Jessica E Wagenseil

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Elastin-insufficient mice show normal cardiovascular remodeling in 2K1C hypertension despite higher baseline pressure and unique cardiovascular architecture
    Jessica E Wagenseil
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 S Euclid Street, St Louis, MO 63110, USA
    Am J Physiol Heart Circ Physiol 293:H574-82. 2007
  2. doi request reprint New insights into elastic fiber assembly
    Jessica E Wagenseil
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Birth Defects Res C Embryo Today 81:229-40. 2007
  3. pmc The importance of elastin to aortic development in mice
    Jessica E Wagenseil
    Dept of Biomedical Engineering, Saint Louis Univ, 3507 Lindell Blvd, St Louis, MO 63103, USA
    Am J Physiol Heart Circ Physiol 299:H257-64. 2010
  4. pmc Reduced vessel elasticity alters cardiovascular structure and function in newborn mice
    Jessica E Wagenseil
    Department of Cell Biology, Washington University School of Medicine, St Louis, MO, USA
    Circ Res 104:1217-24. 2009
  5. pmc Decreased aortic diameter and compliance precedes blood pressure increases in postnatal development of elastin-insufficient mice
    Victoria P Le
    Dept of Biomedical Engineering, Saint Louis Univ, 3507 Lindell Blvd, St Louis, MO 63103, USA
    Am J Physiol Heart Circ Physiol 301:H221-9. 2011
  6. pmc Alternative splicing and tissue-specific elastin misassembly act as biological modifiers of human elastin gene frameshift mutations associated with dominant cutis laxa
    Hideki Sugitani
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 287:22055-67. 2012
  7. pmc A fiber-based constitutive model predicts changes in amount and organization of matrix proteins with development and disease in the mouse aorta
    Jeffrey K Cheng
    Department of Biomedical Engineering, Washington University, St Louis, MO, USA
    Biomech Model Mechanobiol 12:497-510. 2013
  8. pmc Elastin in large artery stiffness and hypertension
    Jessica E Wagenseil
    Department of Biomedical Engineering, Saint Louis University, 3507 Lindell Blvd, St Louis, MO 63103, USA
    J Cardiovasc Transl Res 5:264-73. 2012
  9. ncbi request reprint Effects of elastin haploinsufficiency on the mechanical behavior of mouse arteries
    Jessica E Wagenseil
    Department of Cell Biology and Physiology, CB 8228, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Am J Physiol Heart Circ Physiol 289:H1209-17. 2005
  10. ncbi request reprint Cell orientation influences the biaxial mechanical properties of fibroblast populated collagen vessels
    Jessica E Wagenseil
    Department of Biomedical Engineering, Washington University, One Brookings Dr, St Louis, MO 63110, USA
    Ann Biomed Eng 32:720-31. 2004

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Elastin-insufficient mice show normal cardiovascular remodeling in 2K1C hypertension despite higher baseline pressure and unique cardiovascular architecture
    Jessica E Wagenseil
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 S Euclid Street, St Louis, MO 63110, USA
    Am J Physiol Heart Circ Physiol 293:H574-82. 2007
    ..Therefore, the cardiovascular properties of ELN(+/-) mice are likely due to developmental remodeling in response to altered hemodynamics and reduced elastin levels...
  2. doi request reprint New insights into elastic fiber assembly
    Jessica E Wagenseil
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Birth Defects Res C Embryo Today 81:229-40. 2007
    ....
  3. pmc The importance of elastin to aortic development in mice
    Jessica E Wagenseil
    Dept of Biomedical Engineering, Saint Louis Univ, 3507 Lindell Blvd, St Louis, MO 63103, USA
    Am J Physiol Heart Circ Physiol 299:H257-64. 2010
    ..Understanding the interplay between elastin amounts and hemodynamic forces in developing vessels will help design treatments for human elastinopathies and optimize protocols for tissue engineering...
  4. pmc Reduced vessel elasticity alters cardiovascular structure and function in newborn mice
    Jessica E Wagenseil
    Department of Cell Biology, Washington University School of Medicine, St Louis, MO, USA
    Circ Res 104:1217-24. 2009
    ..Together, these results show that reduced elastin in mice leads to adaptive remodeling, whereas the complete lack of elastin leads to pathological remodeling and death...
  5. pmc Decreased aortic diameter and compliance precedes blood pressure increases in postnatal development of elastin-insufficient mice
    Victoria P Le
    Dept of Biomedical Engineering, Saint Louis Univ, 3507 Lindell Blvd, St Louis, MO 63103, USA
    Am J Physiol Heart Circ Physiol 301:H221-9. 2011
    ..This temporal relationship suggests that targeting large arteries to increase diameter or compliance may be an effective treatment for human hypertension...
  6. pmc Alternative splicing and tissue-specific elastin misassembly act as biological modifiers of human elastin gene frameshift mutations associated with dominant cutis laxa
    Hideki Sugitani
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 287:22055-67. 2012
    ..Our results confirm the critical role of the C-terminal region of tropoelastin in elastic fiber assembly and suggest tissue-specific differences in the elastin assembly pathway...
