R W Thompson

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Monocyte chemotactic activity in human abdominal aortic aneurysms: role of elastin degradation peptides and the 67-kD cell surface elastin receptor
    Kirk A Hance
    Department of Surgery Section of Vascular Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Vasc Surg 35:254-61. 2002
  2. ncbi request reprint Doxycycline in patients with abdominal aortic aneurysms and in mice: comparison of serum levels and effect on aneurysm growth in mice
    Amy K Prall
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68114, USA
    J Vasc Surg 35:923-9. 2002
  3. ncbi request reprint Prolonged administration of doxycycline in patients with small asymptomatic abdominal aortic aneurysms: report of a prospective (Phase II) multicenter study
    B Timothy Baxter
    Department of Surgery, University of Nebraska Medical Center, Omaha, USA
    J Vasc Surg 36:1-12. 2002
  4. ncbi request reprint Retrograde visceral vessel revascularization followed by endovascular aneurysm exclusion as an alternative to open surgical repair of thoracoabdominal aortic aneurysm
    M Wayne Flye
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110 1003, USA
    J Vasc Surg 39:454-8. 2004
  5. ncbi request reprint Suppression of experimental abdominal aortic aneurysms in mice by treatment with pyrrolidine dithiocarbamate, an antioxidant inhibitor of nuclear factor-kappaB
    Federico E Parodi
    Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, One Barnes Jewish Hospital Plaza, St Louis, MO 63110, USA
    J Vasc Surg 41:479-89. 2005
  6. ncbi request reprint MMP inhibition in abdominal aortic aneurysms. Rationale for a prospective randomized clinical trial
    R W Thompson
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Ann N Y Acad Sci 878:159-78. 1999
  7. ncbi request reprint Reflections on the pathogenesis of abdominal aortic aneurysms
    Robert W Thompson
    Department of Surgery Section of Vascular Surgery, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Cardiovasc Surg 10:389-94. 2002
  8. ncbi request reprint Prospects for the medical management of abdominal aortic aneurysms
    Eric F Steinmetz
    Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Vasc Endovascular Surg 37:151-63. 2003
  9. ncbi request reprint Gene expression profiling of abdominal aortic aneurysms
    Robert W Thompson
    Department of Surgery Section of Vascular Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Vasc Surg 35:403-4. 2002
  10. ncbi request reprint "Grape cluster" aneurysm of the right subclavian artery: an unusual manifestation of fibromuscular dysplasia
    Eric F Steinmetz
    Department of Surgery Section of Vascular Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Vasc Surg 17:296-301. 2003

Collaborators

Detail Information

Publications59

  1. ncbi request reprint Monocyte chemotactic activity in human abdominal aortic aneurysms: role of elastin degradation peptides and the 67-kD cell surface elastin receptor
    Kirk A Hance
    Department of Surgery Section of Vascular Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Vasc Surg 35:254-61. 2002
    ....
  2. ncbi request reprint Doxycycline in patients with abdominal aortic aneurysms and in mice: comparison of serum levels and effect on aneurysm growth in mice
    Amy K Prall
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68114, USA
    J Vasc Surg 35:923-9. 2002
    ....
  3. ncbi request reprint Prolonged administration of doxycycline in patients with small asymptomatic abdominal aortic aneurysms: report of a prospective (Phase II) multicenter study
    B Timothy Baxter
    Department of Surgery, University of Nebraska Medical Center, Omaha, USA
    J Vasc Surg 36:1-12. 2002
    ..A secondary goal was to determine how treatment with doxycycline influences circulating levels of matrix metalloproteinase-9 (MMP-9) in this patient population...
  4. ncbi request reprint Retrograde visceral vessel revascularization followed by endovascular aneurysm exclusion as an alternative to open surgical repair of thoracoabdominal aortic aneurysm
    M Wayne Flye
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110 1003, USA
    J Vasc Surg 39:454-8. 2004
    ..This technique has been successfully used in three patients at high risk for conventional repair...
