Heather L True

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint The battle of the fold: chaperones take on prions
    Heather L True
    Department of Cell Biology and Physiology, Washington University, 660 South Euclid Avenue, Campus Box 8228, St Louis, MO 63110, USA
    Trends Genet 22:110-7. 2006
  2. pmc Disease-associated mutant ubiquitin causes proteasomal impairment and enhances the toxicity of protein aggregates
    Elizabeth M H Tank
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Genet 5:e1000382. 2009
  3. ncbi request reprint Deletion of RNQ1 gene reveals novel functional relationship between divergently transcribed Bik1p/CLIP-170 and Sfi1p in spindle pole body separation
    Lisa A Strawn
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8228, St Louis, MO, 63110, USA
    Curr Genet 50:347-66. 2006
  4. pmc Insights into intragenic and extragenic effectors of prion propagation using chimeric prion proteins
    Heather L True
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Prion 2:45-7. 2008
  5. pmc Mutants of the Paf1 complex alter phenotypic expression of the yeast prion [PSI+]
    Lisa A Strawn
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Biol Cell 20:2229-41. 2009
  6. pmc Requirements of Hsp104p activity and Sis1p binding for propagation of the [RNQ(+)] prion
    J Patrick Bardill
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO, USA
    Prion 3:151-60. 2009
  7. pmc Soluble oligomers are sufficient for transmission of a yeast prion but do not confer phenotype
    Jennifer E Dulle
    Department of Cell Biology and Physiology, Washington University in St Louis, St Louis, MO 63110
    J Cell Biol 203:197-204. 2013
  8. pmc Analysis of the [RNQ+] prion reveals stability of amyloid fibers as the key determinant of yeast prion variant propagation
    Tejas Kalastavadi
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MI 63108, USA
    J Biol Chem 285:20748-55. 2010
  9. pmc Prion protein repeat expansion results in increased aggregation and reveals phenotypic variability
    Elizabeth M H Tank
    Department of Cell Biology and Physiology, Washington University School of Medicine, Campus Box 8228, 660 S Euclid Ave, St Louis, MO 63110, USA
    Mol Cell Biol 27:5445-55. 2007
  10. pmc Prion protein insertional mutations increase aggregation propensity but not fiber stability
    Tejas Kalastavadi
    Department of Cell Biology and Physiology, Washington University School of Medicine, Box 8228, 660 South Euclid Avenue, Saint Louis, MO 63110, USA
    BMC Biochem 9:7. 2008

Research Grants

  1. Elucidating the Function of Novel Epigenetic Element
    HEATHER TRUE KROB; Fiscal Year: 2005

Collaborators

  • Tejas Kalastavadi
  • Joanna Masel
  • Kevin C Stein
  • Jennifer E Dulle
  • HEATHER TRUE KROB
  • J Patrick Bardill
  • Elizabeth M H Tank
  • Lisa A Strawn
  • Changyi A Lin
  • David A Harris
  • Vincent J Huang
  • Alex K Lancaster
  • Lisa A Underwood
  • Rachel E Bouttenot
  • Steven R Ellis
  • Sarah A Simpson
  • Jonathan R Fisher
  • Morwan M Osman
  • Amar A Desai

