R N Van Gelder

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Koch's postulates and the polymerase chain reaction
    Russell N Van Gelder
    Ocul Immunol Inflamm 10:235-8. 2002
  2. ncbi request reprint Clean thoughts about dirty genes
    Russell N Van Gelder
    Department of Ophthalmology and Visual Sciences, Washington University Medical School, St Louis, MO 63110, USA
    J Biol Rhythms 19:3-9. 2004
  3. ncbi request reprint Pleiotropic effects of cryptochromes 1 and 2 on free-running and light-entrained murine circadian rhythms
    Russell N Van Gelder
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    J Neurogenet 16:181-203. 2002
  4. ncbi request reprint Circadian rhythms: in the loop at last
    Russell N Van Gelder
    Department of Ophthalmology and Visual Sciences, Washington University, St Louis, MO 63110, USA
    Science 300:1534-5. 2003
  5. ncbi request reprint Tales from the crypt(ochromes)
    Russell N Van Gelder
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    J Biol Rhythms 17:110-20. 2002
  6. ncbi request reprint Non-visual ocular photoreception
    R N Van Gelder
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Ophthalmic Genet 22:195-205. 2001
  7. pmc Timeless genes and jetlag
    Russell N Van Gelder
    Department of Ophthalmology, Washington University Medical School, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 103:17583-4. 2006
  8. ncbi request reprint Recent insights into mammalian circadian rhythms
    Russell N Van Gelder
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Sleep 27:166-71. 2004
  9. ncbi request reprint Frontiers of polymerase chain reaction diagnostics for uveitis
    R N Van Gelder
    Department of Ophthalmology and Visual Sciences, Washington University Medical School, St Louis, MO 63110, USA
    Ocul Immunol Inflamm 9:67-73. 2001
  10. ncbi request reprint Making (a) sense of non-visual ocular photoreception
    Russell N Van Gelder
    Department of Ophthalmology and Visual Sciences, Washington University Medical School, Campus Box 8096, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Trends Neurosci 26:458-61. 2003

Research Grants

  1. A transgenic model of ocular inflammation
    Russell Van Gelder; Fiscal Year: 2007

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Koch's postulates and the polymerase chain reaction
    Russell N Van Gelder
    Ocul Immunol Inflamm 10:235-8. 2002
  2. ncbi request reprint Clean thoughts about dirty genes
    Russell N Van Gelder
    Department of Ophthalmology and Visual Sciences, Washington University Medical School, St Louis, MO 63110, USA
    J Biol Rhythms 19:3-9. 2004
    ..They conclude with a short list of recommendations for researchers working on circadian rhythms in mixed-strain mice...
  3. ncbi request reprint Pleiotropic effects of cryptochromes 1 and 2 on free-running and light-entrained murine circadian rhythms
    Russell N Van Gelder
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    J Neurogenet 16:181-203. 2002
    ..These results suggest that, similar to insect cryptochromes, mammalian cryptochromes function pleiotropically in both circadian rhythm generation and in photic entrainment and behavioral responses...
  4. ncbi request reprint Circadian rhythms: in the loop at last
    Russell N Van Gelder
    Department of Ophthalmology and Visual Sciences, Washington University, St Louis, MO 63110, USA
    Science 300:1534-5. 2003
    ..Both the general script and the specific details of the murine and Drosophila circadian pathways are available at Science's Signal Transduction Knowledge Environment Connections Maps...
  5. ncbi request reprint Tales from the crypt(ochromes)
    Russell N Van Gelder
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    J Biol Rhythms 17:110-20. 2002
    ..The present review summarizes recent research on the functions of cryptochrome in the circadian timekeeping and photic entrainment pathways...
  6. ncbi request reprint Non-visual ocular photoreception
    R N Van Gelder
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Ophthalmic Genet 22:195-205. 2001
    ..Data linking these potential photoreceptors to these phenomena are discussed, and the clinical implications of these findings are explored...
