George M Weinstock
Affiliation: Washington University School of Medicine
- Genome analysis of a highly virulent serotype 1 strain of Streptococcus pneumoniae from West AfricaTiffany M Williams
The Genome Institute, Washington University, St Louis, Missouri, USA
PLoS ONE 7:e26742. 2012..The African serotype 1 strains thus appear to be closely related to each other and different from other pneumococci despite similar genetic content...
- Genomic approaches to studying the human microbiotaGeorge M Weinstock
The Genome Institute, Washington University, St Louis, Missouri 63108, USA
Nature 489:250-6. 2012..These methods are revealing differences in community structure between anatomical sites, between individuals, and between healthy and diseased states, and are transforming our view of human biology...
- The volatile microbiomeGeorge M Weinstock
The Genome Institute, 4444 Forest Park Avenue, Campus Box 8501, Washington University, St Louis, MO 63108, USA
Genome Biol 12:114. 2011..The first detailed temporal study of the human microbiome shows that individual body habitats exhibit surprising variation over time yet maintain distinguishable community structures...
- VarScan: variant detection in massively parallel sequencing of individual and pooled samplesDaniel C Koboldt
The Genome Center at Washington University School of Medicine, St Louis, MO 63108, USA
Bioinformatics 25:2283-5. 2009..We demonstrate VarScan's ability to detect SNPs and indels with high sensitivity and specificity, in both Roche/454 sequencing of individuals and deep Illumina/Solexa sequencing of pooled samples...
- Comparative and demographic analysis of orang-utan genomesDevin P Locke
The Genome Center at Washington University, Washington University School of Medicine, 4444 Forest Park Avenue, Saint Louis, Missouri 63108, USA
Nature 469:529-33. 2011..Overall, the resources and analyses presented here offer new opportunities in evolutionary genomics, insights into hominid biology, and an extensive database of variation for conservation efforts...
- A vertebrate case study of the quality of assemblies derived from next-generation sequencesLiang Ye
The Genome Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, MO 63108, USA
Genome Biol 12:R31. 2011..Nonetheless, these assemblies are sufficient for the identification of the majority of genes and can reveal novel sequences when compared to existing assembly references...