HERBERT W contact VIRGIN

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint In vivo veritas: pathogenesis of infection as it actually happens
    Herbert W Skip Virgin
    Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Nat Immunol 8:1143-7. 2007
  2. pmc The virome in mammalian physiology and disease
    Herbert W Virgin
    Department of Pathology and Immunology, Washington University School of Medicine, Campus Box 8118, 660 South Euclid Avenue, St Louis, MO 63110, USA Electronic address
    Cell 157:142-50. 2014
  3. pmc Immune mechanisms responsible for vaccination against and clearance of mucosal and lymphatic norovirus infection
    KAREN A CHACHU
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    PLoS Pathog 4:e1000236. 2008
  4. pmc Pervasive transcription of a herpesvirus genome generates functionally important RNAs
    Susan P Canny
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    MBio 5:e01033-13. 2014
  5. pmc Protruding domain of capsid protein is necessary and sufficient to determine murine norovirus replication and pathogenesis in vivo
    David W Strong
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    J Virol 86:2950-8. 2012
  6. pmc Specific mutation of a gammaherpesvirus-expressed antigen in response to CD8 T cell selection in vivo
    Joy Loh
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    J Virol 86:2887-93. 2012
  7. pmc Replication of Norovirus in cell culture reveals a tropism for dendritic cells and macrophages
    Christiane E Wobus
    Department of Pathology and Immunology, Washington University School of Medicine St Louis, Missouri, USA
    PLoS Biol 2:e432. 2004
  8. doi request reprint Immunology and the elusive AIDS vaccine
    Herbert W Virgin
    Washington University School of Medicine and Midwest Regional Center of Excellence for Biodefense and Emerging Infectious Disease Research, Campus Box 8118, 660 South Euclid Avenue, Saint Louis, Missouri 63110, USA
    Nature 464:224-31. 2010
  9. ncbi request reprint Immune regulation of viral infection and vice versa
    Herbert W Virgin
    Department of Pathology and Immunology, Center for Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunol Res 32:293-315. 2005
  10. doi request reprint Metagenomics and personalized medicine
    Herbert W Virgin
    Department of Pathology and Immunology, Midwest Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell 147:44-56. 2011

Research Grants

Collaborators

Detail Information

Publications57

  1. ncbi request reprint In vivo veritas: pathogenesis of infection as it actually happens
    Herbert W Skip Virgin
    Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Nat Immunol 8:1143-7. 2007
    ..The study of pathogenesis seeks to define in molecular and genetic terms the difference between these outcomes with the hope of finding ways to prevent disease without losing the symbiotic benefits of microbial colonization...
  2. pmc The virome in mammalian physiology and disease
    Herbert W Virgin
    Department of Pathology and Immunology, Washington University School of Medicine, Campus Box 8118, 660 South Euclid Avenue, St Louis, MO 63110, USA Electronic address
    Cell 157:142-50. 2014
    ..Instead, the genetic and transcriptional identity of mammals is defined in part by our coevolved virome, a concept with profound implications for understanding health and disease. ..
  3. pmc Immune mechanisms responsible for vaccination against and clearance of mucosal and lymphatic norovirus infection
    KAREN A CHACHU
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    PLoS Pathog 4:e1000236. 2008
    ....
  4. pmc Pervasive transcription of a herpesvirus genome generates functionally important RNAs
    Susan P Canny
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    MBio 5:e01033-13. 2014
    ..This is the first description of a function for these RNAs and suggests that novel transcripts emanating from regions of pervasive transcription are critical for the viral life cycle...
  5. pmc Protruding domain of capsid protein is necessary and sufficient to determine murine norovirus replication and pathogenesis in vivo
    David W Strong
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    J Virol 86:2950-8. 2012
    ..We also describe potential interactions between subdomains of the P domain, as well as between other virus elements, which facilitate recovery of MNV using a reverse-genetics system...
  6. pmc Specific mutation of a gammaherpesvirus-expressed antigen in response to CD8 T cell selection in vivo
    Joy Loh
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    J Virol 86:2887-93. 2012
    ..This finding may have relevance for the use of herpesvirus vectors for chronic antigen expression in vivo...
