Mark A Watson

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Gene expression profiling reveals unique molecular subtypes of Neurofibromatosis Type I-associated and sporadic malignant peripheral nerve sheath tumors
    Mark A Watson
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Brain Pathol 14:297-303. 2004
  2. pmc DNMT3A mutations in acute myeloid leukemia
    Timothy J Ley
    Department of Genetics, Genome Center, Washington University, St Louis, MO 63110, USA
    N Engl J Med 363:2424-33. 2010
  3. doi request reprint Array-based comparative genomic hybridization identifies CDK4 and FOXM1 alterations as independent predictors of survival in malignant peripheral nerve sheath tumor
    Jinsheng Yu
    Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, Missouri, USA
    Clin Cancer Res 17:1924-34. 2011
  4. pmc Identification of transcriptional regulatory networks specific to pilocytic astrocytoma
    Hrishikesh Deshmukh
    Department of Pathology and Immunology, Washington University School of Medicine, 660, S, Euclid Ave, St, Louis, MO 63110, USA
    BMC Med Genomics 4:57. 2011
  5. pmc The origin and evolution of mutations in acute myeloid leukemia
    John S Welch
    Department of Medicine, Washington University, St Louis, MO 63110, USA
    Cell 150:264-78. 2012
  6. pmc Use of whole-genome sequencing to diagnose a cryptic fusion oncogene
    John S Welch
    Department of Medicine, Washington University, St Louis, Missouri, USA
    JAMA 305:1577-84. 2011
  7. pmc Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing
    Li Ding
    The Genome Institute, Washington University, St Louis, Missouri 63108, USA
    Nature 481:506-10. 2012
  8. ncbi request reprint Distinct genetic signatures among pilocytic astrocytomas relate to their brain region origin
    Mukesh K Sharma
    Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Cancer Res 67:890-900. 2007
  9. doi request reprint Gene expression profiles of ductal versus acinar adenocarcinoma of the prostate
    Souzan Sanati
    Department of Pathology and Immunology, Division of Anatomic and Molecular Pathology, Washington University School of Medicine, University Medical Center, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Mod Pathol 22:1273-9. 2009
  10. ncbi request reprint PEA3, AP-1, and a unique repetitive sequence all are involved in transcriptional regulation of the breast cancer-associated gene, mammaglobin
    Diane R Hesselbrock
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Breast Cancer Res Treat 89:289-96. 2005

Detail Information

Publications56

  1. ncbi request reprint Gene expression profiling reveals unique molecular subtypes of Neurofibromatosis Type I-associated and sporadic malignant peripheral nerve sheath tumors
    Mark A Watson
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Brain Pathol 14:297-303. 2004
    ..We conclude that distinct molecular classes of MPNST exist and that the ability to stratify these tumors based on unique and biologically relevant gene expression profiles may be important for future targeted therapeutics...
  2. pmc DNMT3A mutations in acute myeloid leukemia
    Timothy J Ley
    Department of Genetics, Genome Center, Washington University, St Louis, MO 63110, USA
    N Engl J Med 363:2424-33. 2010
    ..The genetic alterations responsible for an adverse outcome in most patients with acute myeloid leukemia (AML) are unknown...
  3. doi request reprint Array-based comparative genomic hybridization identifies CDK4 and FOXM1 alterations as independent predictors of survival in malignant peripheral nerve sheath tumor
    Jinsheng Yu
    Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, Missouri, USA
    Clin Cancer Res 17:1924-34. 2011
    ..To identify survival-associated genomic biomarkers, we performed high-resolution array-based comparative genomic hybridization (aCGH) on a large set of MPNSTs...
  4. pmc Identification of transcriptional regulatory networks specific to pilocytic astrocytoma
    Hrishikesh Deshmukh
    Department of Pathology and Immunology, Washington University School of Medicine, 660, S, Euclid Ave, St, Louis, MO 63110, USA
    BMC Med Genomics 4:57. 2011
    ....
  5. pmc The origin and evolution of mutations in acute myeloid leukemia
    John S Welch
    Department of Medicine, Washington University, St Louis, MO 63110, USA
    Cell 150:264-78. 2012
    ..Cells from the founding clone can acquire additional cooperating mutations, yielding subclones that can contribute to disease progression and/or relapse...
  6. pmc Use of whole-genome sequencing to diagnose a cryptic fusion oncogene
    John S Welch
    Department of Medicine, Washington University, St Louis, Missouri, USA
    JAMA 305:1577-84. 2011
    ..Whole-genome sequencing is becoming increasingly available for research purposes, but it has not yet been routinely used for clinical diagnosis...