  5. ncbi request reprint Suppression of experimental abdominal aortic aneurysms in mice by treatment with pyrrolidine dithiocarbamate, an antioxidant inhibitor of nuclear factor-kappaB
    Federico E Parodi
    Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, One Barnes Jewish Hospital Plaza, St Louis, MO 63110, USA
    J Vasc Surg 41:479-89. 2005
    ..The purpose of this study was to determine whether aneurysmal degeneration is influenced by pyrrolidine dithiocarbamate (PDTC), a pharmacologic inhibitor of NF-kappaB...
  6. ncbi request reprint MMP inhibition in abdominal aortic aneurysms. Rationale for a prospective randomized clinical trial
    R W Thompson
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Ann N Y Acad Sci 878:159-78. 1999
    ..While it remains to be determined whether MMP inhibition will have a clinically significant impact on aneurysm expansion, it is expected that this question can be resolved by a properly designed prospective randomized clinical trial...
  7. ncbi request reprint Reflections on the pathogenesis of abdominal aortic aneurysms
    Robert W Thompson
    Department of Surgery Section of Vascular Surgery, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Cardiovasc Surg 10:389-94. 2002
  8. ncbi request reprint Prospects for the medical management of abdominal aortic aneurysms
    Eric F Steinmetz
    Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Vasc Endovascular Surg 37:151-63. 2003
    ..As outlined in this review, better understanding of the biological mechanisms underlying these changes will allow design of novel therapeutic strategies to suppress the process of aneurysmal degeneration...
  9. ncbi request reprint Gene expression profiling of abdominal aortic aneurysms
    Robert W Thompson
    Department of Surgery Section of Vascular Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Vasc Surg 35:403-4. 2002
  10. ncbi request reprint "Grape cluster" aneurysm of the right subclavian artery: an unusual manifestation of fibromuscular dysplasia
    Eric F Steinmetz
    Department of Surgery Section of Vascular Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Vasc Surg 17:296-301. 2003
    ..Successful surgical repair of this lesion is described along with pathological studies demonstrating fibromuscular dysplasia. The occurrence of such lesions and their management is reviewed...
  11. pmc Endoluminal graft repair for abdominal aortic aneurysms in high-risk patients and octogenarians: is it better than open repair?
    G A Sicard
    Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110 1093, USA
    Ann Surg 234:427-35; discussion 435-7. 2001
    ..To analyze the short-term and midterm results of open and endoluminal repair of abdominal aortic aneurysms (AAA) in a large single-center series and specifically in octogenarians...
  12. ncbi request reprint Suppression of experimental abdominal aortic aneurysms in the rat by treatment with angiotensin-converting enzyme inhibitors
    S Liao
    Department of Surgery (Section of Vascular Surgery, Washington University School of Medicine, St Louis, MO, USA
    J Vasc Surg 33:1057-64. 2001
    ..Further studies are needed to elucidate how ACE inhibitors influence aortic wall matrix remodeling during aneurysmal degeneration...
  13. ncbi request reprint Simultaneous analysis of 1176 gene products in normal human aorta and abdominal aortic aneurysms using a membrane-based complementary DNA expression array
    W S Tung
    Department of Surgery, Washington University School of Medicine, MO 63110, USA
    J Vasc Surg 34:143-50. 2001
    ..Further studies will be needed to elucidate the functional and pathophysiologic significance of the individual genes that exhibit altered levels of expression in AAA tissue...
  14. ncbi request reprint Elevated plasma levels of matrix metalloproteinase-9 in patients with abdominal aortic aneurysms: a circulating marker of degenerative aneurysm disease
    D M Hovsepian
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Vasc Interv Radiol 11:1345-52. 2000
    ..The purpose of this study was to further define the utility of elevated MMP-9PL levels in the diagnosis and evaluation of AAAs, and to examine if changes in MMP-9PL can be used as a functional biomarker of degenerative aneurysm disease...
