Yian Wang

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. doi Chemopreventive effects of pioglitazone on chemically induced lung carcinogenesis in mice
    Yian Wang
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Mol Cancer Ther 9:3074-82. 2010
  2. pmc Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene
    Ming You
    Washington University, St Louis, Missouri 63110, USA
    Clin Cancer Res 15:2666-74. 2009
  3. doi Chemoprevention of lung carcinogenesis by the combination of aerosolized budesonide and oral pioglitazone in A/J mice
    Huijing Fu
    Department of Energy, Environmental and Chemical Engineering, Washington University in St Louis, St Louis, Missouri 63110, USA
    Mol Carcinog 50:913-21. 2011
  4. pmc A second genetic variant on chromosome 15q24-25.1 associates with lung cancer
    Pengyuan Liu
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 70:3128-35. 2010
  5. doi Enhanced susceptibility to chemical induction of ovarian tumors in mice with a germ line p53 mutation
    Yian Wang
    Department of Surgery, The Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cancer Res 6:99-109. 2008
  6. pmc EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity
    Haris Vikis
    Washington University, St Louis, Missouri, USA
    Cancer Res 67:4665-70. 2007
  7. pmc Haplotype and cell proliferation analyses of candidate lung cancer susceptibility genes on chromosome 15q24-25.1
    Yan Liu
    Washington University, St Louis, Missouri, USA
    Cancer Res 69:7844-50. 2009
  8. ncbi p53 Transgenic mice are highly susceptible to 4-nitroquinoline-1-oxide-induced oral cancer
    Zhongqiu Zhang
    Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Mol Cancer Res 4:401-10. 2006
  9. ncbi Effect of an epidermal growth factor receptor inhibitor in mouse models of lung cancer
    Ying Yan
    Department of Surgery, The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cancer Res 4:971-81. 2006
  10. doi Identification of Las2, a major modifier gene affecting the Pas1 mouse lung tumor susceptibility locus
    Peng Yuan Liu
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 69:6290-8. 2009

Collaborators

Detail Information

Publications52

  1. doi Chemopreventive effects of pioglitazone on chemically induced lung carcinogenesis in mice
    Yian Wang
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Mol Cancer Ther 9:3074-82. 2010
    ..05) decrease in lung SCC. Induction of apoptosis occurred in both model systems. These data show that pioglitazone significantly inhibited progression of both adenocarcinoma and SCC in the two mouse model systems...
  2. pmc Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene
    Ming You
    Washington University, St Louis, Missouri 63110, USA
    Clin Cancer Res 15:2666-74. 2009
    ..In this study, we further refined this locus to identify a single candidate gene, by fine mapping using microsatellite markers and association studies using high-density single nucleotide polymorphisms (SNP)...
  3. doi Chemoprevention of lung carcinogenesis by the combination of aerosolized budesonide and oral pioglitazone in A/J mice
    Huijing Fu
    Department of Energy, Environmental and Chemical Engineering, Washington University in St Louis, St Louis, Missouri 63110, USA
    Mol Carcinog 50:913-21. 2011
    ..Our results provide evidence that aerosolized budesonide and oral pioglitazone could be a promising drug combination for lung cancer chemoprevention...
  4. pmc A second genetic variant on chromosome 15q24-25.1 associates with lung cancer
    Pengyuan Liu
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 70:3128-35. 2010
    ..42 x 10(-11); OR, 1.60; 95% CI, 1.46-1.74; rs481134: P = 7.01 x 10(-4); OR, 0.81; 95% CI, 0.72-0.92). The second variant on 15q24-25.1, marked by rs481134, explains an additional 13.2% of population attributable risk for lung cancer...
  5. doi Enhanced susceptibility to chemical induction of ovarian tumors in mice with a germ line p53 mutation
    Yian Wang
    Department of Surgery, The Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cancer Res 6:99-109. 2008
    ..These findings indicate that a germ line p53 mutation significantly enhanced DMBA-induced ovarian tumor development and progression...
  6. pmc EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity
    Haris Vikis
    Washington University, St Louis, Missouri, USA
    Cancer Res 67:4665-70. 2007
    ..Our observations show that EGFR-T790M provides a proliferative advantage with respect to WT EGFR and suggest that the enhanced kinase activity of this mutant is the basis for rare cases of inherited susceptibility to lung cancer...