  7. pmc Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing
    Li Ding
    The Genome Institute, Washington University, St Louis, Missouri 63108, USA
    Nature 481:506-10. 2012
    ..These data demonstrate that AML relapse is associated with the addition of new mutations and clonal evolution, which is shaped, in part, by the chemotherapy that the patients receive to establish and maintain remissions...
  8. ncbi request reprint Distinct genetic signatures among pilocytic astrocytomas relate to their brain region origin
    Mukesh K Sharma
    Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Cancer Res 67:890-900. 2007
    ..These results suggest that glial tumors share an intrinsic, lineage-specific molecular signature that reflects the brain region in which their nonmalignant predecessors originated...
  9. doi request reprint Gene expression profiles of ductal versus acinar adenocarcinoma of the prostate
    Souzan Sanati
    Department of Pathology and Immunology, Division of Anatomic and Molecular Pathology, Washington University School of Medicine, University Medical Center, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Mod Pathol 22:1273-9. 2009
    ....
  10. ncbi request reprint PEA3, AP-1, and a unique repetitive sequence all are involved in transcriptional regulation of the breast cancer-associated gene, mammaglobin
    Diane R Hesselbrock
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Breast Cancer Res Treat 89:289-96. 2005
    ..Elucidating these cis-acting elements will impact our understanding of transcription of normal breast and breast cancer-associated genes...
  11. ncbi request reprint Comparative gene expression profile analysis of neurofibromatosis 1-associated and sporadic pilocytic astrocytomas
    David H Gutmann
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 62:2085-91. 2002
    ..We conclude that PAs are genetically unique gliomas with gene expression profiles that resemble those of fetal astrocytes and, to a lesser extent, oligodendroglial precursors...
  12. doi request reprint Detection of disseminated tumor cells in the bone marrow of breast cancer patients using multiplex gene expression measurements identifies new therapeutic targets in patients at high risk for the development of metastatic disease
    Chidananda M Siddappa
    Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Breast Cancer Res Treat 137:45-56. 2013
    ....
  13. pmc High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples
    Jacqueline E Payton
    Department of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University Medical School, St Louis, Missouri 63110, USA
    J Clin Invest 119:1714-26. 2009
    ....
  14. ncbi request reprint Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma
    Eriks A Lusis
    Division of Neuropathology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 65:7121-6. 2005
    ....
  15. ncbi request reprint Identification of a unique gene expression signature that differentiates hepatocellular adenoma from well-differentiated hepatocellular carcinoma
    Zong Ming E Chen
    Lauren V Ackerman Laboratory of Surgical Pathology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Am J Surg Pathol 29:1600-8. 2005
    ....
  16. ncbi request reprint Variance in the expression of 5-Fluorouracil pathway genes in colorectal cancer
    Elizabeth A Kidd
    Department of Medicine, Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Cancer Res 11:2612-9. 2005
    ..These variations in gene expression could provide valuable insights for optimizing treatment selection for patients with colorectal cancer...
  17. ncbi request reprint DNA methylotype analysis in colorectal cancer
    Jinsheng Yu
    Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Oncol Rep 20:921-7. 2008
    ..62, P=0.003), but not for CDKN2A and DPYD. In conclusion, distinctive DNA methylotypes exist in colorectal cancer and may depict a distinct biology in apparently homogeneous tumors...
  18. pmc Molecular characterization of human meningiomas by gene expression profiling using high-density oligonucleotide microarrays
    Mark A Watson
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Am J Pathol 161:665-72. 2002
    ..This report represents the first gene expression profiling studies of meningiomas and identifies some initial candidate genes that may provide further insights into the genetic basis for meningioma pathogenesis...
  19. pmc Acquired copy number alterations in adult acute myeloid leukemia genomes
    Matthew J Walter
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 106:12950-5. 2009
    ....
  20. ncbi request reprint Gene expression profiling of the irinotecan pathway in colorectal cancer
    Jinsheng Yu
    Department of Medicine, Division of Biostatistics, Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, MO 63110, USA
    Clin Cancer Res 11:2053-62. 2005
    ..Our study indicates that gene expression profiling could be valuable for predicting tumor response to chemotherapy and for tailoring therapy to individual cancer patients...
  21. pmc Isolation and molecular profiling of bone marrow micrometastases identifies TWIST1 as a marker of early tumor relapse in breast cancer patients
    Mark A Watson
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Cancer Res 13:5001-9. 2007
    ....
