Research Topics
Genomes and Genes | Hanlin L WangSummaryAffiliation: Washington University School of Medicine Country: USA Publications
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Publications
Detection of human papillomavirus DNA and expression of p16, Rb, and p53 proteins in small cell carcinomas of the uterine cervixHanlin L Wang
Lauren V Ackerman Laboratory of Surgical Pathology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
Am J Surg Pathol 28:901-8. 2004....- Immunohistochemical distinction between primary adenocarcinoma of the bladder and secondary colorectal adenocarcinomaH L Wang
Department of Pathology, University of Chicago Hospitals, Chicago, Illinois, USA
Am J Surg Pathol 25:1380-7. 2001..In addition, our data demonstrate that a panel of immunostains, including CK7, CK20, TM, and beta-catenin, is of diagnostic value in differentiating primary bladder adenocarcinoma from secondary adenocarcinoma of colorectal origin... - Overexpression of c-kit protein is an infrequent event in small cell carcinomas of the uterine cervixHanlin L Wang
Lauren V Ackerman Laboratory of Surgical Pathology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
Mod Pathol 17:732-8. 2004..In comparison with small cell lung cancers, the findings presented in this report may reflect the difference in etiopathogenetic mechanisms underlying these two types of small cell carcinomas... - Identification of a unique gene expression signature that differentiates hepatocellular adenoma from well-differentiated hepatocellular carcinomaZong Ming E Chen
Lauren V Ackerman Laboratory of Surgical Pathology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
Am J Surg Pathol 29:1600-8. 2005.... - Collagenous gastritis: an unusual association with profound weight lossHanlin L Wang
Lauren V Ackerman Laboratory of Surgical Pathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
Arch Pathol Lab Med 128:229-32. 2004..An unusual case of collagenous gastritis was observed in a 37-year-old man who presented with profound weight loss, a feature that has not previously been emphasized... - Exaggerated signet-ring cell change in stromal nodule of prostate: a pseudoneoplastic proliferationHanlin L Wang
Lauren V Ackerman Laboratory of Surgical Pathology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110 1093, U S A
Am J Surg Pathol 26:1066-70. 2002..This case demonstrates that signet-ring cell change may occur in benign, hyperplastic, prostatic stromal cells in the absence of cellular damage... - Carcinomatous arteriopathy as an unusual feature of pulmonary spread of cholangiocarcinoma arising in Caroli diseaseHanlin L Wang
Department of Pathology, The University of Chicago Hospitals, Ill, USA
Arch Pathol Lab Med 126:717-20. 2002..We report a unique case of cholangiocarcinoma that arose in Caroli disease. Postmortem examination revealed extensive pulmonary vascular spread in the form of carcinomatous arteriopathy... - Expression of mucins, SIMA, villin, and CDX2 in small-intestinal adenocarcinomaMegan Q Zhang
Lauren V Ackerman Laboratory of Surgical Pathology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
Am J Clin Pathol 128:808-16. 2007..These observations further support the notion that SIA is immunophenotypically distinct from CRC despite their morphologic similarity... - Metachronous squamous cell carcinomas evolving from independent oropharyngeal and pulmonary squamous papillomas: association with human papillomavirus 11 and lack of aberrant p53, Rb, and p16 protein expressionHaodong Xu
Lauren V. Ackerman Laboratory of Surgical Pathology, Washington University School of Medicine, St. Louis, MO 63110-1093, USA
Hum Pathol 35:1419-22. 2004..These observations indicate that human papillomavirus 11-associated neoplastic transformation and tumor progression in the respiratory tract may not involve aberrant regulation of the p53 and Rb signaling pathways... - Immunohistochemical evaluation of adenomatous polyposis coli, beta-catenin, c-Myc, cyclin D1, p53, and retinoblastoma protein expression in syndromic and sporadic fundic gland polypsAnjum Hassan
Lauren V Ackerman Laboratory of Surgical Pathology, Washington University, St. Louis, MO 63110-1093, USA
Hum Pathol 35:328-34. 2004..These findings may explain at least in part why fundic gland polyps show a negligible malignant potential even in the presence of dysplasia... - Epstein-Barr virus gastritis: an underrecognized form of severe gastritis simulating gastric lymphomaZong Ming E Chen
