Lawrence Tychsen

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Horizontal rectus muscle anatomy in naturally and artificially strabismic monkeys
    Anita Narasimhan
    Department of Ophthalmology, University of California, Los Angeles, CA, USA
    Invest Ophthalmol Vis Sci 48:2576-88. 2007
  2. doi request reprint Phakic intraocular lens correction of high ametropia in children with neurobehavioral disorders
    Lawrence Tychsen
    Department of Ophthalmology and Visual Sciences, St Louis Children s Hospital at Washington University School of Medicine, St Louis, MO 63110, USA
    J AAPOS 12:282-9. 2008
  3. ncbi request reprint Correction of large amblyopiogenic refractive errors in children using the excimer laser
    Lawrence Tychsen
    Department of Ophthalmology and Visual Sciences, St Louis Children s Hospital at Washington University School of Medicine, Missouri 63110, USA
    J AAPOS 9:224-33. 2005
  4. ncbi request reprint Can ophthalmologists repair the brain in infantile esotropia? Early surgery, stereopsis, monofixation syndrome, and the legacy of Marshall Parks
    Lawrence Tychsen
    Department of Ophthalmology and Visual Sciences, Anatomy and Neurobiology, and Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J AAPOS 9:510-21. 2005
  5. ncbi request reprint Paucity of horizontal connections for binocular vision in V1 of naturally strabismic macaques: Cytochrome oxidase compartment specificity
    Lawrence Tychsen
    Departments of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Comp Neurol 474:261-75. 2004
  6. ncbi request reprint Early versus delayed repair of infantile strabismus in macaque monkeys: II. Effects on motion visually evoked responses
    Lawrence Tychsen
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Invest Ophthalmol Vis Sci 45:821-7. 2004
  7. ncbi request reprint Refractive surgery for high bilateral myopia in children with neurobehavioral disorders: 1. Clear lens extraction and refractive lens exchange
    Lawrence Tychsen
    Department of Ophthalmology and Visual Sciences, St Louis Children s Hospital at Washington University School of Medicine, University Medical Center, One Children s Place, St Louis, MO 63110, USA
    J AAPOS 10:357-63. 2006
  8. ncbi request reprint Maldevelopment of convergence eye movements in macaque monkeys with small- and large-angle infantile esotropia
    Lawrence Tychsen
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    Invest Ophthalmol Vis Sci 44:3358-68. 2003
  9. doi request reprint The neural mechanism for Latent (fusion maldevelopment) nystagmus
    Lawrence Tychsen
    Departments of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neuroophthalmol 30:276-83. 2010
  10. ncbi request reprint Refractive surgery for high bilateral myopia in children with neurobehavioral disorders: 2. Laser-assisted subepithelial keratectomy (LASEK)
    Lawrence Tychsen
    Department of Ophthalmology and Visual Sciences, St Louis Children s Hospital at Washington University School of Medicine, University Medical Center, One Children s Place, St Louis, MO 63110, USA
    J AAPOS 10:364-70. 2006

Research Grants

  1. Visual Brain Repair in Infantile Strabismus
    Lawrence Tychsen; Fiscal Year: 2009
  2. EARLY FUNCTIONAL-STRUCTURAL REPAIR OF STRABISMUS
    Lawrence Tychsen; Fiscal Year: 2007
  3. EARLY FUNCTIONAL-STRUCTURAL REPAIR OF STRABISMUS
    Lawrence Tychsen; Fiscal Year: 2006
  4. EARLY FUNCTIONAL-STRUCTURAL REPAIR OF STRABISMUS
    Lawrence Tychsen; Fiscal Year: 2005
  5. EARLY FUNCTIONAL-STRUCTURAL REPAIR OF STRABISMUS
    Lawrence Tychsen; Fiscal Year: 2004
  6. EARLY FUNCTIONAL-STRUCTURAL REPAIR OF STRABISMUS
    Lawrence Tychsen; Fiscal Year: 2003
  7. EARLY FUNCTIONAL-STRUCTURAL REPAIR OF STRABISMUS
    Lawrence Tychsen; Fiscal Year: 2002
  8. EARLY FUNCTIONAL-STRUCTURAL REPAIR OF STRABISMUS
    Lawrence Tychsen; Fiscal Year: 2001
  9. EARLY FUNCTIONAL-STRUCTURAL REPAIR OF STRABISMUS
    Lawrence Tychsen; Fiscal Year: 2000
  10. EARLY FUNCTIONAL/STRUCTURAL REPAIR OF STRABISMUS
    Lawrence Tychsen; Fiscal Year: 1999

