D T Villareal

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Bone mineral density response to estrogen replacement in frail elderly women: a randomized controlled trial
    D T Villareal
    Division of Geriatrics and Gerontology, Washington University School of Medicine, 4488 Forest Park Blvd, St Louis, MO 63108, USA
    JAMA 286:815-20. 2001
  2. pmc Effect of weight loss and exercise therapy on bone metabolism and mass in obese older adults: a one-year randomized controlled trial
    Dennis T Villareal
    Division of Geriatrics and Nutritional Science, Center for Human Nutrition, Washington University School of Medicine, 4488 Forest Park Boulevard, St Louis, MO 63108, USA
    J Clin Endocrinol Metab 93:2181-7. 2008
  3. ncbi request reprint Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults
    Dennis T Villareal
    Geriatrics and Nutritional Science and the Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63108, USA
    Am J Clin Nutr 84:1317-23. 2006
  4. ncbi request reprint Effect of weight loss and exercise on frailty in obese older adults
    Dennis T Villareal
    Center for Human Nutrition, Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Intern Med 166:860-6. 2006
  5. ncbi request reprint Effects of dehydroepiandrosterone on bone mineral density: what implications for therapy?
    Dennis T Villareal
    Division of Geriatrics and Gerontology, Older Adult Health Center, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Treat Endocrinol 1:349-57. 2002
  6. ncbi request reprint Physical frailty and body composition in obese elderly men and women
    Dennis T Villareal
    Washington University Older Adult Health Center, 4488 Forest Park Boulevard, St Louis, MO 63108, USA
    Obes Res 12:913-20. 2004
  7. ncbi request reprint Effects of exercise training added to ongoing hormone replacement therapy on bone mineral density in frail elderly women
    Dennis T Villareal
    Washington University Claude Pepper Older Americans Independence Center, USA
    J Am Geriatr Soc 51:985-90. 2003
  8. ncbi request reprint Clinical outcomes of possible versus probable Alzheimer's disease
    Dennis T Villareal
    Division of Geriatrics and Gerontology, and the Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, MO 63108, USA
    Neurology 61:661-7. 2003
  9. ncbi request reprint The effects of caloric restriction- and exercise-induced weight loss on left ventricular diastolic function
    Matt M Riordan
    Cardiovascular Biophysics Laboratory, Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Heart Circ Physiol 294:H1174-82. 2008
  10. ncbi request reprint Lower extremity muscle size and strength and aerobic capacity decrease with caloric restriction but not with exercise-induced weight loss
    Edward P Weiss
    Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    J Appl Physiol 102:634-40. 2007

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Bone mineral density response to estrogen replacement in frail elderly women: a randomized controlled trial
    D T Villareal
    Division of Geriatrics and Gerontology, Washington University School of Medicine, 4488 Forest Park Blvd, St Louis, MO 63108, USA
    JAMA 286:815-20. 2001
    ..Although hormone replacement therapy (HRT) is an established approach for osteoporosis prevention, little is known about the osteoprotective effects of HRT in frail elderly women...
  2. pmc Effect of weight loss and exercise therapy on bone metabolism and mass in obese older adults: a one-year randomized controlled trial
    Dennis T Villareal
    Division of Geriatrics and Nutritional Science, Center for Human Nutrition, Washington University School of Medicine, 4488 Forest Park Boulevard, St Louis, MO 63108, USA
    J Clin Endocrinol Metab 93:2181-7. 2008
    ..Although weight loss and exercise ameliorates frailty and improves cardiac risk factors in obese older adults, the long-term effect of lifestyle intervention on bone metabolism and mass is unknown...
  3. ncbi request reprint Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults
    Dennis T Villareal
    Geriatrics and Nutritional Science and the Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63108, USA
    Am J Clin Nutr 84:1317-23. 2006
    ..Coronary heart disease (CHD) risk factors increase with age and body mass index (BMI; in kg/m2). However, whether lifestyle intervention ameliorates metabolic CHD risk factors in obese older adults is unknown...
