Douglas M Tollefsen

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Heparin cofactor II modulates the response to vascular injury
    Douglas M Tollefsen
    Division of Hematology, Campus Box 8125, Washington University Medical School, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Arterioscler Thromb Vasc Biol 27:454-60. 2007
  2. ncbi request reprint Heparin cofactor II deficiency
    Douglas M Tollefsen
    Hematology Division, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Pathol Lab Med 126:1394-400. 2002
  3. ncbi request reprint Does heparin cofactor II modulate atherosclerosis and restenosis?
    Douglas M Tollefsen
    Hematology Division, Department of Medicine, Washington University Medical School, 660 South Euclid Ave, St Louis, MO 63110, USA
    Circulation 109:2682-4. 2004
  4. pmc Vascular dermatan sulfate regulates the antithrombotic activity of heparin cofactor II
    Li He
    Division of Hematology, Washington University Medical School, 660 South Euclid Ave, St Louis, MO 63110, USA
    Blood 111:4118-25. 2008
  5. ncbi request reprint Antithrombotic activity of dermatan sulfate in heparin cofactor II-deficient mice
    Cristina P Vicente
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Blood 104:3965-70. 2004
  6. doi request reprint Vascular dermatan sulfate and heparin cofactor II
    Douglas M Tollefsen
    Washington University Medical School, St Louis, MO, USA
    Prog Mol Biol Transl Sci 93:351-72. 2010
  7. pmc Fusion proteins comprising annexin V and Kunitz protease inhibitors are highly potent thrombogenic site-directed anticoagulants
    Hsiu Hui Chen
    Division of Hematology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    Blood 105:3902-9. 2005
  8. ncbi request reprint N-Acetylgalactosamine 4,6-O-sulfate residues mediate binding and activation of heparin cofactor II by porcine mucosal dermatan sulfate
    Anna Margrét Halldórsdóttir
    Division of Laboratory Medicine, Department of Pathology and Immunology, Campus Box 8118, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Glycobiology 16:693-701. 2006
  9. pmc Inhibition of antithrombin by Plasmodium falciparum histidine-rich protein II
    Matthew Ndonwi
    Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    Blood 117:6347-54. 2011
  10. pmc Placental dermatan sulfate: isolation, anticoagulant activity, and association with heparin cofactor II
    Tusar K Giri
    Hematology Division, Campus Box 8125, Washington University Medical School, 660 South Euclid Ave, St Louis, MO 63110, USA
    Blood 107:2753-8. 2006

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Heparin cofactor II modulates the response to vascular injury
    Douglas M Tollefsen
    Division of Hematology, Campus Box 8125, Washington University Medical School, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Arterioscler Thromb Vasc Biol 27:454-60. 2007
    ..In addition, HCII deficiency appears to promote neointima formation and atherogenesis in mice. These results suggest that HCII plays a unique and important role in vascular homeostasis...
  2. ncbi request reprint Heparin cofactor II deficiency
    Douglas M Tollefsen
    Hematology Division, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Pathol Lab Med 126:1394-400. 2002
    ....
  3. ncbi request reprint Does heparin cofactor II modulate atherosclerosis and restenosis?
    Douglas M Tollefsen
    Hematology Division, Department of Medicine, Washington University Medical School, 660 South Euclid Ave, St Louis, MO 63110, USA
    Circulation 109:2682-4. 2004
  4. pmc Vascular dermatan sulfate regulates the antithrombotic activity of heparin cofactor II
    Li He
    Division of Hematology, Washington University Medical School, 660 South Euclid Ave, St Louis, MO 63110, USA
    Blood 111:4118-25. 2008
    ..These results support the hypothesis that HCII interacts with DS in the vessel wall after disruption of the endothelium and that this interaction regulates thrombus formation in vivo...
  5. ncbi request reprint Antithrombotic activity of dermatan sulfate in heparin cofactor II-deficient mice
    Cristina P Vicente
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Blood 104:3965-70. 2004
    ....
  6. doi request reprint Vascular dermatan sulfate and heparin cofactor II
    Douglas M Tollefsen
    Washington University Medical School, St Louis, MO, USA
    Prog Mol Biol Transl Sci 93:351-72. 2010
    ..These observations suggest that a major function of the HCII-DS system is to regulate the physiologic response to arterial injury...
  7. pmc Fusion proteins comprising annexin V and Kunitz protease inhibitors are highly potent thrombogenic site-directed anticoagulants
    Hsiu Hui Chen
    Division of Hematology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    Blood 105:3902-9. 2005
    ..ANV-KPI fusion proteins represent a new class of anticoagulants that specifically target the anionic membrane-associated coagulation enzyme complexes present at sites of thrombogenesis and are potentially useful as antithrombotic agents...