Collaborators

Detail Information

Publications30

  1. pmc Horizontal rectus muscle anatomy in naturally and artificially strabismic monkeys
    Anita Narasimhan
    Department of Ophthalmology, University of California, Los Angeles, CA, USA
    Invest Ophthalmol Vis Sci 48:2576-88. 2007
    ..This experiment was conducted to investigate whether such abnormalities are associated with artificial or naturally occurring strabismus in monkeys...
  2. doi request reprint Phakic intraocular lens correction of high ametropia in children with neurobehavioral disorders
    Lawrence Tychsen
    Department of Ophthalmology and Visual Sciences, St Louis Children s Hospital at Washington University School of Medicine, St Louis, MO 63110, USA
    J AAPOS 12:282-9. 2008
    ..We report the results of refractive surgery in a series of these children treated using bilateral or unilateral phakic intraocular lenses (IOLs) for ametropia >10 D...
  3. ncbi request reprint Correction of large amblyopiogenic refractive errors in children using the excimer laser
    Lawrence Tychsen
    Department of Ophthalmology and Visual Sciences, St Louis Children s Hospital at Washington University School of Medicine, Missouri 63110, USA
    J AAPOS 9:224-33. 2005
    ..We sought to determine whether laser subepithelial keratomileusis (LASEK) and photorefractive keratectomy (PRK) are effective methods for correcting amblyopiogenic refractive errors in children...
  4. ncbi request reprint Can ophthalmologists repair the brain in infantile esotropia? Early surgery, stereopsis, monofixation syndrome, and the legacy of Marshall Parks
    Lawrence Tychsen
    Department of Ophthalmology and Visual Sciences, Anatomy and Neurobiology, and Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J AAPOS 9:510-21. 2005
    ..The purpose of this work is to pay tribute to Parks' legacy by showing how human and animal studies, conducted largely during the last 25 years, support both his clinical insights and treatment philosophy...
  5. ncbi request reprint Paucity of horizontal connections for binocular vision in V1 of naturally strabismic macaques: Cytochrome oxidase compartment specificity
    Lawrence Tychsen
    Departments of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Comp Neurol 474:261-75. 2004
    ..They also provide the first detailed description of the V1 maldevelopments associated with unrepaired natural, infantile-onset strabismus in primates...
  6. ncbi request reprint Early versus delayed repair of infantile strabismus in macaque monkeys: II. Effects on motion visually evoked responses
    Lawrence Tychsen
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Invest Ophthalmol Vis Sci 45:821-7. 2004
    ..The purpose of this study was to determine how early versus delayed repair of strabismus influences the development or maldevelopment of motion VEPs...
  7. ncbi request reprint Refractive surgery for high bilateral myopia in children with neurobehavioral disorders: 1. Clear lens extraction and refractive lens exchange
    Lawrence Tychsen
    Department of Ophthalmology and Visual Sciences, St Louis Children s Hospital at Washington University School of Medicine, University Medical Center, One Children s Place, St Louis, MO 63110, USA
    J AAPOS 10:357-63. 2006
    ..We report the results of refractive surgery in a series of these children treated using lensectomy alone (clear lens extraction), or lensectomy with simultaneous implantation of an intraocular lens (refractive lens exchange)...
  8. ncbi request reprint Maldevelopment of convergence eye movements in macaque monkeys with small- and large-angle infantile esotropia
    Lawrence Tychsen
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    Invest Ophthalmol Vis Sci 44:3358-68. 2003
    ..To describe symmetric convergence eye movements evoked by disparity and/or accommodative cues in esotropic macaque monkeys, with the goal of determining whether these animals have the vergence deficits found in humans with esotropia...
  9. doi request reprint The neural mechanism for Latent (fusion maldevelopment) nystagmus
    Lawrence Tychsen
    Departments of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neuroophthalmol 30:276-83. 2010