  4. ncbi request reprint Effect of weight loss and exercise on frailty in obese older adults
    Dennis T Villareal
    Center for Human Nutrition, Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Intern Med 166:860-6. 2006
    ..However, appropriate treatment for obese older persons is unknown. We evaluated the effects of weight loss and exercise therapy on physical function and body composition in obese older persons...
  5. ncbi request reprint Effects of dehydroepiandrosterone on bone mineral density: what implications for therapy?
    Dennis T Villareal
    Division of Geriatrics and Gerontology, Older Adult Health Center, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Treat Endocrinol 1:349-57. 2002
    ....
  6. ncbi request reprint Physical frailty and body composition in obese elderly men and women
    Dennis T Villareal
    Washington University Older Adult Health Center, 4488 Forest Park Boulevard, St Louis, MO 63108, USA
    Obes Res 12:913-20. 2004
    ..To evaluate the prevalence of frailty and interrelationships among body composition, physical function, and quality of life in community-dwelling obese elderly (OE) persons...
  7. ncbi request reprint Effects of exercise training added to ongoing hormone replacement therapy on bone mineral density in frail elderly women
    Dennis T Villareal
    Washington University Claude Pepper Older Americans Independence Center, USA
    J Am Geriatr Soc 51:985-90. 2003
    ..To determine whether exercise training added to ongoing hormone replacement therapy (HRT) increases bone mineral density (BMD) in physically frail elderly women...
  8. ncbi request reprint Clinical outcomes of possible versus probable Alzheimer's disease
    Dennis T Villareal
    Division of Geriatrics and Gerontology, and the Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, MO 63108, USA
    Neurology 61:661-7. 2003
    ..To determine whether Alzheimer's disease (AD) associated with comorbidities or atypical features (possible AD) is marked by differences in clinical course and outcomes compared with uncomplicated AD (probable AD)...
  9. ncbi request reprint The effects of caloric restriction- and exercise-induced weight loss on left ventricular diastolic function
    Matt M Riordan
    Cardiovascular Biophysics Laboratory, Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Heart Circ Physiol 294:H1174-82. 2008
    ..13) tended to increase. We conclude that weight loss, whether induced by CR or Ex, has salutary effects on diastolic function...
  10. ncbi request reprint Lower extremity muscle size and strength and aerobic capacity decrease with caloric restriction but not with exercise-induced weight loss
    Edward P Weiss
    Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    J Appl Physiol 102:634-40. 2007
    ..These findings suggest that, during EX, the body adapts to maintain or even enhance physical performance capacity...
  11. pmc Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial
    Edward P Weiss
    Division of Geriatrics and Nutritional Sciences, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Am J Clin Nutr 84:1033-42. 2006
    ..However, exercise-induced energy expenditure may further improve glucoregulation through mechanisms independent of weight loss...
  12. ncbi request reprint Absence of left ventricular and arterial adaptations to exercise in octogenarians
    Robert J Spina
    Section of Applied Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Appl Physiol 97:1654-9. 2004
    ..Data suggest that the absence of cardiac and arterial adaptations may in part account for the limited gain in aerobic capacity in response to training in the octogenarians...
  13. pmc Exercise but not diet-induced weight loss decreases skeletal muscle inflammatory gene expression in frail obese elderly persons
    Charles P Lambert
    Department of Internal Medicine, Washington University School of Medicine, Campus Box 8303, St Louis, MO 63110, USA
    J Appl Physiol 105:473-8. 2008
    ..05), but weight loss had no effect. In conclusion, exercise but not weight loss had a beneficial effect on markers of muscle inflammation and anabolism in frail obese elderly individuals...
  14. ncbi request reprint Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society
    Dennis T Villareal
    Division of Geriatrics and Nutritional Sciences, Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA
    Obes Res 13:1849-63. 2005
    ..Therefore, weight-loss therapy that minimizes muscle and bone losses is recommended for older persons who are obese and who have functional impairments or medical complications that can benefit from weight loss...
  15. ncbi request reprint Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society
    Dennis T Villareal
    Division of Geriatrics and Nutritional Sciences and Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Clin Nutr 82:923-34. 2005
    ..Therefore, weight-loss therapy that minimizes muscle and bone losses is recommended for older persons who are obese and who have functional impairments or medical complications that can benefit from weight loss...
