institute of Radiology and the Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Nucl Med 48:64-72. 2007..The goal of this study was to conjugate CBTE2A to the alpha-MSH targeting ReCCMSH(Arg(11)) peptide for labeling to (64)Cu and to investigate whether the increased metal-chelate stability with CBTE2A would improve imaging quality... - Monitoring the effect of mild hyperthermia on tumour hypoxia by Cu-ATSM PET scanningRobert J Myerson
Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
Int J Hyperthermia 22:93-115. 2006..The purpose of the present report is to establish methodology that will allow one to use Cu-ATSM PET scanning to detect the impact of hyperthermia on tumour physiology in as little time as possible... - Comparison of molecular markers of hypoxia and imaging with (60)Cu-ATSM in cancer of the uterine cervixPerry W Grigsby
Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Mol Imaging Biol 9:278-83. 2007..To determine if hypoxia-related molecular markers are associated with (60)Cu labeled diacetyl-bis (N4 -methylthiosemicarbazone); ((60)Cu-ATSM) imaging of tumor hypoxia in cervical cancer... - In vivo metabolic phenotyping of myocardial substrate metabolism in rodents: differential efficacy of metformin and rosiglitazone monotherapyKooresh I Shoghi
Mallinckrodt Institute of Radiology, Division of Radiological Sciences, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
Circ Cardiovasc Imaging 2:373-81. 2009..We aimed to assess noninvasively the efficacy of metformin and rosiglitazone monotherapy in normalizing myocardial substrate metabolism in an animal model of type 2 diabetes mellitus... - The advantages of nanoparticles for PETMichael J Welch
Department of Radiology, Washington University, Saint Louis, Missouri 63110, USA
J Nucl Med 50:1743-6. 2009..Organic and inorganic nanostructures are included. Nanoprobes for PET of angiogenesis and cancer are highlighted... - Bromination from the macroscopic level to the tracer radiochemical level: (76)Br radiolabeling of aromatic compounds via electrophilic substitutionDong Zhou
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Bioconjug Chem 20:808-16. 2009.... - Fluorine-18-labeled benzamide analogues for imaging the sigma2 receptor status of solid tumors with positron emission tomographyZhude Tu
Division of Radiological Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Med Chem 50:3194-204. 2007.... - Time course of alterations in myocardial glucose utilization in the Zucker diabetic fatty rat with correlation to gene expression of glucose transporters: a small-animal PET investigationKooresh I Shoghi
Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Nucl Med 49:1320-7. 2008.... - Hybrid image and blood sampling input function for quantification of small animal dynamic PET dataKooresh I Shoghi
Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Nucl Med Biol 34:989-94. 2007..The results highlight limitations in using bsPTAC. The HIBS method, however, yields consistent results, and thus, is a substitute for bsPTAC... - PET-based estradiol challenge as a predictive biomarker of response to endocrine therapy in women with estrogen-receptor-positive breast cancerFarrokh Dehdashti
Division of Nuclear Medicine, Edward Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
Breast Cancer Res Treat 113:509-17. 2009.... - Nuclear receptors PPARbeta/delta and PPARalpha direct distinct metabolic regulatory programs in the mouse heartEileen M Burkart
Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Clin Invest 117:3930-9. 2007.... - In vivo imaging of 64Cu-labeled polymer nanoparticles targeted to the lung endotheliumRaffaella Rossin
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
J Nucl Med 49:103-11. 2008..We have evaluated the use of (64)Cu and PET to noninvasively image the lung uptake and distribution of NPs coated with an anti-ICAM antibody... - Radiochemical synthesis, rodent biodistribution and tumor uptake, and dosimetry calculations of [¹¹C] methylated LY2181308Carmen S Dence
Department of Radiology, Division of Radiological Sciences, Washington University School of Medicine, 510 S Kingshighway Blvd, Saint Louis, MO 63110, USA
Mol Imaging Biol 12:608-15. 2010.... - Three-dimensional maximum a posteriori (MAP) imaging with radiopharmaceuticals labeled with three Cu radionuclidesAnanya Ruangma
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Nucl Med Biol 33:217-26. 2006.... - Radiolabeling and in vivo behavior of copper-64-labeled cross-bridged cyclam ligandsXiankai Sun
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
J Med Chem 45:469-77. 2002..A bifunctional chelator of 2 is a significant candidate for labeling copper radionuclides to biological molecules for diagnostic imaging and targeted radiotherapy... - Positron tomographic assessment of androgen receptors in prostatic carcinomaFarrokh Dehdashti