    ..The unbalanced MSTd drive is evident as the nasalward gaze-holding bias of LN when viewing with either eye...
  10. ncbi request reprint Refractive surgery for high bilateral myopia in children with neurobehavioral disorders: 2. Laser-assisted subepithelial keratectomy (LASEK)
    Lawrence Tychsen
    Department of Ophthalmology and Visual Sciences, St Louis Children s Hospital at Washington University School of Medicine, University Medical Center, One Children s Place, St Louis, MO 63110, USA
    J AAPOS 10:364-70. 2006
    ..We report the results of refractive surgery in a series of these children treated bilaterally using excimer laser technology...
  11. ncbi request reprint Refractive surgery for children: excimer laser, phakic intraocular lens, and clear lens extraction
    Lawrence Tychsen
    Department of Ophthalmology, St Louis Children s Hospital at Washington University Medical Center, St Louis, Missouri 63110, USA
    Curr Opin Ophthalmol 19:342-8. 2008
    ..The article summarizes current recommendations for refractive surgery and outcomes in ametropic children who are spectacle noncompliant and unsuitable for contact lens wear...
  12. ncbi request reprint Early versus delayed repair of infantile strabismus in macaque monkeys: I. ocular motor effects
    Agnes M F Wong
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    J AAPOS 7:200-9. 2003
    ..The purpose of this study was to determine how early versus delayed correction of strabismus influences development and/or maldevelopment of these eye movement pathways...
  13. pmc Spectrum of infantile esotropia in primates: Behavior, brains, and orbits
    Lawrence Tychsen
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    J AAPOS 12:375-80. 2008
    ..We report here a similar spectrum of early-onset esotropia in infant monkeys, with emphasis on the relationship between visuomotor deficits, central nervous system circuitry, and orbital anatomy...
  14. ncbi request reprint Unilateral lens extraction for high anisometropic myopia in children and adolescents
    Asim Ali
    Department of Ophthalmology and Visual Sciences, St Louis Children s Hospital at Washington University School of Medicine, St Louis, Missouri 63110, USA
    J AAPOS 11:153-8. 2007
    ..We report the results of refractive surgery in a series of these children treated using lensectomy alone (clear lens extraction) or lensectomy with simultaneous implantation of an intraocular lens (refractive lens exchange)...
  15. pmc Intramuscular innervation of primate extraocular muscles: unique compartmentalization in horizontal recti
    Roberta Martins da Silva Costa
    Department of Ophthalmology, University ofCalifornia, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 52:2830-6. 2011
    ..To explore the anatomic potential of compartmentalization in all four rectus extraocular muscles (EOMs), evidence was sought of possible regional selectivity in intramuscular innervation of all rectus EOMs...
  16. doi request reprint Repair of strabismus and binocular fusion in children with cerebral palsy: gross motor function classification scale
    Fatema Ghasia
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Invest Ophthalmol Vis Sci 52:7664-71. 2011
    ..The authors limited this study to children with defined CP to determine the success or failure of restoring eye alignment and fusion...
  17. ncbi request reprint Suppression of metabolic activity caused by infantile strabismus and strabismic amblyopia in striate visual cortex of macaque monkeys
    Agnes M F Wong
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO, USA
    J AAPOS 9:37-47. 2005
    ..The purpose of this study was to further elucidate alterations in cortical metabolic activity, with or without amblyopia...
  18. pmc Causing and curing infantile esotropia in primates: the role of decorrelated binocular input (an American Ophthalmological Society thesis)
    Lawrence Tychsen
    Department of Ophthalmology, Washington University School of Medicine, St Louis, Missouri, USA
    Trans Am Ophthalmol Soc 105:564-93. 2007
    ..The author reared normal infant monkeys, under conditions of binocular decorrelation, to determine if this alone was sufficient to cause esotropia and associated behavioral as well as neuroanatomic deficits...
