Gary J Weil

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc The impact of repeated rounds of mass drug administration with diethylcarbamazine plus albendazole on bancroftian filariasis in Papua New Guinea
    Gary J Weil
    Washington University School of Medicine, St Louis, Missouri, USA
    PLoS Negl Trop Dis 2:e344. 2008
  2. ncbi request reprint A rapid-format antibody card test for diagnosis of onchocerciasis
    G J Weil
    Infectious Diseases Division, Barnes Jewish Hospital, St Louis, MO 63110, USA
    J Infect Dis 182:1796-9. 2000
  3. pmc Transcriptomic and proteomic analyses of a Wolbachia-free filarial parasite provide evidence of trans-kingdom horizontal gene transfer
    Samantha N McNulty
    Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS ONE 7:e45777. 2012
  4. pmc A real-time PCR-based assay for detection of Wuchereria bancrofti DNA in blood and mosquitoes
    Ramakrishna U Rao
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Trop Med Hyg 74:826-32. 2006
  5. pmc A qPCR-based multiplex assay for the detection of Wuchereria bancrofti, Plasmodium falciparum and Plasmodium vivax DNA
    Ramakrishna U Rao
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Trans R Soc Trop Med Hyg 103:365-70. 2009
  6. pmc Localization of Wolbachia-like gene transcripts and peptides in adult Onchocerca flexuosa worms indicates tissue specific expression
    Samantha N McNulty
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Parasit Vectors 6:2. 2013
  7. pmc Paragonimus kellicotti flukes in Missouri, USA
    Michael A Lane
    Department of Infectious Diseases, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Emerg Infect Dis 18:1263-7. 2012
  8. pmc Effects of doxycycline on gene expression in Wolbachia and Brugia malayi adult female worms in vivo
    Ramakrishna U Rao
    Infectious Diseases Division, Department of Internal Medicine, St, Louis, Missouri, USA
    J Biomed Sci 19:21. 2012
  9. pmc Transcriptomes and pathways associated with infectivity, survival and immunogenicity in Brugia malayi L3
    Ben Wen Li
    Department of Internal Medicine, Washington University School of Medicine, St, Louis, MO 63110, USA
    BMC Genomics 10:267. 2009
  10. ncbi request reprint Profiling of gender-regulated gene transcripts in the filarial nematode Brugia malayi by cDNA oligonucleotide array analysis
    Ben Wen Li
    Infectious Diseases Division, Washington University School of Medicine, Campus Box 8051, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Mol Biochem Parasitol 143:49-57. 2005

Research Grants

Collaborators

Detail Information

Publications64

  1. pmc The impact of repeated rounds of mass drug administration with diethylcarbamazine plus albendazole on bancroftian filariasis in Papua New Guinea
    Gary J Weil
    Washington University School of Medicine, St Louis, Missouri, USA
    PLoS Negl Trop Dis 2:e344. 2008
    ..This study employed various monitoring methods to assess the impact of repeated rounds of mass drug administration (MDA) on bancroftian filariasis in Papua New Guinea, which has the largest filariasis problem in the Pacific region...
  2. ncbi request reprint A rapid-format antibody card test for diagnosis of onchocerciasis
    G J Weil
    Infectious Diseases Division, Barnes Jewish Hospital, St Louis, MO 63110, USA
    J Infect Dis 182:1796-9. 2000
    ..This new test holds great promise as a simple tool for diagnosis of onchocerciasis...
  3. pmc Transcriptomic and proteomic analyses of a Wolbachia-free filarial parasite provide evidence of trans-kingdom horizontal gene transfer
    Samantha N McNulty
    Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS ONE 7:e45777. 2012
    ..flexuosa lysate and stained specific worm tissues by immunohistology. Future studies will be required to determine the exact functions of Wolbachia-like peptides and proteins in O. flexuosa and to assess their roles in worm biology...
