Beth A Vorderstrasse

Summary

Affiliation: Washington State University
Country: USA

Publications

  1. pmc Alcohol consumption suppresses mammary tumor metastasis in a syngeneic tumor transplantation model
    Beth A Vorderstrasse
    Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Wegner Hall, 1505 Stadium Way, Pullman, WA 99164 6534, USA
    Breast Cancer Res Treat 136:729-37. 2012
  2. pmc Mechanistic exploration of AhR-mediated host protection against Streptococcus pneumoniae infection
    Tao Wang
    Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, WA 99164, USA
    Int Immunopharmacol 13:490-8. 2012
  3. ncbi request reprint Activation of the aryl hydrocarbon receptor diminishes the memory response to homotypic influenza virus infection but does not impair host resistance
    B Paige Lawrence
    Department of Pharmaceutical Sciences, Pharmacology Toxicology Program, College of Pharmacy, Washington State University, Pullman, Washington 99164 6534, USA
    Toxicol Sci 79:304-14. 2004
  4. pmc Activation of the aryl hydrocarbon receptor by TCDD inhibits mammary tumor metastasis in a syngeneic mouse model of breast cancer
    Tao Wang
    Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, Washington 99164, USA
    Toxicol Sci 124:291-8. 2011
  5. pmc Protection against lethal challenge with Streptococcus pneumoniae is conferred by aryl hydrocarbon receptor activation but is not associated with an enhanced inflammatory response
    Beth A Vorderstrasse
    Dept of Environmental Medicine, Box 850, University of Rochester School of Medicine, 575 Elmwood Avenue, Rochester, NY 14642, USA
    Infect Immun 74:5679-86. 2006
  6. ncbi request reprint A dose-response study of the effects of prenatal and lactational exposure to TCDD on the immune response to influenza a virus
    Beth A Vorderstrasse
    Department of Pharmaceutical Sciences, Pharmacology Toxicology Program, and Center for Reproductive Biology, Washington State University, Pullman, Washington 99164 6534, USA
    J Toxicol Environ Health A 69:445-63. 2006
  7. ncbi request reprint Fewer CTL, not enhanced NK cells, are sufficient for viral clearance from the lungs of immunocompromised mice
    Haley D Neff-LaFord
    Department of Pharmaceutical Sciences and the Pharmacology Toxicology Graduate Program, College of Pharmacy, Washington State University, Pullman, WA 99164, USA
    Cell Immunol 226:54-64. 2003
  8. ncbi request reprint A novel effect of dioxin: exposure during pregnancy severely impairs mammary gland differentiation
    Beth A Vorderstrasse
    Department of Pharmaceutical Sciences, Washington State University, Pullman, Washington 99164, USA
    Toxicol Sci 78:248-57. 2004
  9. ncbi request reprint Examining the relationship between impaired host resistance and altered immune function in mice treated with TCDD
    Beth A Vorderstrasse
    Department of Pharmaceutical Sciences, Washington State University, Wegner Hall, Pullman, WA 99264 6534, USA
    Toxicology 188:15-28. 2003
  10. pmc Activation of the aryl hydrocarbon receptor is essential for mediating the anti-inflammatory effects of a novel low-molecular-weight compound
    B Paige Lawrence
    Department of Environmental Medicine, University of Rochester, NY, USA
    Blood 112:1158-65. 2008