  22. ncbi request reprint Mantel statistics to correlate gene expression levels from microarrays with clinical covariates
    William D Shannon
    Department of Medicine, Washington University in St Louis School of Medicine, St Louis, Missouri 63110, USA
    Genet Epidemiol 23:87-96. 2002
    ..We also show how the Mantel statistics can be used to rank subsets of genes, found using standard clustering methods, in terms of differential expression across samples...
  23. pmc Randomized phase II neoadjuvant comparison between letrozole, anastrozole, and exemestane for postmenopausal women with estrogen receptor-rich stage 2 to 3 breast cancer: clinical and biomarker outcomes and predictive value of the baseline PAM50-based int
    Matthew J Ellis
    Siteman Cancer Center, Washington University in St Louis, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Clin Oncol 29:2342-9. 2011
    ..To study this treatment option, responses to three AIs were compared in a randomized phase II neoadjuvant trial designed to select agents for phase III investigations...
  24. pmc Comprehensive genomic studies: emerging regulatory, strategic, and quality assurance challenges for biorepositories
    Sandra A McDonald
    Laboratory for Translational Pathology, Dept of Pathology and Immunology, Washington University School of Medicine, 660 Euclid Ave, Box 8118, St Louis, MO 63110, USA
    Am J Clin Pathol 138:31-41. 2012
    ..We summarize our current experiences and best practices at Washington University Medical School, St Louis, MO, our perceptions of emerging trends, and recommendations...
  25. ncbi request reprint Gene expression profiling of primary tumor cell populations using laser capture microdissection, RNA transcript amplification, and GeneChip microarrays
    Veronica I Luzzi
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Methods Mol Biol 293:187-207. 2005
    ..Particular emphasis is placed on troubleshooting each technical step in the protocol and measures of quality assurance for both RNA isolation and resulting microarray data...
  26. ncbi request reprint Differential NF1, p16, and EGFR patterns by interphase cytogenetics (FISH) in malignant peripheral nerve sheath tumor (MPNST) and morphologically similar spindle cell neoplasms
    Arie Perry
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    J Neuropathol Exp Neurol 61:702-9. 2002
    ..001). Thus, FISH analysis identifies relatively specific genetic patterns that may be useful in selected cases, for which the differential diagnosis includes low- or high-grade MPNST...
  27. pmc Copy-number analysis of topoisomerase and thymidylate synthase genes in frozen and FFPE DNAs of colorectal cancers
    Jinsheng Yu
    Washington University School of Medicine, Department of Pathology and Immunology, Saint Louis, MO, USA
    Pharmacogenomics 9:1459-66. 2008
    ....
  28. pmc Recurring mutations found by sequencing an acute myeloid leukemia genome
    Elaine R Mardis
    Department of Genetics, Washington University, St Louis, MO 63110, USA
    N Engl J Med 361:1058-66. 2009
    ..The full complement of DNA mutations that are responsible for the pathogenesis of acute myeloid leukemia (AML) is not yet known...
  29. pmc Commonly dysregulated genes in murine APL cells
    Wenlin Yuan
    Department of Medicine, Siteman Cancer Center, and Department of Pathology and Immunology, Washington University, St Louis, MO 63110, USA
    Blood 109:961-70. 2007
    ..These studies suggest that the genetic events that lead to APL progression may converge on common pathways that are important for leukemia pathogenesis...
  30. ncbi request reprint Mouse glioma gene expression profiling identifies novel human glioma-associated genes
    David H Gutmann
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Neurol 51:393-405. 2002
    ..The use of this transgenic mouse model to identify novel genetic changes that might underlie the pathogenesis of human high-grade astrocytomas provides a unique opportunity to discover future targets for brain tumor therapy...
  31. pmc Accurate and reproducible gene expression profiles from laser capture microdissection, transcript amplification, and high density oligonucleotide microarray analysis
    Veronica Luzzi
    Department of Pathology and Immunology and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Mol Diagn 5:9-14. 2003
    ..The accuracy and technical reproducibility of the method suggests that expression profiling using transcript amplification and high density oligonucleotide microarrays can be used on a routine basis...
  32. pmc Murine cytomegalovirus paralyzes macrophages by blocking IFN gamma-induced promoter assembly
    Daniel L Popkin
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 100:14309-14. 2003
    ....