  7. pmc Timeless genes and jetlag
    Russell N Van Gelder
    Department of Ophthalmology, Washington University Medical School, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 103:17583-4. 2006
  8. ncbi request reprint Recent insights into mammalian circadian rhythms
    Russell N Van Gelder
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Sleep 27:166-71. 2004
    ..This review is intended as an overview of recent research activity for the interested sleep disorders clinician or researcher...
  9. ncbi request reprint Frontiers of polymerase chain reaction diagnostics for uveitis
    R N Van Gelder
    Department of Ophthalmology and Visual Sciences, Washington University Medical School, St Louis, MO 63110, USA
    Ocul Immunol Inflamm 9:67-73. 2001
    ..Recent technical advances in the technique have broadened its scope considerably. Emerging applications of PCR in pathogen strain typing, rapid screening of differential diagnoses, and pathogen discovery are discussed...
  10. ncbi request reprint Making (a) sense of non-visual ocular photoreception
    Russell N Van Gelder
    Department of Ophthalmology and Visual Sciences, Washington University Medical School, Campus Box 8096, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Trends Neurosci 26:458-61. 2003
    ....
  11. ncbi request reprint Cme review: polymerase chain reaction diagnostics for posterior segment disease
    Russell N Van Gelder
    Department of Ophthalmology and Visual Sciences, Department of Molecular Biology and Pharmacology, Washington University Medical School, Campus Box 8096, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Retina 23:445-52. 2003
    ....
  12. ncbi request reprint Reduced pupillary light responses in mice lacking cryptochromes
    Russell N Van Gelder
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63131, USA
    Science 299:222. 2003
  13. ncbi request reprint Cryptochromes and inner retinal non-visual irradiance detection
    Russell N Van Gelder
    Department of Ophthalmology and Visual Sciences, Washington University Medical School, CB 8096, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Novartis Found Symp 253:31-42; discussion 42-55, 102-9, 281-4. 2003
    ..These findings suggest a model where either classical photopigments or inner retinal photopigments are sufficient for non-visual irradiance detection...
  14. ncbi request reprint Loss of photic entrainment and altered free-running circadian rhythms in math5-/- mice
    Raymond Wee
    Department of Ophthalmology and Visual Sciences, Washington University Medical School, St Louis, Missouri 63110, USA
    J Neurosci 22:10427-33. 2002
    ....
  15. ncbi request reprint Physiologic diversity and development of intrinsically photosensitive retinal ganglion cells
    Daniel C Tu
    Department of Ophthalmology and Visual Sciences, Washington University Medical School, St Louis, Missouri 63110, USA
    Neuron 48:987-99. 2005
    ..These results demonstrate that ipRGCs are the first light-sensitive cells in the retina and suggest previously unappreciated diversity in this cell population...
  16. pmc Influence of the period-dependent circadian clock on diurnal, circadian, and aperiodic gene expression in Drosophila melanogaster
    Yiing Lin
    Department of Genetics, Washington University Medical School, St Louis, MO, 63110, USA
    Proc Natl Acad Sci U S A 99:9562-7. 2002
    ..Thus, the period-dependent circadian clock regulates only a limited set of rhythmically expressed transcripts. Unexpectedly, period regulates basal and light-regulated gene expression to a very broad extent...
  17. pmc Inner retinal photoreception independent of the visual retinoid cycle
    Daniel C Tu
    Department of Ophthalmology and Visual Sciences, Washington University Medical School, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 103:10426-31. 2006
    ..These results demonstrate that the melanopsin-dependent ipRGC photocycle is independent of the visual retinoid cycle...
  18. ncbi request reprint Melanopsin-dependent persistence and photopotentiation of murine pupillary light responses
    Yanli Zhu
    Department of Ophthalmology and Visual Sciences, Washington University Medical School, St Louis, Missouri, USA
    Invest Ophthalmol Vis Sci 48:1268-75. 2007
    ..To determine the relative contributions of inner and outer retinal photoreception to the pupillary light response...
