Jay W Tichelaar
Affiliation: Washington University School of Medicine
- A dominant-negative c-jun mutant inhibits lung carcinogenesis in miceJay W Tichelaar
Department of Surgery, The Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
Cancer Prev Res (Phila) 3:1148-56. 2010..Our results support the concept that AP-1 is a key regulator of mouse lung tumorigenesis, and identify AP-1-dependent transcription as a potential target to prevent lung tumor progression...
- Transcriptomic analysis by RNA-seq reveals AP-1 pathway as key regulator that green tea may rely on to inhibit lung tumorigenesisJing Pan
Department of Surgery, The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri Medical College of Wisconsin Cancer Center, Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin
Mol Carcinog 53:19-29. 2014..Polyphenon E lost its chempreventive function both in vitro and in vivo when AP-1 was inhibited, indicating that AP-1 inhibition is a major pathway through which green tea exhibits chemopreventive effects...
- Neutrophils are required for 3-methylcholanthrene-initiated, butylated hydroxytoluene-promoted lung carcinogenesisHaris G Vikis
Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
Mol Carcinog 51:993-1002. 2012..These data demonstrate that neutrophils are essential to promote tumor growth in the MCA/BHT two-step lung carcinogenesis model...