  33. ncbi request reprint Expression profiles provide insights into early malignant potential and skeletal abnormalities in multiple endocrine neoplasia type 2B syndrome tumors
    Sanjay Jain
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 64:3907-13. 2004
    ..These findings provide molecular evidence that associate the previously unexplained skeletal abnormalities and early malignancy in MEN 2B compared with MEN 2A syndrome...
  34. ncbi request reprint RAS pathway activation and an oncogenic RAS mutation in sporadic pilocytic astrocytoma
    Mukesh K Sharma
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurology 65:1335-6. 2005
  35. doi request reprint Validation of a next-generation sequencing assay for clinical molecular oncology
    Catherine E Cottrell
    Department of Pathology and Immunology, Genomics and Pathology Services, Washington University School of Medicine, St Louis, Missouri
    J Mol Diagn 16:89-105. 2014
    ..The WUCaMP assay is a robust and sensitive method to detect somatic variants of clinical significance in molecular oncology laboratories, with reduced time and cost of genetic analysis allowing for strategic patient management...
  36. doi request reprint Gene expression profiles and differential cytoglobin expression in atrophy and adenocarcinoma of the prostate
    Ashish P Mogal
    Department of Pathology and Immunology, Washington University, St Louis, Missouri, USA
    Prostate 72:931-7. 2012
    ..The precise molecular abnormalities in prostatic atrophy compared to high-grade prostatic intraepithelial neoplasia (HGPIN) and carcinoma have not been fully defined...
  37. pmc Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support
    Scot J Matkovich
    Center for Pharmacogenomics, Washington University, St Louis, MO 63110, USA
    Circulation 119:1263-71. 2009
    ....
  38. ncbi request reprint Reduced renin expression and altered gene transcript profiles in multicystic dysplastic kidneys
    Helen Liapis
    Department of Pathology, Washington University School of Medicine, St Louis, MO, USA
    J Urol 168:1816-20; discussion 1820. 2002
    ..Additionally, global gene transcript profiles were studied in nonhypertensive multicystic dysplasia...
  39. pmc Distal airways in mice exposed to cigarette smoke: Nrf2-regulated genes are increased in Clara cells
    Tracy L Adair-Kirk
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Am J Respir Cell Mol Biol 39:400-11. 2008
    ..These data suggest that the protective response by Clara cells to CS exposure is predominantly regulated by the transcription factor Nrf2...
  40. doi request reprint Correlating EGFR expression with receptor-binding properties and internalization of 64Cu-DOTA-cetuximab in 5 cervical cancer cell lines
    Martin Eiblmaier
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 49:1472-9. 2008
    ....
  41. ncbi request reprint Comparison of clinical targeted next-generation sequence data from formalin-fixed and fresh-frozen tissue specimens
    David H Spencer
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri, USA
    J Mol Diagn 15:623-33. 2013
    ..This study demonstrates that routine processing of FFPE samples has a detectable but negligible effect on NGS data and that these samples can be a reliable substrate for clinical NGS testing. ..
  42. pmc Somatic mutations affect key pathways in lung adenocarcinoma
    Li Ding
    The Genome Center at Washington University, Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Nature 455:1069-75. 2008
    ..Our findings shed further light on several important signalling pathways involved in lung adenocarcinoma, and suggest new molecular targets for treatment...
  43. pmc A new paradigm for biospecimen banking in the personalized medicine era
    Sandra A McDonald
    Laboratory for Translational Pathology, Dept of Pathology and Immunology, Washington University School of Medicine, 660 Euclid Avenue, St Louis, MO 63110, USA
    Am J Clin Pathol 136:679-84. 2011
    ..Successful implementation of this model will require consideration of several financial, medicolegal, and administrative issues...
  44. ncbi request reprint Mammaglobin-based strategies for treatment of breast cancer
    Peter S Goedegebuure
    Department of Surgery, Washington Univesity School of Medicine, St Louis, MO 63110, USA
    Curr Cancer Drug Targets 4:531-42. 2004
    ..In vitro studies have demonstrated that T cell-mediated immune responses can be induced against mammaglobin-derived peptides expressed by MHC molecules on tumor cells and antigen-presenting cells...
  45. pmc PIK3CA and PIK3CB inhibition produce synthetic lethality when combined with estrogen deprivation in estrogen receptor-positive breast cancer
    Robert J Crowder
    Department of Medicine, Division of Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 69:3955-62. 2009
    ..Our results suggest that PI3K inhibitors should target both p110alpha and p110beta catalytic subunits, whether wild-type or mutant, and be combined with endocrine therapy for maximal efficacy when treating ER(+) breast cancer...