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
Am J Surg Pathol 31:1446-51. 2007..This case illustrates the importance of a high index of suspicion to avoid misdiagnosis of gastric lymphoma that requires more aggressive therapies... - Is cytomegalovirus associated with human colorectal tumorigenesis?Olaronke Akintola-Ogunremi
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
Am J Clin Pathol 123:244-9. 2005..These observations demonstrate an absence of CMV proteins and DNA in human colorectal adenocarcinomas and their precursor lesions... - Immunohistochemical investigation of tumorigenic pathways in small intestinal adenocarcinoma: a comparison with colorectal adenocarcinomaMegan Q Zhang
Lauren V Ackerman Laboratory of Surgical Pathology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
Mod Pathol 19:573-80. 2006..Small intestinal tumorigenesis appears to follow a distinct, yet unidentified, molecular pathway(s) from its colorectal counterpart despite their morphologic similarity... - Differential expression of the AP-1 transcription factor family members in human colorectal epithelial and neuroendocrine neoplasmsWanghai Zhang
Department of Medicine, Washington University School of Medicine, St Louis, MO 63110-1093, USA
Am J Clin Pathol 124:11-9. 2005..Up-regulation of c-Jun and Fra-1 is an early event in human colorectal tumorigenesis. Overexpression of Fra-2 may participate in tumor progression... - Value of CDX2, villin, and alpha-methylacyl coenzyme A racemase immunostains in the distinction between primary adenocarcinoma of the bladder and secondary colorectal adenocarcinomaNamsoo Suh
Lauren V Ackerman Laboratory of Surgical Pathology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110-1093, USA
Mod Pathol 18:1217-22. 2005..Lack of CDX2 and villin signals points strongly to a bladder primary... - Expression of beta-catenin in prostatic adenocarcinomas: a comparison with colorectal adenocarcinomasTark A Bismar
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110-1093, USA
Am J Clin Pathol 121:557-63. 2004..The immunophenotypes documented herein also might aid in the distinction between prostatic and colorectal origins when metastasis is encountered... - Expression of p16, Rb, and p53 proteins in squamous cell carcinomas of the anorectal region harboring human papillomavirus DNADanielle W Lu
Lauren V. Ackerman Laboratory of Surgical Pathology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
Mod Pathol 16:692-9. 2003.... 
Aberrant expression of alpha-fetoprotein in intrahepatic cholangiocarcinoma: an exceptional occurrenceKiran Vij
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
Int J Surg Pathol 16:194-8. 2008..To the best of our knowledge, this is the first documented case of AFP-producing intrahepatic cholangiocarcinoma with immunohistochemical evidence confirming the tumor cells to be the source of high-level AFP production...- Epstein-Barr virus hepatitis: diagnostic value of in situ hybridization, polymerase chain reaction, and immunohistochemistry on liver biopsy from immunocompetent patientsNamsoo Suh
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
Am J Surg Pathol 31:1403-9. 2007..However, EBER-positive cells can be sparse and easily overlooked. Immunohistochemistry for EBV latent membrane proteins apparently has no utility in the diagnosis of EBV hepatitis... - Mimics of cholangiocarcinoma: spectrum of diseaseChristine O Menias
Department of Radiology, Mallinckrodt Institute of Radiology, St Louis, MO, USA
Radiographics 28:1115-29. 2008..In most cases, a definitive diagnosis can be established only with histopathologic examination of a biopsy specimen... - Differential expression of alpha-methylacyl coenzyme A racemase in adenocarcinomas of the small and large intestinesZong-Ming E Chen
Lauren V. Ackerman Laboratory of Surgical Pathology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110-1093, USA
Am J Surg Pathol 29:890-6. 2005.... - Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-cateninHanlin L Wang
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
Int J Cancer 101:301-10. 2002..While dysregulated beta-catenin may cause a transcriptional upregulation of the c-myc gene, the c-Myc protein expression appears to be further regulated by a posttranscriptional mechanism(s) during the process of neoplastic progression... - Analysis of protein expression and gene mutation of c-kit in colorectal neuroendocrine carcinomasOlaronke Akintola-Ogunremi