  4. pmc A real-time PCR-based assay for detection of Wuchereria bancrofti DNA in blood and mosquitoes
    Ramakrishna U Rao
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Trop Med Hyg 74:826-32. 2006
    ..We believe that real-time PCR has great potential as a tool for monitoring progress in large-scale filariasis elimination programs...
  5. pmc A qPCR-based multiplex assay for the detection of Wuchereria bancrofti, Plasmodium falciparum and Plasmodium vivax DNA
    Ramakrishna U Rao
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Trans R Soc Trop Med Hyg 103:365-70. 2009
    ..bancrofti and Plasmodium spp. in human populations and for assessing the impact of interventions aimed at controlling or eliminating these diseases...
  6. pmc Localization of Wolbachia-like gene transcripts and peptides in adult Onchocerca flexuosa worms indicates tissue specific expression
    Samantha N McNulty
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Parasit Vectors 6:2. 2013
    ..Proteogenomic studies have shown that many of these Wolbachia-like sequences are expressed in adult worms...
  7. pmc Paragonimus kellicotti flukes in Missouri, USA
    Michael A Lane
    Department of Infectious Diseases, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Emerg Infect Dis 18:1263-7. 2012
    ..We also describe public health interventions that were undertaken to inform the general public and physicians about the disease and its mode of transmission...
  8. pmc Effects of doxycycline on gene expression in Wolbachia and Brugia malayi adult female worms in vivo
    Ramakrishna U Rao
    Infectious Diseases Division, Department of Internal Medicine, St, Louis, Missouri, USA
    J Biomed Sci 19:21. 2012
    ..Most filarial nematodes contain Wolbachia symbionts. The purpose of this study was to examine the effects of doxycycline on gene expression in Wolbachia and adult female Brugia malayi...
  9. pmc Transcriptomes and pathways associated with infectivity, survival and immunogenicity in Brugia malayi L3
    Ben Wen Li
    Department of Internal Medicine, Washington University School of Medicine, St, Louis, MO 63110, USA
    BMC Genomics 10:267. 2009
    ..Radiation effects are especially interesting because irradiated L3 induce partial immunity to filarial infections. The underlying molecular mechanisms responsible for the efficacy of such vaccines are unkown...
  10. ncbi request reprint Profiling of gender-regulated gene transcripts in the filarial nematode Brugia malayi by cDNA oligonucleotide array analysis
    Ben Wen Li
    Infectious Diseases Division, Washington University School of Medicine, Campus Box 8051, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Mol Biochem Parasitol 143:49-57. 2005
    ..malayi; this should lead to improved understanding of reproduction in filarial nematodes. More generally, this approach holds great promise as a means of studying stage-specific or tissue-specific gene expression in parasitic nematodes...
  11. ncbi request reprint Brugia malayi: effects of radiation and culture on gene expression in infective larvae
    Ben Wen Li
    Infectious Diseases Division, Campus Box 8051, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Mol Biochem Parasitol 149:201-7. 2006
    ..This study provides an improved description of the adaptations that accompany the transition from L3i to L3c and the special ability of L3ir to induce protective immunity...
  12. pmc Serological diagnosis of North American Paragonimiasis by Western blot using Paragonimus kellicotti adult worm antigen
    Peter U Fischer
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Trop Med Hyg 88:1035-40. 2013
    ..Antibody reactivity declined after praziquantel treatment. Thus, the P. kellicotti WB appears to be superior to P. westermani WB for diagnosing Pk infections, and it may be useful for assessing responses to treatment...
  13. pmc Persistence of Brugia malayi DNA in vector and non-vector mosquitoes: implications for xenomonitoring and transmission monitoring of lymphatic filariasis
    Peter Fischer
    Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Trop Med Hyg 76:502-7. 2007
    ....
  14. doi request reprint Brugia malayi: whole genome amplification for genomic characterization of filarial parasites
    Samantha N McNulty
    Internal Medicine Infectious Diseases Division, Washington University School of Medicine, Campus Mailbox 8051, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Exp Parasitol 119:256-63. 2008
    ..MDA is useful for whole genome amplification of filarial DNA from very small amounts of starting material. This technology will permit detailed studies of genetic diversity that were not previously feasible...