  7. pmc Haplotype and cell proliferation analyses of candidate lung cancer susceptibility genes on chromosome 15q24-25.1
    Yan Liu
    Washington University, St Louis, Missouri, USA
    Cancer Res 69:7844-50. 2009
    ..We concluded that PSMA4 is a strong candidate mediator of lung cancer cell growth, and may directly affect lung cancer susceptibility through its modulation of cell proliferation and apoptosis...
  8. ncbi p53 Transgenic mice are highly susceptible to 4-nitroquinoline-1-oxide-induced oral cancer
    Zhongqiu Zhang
    Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Mol Cancer Res 4:401-10. 2006
    ....
  9. ncbi Effect of an epidermal growth factor receptor inhibitor in mouse models of lung cancer
    Ying Yan
    Department of Surgery, The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cancer Res 4:971-81. 2006
    ..Thus, gefitinib showed highly promising chemopreventive and chemotherapeutic activity in this mouse model of lung carcinogenesis...
  10. doi Identification of Las2, a major modifier gene affecting the Pas1 mouse lung tumor susceptibility locus
    Peng Yuan Liu
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 69:6290-8. 2009
    ..Deletion of LAS2 was observed in approximately 40% of human lung adenocarcinomas, implying that loss of function of LAS2 may be a key step for lung tumorigenesis...
  11. pmc Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer
    Pengyuan Liu
    Washington University, St Louis, MO 63110, USA
    J Natl Cancer Inst 100:1326-30. 2008
    ..67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects. Thus, further research to elucidate causal variants in the 15q24-25.1 locus that are associated with lung cancer is warranted...
  12. ncbi Enhanced lung tumor development in tobacco smoke-exposed p53 transgenic and Kras2 heterozygous deficient mice
    Ying Yan
    Department of Surgery, Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Inhal Toxicol 19:183-7. 2007
    ..These results indicate that a p53 mutation or loss of a Kras2 allele increases susceptibility to MS-induced lung tumor development...
  13. ncbi Fine mapping and candidate gene analyses of pulmonary adenoma resistance 1, a major genetic determinant of mouse lung adenoma resistance
    Min Wang
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 67:2508-16. 2007
    ..Our findings have narrowed the Par1 QTL region and will greatly facilitate the identification of the major genetic determinant of mouse lung adenoma resistance...
  14. ncbi Induction of invasive mouse skin carcinomas in transgenic mice with mutations in both H-ras and p53
    Zhongqiu Zhang
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 Euclid Avenue, Box 8109, St Louis, Missouri 63110, USA
    Mol Cancer Res 3:563-74. 2005
    ..The present study provides the first in vivo evidence that a germ line p53 mutation and activated H-ras act synergistically to profoundly enhance tumor progression...
  15. ncbi Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice
    Pengyuan Liu
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Genet 38:888-95. 2006
    ..Our findings demonstrate the prospects for using dense SNP maps in laboratory mice to refine previous QTL regions and identify genetic determinants of complex traits...
  16. pmc Chemoprevention of lung squamous cell carcinoma in mice by a mixture of Chinese herbs
    Yian Wang
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer Prev Res (Phila) 2:634-40. 2009
    ..We found that ATB is rapidly absorbed and then distributes to various tissues including the lung. These results indicate that ATB is a potent chemopreventive agent against the development of mouse lung SCCs...
  17. doi Preventive effects of bexarotene and budesonide in a genetically engineered mouse model of small cell lung cancer
    Yian Wang
    Department of Surgery and The Alvin J Siteman Cancer Center and Division of Comparative Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer Prev Res (Phila) 2:1059-64. 2009
    ..Our results indicate that the retinoid X receptor agonist bexarotene may be a potent chemopreventive agent in this cancer type...
  18. doi Chemopreventive effect of a mixture of Chinese Herbs (antitumor B) on chemically induced oral carcinogenesis
    Yian Wang
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Carcinog 52:49-56. 2013
    ..There was no significant body weight loss and there was no other obvious sign of toxicity in Antitumor B-treated mice. These results suggest that Antitumor B is a promising agent for human oral cancer chemoprevention...