  19. pmc Compartmentalized innervation of primate lateral rectus muscle
    Michelle Peng
    Department of Ophthalmology, University of California, Los Angeles, Los Angeles, CA 90095 7002, USA
    Invest Ophthalmol Vis Sci 51:4612-7. 2010
    ..Evidence of possible regional selectivity in LR intramuscular innervation was sought in a study of the anatomic potential of lateral rectus (LR) muscle compartmentalization...
  20. ncbi request reprint Infantile glaucoma and punctal atresia in a child with caudal regression syndrome
    Medhat F Guirgis
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    J AAPOS 7:298-9. 2003
  21. ncbi request reprint Eye movement training and recording in alert macaque monkeys: 1. Operant visual conditioning; 2. Magnetic search coil and head restraint surgical implantation; 3. Calibration and recording
    Paul Foeller
    Departments of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO, USA
    Strabismus 10:5-22. 2002
    ....
  22. ncbi request reprint Effects of extraocular muscle tenotomy on congenital nystagmus in macaque monkeys
    Agnes M F Wong
    Department of Ophthalmology and Visual Sciences, St Louis Children s Hospital at Washington University School of Medicine, St Louis, MO 63110, USA
    J AAPOS 6:100-7. 2002
    ..Extraocular muscle tenotomy has been reported to damp congenital nystagmus in an achiasmatic sheepdog. We performed extraocular muscle tenotomy to evaluate its effects on congenital nystagmus in primates...
  23. pmc Horizontal and vertical optokinetic eye movements in macaque monkeys with infantile strabismus: directional bias and crosstalk
    Fatema Ghasia
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri
    Invest Ophthalmol Vis Sci 55:265-74. 2014
    ....
  24. doi request reprint Long-term results of botulinum toxin-augmented medial rectus recessions for large-angle infantile esotropia
    Gregg T Lueder
    Department of Ophthalmology, St Louis Children s Hospital, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Ophthalmol 153:560-3. 2012
    ..To evaluate the long-term results of medial rectus recessions augmented by botulinum toxin injection for treating infants with large-angle (> 60 prism diopters [PD]) infantile esotropia...
  25. ncbi request reprint Cone-rod retinal dystrophy and Duane retraction syndrome in a patient with achondroplasia
    Medhat F Guirgis
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    J AAPOS 6:400-1. 2002
  26. doi request reprint Frequency and severity of visual sensory and motor deficits in children with cerebral palsy: gross motor function classification scale
    Fatema Ghasia
    Department of Ophthalmology and Visual Sciences, St Louis Children s Hospital at Washington University Medical Center, St Louis, MO, USA
    Invest Ophthalmol Vis Sci 49:572-80. 2008
    ..The goal was to determine whether children with different severities of CP, as defined using the Gross Motor Function Classification System (GMFCS), had different degrees or types of visual dysfunction...
  27. ncbi request reprint X-linked idiopathic infantile nystagmus associated with a missense mutation in FRMD7
    Alan Shiels
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Vis 13:2233-41. 2007
    ..Here we map and identify the genetic mutation underlying X-linked idiopathic infantile nystagmus (XL-IIN) segregating in two Caucasian-American families...
  28. ncbi request reprint Congenital restrictive external ophthalmoplegia and gustatory epiphora associated with fetal isotretinoin toxicity
    Medhat F Guirgis
    St Louis Children s Hospital, One Children s Place, St Louis, MO 63110, USA
    Arch Ophthalmol 120:1094-5. 2002
  29. doi request reprint Duration of binocular decorrelation predicts the severity of latent (fusion maldevelopment) nystagmus in strabismic macaque monkeys
    Michael Richards
    Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada
    Invest Ophthalmol Vis Sci 49:1872-8. 2008
    ..The purpose of this study was to determine how the duration of early-onset strabismus (or timeliness of repair) affects the prevalence of LN in a primate model...
  30. ncbi request reprint Marshall M. Parks, M.D. memorial issue: remembrances
    Richard L Elliott
    Binocul Vis Strabismus Q 20:136-42. 2005

