Research Topics
Genomes and Genes | Douglas M TollefsenSummaryAffiliation: Washington University School of Medicine Country: USA Publications
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Publications
Heparin cofactor II modulates the response to vascular injuryDouglas M Tollefsen
Division of Hematology, Campus Box 8125, Washington University Medical School, 660 South Euclid Avenue, St Louis, MO 63110, USA
Arterioscler Thromb Vasc Biol 27:454-60. 2007..In addition, HCII deficiency appears to promote neointima formation and atherogenesis in mice. These results suggest that HCII plays a unique and important role in vascular homeostasis...- Heparin cofactor II deficiencyDouglas M Tollefsen
Hematology Division, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
Arch Pathol Lab Med 126:1394-400. 2002.... - Does heparin cofactor II modulate atherosclerosis and restenosis?Douglas M Tollefsen
Hematology Division, Department of Medicine, Washington University Medical School, 660 South Euclid Ave, St Louis, MO 63110, USA
Circulation 109:2682-4. 2004 
Vascular dermatan sulfate regulates the antithrombotic activity of heparin cofactor IILi He
Division of Hematology, Washington University Medical School, 660 South Euclid Ave, St Louis, MO 63110, USA
Blood 111:4118-25. 2008..These results support the hypothesis that HCII interacts with DS in the vessel wall after disruption of the endothelium and that this interaction regulates thrombus formation in vivo...- Antithrombotic activity of dermatan sulfate in heparin cofactor II-deficient miceCristina P Vicente
Department of Medicine, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
Blood 104:3965-70. 2004.... 
Vascular dermatan sulfate and heparin cofactor IIDouglas M Tollefsen
Washington University Medical School, St Louis, MO, USA
Prog Mol Biol Transl Sci 93:351-72. 2010..These observations suggest that a major function of the HCII-DS system is to regulate the physiologic response to arterial injury...- Fusion proteins comprising annexin V and Kunitz protease inhibitors are highly potent thrombogenic site-directed anticoagulantsHsiu-Hui Chen
Division of Hematology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
Blood 105:3902-9. 2005..ANV-KPI fusion proteins represent a new class of anticoagulants that specifically target the anionic membrane-associated coagulation enzyme complexes present at sites of thrombogenesis and are potentially useful as antithrombotic agents... - N-Acetylgalactosamine 4,6-O-sulfate residues mediate binding and activation of heparin cofactor II by porcine mucosal dermatan sulfateAnna Margrét Halldórsdóttir
Division of Laboratory Medicine, Department of Pathology and Immunology, Campus Box 8118, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
Glycobiology 16:693-701. 2006..These data support the hypothesis that modification of IdoA-->GalNAc4SO3 subunits in the DS polymer by either 2-O-sulfation of IdoA or 6-O-sulfation of GalNAc can generate molecules with HCII-binding sites and anticoagulant activity... - Inhibition of antithrombin by Plasmodium falciparum histidine-rich protein IIMatthew Ndonwi
Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
Blood 117:6347-54. 2011.... - Placental dermatan sulfate: isolation, anticoagulant activity, and association with heparin cofactor IITusar K Giri
Hematology Division, Campus Box 8125, Washington University Medical School, 660 South Euclid Ave, St Louis, MO 63110, USA
Blood 107:2753-8. 2006..Our data suggest that DS is in a position to activate HCII in the fetal blood vessels or in the stroma of placental villi after injury to the syncytiotrophoblast layer and thereby inhibit fibrin generation in the placenta... - The collection of NFATc1-dependent transcripts in the osteoclast includes numerous genes non-essential to physiologic bone resorptionJulia F Charles
Department of Medicine, Division of Rheumatology, Allergy and Immunology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Bone 51:902-12. 2012..These data highlight the need for rigorous validation studies to complement expression profiling results before functional importance can be assigned to highly regulated genes in any biologic process... - A self-inactivating gamma-retroviral vector reduces manifestations of mucopolysaccharidosis I in miceJason A Metcalf
Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
Mol Ther 18:334-42. 2010..A SIN gamma-RV vector ameliorates clinical manifestations of MPS I in mice and should be safer than an LTR-intact gamma-RV... - Heparin cofactor II inhibits arterial thrombosis after endothelial injuryLi He
Division of Hematology, Department of Internal Medicine, Washington University, St Louis, Missouri 63110, USA
J Clin Invest 109:213-9. 2002..This abnormality was corrected by infusion of purified HCII but not ovalbumin. These observations suggest that HCII might inhibit thrombosis in the arterial circulation... - Accelerated atherogenesis and neointima formation in heparin cofactor II deficient miceCristina P Vicente
Department of Cellular Biology, Institute of Biology, State University of Campinas UNICAMP, Campinas Sao Paulo, Brazil
Blood 110:4261-7. 2007..Heparin did not inhibit neointima formation. We conclude that HCII deficiency promotes atherogenesis and neointima formation and that treatment with dermatan sulfate reduces neointima formation in an HCII-dependent manner... - Heparin cofactor II levels do not predict the development of coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) studyTusar K Giri
Arterioscler Thromb Vasc Biol 25:2689-90. 2005 - Mice lacking the extracellular matrix protein MAGP1 display delayed thrombotic occlusion following vessel injuryClaudio C Werneck
Department of Biochemistry, Institute of Biology, State University of Campinas UNICAMP, Campinas, Brazil
Blood 111:4137-44. 2008..These findings show that MAGP1, a component of microfibrils and vascular elastic fibers, plays a role in hemostasis and thrombosis... - Selective cleavage and anticoagulant activity of a sulfated fucan: stereospecific removal of a 2-sulfate ester from the polysaccharide by mild acid hydrolysis, preparation of oligosaccharides, and heparin cofactor II-dependent anticoagulant activityVitor H Pomin
, , Universidade Federal do Rio de Janeiro, Caixa Postal 68041, Rio de Janeiro, RJ, 21941-590, Brazil
Glycobiology 15:369-81. 2005..We speculate that the template mechanism may predominate over the allosteric effect in the case of the linear sulfated fucan inactivation of thrombin in the presence of heparin cofactor II... - The contributions of the alpha 2 beta 1 integrin to vascular thrombosis in vivoLi He
Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Blood 102:3652-7. 2003..Our results are the first to document a critical in vivo role for the alpha 2 beta 1 integrin in thrombus formation at the vessel wall under conditions of shear following vascular injury... - Binding of exosite ligands to human thrombin. Re-evaluation of allosteric linkage between thrombin exosites I and IIIngrid M Verhamme
Department of Pathology, Vanderbilt University School of Medicine, Medical Center North, Nashville, TN 37232, USA
J Biol Chem 277:6788-98. 2002..The results indicate significant, ligand-specific allosteric coupling between thrombin exosites I and II and catalytic site perturbations but insignificant inter-exosite thermodynamic linkage...