Jason Weber

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc A non-tumor suppressor role for basal p19ARF in maintaining nucleolar structure and function
    Anthony J Apicelli
    Department of Internal Medicine, Division of Molecular Oncology, Washington University School of Medicine, Campus Box 8069, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Mol Cell Biol 28:1068-80. 2008
  2. pmc ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway
    Suzanne N Brady
    Department of Medicine, Division of Molecular Oncology, Washington University School of Medicine, Campus Box 8069, 660 S Euclid Ave, St Louis, MO 63110, USA
    Mol Cell Biol 24:9327-38. 2004
  3. pmc TSC1 sets the rate of ribosome export and protein synthesis through nucleophosmin translation
    Corey L Pelletier
    Division of Molecular Oncology, Department of Internal Medicine, Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Cancer Res 67:1609-17. 2007
  4. pmc Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome
    Leonard B Maggi
    Department of Medicine, Division of Molecular Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell Biol 28:7050-65. 2008
  5. pmc Nucleolar adaptation in human cancer
    Leonard B Maggi
    Department of Medicine, Division of Molecular Oncology, Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Invest 23:599-608. 2005
  6. pmc Nucleophosmin is essential for ribosomal protein L5 nuclear export
    Yue Yu
    Department of Internal Medicine, Division of Molecular Oncology, Siteman Cancer Center, Washington University School of Medicine, Campus Box 8069, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Mol Cell Biol 26:3798-809. 2006
  7. pmc Therapeutic targets in the ARF tumor suppressor pathway
    Anthony J Saporita
    Departments of Internal Medicine and Cell Biology, Division of Molecular Oncology, Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110 USA
    Curr Med Chem 14:1815-27. 2007
  8. pmc Nucleophosmin redistribution following heat shock: a role in heat-induced radiosensitization
    Robert P VanderWaal
    Department of Radiation Oncology, Washington University, St Louis, Missouri 63108, USA
    Cancer Res 69:6454-62. 2009
  9. ncbi request reprint Nucleophosmin mediates mammalian target of rapamycin-dependent actin cytoskeleton dynamics and proliferation in neurofibromin-deficient astrocytes
    Danielle K Sandsmark
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 67:4790-9. 2007
  10. ncbi request reprint Cerebrospinal fluid proteomic analysis reveals dysregulation of methionine aminopeptidase-2 expression in human and mouse neurofibromatosis 1-associated glioma
    Biplab Dasgupta
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 65:9843-50. 2005

Collaborators

  • David Gutmann
  • Pier P Pandolfi
  • David Kwiatkowski
  • Zhi Hong Lu
  • Joseph L Roti Roti
  • Mu Shui Dai
  • Leonard B Maggi
  • Anthony J Apicelli
  • Suzanne N Brady
  • Anthony J Saporita
  • Corey L Pelletier
  • Yue Yu
  • Raleigh D Kladney
  • Robert P VanderWaal
  • Danielle K Sandsmark
  • Balazs Hegedus
  • Biplab Dasgupta
  • Jeffrey M Arbeit
  • Gary G Chiang
  • Robert D Cardiff
  • Clayton R Hunt
  • Jose Sanchez
  • Silvia Grisendi
  • Katherine Weilbaecher
  • Michael Kuchenreuther
  • Rachel M Schwope
  • R Reid Townsend
  • Angela C Hirbe
  • Alexander P Miceli
  • Michael Kuchenruether
  • Crystal L Schulte-Winkeler
  • David Y A Dadey
  • Mary E Olanich
  • Huabiao Zhang
  • Danielle K Scheidenhelm
  • Hua Lu
  • Yijun Yi

