Thomas H Tung

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. doi request reprint Obturator nerve transfer for femoral nerve reconstruction: anatomic study and clinical application
    Thomas H Tung
    Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Plast Reconstr Surg 130:1066-74. 2012
  2. doi request reprint Transfer of the extensor digiti minimi and extensor carpi ulnaris branches of the posterior interosseous nerve to restore intrinsic hand function: case report and anatomic study
    Thomas H Tung
    Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, Saint Louis, MO 63110, USA
    J Hand Surg Am 38:98-103. 2013
  3. pmc Nerve transfer for elbow flexion in radiation-induced brachial plexopathy: a case report
    Thomas H Tung
    Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8238, St Louis, MO, 63110, USA
    Hand (N Y) 4:123-8. 2009
  4. doi request reprint Nerve transfers: indications, techniques, and outcomes
    Thomas H Tung
    Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Hand Surg Am 35:332-41. 2010
  5. pmc The role of T helper cell differentiation in promoting nerve allograft survival with costimulation blockade
    Wilson Z Ray
    Department of Neurological Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosurg 112:386-93. 2010
  6. pmc Costimulation blockade inhibits the indirect pathway of allorecognition in nerve allograft rejection
    Wilson Z Ray
    Department of Neurological Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Muscle Nerve 43:120-6. 2011
  7. pmc Treatment modality affects allograft-derived Schwann cell phenotype and myelinating capacity
    Ayato Hayashi
    Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8238, Saint Louis, MO 63110, USA
    Exp Neurol 212:324-36. 2008
  8. pmc Effect of cold nerve allograft preservation on antigen presentation and rejection
    Wilson Z Ray
    Department of Neurological Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    J Neurosurg 114:256-62. 2011
  9. ncbi request reprint Prolonged limb allograft survival with CD 40 costimulation blockade, T-cell depletion, and megadose donor bone-marrow transfusion
    Thomas H Tung
    Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Microsurgery 25:624-31. 2005
  10. ncbi request reprint Use of motor nerve material in peripheral nerve repair with conduits
    Brendan M Lloyd
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Microsurgery 27:138-45. 2007