  15. ncbi request reprint Functional importance of connective tissue repair during the development of experimental abdominal aortic aneurysms
    M D Huffman
    Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Surgery 128:429-38. 2000
    ..The purpose of this study was to assess the functional importance of connective tissue repair during experimental aneurysmal degeneration...
  16. ncbi request reprint Experimental abdominal aortic aneurysms in mice lacking expression of inducible nitric oxide synthase
    J K Lee
    Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, Saint Louis, MO, USA
    Arterioscler Thromb Vasc Biol 21:1393-401. 2001
    ..Although extensive protein nitration and increased expression of iNOS accompany the development of elastase-induced experimental AAAs, iNOS is not required in this process and its absence may be deleterious...
  17. ncbi request reprint Nitric oxide inhibition increases matrix metalloproteinase-9 expression by rat aortic smooth muscle cells in vitro
    G R Upchurch
    Jobst Vascular Research Laboratories, Section of Vascular Surgery, Department of Surgery, University of Michigan Medical School, USA
    J Vasc Surg 34:76-83. 2001
    ..The hypothesis to be tested was that diminished bioavailable nitric oxide (NO) affects matrix metalloproteinase (MMP) expression and activation in vascular smooth muscle cells (SMCs)...
  18. ncbi request reprint Evolution of vascular fellowship training in the new era of endovascular techniques
    E T Choi
    Section of Vascular Surgery, Barnes-Jewish Hospital, St Louis, MO 63110, USA
    J Vasc Surg 33:S106-10. 2001
    ..We have to critically reevaluate and redefine what constitutes adequate vascular fellow experience in the surgical treatment of abdominal aortic aneurysms...
  19. ncbi request reprint Increased expression of HDJ-2 (hsp40) in carotid artery atherosclerosis: a novel heat shock protein associated with luminal stenosis and plaque ulceration
    T Q Nguyen
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    J Vasc Surg 33:1065-71. 2001
    ....
  20. pmc Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms
    R Pyo
    Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, Wohl Hospital, St Louis, Missouri 63110, USA
    J Clin Invest 105:1641-9. 2000
    ....
  21. ncbi request reprint Oral administration of diferuloylmethane (curcumin) suppresses proinflammatory cytokines and destructive connective tissue remodeling in experimental abdominal aortic aneurysms
    Federico E Parodi
    Section of Vascular Surgery, Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Vasc Surg 20:360-8. 2006
    ..The possibility that dietary ingestion of curcumin may have a beneficial effect in degenerative aortic aneurysms warrants further consideration...
  22. ncbi request reprint Temporal changes in mouse aortic wall gene expression during the development of elastase-induced abdominal aortic aneurysms
    Sarah J Van Vickle-Chavez
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Vasc Surg 43:1010-20. 2006
    ..To characterize temporal changes in mouse aortic wall gene expression associated with the development of experimental abdominal aortic aneurysms...
  23. ncbi request reprint Localized administration of doxycycline suppresses aortic dilatation in an experimental mouse model of abdominal aortic aneurysm
    Michel A Bartoli
    Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, St Louis, MO, USA
    Ann Vasc Surg 20:228-36. 2006
    ..Localized delivery of doxycycline holds promise as a novel strategy to inhibit the progressive expansion of aortic aneurysms, perhaps as a pharmacological adjunct to endovascular (stent graft) treatment...
  24. ncbi request reprint Accelerated enlargement of experimental abdominal aortic aneurysms in a mouse model of chronic cigarette smoke exposure
    Celine Buckley
    Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Am Coll Surg 199:896-903. 2004
    ..Cigarette smoking and pulmonary emphysema are strongly associated with abdominal aortic aneurysms (AAAs), but the biologic mechanisms linking these conditions are undefined...
  25. ncbi request reprint Gender differences in experimental aortic aneurysm formation
    Gorav Ailawadi
    Jobst Vascular Research Laboratories, University of Michigan Medical School, Ann Arbor, USA
    Arterioscler Thromb Vasc Biol 24:2116-22. 2004
    ..It is hypothesized that a male predominance, similar to that in humans, persists in a rodent model of experimental abdominal aortic aneurysm (AAA) via alterations in matrix metalloproteinases (MMPs)...