  7. pmc Replication of Norovirus in cell culture reveals a tropism for dendritic cells and macrophages
    Christiane E Wobus
    Department of Pathology and Immunology, Washington University School of Medicine St Louis, Missouri, USA
    PLoS Biol 2:e432. 2004
    ..The capacity of MNV-1 to replicate in a STAT-1-regulated fashion and the unexpected tropism of a norovirus for cells of the hematopoietic lineage provide important insights into norovirus biology...
  8. doi request reprint Immunology and the elusive AIDS vaccine
    Herbert W Virgin
    Washington University School of Medicine and Midwest Regional Center of Excellence for Biodefense and Emerging Infectious Disease Research, Campus Box 8118, 660 South Euclid Avenue, Saint Louis, Missouri 63110, USA
    Nature 464:224-31. 2010
    ..Here we outline fundamental immunological questions that need to be answered to develop a protective HIV vaccine, and the immediate need to harness a much broader scientific community to achieve this goal...
  9. ncbi request reprint Immune regulation of viral infection and vice versa
    Herbert W Virgin
    Department of Pathology and Immunology, Center for Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunol Res 32:293-315. 2005
    ..Two concepts drive our approach: (1) the simultaneous analysis of immune and viral mechanisms allows novel insights, and (2) genetic tests in vivo are necessary to establish mechanisms...
  10. doi request reprint Metagenomics and personalized medicine
    Herbert W Virgin
    Department of Pathology and Immunology, Midwest Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell 147:44-56. 2011
    ....
  11. pmc Autophagy genes in immunity
    Herbert W Virgin
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Immunol 10:461-70. 2009
    ..This review summarizes phenotypes that result from the inactivation of autophagy genes in the immune system and discusses the pleiotropic functions of autophagy genes in immunity...
  12. doi request reprint Redefining chronic viral infection
    Herbert W Virgin
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell 138:30-50. 2009
    ....
  13. ncbi request reprint CD4 T cell control of acute and latent murine gammaherpesvirus infection requires IFNgamma
    Rebecca L Sparks-Thissen
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, Box 8118, St Louis, MO 63110, USA
    Virology 338:201-8. 2005
    ..Together, data presented here demonstrate that both CD4 T cell-mediated helper-independent control of gammaHV68 replication and inhibition of the establishment of gammaHV68 latency require IFNgamma...
  14. pmc Immune control of the number and reactivation phenotype of cells latently infected with a gammaherpesvirus
    Scott A Tibbetts
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Virol 76:7125-32. 2002
    ..The immune system therefore controls chronic gammaherpesvirus infection by site-specific mechanisms that regulate both the number and reactivation phenotype of latently infected cells...
  15. ncbi request reprint Herpesvirus latency confers symbiotic protection from bacterial infection
    Erik S Barton
    Departments of Pathology and Immunology, Washington University Medical School, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nature 447:326-9. 2007
    ..Thus, whereas the immune evasion capabilities and lifelong persistence of herpesviruses are commonly viewed as solely pathogenic, our data suggest that latency is a symbiotic relationship with immune benefits for the host...
  16. pmc Alpha/beta interferons regulate murine gammaherpesvirus latent gene expression and reactivation from latency
    Erik S Barton
    Department of Pathology and Immunology, Washington University School of Medicine, Campus Box 8118, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
    J Virol 79:14149-60. 2005
    ....
  17. ncbi request reprint A gamma-herpesvirus deficient in replication establishes chronic infection in vivo and is impervious to restriction by adaptive immune cells
    Scott A Tibbetts
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, Box 8118, St Louis, MO 63110, USA
    Virology 353:210-9. 2006
    ..Thus, these data support the conclusion that latency is immunologically silent...
  18. pmc An optimized CD8+ T-cell response controls productive and latent gammaherpesvirus infection
    Douglas C Braaten
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, Box 8118, St Louis, MO 63110, USA
    J Virol 79:2573-83. 2005
    ..The data also demonstrate for the first time that a strong CD8(+) T-cell response can limit long-term latent infection...