  19. ncbi request reprint Partners in time. Circadian rhythms
    R N Van Gelder
    Department of Ophthalmology and Visual Sciences, Washington University Medical School, St Louis, Missouri 63131, USA
    Curr Biol 6:244-6. 1996
    ..Together they control the daily cycle of expression of their own and other loci...
  20. ncbi request reprint Action spectrum of Drosophila cryptochrome
    Sarah J Vanvickle-Chavez
    Departments of Ophthalmology and Visual Sciences, Washington University Medical School, St Louis, Missouri 63110, USA
    J Biol Chem 282:10561-6. 2007
    ..The conferral of light-dependent degradation on a heterologous protein by fusion to cryptochrome may be a useful tool for probing protein function in cell expression systems...
  21. doi request reprint Non-visual photoreception: sensing light without sight
    Russell N Van Gelder
    Department of Ophthalmology, University of Washington Medical School, Seattle, Washington, USA
    Curr Biol 18:R38-9. 2008
    ..This system appears to subserve circadian photic entrainment, the pupillary light response, and a number of other aspects of neurophysiology and behavior...
  22. ncbi request reprint Nonvisual photoreception in the chick iris
    Daniel C Tu
    Department of Ophthalmology and Visual Sciences, Washington University Medical School, St Louis, MO 63110 USA
    Science 306:129-31. 2004
    ..These data characterize a non-opsin photoreception mechanism in a vertebrate eye and suggest a conserved photoreceptive role for cryptochromes in vertebrates...
  23. pmc Melanopsin-dependent light avoidance in neonatal mice
    Juliette Johnson
    Department of Ophthalmology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 107:17374-8. 2010
    ..These results strongly suggest that light activation of ipRGCs may regulate physiological functions such as sleep/wake cycles in preterm and neonatal infants...
  24. ncbi request reprint Herpes simplex virus type 2 as a cause of acute retinal necrosis syndrome in young patients
    R N Van Gelder
    Department of Ophthalmology and Visual Sciences, Washington University Medical School, St. Louis, Missouri
    Ophthalmology 108:869-76. 2001
    ..Because infection with HSV-2 has important medical ramifications, these results suggest that determination of a causal agent should be considered in some cases of ARN syndrome...
  25. ncbi request reprint Circadian rhythms: eyes of the clock
    R N Van Gelder
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Curr Biol 8:R798-801. 1998
    ..Blind organisms maintain this light-induced entrainment, suggesting the existence of a non-visual phototransduction pathway. The photoreceptor is unknown, but several intriguing candidates have recently come to light...
  26. doi request reprint Absence of long-wavelength photic potentiation of murine intrinsically photosensitive retinal ganglion cell firing in vitro
    Kareem Mawad
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO, USA
    J Biol Rhythms 23:387-91. 2008
    ..Further physiologic and biochemical analysis of the ipRGC photoreception is required to reconcile the presence of long-wavelength potentiation at the level of the SCN with its absence in light-induced ipRGC firing...
  27. ncbi request reprint Resetting the clock: Dexras1 defines a path
    Russell N Van Gelder
    Department of Ophthalmology and Visual Sciences, Washington University Medical School, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Neuron 43:603-4. 2004
    ..In this issue of Neuron, Cheng et al. analyze mice lacking Dexras1 (a Ras family GTPase protein) and demonstrate an important role for G(i/o) signaling mediating both photic and nonphotic phase shifts of the circadian clock...
  28. ncbi request reprint Applications of the polymerase chain reaction to diagnosis of ophthalmic disease
    R N Van Gelder
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA
    Surv Ophthalmol 46:248-58. 2001
    ..The strengths and weaknesses of this diagnostic technique are discussed. Additionally, uses of PCR in linking known pathogens to disease, and to discovering novel pathogens, are addressed...
  29. ncbi request reprint Validation of a diagnostic multiplex polymerase chain reaction assay for infectious posterior uveitis
    H Dabil
    Department of Ophthalmology and Visual Sciences, Washington University Medical School, 660 S Euclid Ave, St Louis, MO, USA
    Arch Ophthalmol 119:1315-22. 2001
    ..This assay may reduce the time and cost involved in PCR-based molecular diagnostics of infectious pathogens. CLINICAL RELEVANCE: Mutiplex PCR may allow rapid diagnosis of infectious posterior uveitis...