  15. doi request reprint Brugia malayi: Effects of nitazoxanide and tizoxanide on adult worms and microfilariae of filarial nematodes
    Ramakrishna U Rao
    Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Exp Parasitol 121:38-45. 2009
    ..Neither NTZ nor TZ cleared adult worms or microfilariae in infected gerbils. These results show that NTZ and TZ have potent effects on B. malayi nematodes in vitro. However, they were not effective in vivo...
  16. ncbi request reprint Localization of gender-regulated gene expression in the filarial nematode Brugia malayi
    Daojun Jiang
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, Campus Box 8051, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Int J Parasitol 38:503-12. 2008
    ..Thus, ISH provides a means to independently confirm differential expression of genes identified by other methods. In addition, localization patterns provide insight regarding the function of known or novel genes in the parasite...
  17. pmc Transcription profiling reveals stage- and function-dependent expression patterns in the filarial nematode Brugia malayi
    Ben Wen Li
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St, Louis, MO 63110, USA
    BMC Genomics 13:184. 2012
    ..Although a first draft genome sequence was released in 2007, very little is understood about transcription programs that govern developmental changes required for the parasite's development and survival in its mammalian and insect hosts...
  18. doi request reprint Absence of Wolbachia endobacteria in Chandlerella quiscali, an avian filarial parasite
    Samantha N McNulty
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, Campus Box 8051, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
    J Parasitol 98:382-7. 2012
    ..Further studies of C. quiscali and other Wolbachia-free filarial species may help to clarify the reason(s) that some filarial species require Wolbachia but others do not...
  19. pmc Gender-associated genes in filarial nematodes are important for reproduction and potential intervention targets
    Ben Wen Li
    Infectious Diseases Division, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Negl Trop Dis 5:e947. 2011
    ..We have performed the first genome-wide analysis of gender-associated (GA) gene expression in a filarial nematode to improve understanding of key reproductive processes in these parasites...
  20. pmc Inter and intra-specific diversity of parasites that cause lymphatic filariasis
    Samantha N McNulty
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, United States
    Infect Genet Evol 14:137-46. 2013
    ..Improved information on filarial genetic diversity may increase the chances of success for lymphatic filariasis elimination programs...
  21. pmc Comparing the mitochondrial genomes of Wolbachia-dependent and independent filarial nematode species
    Samantha N McNulty
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    BMC Genomics 13:145. 2012
    ..Comparisons between the mitochondrial genome sequences of Wolbachia-dependent and independent filarial worms may reveal differences indicative of altered mitochondrial function...
  22. pmc A multicenter evaluation of a new antibody test kit for lymphatic filariasis employing recombinant Brugia malayi antigen Bm-14
    Gary J Weil
    Infectious Diseases Division, Washington University School of Medicine, St Louis, MO, USA
    Acta Trop 120:S19-22. 2011
    ..It may also be a useful tool for use in LF endemic countries to monitor the progress of filariasis elimination programs and for post-MDA surveillance...
  23. pmc Endosymbiont DNA in endobacteria-free filarial nematodes indicates ancient horizontal genetic transfer
    Samantha N McNulty
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS ONE 5:e11029. 2010
    ..The mechanisms behind this interdependence are not understood. Interestingly, a minority of filarial species examined to date are naturally Wolbachia-free...
  24. pmc Tissue and stage-specific distribution of Wolbachia in Brugia malayi
    Kerstin Fischer
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS Negl Trop Dis 5:e1174. 2011
    ..Surprisingly, immunohistology and in situ hybridization techniques have not been widely used to monitor Wolbachia distribution during the filarial life cycle...