  19. pmc Antibody-independent control of gamma-herpesvirus latency via B cell induction of anti-viral T cell responses
    Kelly B McClellan
    Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, Missouri, USA
    PLoS Pathog 2:e58. 2006
    ..Exploitation of this property of B cells may allow enhanced vaccine responses to chronic virus infection...
  20. pmc An optimized CD4 T-cell response can control productive and latent gammaherpesvirus infection
    Rebecca L Sparks-Thissen
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Virol 78:6827-35. 2004
    ....
  21. pmc Gamma interferon blocks gammaherpesvirus reactivation from latency in a cell type-specific manner
    Ashley Steed
    Department of Pathology and Immunology and Pathology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Virol 81:6134-40. 2007
    ..These data indicate that the regulation of gammaherpesvirus latency by IFN-gamma is cell type specific and raise the possibility that cell type-specific immune deficiency may alter latency in distinct and important ways...
  22. pmc Histone deacetylases and the nuclear receptor corepressor regulate lytic-latent switch gene 50 in murine gammaherpesvirus 68-infected macrophages
    Megan M Goodwin
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    J Virol 84:12039-47. 2010
    ..Moreover, HDAC3, HDAC4, and NCoR act on the gene 50 promoter and are recruited to this promoter in a retinoic acid-responsive manner. We provide the first example of NCoR-mediated, HDAC-dependent regulation of viral gene expression...
  23. pmc Critical role of CD4 T cells in an antibody-independent mechanism of vaccination against gammaherpesvirus latency
    James Scott McClellan
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Virol 78:6836-45. 2004
    ..Therefore, CD4 T cells play a critical role in immune surveillance of gammaherpesvirus latency and can mediate vaccination against latency in the absence of antibody responses...
  24. pmc Gamma interferon blocks gammaherpesvirus reactivation from latency
    Ashley L Steed
    Washington University School of Medicine, Department of Pathology and Immunology, 660 South Euclid Ave, St Louis, MO 63110, USA
    J Virol 80:192-200. 2006
    ..This demonstrates that IFN-gamma is important for immune surveillance that limits reactivation of gammaHV68 from latency...
  25. ncbi request reprint Host and viral genes that control herpesvirus vasculitis
    Herbert W Virgin
    Washington University School of Medicine, St Louis, MO 63110, USA
    Cleve Clin J Med 69:SII7-12. 2002
  26. pmc Natural killer cells utilize both perforin and gamma interferon to regulate murine cytomegalovirus infection in the spleen and liver
    Joy Loh
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Virol 79:661-7. 2005
    ..Thus, contrary to previous reports, NK cells utilize both Pfp and IFN-gamma to control MCMV infection in the spleen and liver...
  27. pmc Antibody to a lytic cycle viral protein decreases gammaherpesvirus latency in B-cell-deficient mice
    Shivaprakash Gangappa
    Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Virol 76:11460-8. 2002
    ..We confirmed this model by the treatment of latently infected B-cell(-/-) mice with the antiviral drug cidofovir...
  28. ncbi request reprint STAT1-dependent innate immunity to a Norwalk-like virus
    Stephanie M Karst
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 299:1575-8. 2003
    ..The identification of host molecules essential for murine norovirus resistance may provide targets for prevention or control of an important human disease...
  29. pmc Critical role for a high-affinity chemokine-binding protein in gamma-herpesvirus-induced lethal meningitis
    Victor Van Berkel
    Departments of Pathology and Immunology and Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 109:905-14. 2002
    ....
  30. ncbi request reprint Critical role of complement and viral evasion of complement in acute, persistent, and latent gamma-herpesvirus infection
    Sharookh B Kapadia
    Department of Immunology and Pathology, Department of Molecular Microbiology, Washington University School of Medicine, Box 8118, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Immunity 17:143-55. 2002
    ....
  31. pmc MDA-5 recognition of a murine norovirus
    Stephen A McCartney
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Pathog 4:e1000108. 2008
    ..Knowledge of the host response to MNV-1 may provide keys for prevention and treatment of the human disease...
  32. pmc Antibody is critical for the clearance of murine norovirus infection
    KAREN A CHACHU
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    J Virol 82:6610-7. 2008
    ..Together, these data demonstrate that antibody plays an important role in the clearance of MNV and that immunoglobulin G anti-norovirus antibody can play an important role in clearing mucosal infection...