  16. pmc Diet and exercise interventions reduce intrahepatic fat content and improve insulin sensitivity in obese older adults
    Krupa Shah
    Department of Medicine, Division of Geriatrics and Nutritional Science, Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USA
    Obesity (Silver Spring) 17:2162-8. 2009
    ..The addition of exercise to diet therapy improves physical function and other obesity- and aging-related metabolic abnormalities...
  17. ncbi request reprint Effect of CYP1A1 gene polymorphisms on estrogen metabolism and bone density
    Nicola Napoli
    Division of Bone and Mineral Diseases, Washington University School of Medicine, St Louis, MO 63110, USA
    J Bone Miner Res 20:232-9. 2005
    ..We found that variants carrying the A allele (CA and AA) for the C4887A polymorphism have a significantly higher degree of estrogen catabolism and lower femoral BMD...
  18. ncbi request reprint Aerobic power and insulin action improve in response to endurance exercise training in healthy 77-87 yr olds
    Ellen M Evans
    Section of Applied Physiology, Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    J Appl Physiol 98:40-5. 2005
    ....
  19. pmc Dehydroepiandrosterone replacement therapy in older adults: 1- and 2-y effects on bone
    Edward P Weiss
    Division of Geriatrics and Nutritional Sciences, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Am J Clin Nutr 89:1459-67. 2009
    ..Age-related reductions in serum dehydroepiandrosterone (DHEA) concentrations may be involved in bone mineral density (BMD) losses...
  20. ncbi request reprint Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial
    Dennis T Villareal
    Division of Geriatrics and Nutritional Science, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    JAMA 292:2243-8. 2004
    ..DHEA is widely available as a dietary supplement without a prescription...
  21. pmc Weight loss therapy improves pancreatic endocrine function in obese older adults
    Dennis T Villareal
    Division of Geriatrics and Nutritional Science, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Obesity (Silver Spring) 16:1349-54. 2008
    ..Obesity and aging increase the risk of type 2 diabetes (T2D). We evaluated whether weight loss therapy improves pancreatic endocrine function and insulin sensitivity in obese older adults...
  22. pmc Influence of weekend lifestyle patterns on body weight
    Susan B Racette
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Obesity (Silver Spring) 16:1826-30. 2008
    ..To determine whether alterations in diet and/or activity patterns during weekends contribute to weight gain or hinder weight loss...
  23. pmc Endothelial function after high-sugar-food ingestion improves with endurance exercise performed on the previous day
    Edward P Weiss
    Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO, USA
    Am J Clin Nutr 88:51-7. 2008
    ..This may be attributed to hyperglycemia-induced oxidative stress. Acute endurance exercise might improve postprandial endothelial function by enhancing glucoregulation and reducing postprandial hyperglycemia...
  24. pmc Inflammatory osteolysis in diabetic neuropathic (charcot) arthropathies of the foot
    David R Sinacore
    Department of Medicine and Program in Physical Therapy, Washington University School of Medicine, 4444 Forest Park Blvd, St Louis, MO 63108, USA
    Phys Ther 88:1399-407. 2008
    ....
  25. pmc Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans
    Luigi Fontana
    Division of Geriatrics and Nutritional Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Aging Cell 7:681-7. 2008
    ....
  26. pmc TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action
    Dennis T Villareal
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes 59:479-85. 2010
    ..Common variants in the gene TCF7L2 confer the largest effect on the risk of type 2 diabetes. The present study was undertaken to increase our understanding of the mechanisms by which this gene affects type 2 diabetes risk...
  27. ncbi request reprint Peak exercise stroke volume: associations with cardiac structure and diastolic function
    Linda R Peterson
    Claude D Pepper Older Americans Independence Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Appl Physiol 94:1108-14. 2003
    ....
  28. ncbi request reprint One year of caloric restriction in humans: feasibility and effects on body composition and abdominal adipose tissue
    Susan B Racette
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63108 2212, USA
    J Gerontol A Biol Sci Med Sci 61:943-50. 2006
    ..The objectives of this study were to determine the feasibility of prolonged CR in nonobese adults and to compare the effects of CR- and exercise-induced weight loss on body composition and abdominal adiposity...