  25. pmc Laboratory and field evaluation of a new rapid test for detecting Wuchereria bancrofti antigen in human blood
    Gary J Weil
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Am J Trop Med Hyg 89:11-5. 2013
    ..Based on its increased sensitivity and other practical advantages, we believe that the test strip represents a major step forward that will be welcomed by the GPELF and the filariasis research community...
  26. doi request reprint Multiplex proteomics analysis of gender-associated proteins in Brugia malayi
    Daojun Jiang
    Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Parasitol 42:841-50. 2012
    ..ISH results were consistent with RNAi data for C. elegans that linked the homologues of the B. malayi proteins to gamete production and embryogenesis...
  27. ncbi request reprint A comparison of newer tests for the diagnosis of onchocerciasis
    J A Vincent
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Trop Med Parasitol 94:253-8. 2000
    ..volvulus, whereas PCR and antigen testing are potentially more useful for diagnosis of infections in individuals and for monitoring the success of therapy...
  28. pmc Semi-quantitative scoring of an immunochromatographic test for circulating filarial antigen
    Cédric B Chesnais
    Unité Mixte Internationale 233, Institut de Recherche pour le Développement and University of Montpellier 1, Montpellier, France Programme National de Lutte contre l Onchocercose, Ministère de la Santé et de la Population, Brazzaville, Republic of Congo Filariasis and other Tropical Diseases Research Centre, Yaounde, Cameroon Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri
    Am J Trop Med Hyg 89:916-8. 2013
    ....
  29. pmc Genetic characterization of atypical Mansonella (Mansonella) ozzardi microfilariae in human blood samples from northeastern Peru
    Luis A Marcos
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Trop Med Hyg 87:491-4. 2012
    ..All atypical microfilariae were clustered into the Mansonella group and indistinguishable from M. ozzardi based on these DNA markers...
  30. doi request reprint Molecular identification of Schistosoma mattheei from feces of Kinda (Papio cynocephalus kindae) and grayfoot baboons (Papio ursinus griseipes) in Zambia
    Anna H Weyher
    Department of Anthropology, Washington University in St Louis, One Brookings Drive, St Louis, Missouri 63130, USA
    J Parasitol 96:184-90. 2010
    ..Schistosoma mattheei is typically a parasite of bovids, but it can also infect humans. Schistosoma mattheei in baboons in Zambia may affect other wildlife species and humans that live in close proximity to baboons...
  31. pmc Distribution of Brugia malayi larvae and DNA in vector and non-vector mosquitoes: implications for molecular diagnostics
    Sara M Erickson
    Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, St Louis, Missouri, USA
    Parasit Vectors 2:56. 2009
    ..abstract:..
  32. pmc Molecular characterization of the North American lung fluke Paragonimus kellicotti in Missouri and its development in Mongolian gerbils
    Peter U Fischer
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Am J Trop Med Hyg 84:1005-11. 2011
    ..These results demonstrate that P. kellicotti is common in Missouri crayfish. The gerbil model may be useful for research on the pathogenesis, immunology, and treatment of paragonimiasis...
  33. ncbi request reprint Diagnostic tools for filariasis elimination programs
    Gary J Weil
    Infectious Diseases Division, Washington University School of Medicine, Campus Box 8051, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Trends Parasitol 23:78-82. 2007
    ..This article reviews available diagnostic tests for filariasis and their potential use as tools for different phases of filariasis elimination programs...
  34. ncbi request reprint Brugia malayi: effects of antibacterial agents on larval viability and development in vitro
    Ramakrishna U Rao
    Infectious Diseases Division, Internal Medicine Department, Barnes Jewish Hospital and Washington University, School of Medicine, St Louis, MO 63110, USA
    Exp Parasitol 101:77-81. 2002
    ..While it is possible that antibiotics directly affect filarial L3, we believe it is more likely that the effects seen are indirect effects related to bacterial killing...
  35. ncbi request reprint Infectious risks for travelers to the tropics
    F Matthew Kuhlmann
    Infectious Diseases Division, Washington University School of Medicine, USA
    Mo Med 106:263-8. 2009
    ..This paper is a brief overview of travel medicine with an emphasis on infectious disease risks for travelers to the tropics such as traveler's diarrhea, malaria, and vaccine preventable illnesses...