  46. ncbi request reprint Mammaglobin is associated with low-grade, steroid receptor-positive breast tumors from postmenopausal patients, and has independent prognostic value for relapse-free survival time
    Paul N Span
    Department of Chemical Endocrinology, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J Clin Oncol 22:691-8. 2004
    ..The tumor mRNA expression levels of mammaglobin, a novel breast-specific and breast cancer-associated marker, were correlated with disease outcome in 280 patients with primary breast cancer...
  47. ncbi request reprint A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer
    Anil Potti
    Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA
    N Engl J Med 355:570-80. 2006
    ..Indeed, approximately 25 percent of patients with stage IA disease have a recurrence after surgery, suggesting the need to identify patients in this subgroup for more effective therapy...
  48. ncbi request reprint Ganglion-specific patterns of diabetes-modulated gene expression are established in prevertebral and paravertebral sympathetic ganglia prior to the development of neuroaxonal dystrophy
    Steven L Carroll
    Department of Pathology, The University of Alabama School of Medicine, Birmingham, Alabama, USA
    J Neuropathol Exp Neurol 63:1144-54. 2004
    ..These results provide support for the specificity of diabetes-modulated gene expression for selected neuronal subpopulations of sympathetic noradrenergic neurons...
  49. ncbi request reprint Identification of mammaglobin as a novel serum marker for breast cancer
    Jonine L Bernstein
    Departments of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Clin Cancer Res 11:6528-35. 2005
    ..The present studies were undertaken to develop the mammaglobin protein as a serum biomarker for detection of breast cancer...
  50. ncbi request reprint Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues
    Shyra J Miller
    Division of Experimental Hematology, Cincinnati Children s Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Cancer Res 66:2584-91. 2006
    ....
  51. ncbi request reprint Optimized tissue processing and staining for laser capture microdissection and nucleic acid retrieval
    Lora E Huang
    Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52246, USA
    Methods Enzymol 356:49-62. 2002
  52. ncbi request reprint Detection of malondialdehyde DNA adducts in human colorectal mucosa: relationship with diet and the presence of adenomas
    Chiara Leuratti
    Medical Research Council Toxicology Unit, University of Leicester, Leicester LE1 9HN, United Kingdom
    Cancer Epidemiol Biomarkers Prev 11:267-73. 2002
    ..061). When levels of adducts were compared in individuals with and without adenomas, there was a trend for higher levels in individuals presenting with adenomas especially in the highest category of M(1)-dG adducts (P < 0.005)...
  53. ncbi request reprint A variable fold change threshold determines significance for expression microarrays
    Thomas J Mariani
    Division of Pulmonary and Critical Care, Department of Medicine, Brigham and Women s Hospital at Harvard Medical School, Boston, Massachusetts 02115, USA
    FASEB J 17:321-3. 2003
    ..We suggest that this approach can be widely used to improve prediction of significant changes in gene expression for oligonucleotide-based microarray experiments and reduce false leads, even in the absence of replicates...
  54. ncbi request reprint Plasminogen activator inhibitor-1 gene polymorphism and colorectal cancer risk and prognosis
    Alexandre Loktionov
    MRC Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 2XY, UK
    Cancer Lett 189:189-96. 2003
    ..02, 95% confidence interval, 1.15-31.54). Our results suggest that PAI-1 genotype may be a useful prognostic marker for colorectal cancer, however further specifically designed studies are needed to assess its value in this respect...
  55. ncbi request reprint DNA repair pathway profiling and microsatellite instability in colorectal cancer
    Jinsheng Yu
    Department of Medicine, Washington University School of Medicine and Siteman Cancer Center, Saint Louis, Missouri 63110 1093, USA
    Clin Cancer Res 12:5104-11. 2006
    ..DNA repair is conducted by distinct pathways of genes, many of which are thought to be altered in colorectal cancer. However, there has been little characterization of these pathways in colorectal cancer...
  56. pmc Celecoxib pre-treatment in human colorectal adenocarcinoma patients is associated with gene expression alterations suggestive of diminished cellular proliferation
    James Todd Auman
    UNC Institute for Pharmacogenomics and Individualized Therapy, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599 7360, United States
    Eur J Cancer 44:1754-60. 2008
    ..Celecoxib pre-treatment for 7 d in vivo is associated with alterations in colorectal adenocarcinoma gene expression which are suggestive of diminished cellular proliferation...