  19. ncbi Degradation of lung adenoma susceptibility 1, a major candidate mouse lung tumor modifier, is required for cell cycle progression
    Yan Liu
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer Res 67:10207-13. 2007
    ..The differential degradation of Las1-A/J and Las-B6 has important implications for its intracellular function and may eventually explain Las1-A/J in lung tumorigenesis...
  20. pmc Cumulative effect of multiple loci on genetic susceptibility to familial lung cancer
    Pengyuan Liu
    Washington University, St Louis, MO 63110, USA
    Cancer Epidemiol Biomarkers Prev 19:517-24. 2010
    ..1, we further determined the cumulative association of these four genetic regions and the population attributable risk percent of familial lung cancer they account for...
  21. pmc A dominant-negative c-jun mutant inhibits lung carcinogenesis in mice
    Jay W Tichelaar
    Department of Surgery, The Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Cancer Prev Res (Phila) 3:1148-56. 2010
    ..Our results support the concept that AP-1 is a key regulator of mouse lung tumorigenesis, and identify AP-1-dependent transcription as a potential target to prevent lung tumor progression...
  22. doi Aerosolized bexarotene inhibits lung tumorigenesis without increasing plasma triglyceride and cholesterol levels in mice
    Qi Zhang
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer Prev Res (Phila) 4:270-6. 2011
    ..These results indicate that aerosolization may be a safe and effective route of administering bexarotene for chemoprevention of lung cancer...
  23. ncbi Farnesyltransferase inhibitors are potent lung cancer chemopreventive agents in A/J mice with a dominant-negative p53 and/or heterozygous deletion of Ink4a/Arf
    Zhongqiu Zhang
    Department of Surgery and The Alvin J Siteman Cancer Center, Campus Box 8109, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Oncogene 22:6257-65. 2003
    ..In fact, L-778,123 is more effective in inhibiting primary lung progression in mice with a p53 mutation and/or an Ink4a/Arf deletion than in wild-type animals...
  24. pmc Efficacy of polyphenon E, red ginseng, and rapamycin on benzo(a)pyrene-induced lung tumorigenesis in A/J mice
    Ying Yan
    Department of Surgery, The Alvin J Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Neoplasia 8:52-8. 2006
    ..The results of these investigations demonstrate that polyphenon E, red ginseng, and rapamycin significantly inhibit pulmonary adenoma formation and growth in A/J mice...
  25. ncbi A gene expression signature that can predict green tea exposure and chemopreventive efficacy of lung cancer in mice
    Yan Lu
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 66:1956-63. 2006
    ..These experiments identified patterns of gene expressions that both offer clues for green tea's potential mechanisms of action and provide a molecular signature specific for green tea exposure...
  26. ncbi Efficacy of the farnesyltransferase inhibitor R115777 in a rat mammary tumor model: role of Ha-ras mutations and use of microarray analysis in identifying potential targets
    Ruisheng Yao
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Carcinogenesis 27:1420-31. 2006
    ..Elucidation of gene expression changes in FTI-treated or control rat mammary adenocarcinomas will help in identifying potential pharmacodynamic markers of FTI treatment as well as potential molecular targets of R115777 and other FTIs...
  27. ncbi Analysis of the Par2 modifier of pulmonary adenoma formation in mice
    Min Wang
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Exp Lung Res 31:193-204. 2005
    ..The authors recently conducted studies to positionally clone the Par2 gene. This review summarizes the effort and progress towards the identification of Par2 candidates...
  28. ncbi Pas1c1 is a candidate for the mouse pulmonary adenoma susceptibility 1 locus
    Min Wang
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8109, St Louis, MO 63110, USA
    Oncogene 24:1958-63. 2005
    ..These results support that Pas1c1 as a candidate for the Pas1 locus and the strain-specific isoforms may have differential effects on cell proliferation...
  29. ncbi Identification of genetic polymorphisms through comparative DNA sequence analysis on the K-ras gene: implications for lung tumor susceptibility
    Min Wang
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Exp Lung Res 31:165-77. 2005
    ....