  29. ncbi request reprint Attenuation of cardiovascular adaptations to exercise in frail octogenarians
    Ali A Ehsani
    Section of Applied Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Appl Physiol 95:1781-8. 2003
    ..Furthermore, Q likely plays a greater role in the adaptive increase in V(O2 peak) in old men than old women...
  30. ncbi request reprint DHEA enhances effects of weight training on muscle mass and strength in elderly women and men
    Dennis T Villareal
    Division of Geriatrics and Nutritional Science, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Endocrinol Metab 291:E1003-8. 2006
    ..This study provides evidence that DHEA replacement has the beneficial effect of enhancing the increases in muscle mass and strength induced by heavy resistance exercise in elderly individuals...
  31. ncbi request reprint Bone mineral density response to caloric restriction-induced weight loss or exercise-induced weight loss: a randomized controlled trial
    Dennis T Villareal
    Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Intern Med 166:2502-10. 2006
    ..We tested the hypothesis that EX-induced weight loss is associated with less bone loss compared with CR-induced weight loss...
  32. pmc Effects of soy protein isolate and moderate exercise on bone turnover and bone mineral density in postmenopausal women
    Ellen M Evans
    Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    Menopause 14:481-8. 2007
    ..The aim of this study was to assess the independent and additive effects of soy protein isolate (SPI) and moderate-intensity exercise (EX) on bone turnover and bone mineral density (BMD)...
  33. ncbi request reprint Calorie restriction or exercise: effects on coronary heart disease risk factors. A randomized, controlled trial
    Luigi Fontana
    Division of Geriatrics and Nutritional Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 293:E197-202. 2007
    ..Data from the present study provide evidence that CR- and EX-induced negative energy balance result in substantial and similar improvements in the major risk factors for CHD in normal-weight and overweight middle-aged adults...
  34. ncbi request reprint Low bone mass in subjects on a long-term raw vegetarian diet
    Luigi Fontana
    Section of Applied Physiology, Division of Geriatrics and Nutritional Science, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Intern Med 165:684-9. 2005
    ..Little is known regarding the health effects of a raw food (RF) vegetarian diet...
  35. pmc Caloric restriction but not exercise-induced reductions in fat mass decrease plasma triiodothyronine concentrations: a randomized controlled trial
    Edward P Weiss
    Division of Geriatrics and Nutritional Sciences, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Rejuvenation Res 11:605-9. 2008
    ..This effect does not appear to be attributable to changes in body fat mass because a comparable decrease in T(3) concentration was not observed in response to an exercise-induced fat mass reduction...
  36. pmc Kir6.2 variant E23K increases ATP-sensitive K+ channel activity and is associated with impaired insulin release and enhanced insulin sensitivity in adults with normal glucose tolerance
    Dennis T Villareal
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes 58:1869-78. 2009
    ..To avoid confounding effects of hyperglycemia, insulin secretion and action were studied in subjects with the variant who had normal glucose tolerance...
  37. pmc Effects of polymorphisms of the sex hormone-binding globulin (SHBG) gene on free estradiol and bone mineral density
    Nicola Napoli
    Division of Bone and Mineral Diseases at Washington University School of Medicine, Campus Box 8301, 660 South Euclid Ave St Louis, MO 63110, USA
    Bone 45:1169-74. 2009
    ....
  38. ncbi request reprint Comparison of methods for assessing abdominal adipose tissue from magnetic resonance images
    Hassan Arif
    Department of Nutrition and Dietetics, St Louis University, 3437 Caroline Street, Room 3076, St Louis, MO 63104, USA
    Obesity (Silver Spring) 15:2240-4. 2007
    ..To compare the inter-rater and intra-rater reliability and analysis time of two methods for quantifying visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) volumes from magnetic resonance (MR) images...
  39. pmc Weight-loss therapy improves endurance capacity in obese older adults
    Krupa Shah
    J Am Geriatr Soc 56:1157-9. 2008
  40. ncbi request reprint Effects of exercise training on bone mineral density in frail older women and men: a randomised controlled trial
    Dennis T Villareal
    Age Ageing 33:309-12. 2004