  7. pmc A fiber-based constitutive model predicts changes in amount and organization of matrix proteins with development and disease in the mouse aorta
    Jeffrey K Cheng
    Department of Biomedical Engineering, Washington University, St Louis, MO, USA
    Biomech Model Mechanobiol 12:497-510. 2013
    ..Relating quantifiable changes in arterial mechanics with changes in extracellular matrix (ECM) protein amounts will help in understanding developmental remodeling and in producing treatments for human diseases affecting ECM proteins...
  8. pmc Elastin in large artery stiffness and hypertension
    Jessica E Wagenseil
    Department of Biomedical Engineering, Saint Louis University, 3507 Lindell Blvd, St Louis, MO 63103, USA
    J Cardiovasc Transl Res 5:264-73. 2012
    ..Therapies that have a direct effect on arterial stiffness through alterations to the elastic fibers in the wall may be an effective treatment for essential hypertension...
  9. ncbi request reprint Effects of elastin haploinsufficiency on the mechanical behavior of mouse arteries
    Jessica E Wagenseil
    Department of Cell Biology and Physiology, CB 8228, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Am J Physiol Heart Circ Physiol 289:H1209-17. 2005
    ..The mechanical behavior of ELN(+/-) arteries is likely due to the reduced elastin content combined with adaptive remodeling during vascular development...
  10. ncbi request reprint Cell orientation influences the biaxial mechanical properties of fibroblast populated collagen vessels
    Jessica E Wagenseil
    Department of Biomedical Engineering, Washington University, One Brookings Dr, St Louis, MO 63110, USA
    Ann Biomed Eng 32:720-31. 2004
    ..After Cyto D treatment, the FPCVs remained more extensible in the direction perpendicular to the cell orientation, even though a preferred collagen fiber orientation was not observed in the microscopy images...
  11. ncbi request reprint Elastic fiber formation: a dynamic view of extracellular matrix assembly using timer reporters
    Beth A Kozel
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Physiol 207:87-96. 2006
    ..Time-lapse imaging combined with the use of Timer constructs provides unique tools for studying the temporal and spatial aspects of extracellular matrix formation by live cells...
  12. pmc Effect of storage duration on the mechanical behavior of mouse carotid artery
    Mazyar Amin
    Department of Biomedical Engineering, St Louis University, St Louis, MO 63103, USA
    J Biomech Eng 133:071007. 2011
    ..We conclude that histology sections yield a more consistent measurement of the unloaded dimensions and that there are no significant changes in the mechanical behavior of mouse carotid artery with storage up to 28 days...
  13. pmc Vascular extracellular matrix and arterial mechanics
    Jessica E Wagenseil
    Department of Biomedical Engineering, Saint Louis University, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Physiol Rev 89:957-89. 2009
    ..We also discuss mechanical models that can be used to design better tissue-engineered vessels and to test the efficacy of clinical treatments...
  14. ncbi request reprint One-dimensional viscoelastic behavior of fibroblast populated collagen matrices
    Jessica E Wagenseil
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 S Euclid, CB 8228, St Louis, MO 63110, USA
    J Biomech Eng 125:719-25. 2003
    ..The peak force, hysteresis and shape of the force-stretch curve are affected by the stretch rate, rest period, stretch amplitude and the number and magnitude of preconditioning cycles...
  15. ncbi request reprint Mechanical properties of dilated human ascending aorta
    Ruth J Okamoto
    Department of Mechanical Engineering, Washington University, St Louis, MO 63130 4899, USA
    Ann Biomed Eng 30:624-35. 2002
    ..35 +/- 0.37 MPa, n= 14) than younger (2.04 +/- 0.46 MPa, n = 11, age <50 years). These changes in mechanical properties suggest that age may influence the risk of aortic dissection or rupture of dilated ascending aorta...
  16. pmc Extracellular matrix and the mechanics of large artery development
    Jeffrey K Cheng
    Department of Biomedical Engineering, Washington University, St Louis, MO 63103, USA
    Biomech Model Mechanobiol 11:1169-86. 2012
    ..A review of constitutive models and growth and remodeling theories is presented, along with future directions to improve understanding of ECM and the mechanics of large artery development...
  17. ncbi request reprint Modeling cell and matrix anisotropy in fibroblast populated collagen vessels
    Jessica E Wagenseil
    Department of Biomedical Engineering, CB 1097 Washington University, St Louis, MO 63130, USA
    Biomech Model Mechanobiol 6:151-62. 2007
    ..Additional microstructural measurements of the collagen matrix may help to more precisely determine the relative contributions of cells and matrix...
  18. pmc A constrained mixture model for developing mouse aorta
    Jessica E Wagenseil
    Department of Biomedical Engineering, Saint Louis University, 3507 Lindell Blvd, St Louis, MO 63110, USA
    Biomech Model Mechanobiol 10:671-87. 2011
    ..With these alterations, the model approximates experimental data on the mechanical properties and dimensions of aorta from 3- to 30-day-old mice...