  36. ncbi request reprint Gender-specific gene expression in Brugia malayi
    M L Michalski
    Department of Molecular Microbiology and Microbial Pathogenesis, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Biochem Parasitol 104:247-57. 1999
    ..These two complimentary techniques may be generally applicable to the study of gender-specific (and by analogy stage specific) gene expression in other nematodes...
  37. ncbi request reprint Effects of gamma radiation on Brugia malayi infective larvae and their intracellular Wolbachia bacteria
    R Rao
    Infectious Diseases Division, Department of Internal Medicine, School of Medicine, Washington University, Campus Box 8051, 660 S Euclid Ave, St Louis, MO 63110, USA
    Parasitol Res 97:219-27. 2005
    ..In contrast, jirds injected with irradiated L3 did not develop microfilaremia or antibodies to wsp. Additional studies are needed to test the hypothesis that irradiation retards growth and development of filarial L3 by killing Wolbachia...
  38. ncbi request reprint Identification of paramyosin as a potential protective antigen against Brugia malayi infection in jirds
    B W Li
    Department of Medicine, Washington University School of Medicine, St Louis, MO
    Mol Biochem Parasitol 49:315-23. 1991
    ..Most sera from infected jirds do not contain antibody to paramyosin. Additional studies are needed to determine whether paramyosin is actually protective in this filariasis model...
  39. pmc Chest CT features of North American paragonimiasis
    Travis S Henry
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA
    AJR Am J Roentgenol 198:1076-83. 2012
    ....
  40. pmc Detection of Brugia parasite DNA in human blood by real-time PCR
    Ramakrishna U Rao
    Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8051, St Louis, MO 63110, USA
    J Clin Microbiol 44:3887-93. 2006
    ..timori endemicity on Alor Island, Indonesia, where microfilaria-positive individuals had low densities after mass treatment. Thus, the Eclipse MGB real-time PCR assay is a sensitive means of detecting Brugia parasite DNA in human blood...
  41. ncbi request reprint Parasite antigenemia without microfilaremia in bancroftian filariasis
    G J Weil
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Am J Trop Med Hyg 55:333-7. 1996
    ..bancrofti infections are relatively common in endemic areas. Additional studies are needed to determine the clinical significance, prognosis, and optimal management of such infections...
  42. ncbi request reprint Persistence of parasite antigenemia following diethylcarbamazine therapy of bancroftian filariasis
    G J Weil
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    Am J Trop Med Hyg 38:589-95. 1988
    ....
  43. ncbi request reprint An embryo-associated fatty acid-binding protein in the filarial nematode Brugia malayi
    Michelle L Michalski
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Mol Biochem Parasitol 124:1-10. 2002
    ....
  44. ncbi request reprint Brugia malayi: effects of gamma radiation on adult worms and their intracellular Wolbachia bacteria
    Ramakrishna U Rao
    Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Exp Parasitol 109:87-93. 2005
    ..These effects are essentially the same as those observed in adult worms treated with doxycycline. These studies suggest that effects of irradiation on reproduction in Brugia malayi may be caused by effects of irradiation on Wolbachia...
  45. ncbi request reprint Quantitative analysis of gender-regulated transcripts in the filarial nematode Brugia malayi by real-time RT-PCR
    Ben Wen Li
    Infectious Diseases Division, Washington University School of Medicine, Campus Box 8051, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Mol Biochem Parasitol 137:329-37. 2004
    ..Our results represent an important step toward improved understanding of the molecular biology of reproduction in filarial nematodes...
  46. ncbi request reprint Use of parasite antigen detection to monitor macrofilaricidal therapy in Brugia malayi-infected jirds
    R Chandrashekar
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    J Parasitol 76:122-4. 1990
    ..Parasite antigen levels were stable throughout the study in control animals. These preliminary results suggest that parasite antigen detection is useful as a means of noninvasively monitoring the efficacy of anti-filarial drug therapy...