Collaborators

Detail Information

Publications33

  1. doi request reprint Obturator nerve transfer for femoral nerve reconstruction: anatomic study and clinical application
    Thomas H Tung
    Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Plast Reconstr Surg 130:1066-74. 2012
    ....
  2. doi request reprint Transfer of the extensor digiti minimi and extensor carpi ulnaris branches of the posterior interosseous nerve to restore intrinsic hand function: case report and anatomic study
    Thomas H Tung
    Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, Saint Louis, MO 63110, USA
    J Hand Surg Am 38:98-103. 2013
    ....
  3. pmc Nerve transfer for elbow flexion in radiation-induced brachial plexopathy: a case report
    Thomas H Tung
    Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8238, St Louis, MO, 63110, USA
    Hand (N Y) 4:123-8. 2009
    ..The patient recovered MRC grade 4/5 elbow flexion after surgery. The characteristics of this disorder and surgical treatment options are reviewed...
  4. doi request reprint Nerve transfers: indications, techniques, and outcomes
    Thomas H Tung
    Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Hand Surg Am 35:332-41. 2010
    ....
  5. pmc The role of T helper cell differentiation in promoting nerve allograft survival with costimulation blockade
    Wilson Z Ray
    Department of Neurological Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosurg 112:386-93. 2010
    ....
  6. pmc Costimulation blockade inhibits the indirect pathway of allorecognition in nerve allograft rejection
    Wilson Z Ray
    Department of Neurological Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Muscle Nerve 43:120-6. 2011
    ..The indirect pathway is required to induce costimulatory blockade immune hyporesponsiveness...
  7. pmc Treatment modality affects allograft-derived Schwann cell phenotype and myelinating capacity
    Ayato Hayashi
    Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8238, Saint Louis, MO 63110, USA
    Exp Neurol 212:324-36. 2008
    ..However, we found that co-stimulatory blockade facilitate optimal myelin formation and maturation of SCs as indicated by protein expression of myelin basic protein (MBP), connexin-32 and phospho-Akt...
  8. pmc Effect of cold nerve allograft preservation on antigen presentation and rejection
    Wilson Z Ray
    Department of Neurological Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    J Neurosurg 114:256-62. 2011
    ..The objective of this investigation was to study the effect of progressive periods of cold nerve allograft preservation on antigen presentation and the alloimmune response...
  9. ncbi request reprint Prolonged limb allograft survival with CD 40 costimulation blockade, T-cell depletion, and megadose donor bone-marrow transfusion
    Thomas H Tung
    Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Microsurgery 25:624-31. 2005
    ..While allograft survival was prolonged, tolerance was not achieved, and the mechanism of rejection was more consistent with a chronic process...
  10. ncbi request reprint Use of motor nerve material in peripheral nerve repair with conduits
    Brendan M Lloyd
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Microsurgery 27:138-45. 2007
    ..These findings suggest that intact nerve architecture, regardless of neurotrophic or biochemical factors, is a prerequisite for the beneficial effect of motor nerve grafting...
  11. ncbi request reprint Chimerism after vascularized limb versus bone marrow transplantation
    Michael Cohen
    Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Reconstr Microsurg 22:375-84. 2006
    ..The marrow component of a limb allograft is thus more effective at inducing microchimerism compared to a comparable dose of bone marrow suspension...
  12. ncbi request reprint Survival of long nerve allografts following donor antigen pretreatment: a pilot study
    Thomas H Tung
    Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Reconstr Microsurg 22:443-9. 2006
    ..Furthermore, tolerance to long nerve allografts has immediate applicability to clinical requirements for bridging multiple, complex, long nerve gaps...
  13. ncbi request reprint Immune unresponsiveness by intraportal UV-B-irradiated donor antigen administration requires persistence of donor antigen in a nerve allograft model
    Thomas H Tung
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Reconstr Microsurg 20:43-51. 2004
    ....
  14. ncbi request reprint TH1/TH2 cytokine profile of the immune response in limb component transplantation
    Thomas H Tung
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Plast Reconstr Surg 116:557-66. 2005
    ..The purpose of this study was to define the cytokine secretion pattern during limb allograft rejection and to determine its correlation to differential tissue antigenicity of limb allograft components...
  15. pmc Nerve regeneration in rat limb allografts: evaluation of acute rejection rescue
    Ying Yan
    Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Plast Reconstr Surg 131:499e-511e. 2013
    ..The present study was designed to characterize the effect of acute rejection on nerve regeneration and functional recovery in the setting of orthotopic limb transplantation...
  16. ncbi request reprint Results of reinnervation of the biceps and brachialis muscles with a double fascicular transfer for elbow flexion
    Susan E Mackinnon
    Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Hand Surg Am 30:978-85. 2005
    ..To report the results of a surgical technique of nerve transfer to reinnervate the brachialis muscle and the biceps muscle to restore elbow flexion after brachial plexus injury...
  17. ncbi request reprint Effect of FK506 on peripheral nerve regeneration through long grafts in inbred swine
    John N Jensen
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Ann Plast Surg 54:420-7. 2005
    ..Treatment with FK506 resulted in a trend toward enhanced axonal regeneration through nerve autografts and allografts in a large-animal model with defined histocompatibility barriers...