Detail Information

Publications11

  1. pmc A non-tumor suppressor role for basal p19ARF in maintaining nucleolar structure and function
    Anthony J Apicelli
    Department of Internal Medicine, Division of Molecular Oncology, Washington University School of Medicine, Campus Box 8069, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Mol Cell Biol 28:1068-80. 2008
    ..Thus, basal ARF proteins act as a monitor of steady-state ribosome biogenesis and growth independent of their ability to prevent unwarranted hyperproliferation...
  2. pmc ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway
    Suzanne N Brady
    Department of Medicine, Division of Molecular Oncology, Washington University School of Medicine, Campus Box 8069, 660 S Euclid Ave, St Louis, MO 63110, USA
    Mol Cell Biol 24:9327-38. 2004
    ..By actively sequestering NPM in the nucleolus, ARF utilizes an additional mechanism of tumor suppression, one that is readily antagonized by Mdm2...
  3. pmc TSC1 sets the rate of ribosome export and protein synthesis through nucleophosmin translation
    Corey L Pelletier
    Division of Molecular Oncology, Department of Internal Medicine, Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Cancer Res 67:1609-17. 2007
    ....
  4. pmc Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome
    Leonard B Maggi
    Department of Medicine, Division of Molecular Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell Biol 28:7050-65. 2008
    ..These results support the idea that NPM-regulated ribosome export is a fundamental process in cell growth...
  5. pmc Nucleolar adaptation in human cancer
    Leonard B Maggi
    Department of Medicine, Division of Molecular Oncology, Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Invest 23:599-608. 2005
    ..In this review, we will discuss how historical measurements of the nucleolus are being translated into contemporary studies of nucleolar dysfunction in human cancer...
  6. pmc Nucleophosmin is essential for ribosomal protein L5 nuclear export
    Yue Yu
    Department of Internal Medicine, Division of Molecular Oncology, Siteman Cancer Center, Washington University School of Medicine, Campus Box 8069, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Mol Cell Biol 26:3798-809. 2006
    ..Inhibition of NPM shuttling or loss of NPM blocked the nuclear export of rpL5 and 5S rRNA, resulting in cell cycle arrest and demonstrating that NPM and its nuclear export provide a unique and necessary chaperoning activity to rpL5/5S...
  7. pmc Therapeutic targets in the ARF tumor suppressor pathway
    Anthony J Saporita
    Departments of Internal Medicine and Cell Biology, Division of Molecular Oncology, Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110 USA
    Curr Med Chem 14:1815-27. 2007
    ..We will discuss potential therapeutic targets in the ARF pathway, and some preliminary attempts at enhancing or restoring the activity of this important tumor suppressor...
  8. pmc Nucleophosmin redistribution following heat shock: a role in heat-induced radiosensitization
    Robert P VanderWaal
    Department of Radiation Oncology, Washington University, St Louis, Missouri 63108, USA
    Cancer Res 69:6454-62. 2009
    ..NPM knockdown reduces heat-induced inhibition of DNA DSB repair. Also, these results suggest that NPM associates with nuclear matrix attachment region DNA in heat-shocked cells...
  9. ncbi request reprint Nucleophosmin mediates mammalian target of rapamycin-dependent actin cytoskeleton dynamics and proliferation in neurofibromin-deficient astrocytes
    Danielle K Sandsmark
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 67:4790-9. 2007
    ....
  10. ncbi request reprint Cerebrospinal fluid proteomic analysis reveals dysregulation of methionine aminopeptidase-2 expression in human and mouse neurofibromatosis 1-associated glioma
    Biplab Dasgupta
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 65:9843-50. 2005
    ..These observations suggest that MetAP2 is regulated by neurofibromin, and that MetAP2 inhibitors could be potentially employed to treat NF1-associated tumor proliferation...
  11. pmc Tuberous sclerosis complex 1: an epithelial tumor suppressor essential to prevent spontaneous prostate cancer in aged mice
    Raleigh D Kladney
    Division of Molecular Oncology, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Cancer Res 70:8937-47. 2010
    ..1 prostatic epithelial knockout mice. Thus, TSC1 inactivation distal to PI3K and AKT activation is sufficient to activate a molecular signaling cascade producing prostatic neoplasia and focal carcinogenesis...