  30. ncbi K-ras mutations in lung tumors from p53 mutant mice exposed to cigarette smoke
    Ruisheng Yao
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri, USA
    Exp Lung Res 31:271-81. 2005
    ..These results suggest that tobacco smoke enhances lung tumorigenesis primarily through promoting spontaneously occurring K-ras mutations...
  31. doi Quantitative monitoring of adenocarcinoma development in rodents by magnetic resonance imaging
    Joel R Garbow
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Cancer Res 14:1363-7. 2008
    ..The goal of this work was to monitor quantitatively the development and progression of adenocarcinoma in a time course study of mice treated with the carcinogen urethane using in vivo small-animal magnetic resonance imaging (MRI)...
  32. ncbi Pol iota is a candidate for the mouse pulmonary adenoma resistance 2 locus, a major modifier of chemically induced lung neoplasia
    Min Wang
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Cancer Res 64:1924-31. 2004
    ..Thus, our data support the Pol iota gene as a modifier of lung tumorigenesis by altering DNA polymerase activity...
  33. ncbi Cancer chemopreventive activity of a mixture of Chinese herbs (antitumor B) in mouse lung tumor models
    Zhongqiu Zhang
    Department of Surgery and The Alvin J Siteman Cancer Center, Campus Box 8109, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Oncogene 23:3841-50. 2004
    ..Furthermore, ATB exhibited an enhanced inhibitory effect in animals harboring genetic alterations (Kras2, p53, and Ink4a/Arf), which are often seen in human lung adenocarcinomas...
  34. doi Aerosolized 3-bromopyruvate inhibits lung tumorigenesis without causing liver toxicity
    Qi Zhang
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Cancer Prev Res (Phila) 5:717-25. 2012
    ..The ability of 3-bromopyruvate to inhibit mouse lung tumorigenesis, in part through induction of apoptosis, merits further investigation of this compound as a chemopreventive agent for human lung cancer...
  35. pmc Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice
    Zhongqiu Zhang
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 100:12642-7. 2003
    ..Clearly, Kras2 affects lung tumor progression only, and Las1 is likely to affect lung tumor multiplicity...
  36. ncbi Organ-specific expression profiles of rat mammary gland, liver, and lung tissues treated with targretin, 9-cis retinoic acid, and 4-hydroxyphenylretinamide
    Yian Wang
    Department of Surgery and The Alvin J Siteman Cancer Center, Campus Box 8109, Washington University School of Medicine, 660 South, Euclid Avenue, St Louis, MO 63110, USA
    Mol Cancer Ther 5:1060-72. 2006
    ..These expression signatures could provide useful pharmacodynamic biomarkers for retinoid treatment and chemoprevention...
  37. doi Effect of dietary Polyphenon E and EGCG on lung tumorigenesis in A/J Mice
    Qi Zhang
    Department of Surgery and Alvin J Siteman Cancer Center, Washington University in St Louis, 660 South Euclid Avenue, Campus Box 8109, St Louis, Missouri 63110, USA
    Pharm Res 27:1066-71. 2010
    ..To compare the chemopreventive efficacy of Polyphenon E (Poly E), (-)-epigallocatechin-3-gallate (EGCG) and Polyphenon E without EGCG (Poly E-EGCG) on the development of benzo(a)pyrene (B(a)P)-induced lung tumors in A/J mice...
  38. ncbi Budesonide exerts its chemopreventive efficacy during mouse lung tumorigenesis by modulating gene expressions
    Ruisheng Yao
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Oncogene 23:7746-52. 2004
    ..Our results indicate that the chemopreventive effects of budesonide in the mouse lung tumorigenesis assay involved increase and decrease expression of a wide variety of genes in multiple signaling pathways...
  39. pmc Altered gene expression profile in mouse bladder cancers induced by hydroxybutyl(butyl)nitrosamine
    Ruisheng Yao
    Department of Surgery and The Alvin J Siteman Cancer Center, Campus Box 8109, Washington University School of Medicine, St Louis, MO 63110, USA
    Neoplasia 6:569-77. 2004
    ....