  18. ncbi request reprint Combined treatment with CD40 costimulation blockade, T-cell depletion, low-dose irradiation, and donor bone marrow transfusion in limb allograft survival
    Thomas H Tung
    Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Plast Surg 55:512-8. 2005
    ..However, tolerance was not achieved, and histology suggests chronic rejection as a possible cause of allograft loss...
  19. ncbi request reprint Costimulation blockade inhibits the indirect pathway of allorecognition in nerve allograft rejection
    Wilson Z Ray
    Department of Neurological Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Muscle Nerve 43:120-6. 2011
    ..The indirect pathway is required to induce costimulatory blockade immune hyporesponsiveness. Muscle Nerve, 2011...
  20. doi request reprint Fibrin glue mitigates the learning curve of microneurosurgical repair
    Elizabeth L Whitlock
    Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Microsurgery 30:218-22. 2010
    ..Fibrin glue may be considered as an alternative to microepineurial suture repair, particularly in the setting of relative surgeon inexperience with microsurgical technique...
  21. ncbi request reprint Nerve transfers to the biceps and brachialis branches to improve elbow flexion strength after brachial plexus injuries
    Thomas H Tung
    Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    J Neurosurg 98:313-8. 2003
    ..In this study the authors evaluated the outcome in patients with brachial plexus injuries who underwent nerve transfers to the biceps and the brachialis branches of the musculocutaneous nerve...
  22. ncbi request reprint Nerve reconstruction in lumbosacral plexopathy. Case report and review of the literature
    Thomas H Tung
    Division of Plastic and Reconstructive Surgery and Department of Neurosurgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosurg 102:86-91. 2005
    ..With the assistance of a foot-drop splint, the patient ambulates well and is able to ski. Operative details and the relevant literature are reviewed...
  23. ncbi request reprint Induction of regional collateral sprouting following muscle denervation
    Jason W Koob
    Departments of Plastic and Reconstructive Surgery, Washington University, Saint Louis, Missouri, USA
    Laryngoscope 117:1735-40. 2007
    ..We hypothesize that epineurial injury is required to induce collateral sprouting toward a neighboring denervated muscle...
  24. pmc A novel model for evaluating nerve regeneration in the composite tissue transplant: the murine heterotopic limb transplant
    Ying Yan
    Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8238, St Louis, MO 63110 USA
    Hand (N Y) 6:304-12. 2011
    ..We also compare the effects of various immunosuppressive regimens on nerve regeneration in this model...
  25. pmc The feasibility of diaphragmatic transplantation as potential therapy for treatment of respiratory failure associated with Duchenne muscular dystrophy: acute canine model
    Alexander Sasha Krupnick
    Department of Surgery, Division of Cardiothoracic Surgery, Thoracic Immunobiology Laboratory, Division of Plastic and Reconstructive Surgery, Washington University in St Louis, St Louis, MO 63110, USA
    J Thorac Cardiovasc Surg 135:1398-9. 2008
  26. ncbi request reprint Effect of nondepleting anti-CD4 monoclonal antibody (Rib 5/2) plus donor antigen pretreatment in peripheral nerve allotransplantation
    Vaishali B Doolabh
    Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Microsurgery 22:329-34. 2002
    ..Histologic evaluation demonstrated better regeneration in the allograft recipients receiving both donor antigen and antibody, compared to recipients of untreated allografts or treatment with antigen or antibody alone...
  27. ncbi request reprint Effects of motor versus sensory nerve grafts on peripheral nerve regeneration
    Chris M Nichols
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Exp Neurol 190:347-55. 2004
    ..05). These data suggest that use of motor or mixed nerve grafts, rather than sensory nerve grafts, will optimize regeneration across mixed nerve defects...
  28. ncbi request reprint Median to radial nerve transfer for treatment of radial nerve palsy. Case report
    Susan E Mackinnon
    Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosurg 107:666-71. 2007
    ..This median to radial nerve transfer offers an alternative to nerve repair, graft, or tendon transfer for the treatment of radial nerve palsy...
  29. ncbi request reprint Traumatic brachial plexus injuries
    Jason M Rovak
    Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, USA
    Mo Med 103:632-6. 2006
    ..Surgical options have changed with technological advances in microsurgery, and the availability of long-term outcome data following plexus reconstruction...
  30. pmc Motor nerve transfers to restore extrinsic median nerve function: case report
    Eugene C Hsiao
    Department of Surgery, Division of Plastic and Reconstructive Surgery, School of Medicine, Washington University, 660 S Euclid, Campus Box 8238, Saint Louis, MO, 63110, USA
    Hand (N Y) 4:92-7. 2009
    ....
  31. ncbi request reprint Strain differences in autotomy in mice after peripheral nerve transection or repair
    Roee E Rubinstein
    Washington University School of Medicine, St Louis, MO 63110, USA
    Microsurgery 23:363-8. 2003
    ..Two strains, C57BL/6J and C57BL/10J, were found to be highly resistant to self-mutilation, and are thus ideal animal models for peripheral-nerve and whole-limb transplant studies...
  32. pmc Reconstruction of posterior interosseous nerve injury following biceps tendon repair: case report and cadaveric study
    David B Mokhtee
    Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8238, St Louis, MO, 63110, USA
    Hand (N Y) 4:134-9. 2009
    ..Finally, we advocate consideration for identification of the posterior interosseous nerve prior to reattachment of the biceps tendon to the radial tuberosity...
  33. ncbi request reprint The spectrum of complications of immunosuppression: is the time right for hand transplantation?
    Michael J Brenner
    Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Bone Joint Surg Am 84:1861-70. 2002