  33. pmc Early B-cell activation after West Nile virus infection requires alpha/beta interferon but not antigen receptor signaling
    Whitney E Purtha
    Departments of Medicine, Molecular Microbiology and Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8051, St Louis, MO 63110, USA
    J Virol 82:10964-74. 2008
    ....
  34. pmc Murine gammaherpesvirus 68 infection is associated with lymphoproliferative disease and lymphoma in BALB beta2 microglobulin-deficient mice
    Vera L Tarakanova
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Virol 79:14668-79. 2005
    ..Our findings suggest that gammaHV68 induces lymphomas via hit-and-run oncogenesis, paracrine effects, or stimulation of chronic inflammation...
  35. pmc Gamma-herpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replication
    Vera L Tarakanova
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Host Microbe 1:275-86. 2007
    ..Thus, activation of proximal components of the DNA damage signaling response is an active viral kinase-driven strategy required for efficient gamma-herpesvirus replication...
  36. pmc MHV68 complement regulatory protein facilitates MHV68 replication in primary macrophages in a complement independent manner
    Vera L Tarakanova
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Virology 396:323-8. 2010
    ..This study shows a novel, complement independent cell-type-specific function of a gammaherpesvirus RCA protein...
  37. pmc Identification of the in vivo role of a viral bcl-2
    Shivaprakash Gangappa
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Med 195:931-40. 2002
    ..As gamma-herpesviruses primarily cause human disease during chronic infection, these chronic disease genes may be important targets for therapeutic intervention...
  38. pmc Effective vaccination against long-term gammaherpesvirus latency
    Scott A Tibbetts
    Department of Pathology and Immunology and Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Virol 77:2522-9. 2003
    ..These results demonstrate the potential of a memory immune response against gammaherpesviruses to alter long-term latency and suggest that limiting long-term latent infection in a clinically relevant situation is an attainable goal...
  39. pmc Effective control of chronic gamma-herpesvirus infection by unconventional MHC Class Ia-independent CD8 T cells
    Douglas C Braaten
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS Pathog 2:e37. 2006
    ..We speculate that similar unconventional CD8 T cells may be able to control of other chronic viral infections, especially when viruses evade immunity by inhibiting generation of Class Ia-restricted T cells...
  40. pmc Establishment and maintenance of gammaherpesvirus latency are independent of infective dose and route of infection
    Scott A Tibbetts
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Virol 77:7696-701. 2003
    ..These results demonstrate that the equilibrium level of establishment of gammaherpesvirus latency is independent of the infectious dose and route of infection...
  41. pmc Latent herpesvirus infection arms NK cells
    Douglas W White
    Division of Rheumatology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Blood 115:4377-83. 2010
    ..Thus, the immune environment created by latent herpesvirus infection provides a mechanism whereby host NK-cell function is enhanced in vivo...
  42. pmc Murine norovirus: a model system to study norovirus biology and pathogenesis
    Christiane E Wobus
    Department of Pathology and Immunology, Box 8118, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    J Virol 80:5104-12. 2006
  43. pmc Granzymes and caspase 3 play important roles in control of gammaherpesvirus latency
    Joy Loh
    Dept of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, Box 8118, St Louis, MO 63110, USA
    J Virol 78:12519-28. 2004
    ..The requirement for specific granzymes differs for early versus late forms of latent infection. These data indicate that different granzymes play important and distinct roles in regulating latent gammaherpesvirus infection...
  44. pmc Physical association of the K3 protein of gamma-2 herpesvirus 68 with major histocompatibility complex class I molecules with impaired peptide and beta(2)-microglobulin assembly
    Y Y Lawrence Yu
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Virol 76:2796-803. 2002
    ..The detection of K3 with class I assembly intermediates raises the possibility that molecular chaperones involved in class I assembly are involved in K3-mediated class I regulation...