The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO, 63110, USA
Eur J Nucl Med Mol Imaging 32:344-50. 2005.... - Impact of reversible trapping of tracer and the presence of blood metabolites on measurements of myocardial glucose utilization performed by PET and 18F-fluorodeoxyglucose using the Patlak methodPilar Herrero
Division of Radiological Sciences, Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Nucl Med Biol 31:883-92. 2004..Although further studies will be required to elucidate the reason for the egress of tracer from myocardium, not accounting for it will result in erroneous estimates of MGU... - Evaluation of 64Cu- and 125I-radiolabeled bitistatin as potential agents for targeting alpha v beta 3 integrins in tumor angiogenesisPaul McQuade
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
Bioconjug Chem 15:988-96. 2004..Radiolabeled ligands of this type may be useful in the targeting of tumor angiogenesis, but the choice of radiolabeling approach has a significant impact on the in vivo properties of the radioligand... - MicroPET imaging of a gastrin-releasing peptide receptor-positive tumor in a mouse model of human prostate cancer using a 64Cu-labeled bombesin analogueBuck E Rogers
Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Bioconjug Chem 14:756-63. 2003..This study demonstrates that (64)Cu-DOTA-Aoc-BN(7-14) can be used to detect GRPR-positive tumors by PET imaging... - In vivo assessment of tumor hypoxia in lung cancer with 60Cu-ATSMFarrokh Dehdashti
Division of Nuclear Medicine, Edward Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
Eur J Nucl Med Mol Imaging 30:844-50. 2003..04; P=0.9). (60)Cu-ATSM-PET can be readily performed in patients with NSCLC and the tumor uptake of (60)Cu-ATSM reveals clinically unique information about tumor oxygenation that is predictive of tumor response to therapy... - Assessing tumor hypoxia in cervical cancer by positron emission tomography with 60Cu-ATSM: relationship to therapeutic response-a preliminary reportFarrokh Dehdashti
Division of Nuclear Medicine, Edward Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
Int J Radiat Oncol Biol Phys 55:1233-8. 2003..We have investigated whether pretreatment tumor hypoxia assessed by positron emission tomography (PET) with Cu-60 diacetyl-bis(N(4)-methylthiosemicarbazone) ((60)Cu-ATSM) predicts responsiveness to subsequent therapy in cervical cancer... - In vivo behavior of copper-64-labeled methanephosphonate tetraaza macrocyclic ligandsXiankai Sun
The Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
J Biol Inorg Chem 8:217-25. 2003..Metabolism studies of (64)Cu-DO2P in rat liver suggest that the DO2P ligand may be used as a bifunctional chelator for copper radionuclides in radiodiagnostic or radiotherapeutic studies... - Robotic preparation of Sodium Acetate C 11 Injection for use in clinical PETStephen M Moerlein
The Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, Saint Louis, MO 63110, USA
Nucl Med Biol 29:613-21. 2002..Moreover, its design flexibility permits synthesis of additional (11)C- or (18)F-labeled PET tracers within the same shielded hot cell... - 64Cu-labeled folate-conjugated shell cross-linked nanoparticles for tumor imaging and radiotherapy: synthesis, radiolabeling, and biologic evaluationRaffaella Rossin
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
J Nucl Med 46:1210-8. 2005..For these reasons, functionalized SCKs are promising drug-delivery agents for imaging and therapy of early-stage solid tumors... - Measurement of input functions in rodents: challenges and solutionsRichard Laforest
Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Nucl Med Biol 32:679-85. 2005..To be able to implement these approaches in rodent models of disease using small-animal PET (microPET), it is imperative that the input function is measured accurately... - Enhancing targeted radiotherapy by copper(II)diacetyl- bis(N4-methylthiosemicarbazone) using 2-deoxy-D-glucoseRebecca L Aft
Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
Cancer Res 63:5496-504. 2003..Our data indicate that the strategy of combining tumor-specific cytotoxic agents that function by differing mechanisms can result in an effective, selective, tumor-specific cell death with minimal effect on the host... - In vivo skeletal imaging of 18F-fluoride with positron emission tomography reveals damage- and time-dependent responses to fatigue loading in the rat ulnaMatthew J Silva
Department of Orthopaedic Surgery, Washington University School of Medicine, 1 Barnes Jewish Hospital Plaza, Suite 11300 WP, St Louis, MO 63110, USA
Bone 39:229-36. 2006.... - Assessment of myocardial blood flow using 15O-water and 1-11C-acetate in rats with small-animal PETPilar Herrero
Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Nucl Med 47:477-85. 2006..This feasibility study was undertaken to determine whether myocardial blood flow (MBF, mL/g/min) could be quantified noninvasively in small rodents using microPET and 15O-water or 1-11C-acetate... - Comparative in vivo behavior studies of cyclen-based copper-64 complexes: regioselective synthesis, X-ray structure, radiochemistry, log P, and biodistributionJeongsoo Yoo
Mallinckrodt Institute of Radiology, Washington University School of Medicine, Campus Box 8225, 510 South Kingshighway Boulevard, St. Louis, Missouri 63110, USA
J Med Chem 47:6625-37. 2004..Trans-substituted complexes structure isomers Cu-3 and Cu-4 showed better clearance and lower retention from all organs than their cis-counterparts Cu-5 and Cu-6... - Synthesis, radiolabeling, and in vivo evaluation of an 18F-labeled isatin analog for imaging caspase-3 activation in apoptosisDong Zhou
Division of Radiological Sciences, Washington University School of Medicine, 510 South Kingshighway Boulevard, St. Louis, MO 63110, USA
Bioorg Med Chem Lett 16:5041-6. 2006..These data suggest that [(18)F]WC-II-89 is a potential radiotracer for imaging caspase-3 activation in tissues undergoing apoptosis... - Design and synthesis of functionalized cyclopentadienyl tricarbonylmetal complexes for technetium-94m PET imaging of estrogen receptorsHeather M Bigott
Division of Radiological Sciences, Washington University School of Medicine, 510 S. Kingshighway, Campus Box 8225, St. Louis, Missouri 63110, USA
Bioconjug Chem 16:255-64. 2005..This further demonstrates the versatility of the double ligand transfer reaction and indicates that the synthesis of technetium and rhenium radiolabeled agents for breast tumor imaging and therapy is also likely to be successful... - A potential Dubin-Johnson syndrome imaging agent: synthesis, biodistribution, and microPET imagingJeongsoo Yoo
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St Louis, MO 63110, USA
Mol Imaging 4:18-29. 2005..The significant difference between the biodistribution data and microPET images of the normal and TR(-) rats demonstrates that this new (64)Cu complex may allow noninvasive diagnosis of DJS in humans... - Synthesis and in vivo evaluation of 2 high-affinity 76Br-labeled sigma2-receptor ligandsDouglas J Rowland
Department of Radiology, Washington University in St Louis, Saint Louis, Missouri, USA
J Nucl Med 47:1041-8. 2006..These are 5-bromo-N-(4-(3,4-dihydro-6,7-dimethoxyisoquinolin-2(1H)-yl)butyl)-2,3-dimethoxybenzamide (compound (1)) and 5-bromo-N-(2-(3,4-dihydro-6,7-dimethoxyisoquinolin-2(1H)-yl)ethyl)-2-methoxybenzamide (compound (2))... - Copper bis(thiosemicarbazone) complexes as hypoxia imaging agents: structure-activity relationshipsJason L J Dearling
Biosciences Department, University of Kent, Canterbury CT2 7NJ, UK
J Biol Inorg Chem 7:249-59. 2002..The radioactivity uptake/release behaviour in the cells provides insight into possible mechanisms, and a model for hypoxia-selective intracellular trapping is discussed... - Synthesis and biological evaluation of a fluorine-18-labeled nonsteroidal androgen receptor antagonist, N-(3-[18F]fluoro-4-nitronaphthyl)-cis-5-norbornene-endo-2,3-dicarboxylic imideEphraim E Parent
Department of Chemistry, University of Illinois, Urbana, IL 61801, USA
Nucl Med Biol 33:615-24. 2006..Although 3-[(18)F]F-NNDI has significant affinity for AR, it showed limited promise as a PET imaging agent because of its poor target tissue distribution properties... - Intra-tumoral distribution of (64)Cu-ATSM: a comparison study with FDGAtsushi Obata
Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo, 606-8151 Kyoto, Japan
Nucl Med Biol 30:529-34. 2003..18)F]FDG was distributed more widely with highest levels in the inner regions where pre-necrotic cells were mainly observed. (64)Cu-ATSM appears to be useful for the detection of hypoxic but active tumor cell regions in vivo... - Tumor hypoxia detected by positron emission tomography with 60Cu-ATSM as a predictor of response and survival in patients undergoing Neoadjuvant chemoradiotherapy for rectal carcinoma: a pilot studyDavid W Dietz
Department of Colorectal Surgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
Dis Colon Rectum 51:1641-8. 2008.... - Cell line-dependent differences in uptake and retention of the hypoxia-selective nuclear imaging agent Cu-ATSMPaul Burgman
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Nucl Med Biol 32:623-30. 2005..In this study, we examined the mechanisms underlying the uptake of (64)Cu in cells incubated with (64)Cu-ATSM... - Preparation of 66Ga- and 68Ga-labeled Ga(III)-deferoxamine-folate as potential folate-receptor-targeted PET radiopharmaceuticalsCarla J Mathias