  8. ncbi request reprint N-Acetylgalactosamine 4,6-O-sulfate residues mediate binding and activation of heparin cofactor II by porcine mucosal dermatan sulfate
    Anna Margrét Halldórsdóttir
    Division of Laboratory Medicine, Department of Pathology and Immunology, Campus Box 8118, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Glycobiology 16:693-701. 2006
    ..These data support the hypothesis that modification of IdoA-->GalNAc4SO3 subunits in the DS polymer by either 2-O-sulfation of IdoA or 6-O-sulfation of GalNAc can generate molecules with HCII-binding sites and anticoagulant activity...
  9. pmc Inhibition of antithrombin by Plasmodium falciparum histidine-rich protein II
    Matthew Ndonwi
    Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    Blood 117:6347-54. 2011
    ....
  10. pmc Placental dermatan sulfate: isolation, anticoagulant activity, and association with heparin cofactor II
    Tusar K Giri
    Hematology Division, Campus Box 8125, Washington University Medical School, 660 South Euclid Ave, St Louis, MO 63110, USA
    Blood 107:2753-8. 2006
    ..Our data suggest that DS is in a position to activate HCII in the fetal blood vessels or in the stroma of placental villi after injury to the syncytiotrophoblast layer and thereby inhibit fibrin generation in the placenta...
  11. pmc The collection of NFATc1-dependent transcripts in the osteoclast includes numerous genes non-essential to physiologic bone resorption
    Julia F Charles
    Department of Medicine, Division of Rheumatology, Allergy and Immunology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Bone 51:902-12. 2012
    ..These data highlight the need for rigorous validation studies to complement expression profiling results before functional importance can be assigned to highly regulated genes in any biologic process...
  12. pmc A self-inactivating gamma-retroviral vector reduces manifestations of mucopolysaccharidosis I in mice
    Jason A Metcalf
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Mol Ther 18:334-42. 2010
    ..A SIN gamma-RV vector ameliorates clinical manifestations of MPS I in mice and should be safer than an LTR-intact gamma-RV...
  13. pmc Heparin cofactor II inhibits arterial thrombosis after endothelial injury
    Li He
    Division of Hematology, Department of Internal Medicine, Washington University, St Louis, Missouri 63110, USA
    J Clin Invest 109:213-9. 2002
    ..This abnormality was corrected by infusion of purified HCII but not ovalbumin. These observations suggest that HCII might inhibit thrombosis in the arterial circulation...
  14. pmc Accelerated atherogenesis and neointima formation in heparin cofactor II deficient mice
    Cristina P Vicente
    Department of Cellular Biology, Institute of Biology, State University of Campinas UNICAMP, Campinas Sao Paulo, Brazil
    Blood 110:4261-7. 2007
    ..Heparin did not inhibit neointima formation. We conclude that HCII deficiency promotes atherogenesis and neointima formation and that treatment with dermatan sulfate reduces neointima formation in an HCII-dependent manner...
  15. ncbi request reprint Heparin cofactor II levels do not predict the development of coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study
    Tusar K Giri
    Arterioscler Thromb Vasc Biol 25:2689-90. 2005
  16. pmc Mice lacking the extracellular matrix protein MAGP1 display delayed thrombotic occlusion following vessel injury
    Claudio C Werneck
    Department of Biochemistry, Institute of Biology, State University of Campinas UNICAMP, Campinas, Brazil
    Blood 111:4137-44. 2008
    ..These findings show that MAGP1, a component of microfibrils and vascular elastic fibers, plays a role in hemostasis and thrombosis...
  17. ncbi request reprint Selective cleavage and anticoagulant activity of a sulfated fucan: stereospecific removal of a 2-sulfate ester from the polysaccharide by mild acid hydrolysis, preparation of oligosaccharides, and heparin cofactor II-dependent anticoagulant activity
    Vitor H Pomin
    Laboratório de Tecido Conjuntivo, Hospital Universitario Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Caixa Postal 68041, Rio de Janeiro, RJ, 21941 590, Brazil
    Glycobiology 15:369-81. 2005
    ..We speculate that the template mechanism may predominate over the allosteric effect in the case of the linear sulfated fucan inactivation of thrombin in the presence of heparin cofactor II...
  18. ncbi request reprint The contributions of the alpha 2 beta 1 integrin to vascular thrombosis in vivo
    Li He
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Blood 102:3652-7. 2003
    ..Our results are the first to document a critical in vivo role for the alpha 2 beta 1 integrin in thrombus formation at the vessel wall under conditions of shear following vascular injury...
  19. ncbi request reprint Binding of exosite ligands to human thrombin. Re-evaluation of allosteric linkage between thrombin exosites I and II
    Ingrid M Verhamme
    Department of Pathology, Vanderbilt University School of Medicine, Medical Center North, Nashville, TN 37232, USA
    J Biol Chem 277:6788-98. 2002
    ..The results indicate significant, ligand-specific allosteric coupling between thrombin exosites I and II and catalytic site perturbations but insignificant inter-exosite thermodynamic linkage...