Research Grants14

  1. Visual Brain Repair in Infantile Strabismus
    Lawrence Tychsen; Fiscal Year: 2009
    ..It is a leading cause of permanent vision loss due to interocular suppression (amblyopia). The animal model will help us improve surgical and neuropharmacological treatments for these disorders. ..
  2. EARLY FUNCTIONAL-STRUCTURAL REPAIR OF STRABISMUS
    Lawrence Tychsen; Fiscal Year: 2007
    ..The experiments proposed here could lead to refined treatments and functional cures in humans, and reveal the biological mechanisms responsible for this common childhood visual disorder. ..
  3. EARLY FUNCTIONAL-STRUCTURAL REPAIR OF STRABISMUS
    Lawrence Tychsen; Fiscal Year: 2006
    ..The experiments proposed here could lead to refined treatments and functional cures in humans, and reveal the biological mechanisms responsible for this common childhood visual disorder. ..
  4. EARLY FUNCTIONAL-STRUCTURAL REPAIR OF STRABISMUS
    Lawrence Tychsen; Fiscal Year: 2005
    ..The experiments proposed here could lead to refined treatments and functional cures in humans, and reveal the biological mechanisms responsible for this common childhood visual disorder. ..
  5. EARLY FUNCTIONAL-STRUCTURAL REPAIR OF STRABISMUS
    Lawrence Tychsen; Fiscal Year: 2004
    ..The experiments proposed here could lead to refined treatments and functional cures in humans, and reveal the biological mechanisms responsible for this common childhood visual disorder. ..
  6. EARLY FUNCTIONAL-STRUCTURAL REPAIR OF STRABISMUS
    Lawrence Tychsen; Fiscal Year: 2003
    ..The experiments proposed here could lead to refined treatments and functional cures in humans, and reveal the biological mechanisms responsible for this common childhood visual disorder. ..
  7. EARLY FUNCTIONAL-STRUCTURAL REPAIR OF STRABISMUS
    Lawrence Tychsen; Fiscal Year: 2002
    ..The experiments proposed here could lead to refined treatments aimed at achieving functional cures, as well as a fundamental advance in understanding the biological mechanism of a common pediatric visual disorder. ..
  8. EARLY FUNCTIONAL-STRUCTURAL REPAIR OF STRABISMUS
    Lawrence Tychsen; Fiscal Year: 2001
    ..The experiments proposed here could lead to refined treatments aimed at achieving functional cures, as well as a fundamental advance in understanding the biological mechanism of a common pediatric visual disorder. ..
  9. EARLY FUNCTIONAL-STRUCTURAL REPAIR OF STRABISMUS
    Lawrence Tychsen; Fiscal Year: 2000
    ..The experiments proposed here could lead to refined treatments aimed at achieving functional cures, as well as a fundamental advance in understanding the biological mechanism of a common pediatric visual disorder. ..
  10. EARLY FUNCTIONAL/STRUCTURAL REPAIR OF STRABISMUS
    Lawrence Tychsen; Fiscal Year: 1999
    ..The experiments proposed here could lead to refined treatments aimed at achieving functional cures, as well as a fundamental advance in understanding the biological mechanism of a common pediatric visual disorder. ..
  11. Visual Brain Repair in Infantile Strabismus
    Lawrence Tychsen; Fiscal Year: 2010
    ..It is a leading cause of permanent vision loss due to interocular suppression (amblyopia). The animal model will help us improve surgical and neuropharmacological treatments for these disorders. ..