  40. pmc Identification of a novel tumor suppressor gene p34 on human chromosome 6q25.1
    Min Wang
    School of Medicine, Washington University, 660 Euclid Avenue, St Louis, MO, USA
    Cancer Res 67:93-9. 2007
    ..Our results suggest that p34 may be a novel tumor suppressor gene involved in sporadic lung cancer but it seems not to be the candidate familial lung cancer susceptibility gene linked to chromosomal region 6q23-25...
  41. doi Beetroot red (betanin) inhibits vinyl carbamate- and benzo(a)pyrene-induced lung tumorigenesis through apoptosis
    Qi Zhang
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Carcinog 52:686-91. 2013
    ..Our data show that betanin significantly inhibits lung tumorigenesis in A/J mice and merits investigation as a chemopreventive agent for human lung cancer...
  42. pmc Efficacy of deguelin and silibinin on benzo(a)pyrene-induced lung tumorigenesis in A/J mice
    Ying Yan
    Department of Surgery, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Neoplasia 7:1053-7. 2005
    ..Thus, deguelin appears to be a promising new preventive agent for lung cancer and may be considered for further studies in other animal models and in clinical trials...
  43. ncbi Tobacco smoke-induced lung tumorigenesis in mutant A/J mice with alterations in K-ras, p53, or Ink4a/Arf
    Yian Wang
    Department of Surgery, School of Medicine, Siteman Cancer Center, The Washington University in St Louis, 660 S Euclid Avenue, St Louis, MO, USA
    Oncogene 24:3042-9. 2005
    ....
  44. pmc 26S proteasome activity is down-regulated in lung cancer stem-like cells propagated in vitro
    Jing Pan
    Department of Surgery, Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 5:e13298. 2010
    ....
  45. pmc Chemopreventive effect of aerosolized polyphenon E on lung tumorigenesis in A/J mice
    Ying Yan
    Department of Surgery, The Alvin J Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Neoplasia 9:401-5. 2007
    ..These results indicate that aerosol delivery of PolyE, but not EGCG, may be a useful chemopreventive protocol in subjects at high risk for lung cancer...
  46. ncbi A chemically induced model for squamous cell carcinoma of the lung in mice: histopathology and strain susceptibility
    Yian Wang
    Department of Surgery and the Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 64:1647-54. 2004
    ..Furthermore, this model can be used in determining genetic modifiers that contribute to susceptibility or resistance to lung SCC development...
  47. doi Transcriptomic analysis by RNA-seq reveals AP-1 pathway as key regulator that green tea may rely on to inhibit lung tumorigenesis
    Jing Pan
    Department of Surgery, The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri Medical College of Wisconsin Cancer Center, Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin
    Mol Carcinog 53:19-29. 2014
    ..Polyphenon E lost its chempreventive function both in vitro and in vivo when AP-1 was inhibited, indicating that AP-1 inhibition is a major pathway through which green tea exhibits chemopreventive effects...
  48. doi Animal models of lung cancer characterization and use for chemoprevention research
    Yian Wang
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Prog Mol Biol Transl Sci 105:211-26. 2012
    ....
  49. pmc RASSF1A promoter methylation and Kras2 mutations in non small cell lung cancer
    Jie Li
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Neoplasia 5:362-6. 2003
    ..Our results indicate a trend of inverse relationship between Kras2 activation and RASSF1A promoter methylation in the majority of human lung adenocarcinomas and large cell carcinomas...
  50. ncbi Mice with alterations in both p53 and Ink4a/Arf display a striking increase in lung tumor multiplicity and progression: differential chemopreventive effect of budesonide in wild-type and mutant A/J mice
    Yian Wang
    Department of Surgery, The Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Cancer Res 63:4389-95. 2003
    ..Thus, the mutant A/J mouse model should prove useful for chemoprevention studies...
  51. pmc Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5
    Jen C Wang
    Department of Psychiatry, Washington University, 660 South Euclid, PO BOX 8134, St Louis, MO 63110, USA
    Hum Mol Genet 18:3125-35. 2009
    ....
  52. doi Mouse models of lung squamous cell carcinomas
    Michael S You
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer Metastasis Rev 32:77-82. 2013
    ..Here, we review the application of mouse lung squamous cell carcinoma models with different stages of squamous lesions and squamous cell carcinomas to cancer development and chemoprevention studies...