Research Grants

Detail Information

Publications11

  1. pmc Alcohol consumption suppresses mammary tumor metastasis in a syngeneic tumor transplantation model
    Beth A Vorderstrasse
    Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Wegner Hall, 1505 Stadium Way, Pullman, WA 99164 6534, USA
    Breast Cancer Res Treat 136:729-37. 2012
    ..2 cells in vitro. Our results indicate that, for this murine model, alcohol consumption does not exacerbate tumor metastasis, and that High alcohol consumption reduces tumor spread...
  2. pmc Mechanistic exploration of AhR-mediated host protection against Streptococcus pneumoniae infection
    Tao Wang
    Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, WA 99164, USA
    Int Immunopharmacol 13:490-8. 2012
    ..Results showed that TCDD must be administered in advance of exposure to bacteria, suggesting that the lung environment is rendered inhospitable to the pathogens...
  3. ncbi request reprint Activation of the aryl hydrocarbon receptor diminishes the memory response to homotypic influenza virus infection but does not impair host resistance
    B Paige Lawrence
    Department of Pharmaceutical Sciences, Pharmacology Toxicology Program, College of Pharmacy, Washington State University, Pullman, Washington 99164 6534, USA
    Toxicol Sci 79:304-14. 2004
    ..These findings have implications for determining the mechanisms by which AhR ligands adversely affect lymphocyte function and understanding the mechanisms that control the acquisition of immunological memory...
  4. pmc Activation of the aryl hydrocarbon receptor by TCDD inhibits mammary tumor metastasis in a syngeneic mouse model of breast cancer
    Tao Wang
    Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, Washington 99164, USA
    Toxicol Sci 124:291-8. 2011
    ..These observations in immunologically intact animals warrant further investigation into the mechanism of the protective effects of AhR activation and support the promise for use of AhR modulators to treat breast cancer...
  5. pmc Protection against lethal challenge with Streptococcus pneumoniae is conferred by aryl hydrocarbon receptor activation but is not associated with an enhanced inflammatory response
    Beth A Vorderstrasse
    Dept of Environmental Medicine, Box 850, University of Rochester School of Medicine, 575 Elmwood Avenue, Rochester, NY 14642, USA
    Infect Immun 74:5679-86. 2006
    ..This suggests that the protective effect of AhR activation is not the result of altered immune function but instead may reflect a direct effect on the response of lung cells to infection...
  6. ncbi request reprint A dose-response study of the effects of prenatal and lactational exposure to TCDD on the immune response to influenza a virus
    Beth A Vorderstrasse
    Department of Pharmaceutical Sciences, Pharmacology Toxicology Program, and Center for Reproductive Biology, Washington State University, Pullman, Washington 99164 6534, USA
    J Toxicol Environ Health A 69:445-63. 2006
    ..Moreover, we demonstrate a clear dose at which no observable effects on immune function later in life were detected...
  7. ncbi request reprint Fewer CTL, not enhanced NK cells, are sufficient for viral clearance from the lungs of immunocompromised mice
    Haley D Neff-LaFord
    Department of Pharmaceutical Sciences and the Pharmacology Toxicology Graduate Program, College of Pharmacy, Washington State University, Pullman, WA 99164, USA
    Cell Immunol 226:54-64. 2003
    ..In contrast, removal of CD8+ T cells ablated virus-specific cytolytic activity. These results demonstrate that the pulmonary CTL response to influenza virus is robust and few CTL are necessary for viral clearance...
  8. ncbi request reprint A novel effect of dioxin: exposure during pregnancy severely impairs mammary gland differentiation
    Beth A Vorderstrasse
    Department of Pharmaceutical Sciences, Washington State University, Pullman, Washington 99164, USA
    Toxicol Sci 78:248-57. 2004
    ....
  9. ncbi request reprint Examining the relationship between impaired host resistance and altered immune function in mice treated with TCDD
    Beth A Vorderstrasse
    Department of Pharmaceutical Sciences, Washington State University, Wegner Hall, Pullman, WA 99264 6534, USA
    Toxicology 188:15-28. 2003
    ....
  10. pmc Activation of the aryl hydrocarbon receptor is essential for mediating the anti-inflammatory effects of a novel low-molecular-weight compound
    B Paige Lawrence
    Department of Environmental Medicine, University of Rochester, NY, USA
    Blood 112:1158-65. 2008
    ..These data identify the AhR protein as key molecular target of VAF347 and its essential role for mediating the anti-inflammatory effects of the compound in vitro and in vivo...
  11. ncbi request reprint Influence of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the antigen-presenting activity of dendritic cells
    Beth A Vorderstrasse
    Department of Environmental and Molecular Toxicology and Environmental Health Sciences Center, Oregon State University, Corvallis, Oregon 97331, USA
    Toxicol Sci 72:103-12. 2003
    ..This, in turn, may alter the survival of the T cells, the DC, or both, and might lead to dysregulation of the immune response...

Research Grants1

  1. Dissecting a novel role of dioxin in breast cancer susceptibility
    BETH VORDERSTRASSE; Fiscal Year: 2007
    ..This is an innovative idea and will foster a new direction in breast cancer research. ..