Department of Industrial and Physical Pharmacy, Purdue University, West, Lafayette, IN, USA
Nucl Med Biol 30:725-31. 2003..The autoradiographic images of 1 mm tumor sections demonstrate the gross heterogeneity of the KB cell tumor xenograft, as well as subtle disparity in the regional accumulation of the two radiotracers... - Molecular (functional) imaging for radiotherapy applications: an RTOG symposiumJ D Chapman
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Int J Radiat Oncol Biol Phys 55:294-301. 2003 - Synthesis and biological evaluation of a nonsteroidal bromine-76-labeled androgen receptor ligand 3-[76Br]bromo-hydroxyflutamideEphraim E Parent
Department of Chemistry, University of Illinois, Urbana, IL 61801, USA
Nucl Med Biol 33:705-13. 2006..In our efforts to develop a nonsteroidal AR-specific imaging agent, we synthesized (+/-)-3-[(76)Br]bromo-hydroxyflutamide ((76)Br-), an analog of hydroxyflutamide, the active metabolite of the AR antagonist ligand flutamide... - New approach to fully automated synthesis of sodium [18F]fluoroacetate -- a simple and fast method using a commercial synthesizerLi-Quan Sun
Biomedical Imaging Research Center, University of Fukui, Yoshida, Japan
Nucl Med Biol 33:153-8. 2006..2 +/- 4.8%, decay corrected). The radiochemical purity of sodium [(18)F]fluoroacetate was greater than 99%... - Update on PET radiopharmaceuticals: life beyond fluorodeoxyglucoseChyng Yann Shiue
Department of Radiology, University of Pennsylvania School of Medicine, 1 Silverstein, 3400 Spruce Street, Philadelphia, PA 19104, USA
Radiol Clin North Am 42:1033-53, viii. 2004..This article lists some of the radiotracers that are available for PET studies in neuroscience and oncology. The prospects for developing other new radiotracers for imaging other organ diseases also seem to be promising... - Basic characterization of 64Cu-ATSM as a radiotherapy agentAtsushi Obata
Biomedical Imaging Research Center, University of Fukui, Matsuoka, Fukui 910-1193, Japan
Nucl Med Biol 32:21-8. 2005..These data allow us to postulate that 64Cu-ATSM will be able to attack the hypoxic tumor cells directly, as well as potentially affecting the peripheral nonhypoxic regions indirectly by the beta- particle decay of 64Cu... - Assessment of regional tumor hypoxia using 18F-fluoromisonidazole and 64Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone) positron emission tomography: Comparative study featuring microPET imaging, Po2 probe measurement, autoradiography, and fluorescent micJoseph A O'Donoghue
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Int J Radiat Oncol Biol Phys 61:1493-502. 2005..To compare two potential positron emission tomography (PET) tracers of tumor hypoxia in an animal model... - Synthesis and biodistribution of fluorine-18-labeled fluorocyclofenils for imaging the estrogen receptorJai Woong Seo
Department of Chemistry, Inha University, Inchon 402 751, Korea
Nucl Med Biol 34:383-90. 2007.... - Synthesis and biological evaluation of [18F]bicalutamide, 4-[76Br]bromobicalutamide, and 4-[76Br]bromo-thiobicalutamide as non-steroidal androgens for prostate cancer imagingEphraim E Parent
Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, Illinois 61801, USA
J Med Chem 50:1028-40. 2007..Androgen target tissue uptake was evident in castrated adult male rats; however, in DES-treated, AR-positive, tumor-bearing male mice, tumor uptake was low... - Automatic synthesis of 16 alpha-[(18)F]fluoro-17beta-estradiol using a cassette-type [(18)F]fluorodeoxyglucose synthesizerTetsuya Mori
Biomedical Imaging Research Center, University of Fukui, Matsuoka, Fukui 910 1193, Japan
Nucl Med Biol 33:281-6. 2006..The final product was stable for more than 6 h in saline containing sodium ascorbate. This new preparation system enables us to produce [(18)F]FES safe for clinical use with high and reproducible yield...
Research Grants
- TARGETED METAL CHELATORS FOR DIAGNOSTIC IMAGINGMichael Welch; Fiscal Year: 1993....
- TARGETED METAL CHELATORS FOR DIAGNOSTIC IMAGINGMichael Welch; Fiscal Year: 2001..The synthesis characterization and physicochemical studies will be carried out at Texas A&M University while the in vitro and in vivo evaluation of the pharmaceutical preparations will be undertaken at Washington University. ..
- PET RADIOPHARMACEUTICALS FOR CARDIAC AND OTHER STUDIESMichael Welch; Fiscal Year: 2002..The overall goal of this application is to develop and evaluate new PET radiopharmaceuticals that have potential for evaluating diseases of th heart, lung, and vasculature. ..
- Radionuclide Resource for Cancer ApplicationsMichael Welch; Fiscal Year: 2007..A training program is proposed and dissemination of information is an important part of this resource. ..