  30. ncbi request reprint Real-time quantitative polymerase chain reaction diagnosis of infectious posterior uveitis
    Lydia L Dworkin
    Department of Ophthalmology and Visual Sciences, Campus Box 8096, Washington University Medical School, 660 S Euclid Ave, St Louis, MO 63110, USA
    Arch Ophthalmol 120:1534-9. 2002
    ..To validate a real-time polymerase chain reaction (PCR) assay allowing rapid and sensitive detection and quantitation of 4 common infectious posterior uveitis pathogens...
  31. pmc Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver
    Matthew L Batten
    Department of Ophthalmology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 279:10422-32. 2004
    ..We conclude that Lrat-/- mice may serve as an animal model with early onset severe retinal dystrophy and severe retinyl ester deprivation...
  32. doi request reprint Prospective comparison of microbial culture and polymerase chain reaction in the diagnosis of corneal ulcer
    Elma Kim
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    Am J Ophthalmol 146:714-23, 723.e1. 2008
    ..To compare polymerase chain reaction (PCR) to microbial culture for the detection and identification of bacterial and fungal pathogens in microbial keratitis...
  33. doi request reprint Aqueous and vitreous concentrations following topical administration of 1% voriconazole in humans
    G Atma Vemulakonda
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Ophthalmol 126:18-22. 2008
    ..To determine the penetration of 1% voriconazole solution into the aqueous and vitreous following topical administration...
  34. ncbi request reprint The imprinted gene Magel2 regulates normal circadian output
    Serguei V Kozlov
    Cancer and Developmental Biology Laboratory, National Cancer Institute, Frederick, Maryland 21702, USA
    Nat Genet 39:1266-72. 2007
    ....
  35. ncbi request reprint Effect of vitamin A depletion on nonvisual phototransduction pathways in cryptochromeless mice
    Carol L Thompson
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    J Biol Rhythms 19:504-17. 2004
    ..These data demonstrate that both cryptochromes and opsins regulate nonvisual photoresponses...
  36. ncbi request reprint Melanopsin is required for non-image-forming photic responses in blind mice
    Satchidananda Panda
    Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA
    Science 301:525-7. 2003
    ..This indicates the importance of both nonvisual and classical visual photoreceptor systems for nonvisual photic responses in mammals...
  37. ncbi request reprint Muscle expression of human retinol-binding protein (RBP). Suppression of the visual defect of RBP knockout mice
    Loredana Quadro
    Institute of Cancer Research, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 277:30191-7. 2002
    ..No human RBP was found in the retinal pigment epithelium of the transgenic mice, indicating that retinol uptake by the eye does not entail endocytosis of the carrier RBP...
  38. pmc Pharmacological and rAAV gene therapy rescue of visual functions in a blind mouse model of Leber congenital amaurosis
    Matthew L Batten
    Department of Ophthalmology, University of Washington, Seattle, Washington, United States of America
    PLoS Med 2:e333. 2005
    ..One cause of LCA is loss of the enzyme lecithin:retinol acyl transferase (LRAT), which is required for regeneration of the visual photopigment in the retina...
  39. doi request reprint Idiopathic no more: clues to the pathogenesis of Fuchs heterochromic iridocyclitis and glaucomatocyclitic crisis
    Russell N Van Gelder
    Am J Ophthalmol 145:769-71. 2008
  40. doi request reprint How the clock sees the light
    Russell N Van Gelder
    Nat Neurosci 11:628-30. 2008
  41. ncbi request reprint Diagnosis of microsporidia keratitis by polymerase chain reaction
    Michael S Conners
    Arch Ophthalmol 122:283-4. 2004

Research Grants2

  1. A transgenic model of ocular inflammation
    Russell Van Gelder; Fiscal Year: 2007
    ....