  45. pmc Murine noroviruses comprising a single genogroup exhibit biological diversity despite limited sequence divergence
    Larissa B Thackray
    Department of Pathology and Immunology, Box 8118, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    J Virol 81:10460-73. 2007
    ..The isolation and characterization of multiple MNV strains illustrate how genetic analysis may underestimate the biological diversity of noroviruses and provide a molecular map for future studies of MNV biology...
  46. ncbi request reprint Coronavirus replication does not require the autophagy gene ATG5
    Zijiang Zhao
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Autophagy 3:581-5. 2007
    ..We conclude that neither ATG5 nor an intact autophagic pathway re required for MHV replication or release...
  47. pmc Murine cytomegalovirus paralyzes macrophages by blocking IFN gamma-induced promoter assembly
    Daniel L Popkin
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 100:14309-14. 2003
    ....
  48. pmc Murine cytomegalovirus infection inhibits tumor necrosis factor alpha responses in primary macrophages
    Daniel L Popkin
    Department of Pathology, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    J Virol 77:10125-30. 2003
    ..These findings provide a mechanism by which MCMV can evade the effects of an important host cytokine in macrophages...
  49. pmc Identification and sequencing of a novel rodent gammaherpesvirus that establishes acute and latent infection in laboratory mice
    Joy Loh
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, Box 8118, St Louis, MO 63110, USA
    J Virol 85:2642-56. 2011
    ..As these ORFs may function as immunomodulatory or virulence factors, RHVP presents new opportunities for the study of mechanisms of immune evasion by gammaherpesviruses...
  50. ncbi request reprint Virus subversion of the MHC class I peptide-loading complex
    Lonnie Lybarger
    Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunity 18:121-30. 2003
    ..Thus, mK3 subverts TAP/tapasin to specifically target class I molecules for destruction...
  51. pmc Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens
    Zijiang Zhao
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Host Microbe 4:458-69. 2008
    ....
  52. pmc Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo
    Deborah J Lenschow
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Virol 79:13974-83. 2005
    ..Finally, we demonstrate that ISG15's LRLRGG motif is also required for its antiviral activity. We conclude that ISG15 can be directly antiviral...
  53. pmc High-resolution cryo-electron microscopy structures of murine norovirus 1 and rabbit hemorrhagic disease virus reveal marked flexibility in the receptor binding domains
    Umesh Katpally
    Donald Danforth Plant Science Center, 975 North Warson Road, Saint Louis, MO 63132, USA
    J Virol 84:5836-41. 2010
    ..Connections between the P and shell domains and between the floating P domains were modeled. This observed P-domain flexibility likely facilitates virus-host receptor interactions...
  54. pmc Murine gammaherpesvirus 68 has evolved gamma interferon and stat1-repressible promoters for the lytic switch gene 50
    Megan M Goodwin
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, Box 8118, St Louis, MO 63110, USA
    J Virol 84:3711-7. 2010
    ....
  55. pmc Structure of antibody-neutralized murine norovirus and unexpected differences from viruslike particles
    Umesh Katpally
    Donald Danforth Plant Science Center, 975 North Warson Road, Saint Louis, MO 63132, USA
    J Virol 82:2079-88. 2008
    ..These unique features of MNV suggest that at least some caliciviruses undergo a capsid maturation process akin to that observed with other plant and bacterial viruses...
  56. ncbi request reprint The autophagy gene ATG5 plays an essential role in B lymphocyte development
    Brian C Miller
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Autophagy 4:309-14. 2008
    ..In addition, B-1a B cells require ATG5 for their maintenance in the periphery. We conclude that ATG5 is differentially required at discrete stages of development in distinct, but closely related, cell lineages...
  57. pmc Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine
    Ken Cadwell
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell 141:1135-45. 2010
    ....

Research Grants57

  1. ASM Conference on Viral Immune Evasion
    Herbert Virgin; Fiscal Year: 2005
    ..This should foster their career development. ..
  2. IMMUNOLOGIC CONTROL OF GAMMAHERPESVIRUS LATENCY
    Herbert Virgin; Fiscal Year: 2009
    ..Understanding this mechanism for maintenance of latency may allow us to interfere with or control latency in an appropriate way, thus preventing the ill effects of chronic herpesvirus infection. ..