Lauren V Ackerman Laboratory of Surgical Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Am J Surg Pathol 27:1551-8. 2003..More importantly, our observations may have potential therapeutic implications since specific tyrosine kinase inhibitors have shown promise in the management of patients with kit-expressing malignancies... - Prevalence and typing of HPV DNA in atypical squamous cells in pregnant womenDanielle W Lu
Department of Pathology, Huntington Memorial Hospital, 100 West California Boulevard, Pasadena, California 91105, USA
Acta Cytol 47:1008-16. 2003..To determine the prevalence and typing of HPV DNA in pregnant women with a diagnosis of atypical squamous cells (ASC) and to assess whether pregnancy-related changes contribute to the diagnosis of ASC... - Granulomatous inflammatory pseudotumor of the spleen: association with Epstein-Barr virusMegan Q Zhang
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
Appl Immunohistochem Mol Morphol 17:259-63. 2009..To our knowledge, this case represents a rare example of splenic inflammatory pseudotumor with exuberant granulomatous reaction in association with Epstein-Barr viral infection... - Deletion of the AU-rich RNA binding protein Apobec-1 reduces intestinal tumor burden in Apc(min) miceValerie Blanc
Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
Cancer Res 67:8565-73. 2007..These findings suggest that deletion of apobec-1, by modulating expression of AU-rich RNA targets, provides an important mechanism for attenuating a dominant genetic restriction point in intestinal adenoma formation... - Alteration of cytokeratin 7 and cytokeratin 20 expression profile is uniquely associated with tumorigenesis of primary adenocarcinoma of the small intestineZong Ming E Chen
Lauren V Ackerman Laboratory of Surgical Pathology, Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110 1093, USA
Am J Surg Pathol 28:1352-9. 2004..This unique pattern may be of diagnostic value in distinguishing primary small intestinal adenocarcinoma from secondary colorectal adenocarcinoma... - Reactive hemophagocytic syndrome complicating the treatment of inflammatory bowel diseaseDustin G James
Division of Gastroenterology, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
Inflamm Bowel Dis 12:573-80. 2006..The aims of this study were to describe the clinical and laboratory features of RHS associated with IBD and to review diagnostic criteria, treatment options, and pathogenesis... - Value of Islet 1 and PAX8 in identifying metastatic neuroendocrine tumors of pancreatic originJamie Koo
Department of Pathology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Mod Pathol 25:893-901. 2012.... - Value of glypican 3 immunostaining in the diagnosis of hepatocellular carcinoma on needle biopsyFlorencia Anatelli
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
Am J Clin Pathol 130:219-23. 2008..Our findings emphasize that GPC3 immunoreactivity can be focal and that negative staining should not be viewed as evidence to exclude the diagnosis of HCC in challenging needle biopsy specimens... - Absence of Y chromosome in human placental site trophoblastic tumorPei Hui
Department of Pathology, Yale University, New Haven, CT 06520 8023, USA
Mod Pathol 20:1055-60. 2007.... - Expression of alpha-methylacyl-coenzyme A racemase in nephrogenic adenomaAnita Gupta
Department of Pathology, Northwestern Memorial Hospital Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
Am J Surg Pathol 28:1224-9. 2004..These findings could be explained by possible renal tubular origin or renal differentiation, at least in a subset, of nephrogenic adenomas... - Expression of epidermal growth factor receptor in squamous cell carcinomas of the anal canal is independent of gene amplificationGustavo Alvarez
Lauren V Ackerman Laboratory of Surgical Pathology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110-1093, USA
Mod Pathol 19:942-9. 2006..These observations may have important therapeutic implications since EGFR-based targeted therapies have shown promise for other malignant neoplasms... - Diagnostic utility of CD10 in benign and malignant extrahepatic bile duct lesionsMaria Tretiakova
Department of Pathology, University of Chicago Medical Center, Chicago, IL, USA
Am J Surg Pathol 36:101-8. 2012.... 