  47. ncbi request reprint Circulating parasite antigen in Brugia pahangi-infected jirds
    G J Weil
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    J Parasitol 76:78-84. 1990
    ..This technique should facilitate drug and vaccine studies in this important experimental filariasis model...
  48. pmc A review of factors that influence individual compliance with mass drug administration for elimination of lymphatic filariasis
    Alison Krentel
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Negl Trop Dis 7:e2447. 2013
    ..This paper reports results from a comprehensive review of factors that affect compliance with MDA...
  49. pmc Knowledge and practice related to compliance with mass drug administration during the Egyptian national filariasis elimination program
    Khaled M Abd Elaziz
    Department of Community, Environmental, and Occupational Medicine, Faculty of Medicine, and Research and Training Center on Vector of Diseases Ain Shams University, Cairo, Egypt
    Am J Trop Med Hyg 89:260-4. 2013
    ..Adverse events reported by 18.4% of participants were mild and more common in females. This study has provided new information on factors associated with MDA compliance during Egypt's successful LF elimination program...
  50. doi request reprint Human paragonimiasis in North America following ingestion of raw crayfish
    Michael A Lane
    Infectious Diseases Division, Washington University, St Louis, Missouri 63110, USA
    Clin Infect Dis 49:e55-61. 2009
    ..Physicians should consider the possibility that patients who present with cough, fever, hemoptysis, and eosinophilia may have paragonimiasis...
  51. ncbi request reprint Circulating immune complex-associated parasite antigens in human onchocerciasis
    R Chandrashekar
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri
    J Infect Dis 162:1159-64. 1990
    ..These antigens may be useful as targets for improved diagnostic tests for onchocerciasis based on parasite antigen detection...
  52. ncbi request reprint Effect of CGP 20376 on Brugia malayi and parasite antigenemia in jirds
    R Chandrashekar
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    J Parasitol 77:479-82. 1991
    ..Parasite antigen levels in jird sera were consistent with parasitological results in all treatment groups, but antigen clearance was incomplete in some cases after apparently successful treatment of mature and immature infections...
  53. ncbi request reprint Evaluation of a rapid-format antibody test and the tuberculin skin test for diagnosis of tuberculosis in two contrasting endemic settings
    S J McConkey
    Infectious Diseases Division, Washington University School of Medicine and Barnes Jewish Hospital, St Louis, Missouri 63110, USA
    Int J Tuberc Lung Dis 6:246-52. 2002
    ..We evaluated a rapid-format antibody card test and the tuberculin skin test for diagnosis of active tuberculosis (TB) in high (Cairo, Egypt) and low (St. Louis, USA) prevalence areas...
  54. ncbi request reprint A woman from Honduras with a painful forearm and fever
    Erik R Dubberke
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Trop Med Hyg 78:697-8. 2008
  55. ncbi request reprint The impact of single-dose diethylcarbamazine treatment of bancroftian filariasis in a low-endemicity setting in Egypt
    Reda M R Ramzy
    Research and Training Center on Vectors of Diseases, Ain Shams University, Cairo, Egypt
    Am J Trop Med Hyg 67:196-200. 2002
    ....
  56. pmc A critical appraisal of molecular xenomonitoring as a tool for assessing progress toward elimination of Lymphatic Filariasis
    Hoda A Farid
    Research and Training Center on Vectors of Diseases, Ain Shams University, Cairo, Egypt
    Am J Trop Med Hyg 77:593-600. 2007
    ..We conclude that MX is a powerful tool for monitoring the impact of MDA on filariasis endemicity and transmission...
  57. ncbi request reprint Effect of yearly mass drug administration with diethylcarbamazine and albendazole on bancroftian filariasis in Egypt: a comprehensive assessment
    Reda M R Ramzy
    Research and Training Centre on Vectors of Diseases, Ain Shams University, Cairo, Egypt
    Lancet 367:992-9. 2006
    ..5 million in 181 localities). We assessed the effect of five yearly rounds of MDA on filariasis in four sentinel villages in Egypt...