  3. T Cell Vaccination Against gamma-herpesvirus Latency
    Herbert Virgin; Fiscal Year: 2004
    ..HV68 latencyAim 2) Identify latency associated antigens recognized by T cells Aim 3) Test the effects of vaccination with latency associated antigens. ..
  4. Immunity and Pathogenesis of a Novel Calicivirus
    Herbert Virgin; Fiscal Year: 2004
    ..Aim 2. Determine the role of the innate immune response in control of MCV1 infection. Aim 3. Determine the role of the adaptive immune response in clearance of, and vaccination against, MCV1 infection. ..
  5. REGULATION OF GAMMA HERPESVIRUS LATENCY & TUMORIGENESIS
    Herbert Virgin; Fiscal Year: 1999
    ..Aim 3. Characterization of gamma HV 68 latency and tumor associated gene expression. Aim 4. Generation and analysis of gamma HV68 mutants in latency and tumor-associated genes. ..
  6. T Cell Vaccination Against gamma-herpesvirus Latency
    Herbert Virgin; Fiscal Year: 2003
    ..HV68 latencyAim 2) Identify latency associated antigens recognized by T cells Aim 3) Test the effects of vaccination with latency associated antigens. ..
  7. T Cell Vaccination Against gamma-herpesvirus Latency
    Herbert Virgin; Fiscal Year: 2002
    ..HV68 latencyAim 2) Identify latency associated antigens recognized by T cells Aim 3) Test the effects of vaccination with latency associated antigens. ..
  8. Vascular Injury and Atherosclerosis During Herpesvirus *
    Herbert Virgin; Fiscal Year: 2005
    ..This will allow us to manipulate the immune system to prevent atherosclerosis induction by virus infection, and potentially to vaccinate against virus induced atherosclerosis. ..
  9. Search for Infectious Etiology of Wegener's Disease
    Herbert Virgin; Fiscal Year: 2003
    ..The benefits of identifying potential etiologies for Wegener's are great, preliminary data shows that the methods are in hand, and the team assembled is well qualified to undertake the proposed studies. ..
  10. MECHANISM OF GAMMA-HERPESVIRUS DAF/MCP HOMOLOG
    Herbert Virgin; Fiscal Year: 2003
    ..abstract_text> ..
  11. Vascular Injury and Atherosclerosis During Herpesvirus *
    Herbert Virgin; Fiscal Year: 2003
    ..This will allow us to manipulate the immune system to prevent atherosclerosis induction by virus infection, and potentially to vaccinate against virus induced atherosclerosis. ..
  12. REGULATION OF GAMMA HERPESVIRUS LATENCY & TUMORIGENESIS
    Herbert Virgin; Fiscal Year: 2003
    ..Aim 2: Identify the role of latency and tumor-associated genes in B cell proliferation and survival. Aim 3: Identify the mechanism by which v-Bcl-2 regulates gammaHV68 latency. ..
  13. MECHANISM OF GAMMA-HERPESVIRUS DAF/MCP HOMOLOG
    Herbert Virgin; Fiscal Year: 2004
    ..abstract_text> ..
  14. Vascular Injury and Atherosclerosis During Herpesvirus *
    Herbert Virgin; Fiscal Year: 2004
    ..This will allow us to manipulate the immune system to prevent atherosclerosis induction by virus infection, and potentially to vaccinate against virus induced atherosclerosis. ..
  15. Immunity and Pathogenesis of a Novel Calicivirus
    Herbert Virgin; Fiscal Year: 2007
    ..Aim 2. Determine the role of the innate immune response in control of MCV1 infection. Aim 3. Determine the role of the adaptive immune response in clearance of, and vaccination against, MCV1 infection. ..
  16. Regulation of Y-herpesvirus latency and tumorigenesis
    Herbert Virgin; Fiscal Year: 2005
    ..Aim 2: Identify the role of latency and tumor-associated genes in B cell proliferation and survival. Aim 3: Identify the mechanism by which v-Bcl-2 regulates gammaHV68 latency. ..