Lymphovascular invasion in colorectal cancer: an interobserver variability studyElizabeth I Harris
Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Am J Surg Pathol 32:1816-21. 2008..This study was undertaken to examine such interobserver variability, and we hypothesized that the use of immunohistochemical markers for vascular and lymphatic channels could improve interobserver agreement...- Depression, anxiety, and nonalcoholic steatohepatitisJill E Elwing
Division of Gastroenterology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
Psychosom Med 68:563-9. 2006..Additional investigation will be required to determine if depression and anxiety affect the development or progression of NASH and serve as modifiable risk factors... - Reduced CD1d expression in colonic epithelium in microscopic colitisYimin Ge
Department of Pathology, University of Texas Medical Branch, Galveston 77555-0588, USA
Appl Immunohistochem Mol Morphol 14:309-13. 2006..001). These findings suggest that microscopic colitis is associated with decreased epithelial expression of CD1d, an important immunoregulatory molecule in the gastrointestinal tract... - Resistance to mammary carcinogenesis in Copenhagen rats: potential roles of vascular endothelial growth factor and mast cellsChengshi Quan
Department of Pediatrics, College of Medicine, M/C 856, University of Illinois at Chicago, Chicago, IL 60612, USA
Cancer Lett 186:165-75. 2002.... - Clinical recognition of Al type amyloidosis of the luminal gastrointestinal tractDustin G James
Division of Gastroenterology, Washington University School of Medicine, St Louis, Missouri, USA
Clin Gastroenterol Hepatol 5:582-8. 2007..The aim of this investigation was to characterize the clinical presentation, endoscopic findings, and histopathologic correlates in a series of patients with systemic AL amyloidosis of the luminal gastrointestinal tract... - Fulminant adenovirus hepatitis following bone marrow transplantation. A case report and brief review of the literatureWei Hua Wang
Lauren V. Ackerman Laboratory of Surgical Pathology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110-1093, USA
Arch Pathol Lab Med 127:e246-8. 2003..The diagnosis was established by histologic and immunohistochemical examination of a liver biopsy and was confirmed by liver tissue and blood cultures... - Metastatic foci of signet ring cell carcinoma in a tubular adenoma of the colonTarek A Bismar
Department of Pathology and Immunology, Lauren V. Ackerman Laboratory of Surgical Pathology, Washington University School of Medicine, St Louis, MO 63110-1093, USA
Arch Pathol Lab Med 127:1509-12. 2003..This case illustrates the necessity of submitting all polyps entirely and the importance of examining them carefully... - Glypican-3 as a useful diagnostic marker that distinguishes hepatocellular carcinoma from benign hepatocellular mass lesionsHanlin L Wang
Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Arch Pathol Lab Med 132:1723-8. 2008..The currently available ancillary tools are suboptimal in terms of sensitivity and specificity... - Coexpression of c-kit and bcl-2 in small cell carcinoma and large cell neuroendocrine carcinoma of the lungRandi J A LaPoint
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Elmwood 601, Rochester, NY 14642, USA
Appl Immunohistochem Mol Morphol 15:401-6. 2007..Therapeutic targeting on both c-kit and bcl-2 molecules might be beneficial in the management of patients with high grade neuroendocrine carcinomas of the lung in the future... - High-grade neuroendocrine carcinomas of the lung express K homology domain containing protein overexpressed in cancer but carcinoid tumors do notHaodong Xu
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Hum Pathol 38:555-63. 2007..Our findings of equivalent IGF-II expression in KOC-positive SCLC and LCNEC and KOC-negative carcinoid tumors suggest different regulatory mechanisms involved in the control of IGF-II expression in these tumors... - Diagnostic utility of S100P and von Hippel-Lindau gene product (pVHL) in pancreatic adenocarcinoma-with implication of their roles in early tumorigenesisFan Lin
Department of Laboratory Medicine, Geisinger Medical Center, Danville, PA 17822, USA
Am J Surg Pathol 32:78-91. 2008.... - Extrapulmonary small cell carcinomas express K homology domain containing protein overexpressed in cancer, but carcinoid tumors do notRochelle Simon
Department of Pathology and Laboratory Medicine, PO Box 626, University of Rochester Medical Center, Rochester, NY 14642, USA
Hum Pathol 38:1178-83. 2007....