  58. ncbi request reprint Bancroftian filariasis: effect of repeated treatment with diethylcarbamazine and albendazole on microfilaraemia, antigenaemia and antifilarial antibodies
    Hanan Helmy
    Research and Training Center on Vectors of Diseases, Faculty of Science Building, Ain Shams University, Abbassia Square, Cairo 11566, Egypt
    Trans R Soc Trop Med Hyg 100:656-62. 2006
    ..These findings have important implications regarding strategies for monitoring the effects of MDA in populations...
  59. ncbi request reprint Effects of combined diethylcarbamazine and albendazole treatment of bancroftian filariasis on parasite uptake and development in Culex pipiens L
    Hoda A Farid
    Research and Training Center on Vectors of Diseases, Ain Shams University, Cairo, Egypt
    Am J Trop Med Hyg 73:108-14. 2005
    ..Multi-dose MDA (especially in the first year) might interrupt transmission with fewer cycles than single-dose treatment...
  60. ncbi request reprint Duplex Doppler sonographic assessment of the effects of diethylcarbamazine and albendazole therapy on adult filarial worms and adjacent host tissues in Bancroftian filariasis
    Omar Hussein
    Department of Radiology, Department of Community, Environmental, and Occupational Medicine, and Research and Training Center on Vectors of Diseases, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    Am J Trop Med Hyg 71:471-7. 2004
    ..These results show that DEC/ALB is highly active against adult W. bancrofti. They also suggest that host responses to dying adult worms are important in the pathogenesis of filarial hydroceles...
  61. ncbi request reprint Relationships between Wuchereria bancrofti microfilaria counts in human blood and parasite uptake and maturation in Culex pipiens, with observations on the effects of diethylcarbamazine treatment on these parameters
    Hoda A Farid
    Research and Training Center on Vectors of Diseases, Ain Shams University, Abbassia, Cairo, Egypt
    Am J Trop Med Hyg 68:286-93. 2003
    ..9% 6-7 months after treatment; similar reductions were observed for MF uptake, MF/mosquito, infectivity, and L3/mosquito. Thus, single-dose diethylcarbamazine had a major impact on MF ingestion and L3 production by mosquitoes...
  62. pmc The effect of compliance on the impact of mass drug administration for elimination of lymphatic filariasis in Egypt
    Maged El-Setouhy
    Research and Training Center on Vectors of Diseases, Faculty of Science Building, Ain Shams University, Abbassia, Cairo, Egypt
    Am J Trop Med Hyg 77:1069-73. 2007
    ..These results underscore the importance of compliance for LF elimination programs based on MDA and suggest that two ingested doses of MDA are as effective as five doses for reducing filariasis infection rates...
  63. ncbi request reprint A randomized clinical trial comparing single- and multi-dose combination therapy with diethylcarbamazine and albendazole for treatment of bancroftian filariasis
    Maged El Setouhy
    Faculty of Medicine, Research and Training Center on Vectors of Diseases, Ain Shams University, Abbassia, Cairo, Egypt
    Am J Trop Med Hyg 70:191-6. 2004
    ....
  64. pmc Determinants of success in national programs to eliminate lymphatic filariasis: a perspective identifying essential elements and research needs
    Dominique Kyelem
    Lymphatic Filariasis Support Center, Task Force for Child Survival and Development, Decatur, Georgia 30030, USA
    Am J Trop Med Hyg 79:480-4. 2008
    ..While addressing these challenges is important, many key determinants of program success are already clearly understood; operationalizing these as soon as possible will greatly increase the potential for national program success...

Research Grants4

  1. Research for the Elimination of Lymphatic Filariasis
    Gary Weil; Fiscal Year: 2007
    ..Lessons learned in Egypt will benefit PELFs around the world. ..