  17. Search for Infectious Etiology of Wegener's Disease
    Herbert Virgin; Fiscal Year: 2002
    ..The benefits of identifying potential etiologies for Wegener's are great, preliminary data shows that the methods are in hand, and the team assembled is well qualified to undertake the proposed studies. ..
  18. MECHANISM OF GAMMA-HERPESVIRUS DAF/MCP HOMOLOG
    Herbert Virgin; Fiscal Year: 2002
    ..abstract_text> ..
  19. MECHANISMS OF VIRUS-INDUCED ELASTIC ARTERITIS
    Herbert Virgin; Fiscal Year: 1999
    ..Aim 2. Determine the mechanism by which IFNgamma regulates arteritis. Aim 3. Determine the mechanism by which B cells regulate arteritis. ..
  20. SUSCEPTIBILILTY GENE-VIRUS INTERACTIONS IN INFLAMMATORY BOWEL DISEASE
    HERBERT W contact VIRGIN; Fiscal Year: 2010
    ....
  21. IMMUNITY AND PATHOGENESIS OF A NOVEL NOROVIRUS
    Herbert W Virgin; Fiscal Year: 2010
    ....
  22. Norovirus Infection of Dendritic Cells and Macrophages
    Herbert W Virgin; Fiscal Year: 2010
    ..The proposed studies will provide fundamental information about the binding, entry, and uncoating of a very important genus of viruses that incudes many human pathogens. ..
  23. MECHANISMS OF VIRUS-INDUCED ELASTIC ARTERITIS
    Herbert Virgin; Fiscal Year: 2001
    ..Aim 2. Determine the mechanism by which IFNgamma regulates arteritis. Aim 3. Determine the mechanism by which B cells regulate arteritis. ..
  24. IMMUNOLOGIC CONTROL OF GAMMAHERPESVIRUS LATENCY
    Herbert W Virgin; Fiscal Year: 2010
    ..Understanding this mechanism for maintenance of latency may allow us to interfere with or control latency in an appropriate way, thus preventing the ill effects of chronic herpesvirus infection. ..
  25. REGULATION OF GAMMA HERPESVIRUS LATENCY & TUMORIGENESIS
    Herbert Virgin; Fiscal Year: 2002
    ..Aim 3. Characterization of gamma HV 68 latency and tumor associated gene expression. Aim 4. Generation and analysis of gamma HV68 mutants in latency and tumor-associated genes. ..
  26. Search for Infectious Etiology of Wegener's Disease
    Herbert Virgin; Fiscal Year: 2001
    ..The benefits of identifying potential etiologies for Wegener's are great, preliminary data shows that the methods are in hand, and the team assembled is well qualified to undertake the proposed studies. ..
  27. MECHANISMS OF VIRUS-INDUCED ELASTIC ARTERITIS
    Herbert Virgin; Fiscal Year: 2002
    ..Aim 2. Determine the mechanism by which IFNgamma regulates arteritis. Aim 3. Determine the mechanism by which B cells regulate arteritis. ..
  28. IMMUNITY AND PATHOGENESIS OF A NOVEL NOROVIRUS
    Herbert W Virgin; Fiscal Year: 2010
    ....
  29. Regulation of Y-herpesvirus latency and tumorigenesis
    Herbert Virgin; Fiscal Year: 2006
    ..Aim 2: Identify the role of latency and tumor-associated genes in B cell proliferation and survival. Aim 3: Identify the mechanism by which v-Bcl-2 regulates gammaHV68 latency. ..
  30. Norovirus Infection of Dendritic Cells and Macrophages
    Herbert Virgin; Fiscal Year: 2007
    ..Determine the cellular and molecular basis of MNV-1 cell tropism. The proposed studies will provide fundamental information about the binding, entry, and uncoating of a very important genus of viruses that includes many human pathogens. ..
  31. Regulation of gamma herpesvirus latency and tumorigenesis
    Herbert Virgin; Fiscal Year: 2007
    ..Aim 2: Identify the role of latency and tumor-associated genes in B cell proliferation and survival. Aim 3: Identify the mechanism by which v-Bcl-2 regulates gammaHV68 latency. ..
  32. IMMUNITY AND PATHOGENESIS OF A NOVEL NOROVIRUS
    Herbert Virgin; Fiscal Year: 2009
    ....