Detail Information

Publications18

  1. ncbi request reprint The battle of the fold: chaperones take on prions
    Heather L True
    Department of Cell Biology and Physiology, Washington University, 660 South Euclid Avenue, Campus Box 8228, St Louis, MO 63110, USA
    Trends Genet 22:110-7. 2006
    ..In fact, it seems that the prions usurp the refolding machinery and actually employ chaperones to propagate the prion state. Recent data has begun to uncover the mechanism behind this unique relationship...
  2. pmc Disease-associated mutant ubiquitin causes proteasomal impairment and enhances the toxicity of protein aggregates
    Elizabeth M H Tank
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Genet 5:e1000382. 2009
    ..Furthermore, we suggest a model whereby chronic UPS impairment could inflict deleterious consequences on proper protein aggregate sequestration...
  3. ncbi request reprint Deletion of RNQ1 gene reveals novel functional relationship between divergently transcribed Bik1p/CLIP-170 and Sfi1p in spindle pole body separation
    Lisa A Strawn
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8228, St Louis, MO, 63110, USA
    Curr Genet 50:347-66. 2006
    ..These results suggest that Bik1p has a previously uncharacterized function in the separation of duplicated SPBs...
  4. pmc Insights into intragenic and extragenic effectors of prion propagation using chimeric prion proteins
    Heather L True
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Prion 2:45-7. 2008
    ..We found that repeat expansions in the chimeric prion proteins increase the propensity to initiate prion propagation and enhance the formation of amyloid fibers without significantly altering fiber stability...
  5. pmc Mutants of the Paf1 complex alter phenotypic expression of the yeast prion [PSI+]
    Lisa A Strawn
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Biol Cell 20:2229-41. 2009
    ..Finally, we demonstrate that the CTR9 deletion alters several [PSI+]-dependent phenotypes. This provides one example of how [PSI+] and genetic modifiers can interact to uncover and regulate phenotypic variability...
  6. pmc Requirements of Hsp104p activity and Sis1p binding for propagation of the [RNQ(+)] prion
    J Patrick Bardill
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO, USA
    Prion 3:151-60. 2009
    ..Additionally, we show that the L94A mutation in Rnq1p, which reduces its interaction with Sis1p, prevents Rnq1p from maintaining a prion and inducing [PSI(+)]...
  7. pmc Soluble oligomers are sufficient for transmission of a yeast prion but do not confer phenotype
    Jennifer E Dulle
    Department of Cell Biology and Physiology, Washington University in St Louis, St Louis, MO 63110
    J Cell Biol 203:197-204. 2013
    ..Furthermore, the nontoxic, self-replicating amyloid conformers of yeast prion proteins have again provided valuable insight into the mechanisms of amyloid formation and propagation in cells. ..
  8. pmc Analysis of the [RNQ+] prion reveals stability of amyloid fibers as the key determinant of yeast prion variant propagation
    Tejas Kalastavadi
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MI 63108, USA
    J Biol Chem 285:20748-55. 2010
    ....
  9. pmc Prion protein repeat expansion results in increased aggregation and reveals phenotypic variability
    Elizabeth M H Tank
    Department of Cell Biology and Physiology, Washington University School of Medicine, Campus Box 8228, 660 S Euclid Ave, St Louis, MO 63110, USA
    Mol Cell Biol 27:5445-55. 2007
    ..Both of these characteristics may contribute to the phenotypic variability associated with PrP repeat expansion diseases...
  10. pmc Prion protein insertional mutations increase aggregation propensity but not fiber stability
    Tejas Kalastavadi
    Department of Cell Biology and Physiology, Washington University School of Medicine, Box 8228, 660 South Euclid Avenue, Saint Louis, MO 63110, USA
    BMC Biochem 9:7. 2008
    ..In this study we have attempted to understand the biochemical properties of these chimeric proteins and to establish a system to study the properties of the ORD of PrP both in vivo and in vitro...
  11. pmc Heterologous prion interactions are altered by mutations in the prion protein Rnq1p
    J Patrick Bardill
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Mol Biol 388:583-96. 2009
    ..These data suggest that this region is important in defining the structure of the [RNQ+] strain variants. These data are consistent with a model of [PSI+] induction caused by physical interactions between Rnq1p and Sup35p...
  12. pmc The [RNQ+] prion: a model of both functional and pathological amyloid
    Kevin C Stein
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO, USA
    Prion 5:291-8. 2011
    ..Thus, the [RNQ+] prion provides a tractable model that has the potential to reveal significant insight into the factors that dictate how amyloid structures are initiated and propagated in both physiological and pathological contexts...
  13. pmc The Sua5 protein is essential for normal translational regulation in yeast
    Changyi A Lin
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Mol Cell Biol 30:354-63. 2010
    ..This study reveals a critical role for Sua5 and the t(6)A(37) modification in translational fidelity...
  14. pmc The spontaneous appearance rate of the yeast prion [PSI+] and its implications for the evolution of the evolvability properties of the [PSI+] system
    Alex K Lancaster
    Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Genetics 184:393-400. 2010
    ....
  15. pmc Regulation of the Hsp104 middle domain activity is critical for yeast prion propagation
    Jennifer E Dulle
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 9:e87521. 2014
    ..This shows the importance of elucidating the function of the M-domain in order to understand the role of Hsp104 in the propagation of different prions and prion variants. ..
  16. pmc Extensive diversity of prion strains is defined by differential chaperone interactions and distinct amyloidogenic regions
    Kevin C Stein
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Genet 10:e1004337. 2014
    ..This helps reveal the complex interdependent factors that influence how a particular amyloid structure may dictate disease pathology and progression. ..
  17. pmc Spontaneous variants of the [RNQ+] prion in yeast demonstrate the extensive conformational diversity possible with prion proteins
    Vincent J Huang
    Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America
    PLoS ONE 8:e79582. 2013
    ..Collectively, this work shows the broad spectrum of available amyloid conformations, and thereby expands the foundation for studying the complex factors that interact to regulate the propagation of distinct aggregate structures. ..
  18. ncbi request reprint New insights into prion structure and toxicity
    David A Harris
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neuron 50:353-7. 2006
    ..In this review, we will highlight recent studies that shed new light on these important issues...

Research Grants2

  1. Elucidating the Function of Novel Epigenetic Element
    HEATHER TRUE KROB; Fiscal Year: 2005
    ....