Research Topics

Genomes and Genes


Xiaowei Wang


Affiliation: Washington University School of Medicine
Country: USA


  1. Zhou Y, Zhang Q, Gao G, Zhang X, Liu Y, Yuan S, et al. Role of WDHD1 in Human Papillomavirus-Mediated Oncogenesis Identified by Transcriptional Profiling of E7-Expressing Cells. J Virol. 2016;90:6071-6084 pubmed publisher
    ..These studies shed light on mechanisms by which HPV induces genomic instability and have therapeutic implications. ..
  2. request reprint
    Wang X, El Naqa I. Prediction of both conserved and nonconserved microRNA targets in animals. Bioinformatics. 2008;24:325-32 pubmed
    ..All the predicted targets were imported into an online database miRDB, which is freely accessible at ..
  3. Wong N, Liu W, Wang X. WU-CRISPR: characteristics of functional guide RNAs for the CRISPR/Cas9 system. Genome Biol. 2015;16:218 pubmed publisher
    ..These features are used to develop a bioinformatics tool for genome-wide design of sgRNAs with improved efficiency. These sgRNAs as well as the design tool are freely accessible via a web server, WU-CRISPR ( ). ..
  4. Huang J, Eilbeck K, Smith B, Blake J, DOU D, Huang W, et al. The development of non-coding RNA ontology. Int J Data Min Bioinform. 2016;15:214-232 pubmed
    ..By providing a formally defined ncRNA controlled vocabulary, the NCRO aims to fill a specific and highly needed niche in semantic annotation of large amounts of ncRNA biological and clinical data. ..
  5. Spandidos A, Wang X, Wang H, Dragnev S, Thurber T, Seed B. A comprehensive collection of experimentally validated primers for Polymerase Chain Reaction quantitation of murine transcript abundance. BMC Genomics. 2008;9:633 pubmed publisher
    ..This feature is increasingly attractive for confirming and/or making more precise data trends observed from experiments performed with DNA microarrays. ..
  6. Wang X, Wang X, Varma R, Beauchamp L, Magdaleno S, Sendera T. Selection of hyperfunctional siRNAs with improved potency and specificity. Nucleic Acids Res. 2009;37:e152 pubmed publisher
    ..The siRNA design web server is available at ..
  7. Wong N, Wang X. miRDB: an online resource for microRNA target prediction and functional annotations. Nucleic Acids Res. 2015;43:D146-52 pubmed publisher
    ..These miRNAs, as well as associated functional annotations, are presented in the FuncMir Collection in miRDB. ..
  8. Khwaja S, Baker C, Haynes W, Spencer C, Gay H, Thorstad W, et al. High E6 Gene Expression Predicts for Distant Metastasis and Poor Survival in Patients With HPV-Positive Oropharyngeal Squamous Cell Carcinoma. Int J Radiat Oncol Biol Phys. 2016;95:1132-41 pubmed publisher
    ..Validation in a multi-institutional prospective clinical trial is required to assess the utility of E6 gene expression as a clinically useful prognostic biomarker. ..