  33. Norovirus Infection of Dendritic Cells and Macrophages
    Herbert Virgin; Fiscal Year: 2006
    ..Determine the cellular and molecular basis of MNV-1 cell tropism. The proposed studies will provide fundamental information about the binding, entry, and uncoating of a very important genus of viruses that includes many human pathogens. ..
  34. Immunity and Pathogenesis of a Novel Calicivirus
    Herbert Virgin; Fiscal Year: 2006
    ..Aim 2. Determine the role of the innate immune response in control of MCV1 infection. Aim 3. Determine the role of the adaptive immune response in clearance of, and vaccination against, MCV1 infection. ..
  35. REGULATION OF GAMMA HERPESVIRUS LATENCY & TUMORIGENESIS
    Herbert Virgin; Fiscal Year: 2000
    ..Aim 3. Characterization of gamma HV 68 latency and tumor associated gene expression. Aim 4. Generation and analysis of gamma HV68 mutants in latency and tumor-associated genes. ..
  36. MECHANISM OF GAMMA-HERPESVIRUS DAF/MCP HOMOLOG
    Herbert Virgin; Fiscal Year: 2000
    ..abstract_text> ..
  37. MECHANISM OF GAMMA-HERPESVIRUS DAF/MCP HOMOLOG
    Herbert Virgin; Fiscal Year: 2001
    ..abstract_text> ..
  38. Vascular Injury and Atherosclerosis During Herpesvirus *
    Herbert Virgin; Fiscal Year: 2002
    ..This will allow us to manipulate the immune system to prevent atherosclerosis induction by virus infection, and potentially to vaccinate against virus induced atherosclerosis. ..
  39. Immunity and Pathogenesis of a Novel Calicivirus
    Herbert Virgin; Fiscal Year: 2003
    ..Aim 2. Determine the role of the innate immune response in control of MCV1 infection. Aim 3. Determine the role of the adaptive immune response in clearance of, and vaccination against, MCV1 infection. ..
  40. Norovirus Infection of Dendritic Cells and Macrophages
    Herbert Virgin; Fiscal Year: 2009
    ..The proposed studies will provide fundamental information about the binding, entry, and uncoating of a very important genus of viruses that incudes many human pathogens. ..
  41. Regulation of Y-herpesvirus latency and tumorigenesis
    Herbert Virgin; Fiscal Year: 2004
    ..Aim 2: Identify the role of latency and tumor-associated genes in B cell proliferation and survival. Aim 3: Identify the mechanism by which v-Bcl-2 regulates gammaHV68 latency. ..
  42. Immunity and Pathogenesis of a Novel Calicivirus
    Herbert Virgin; Fiscal Year: 2005
    ..Aim 2. Determine the role of the innate immune response in control of MCV1 infection. Aim 3. Determine the role of the adaptive immune response in clearance of, and vaccination against, MCV1 infection. ..
  43. T Cell Vaccination Against gamma-herpesvirus Latency
    Herbert Virgin; Fiscal Year: 2005
    ..HV68 latencyAim 2) Identify latency associated antigens recognized by T cells Aim 3) Test the effects of vaccination with latency associated antigens. ..
  44. REGULATION OF GAMMA HERPESVIRUS LATENCY & TUMORIGENESIS
    Herbert Virgin; Fiscal Year: 2001
    ..Aim 3. Characterization of gamma HV 68 latency and tumor associated gene expression. Aim 4. Generation and analysis of gamma HV68 mutants in latency and tumor-associated genes. ..
  45. Search for Infectious Etiology of Wegener's Disease
    Herbert Virgin; Fiscal Year: 2000
    ..The benefits of identifying potential etiologies for Wegener's are great, preliminary data shows that the methods are in hand, and the team assembled is well qualified to undertake the proposed studies. ..
  46. MECHANISMS OF VIRUS-INDUCED ELASTIC ARTERITIS
    Herbert Virgin; Fiscal Year: 2000
    ..Aim 2. Determine the mechanism by which IFNgamma regulates arteritis. Aim 3. Determine the mechanism by which B cells regulate arteritis. ..