  26. ncbi request reprint Overt ischemic colitis after endovascular repair of aortoiliac aneurysms
    Patrick J Geraghty
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110 1094, USA
    J Vasc Surg 40:413-8. 2004
    ..To analyze the relationship between perioperative HA occlusion and postoperative ischemic colitis, we reviewed our experience over 2 years with Food and Drug Administration-approved endovascular graft devices for treatment of AIAs...
  27. ncbi request reprint Pathophysiology of abdominal aortic aneurysms: insights from the elastase-induced model in mice with different genetic backgrounds
    Robert W Thompson
    Department of Surgery Section of Vascular Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Ann N Y Acad Sci 1085:59-73. 2006
    ..Investigations on mice from different genetic backgrounds are also beginning to offer a novel approach to evaluate the genetic basis for susceptibility to aneurysm development...
  28. ncbi request reprint Challenges and opportunities in abdominal aortic aneurysm research
    Momtaz Wassef
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    J Vasc Surg 45:192-8. 2007
    ....
  29. pmc Critical role of dipeptidyl peptidase I in neutrophil recruitment during the development of experimental abdominal aortic aneurysms
    Monica B Pagano
    Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63124, USA
    Proc Natl Acad Sci U S A 104:2855-60. 2007
    ..These findings suggest that DPPI and/or granule-associated serine proteases are necessary for neutrophil recruitment into the diseased aorta and that these proteases act to amplify vascular wall inflammation that leads to AAAs...
  30. ncbi request reprint Cigarette smoking increases aortic dilatation without affecting matrix metalloproteinase-9 and -12 expression in a modified mouse model of aneurysm formation
    Michel P Bergoeing
    Department of Surgery Section of Vascular Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Vasc Surg 45:1217-1227. 2007
    ..We have attempted to adapt the elastase-perfused animal model to determine whether tobacco exposure can lower the threshold of aortic injury necessary for AAA development...
  31. ncbi request reprint Reviving the vascular surgeon-scientist: an interim assessment of the jointly sponsored Lifeline Foundation/National Heart, Lung, and Blood Institute William J. von Liebig Mentored Clinical Scientist Development (K08) Program
    Robert W Thompson
    Department of Surgery Section of Vascular Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Vasc Surg 45:A2-7. 2007
    ..The von Liebig K08 program has therefore been an effective vehicle to stimulate research career development in the field of vascular surgery...
  32. pmc Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice
    Jiusong Sun
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 117:3359-68. 2007
    ....
  33. pmc A randomized, placebo-controlled trial of doxycycline after endoluminal aneurysm repair
    Amy E Hackmann
    Department of Surgery Section of Vascular Surgery, Washington University School of Medicine, St Louis, MO
    J Vasc Surg 48:519-26; discussion 526. 2008
    ..The goal of this study was to evaluate the effect of a MMP inhibitor, doxycycline, on EVAR...
  34. ncbi request reprint Atherosclerotic Vascular Disease Conference: Writing Group III: pathophysiology
    David P Faxon
    Circulation 109:2617-25. 2004
  35. ncbi request reprint Type II endoleak after endovascular abdominal aortic aneurysm repair: a conservative approach with selective intervention is safe and cost-effective
    Eric Steinmetz
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Vasc Surg 39:306-13. 2004
    ..The purpose of this study was to evaluate the safety and cost-effectiveness of the conservative approach of embolizing type II endoleak only when persistent for more than 6 months and associated with aneurysm sac growth of 5 mm or more...
  36. ncbi request reprint Delayed complications after endovascular AAA repair in women
    Murray L Shames
    Division of Vascular and Endovascular Surgery, University of South Florida, Tampa 33606, USA
    J Endovasc Ther 10:10-5. 2003
    ..To assess whether women suffer more delayed complications or require more interventions after endovascular abdominal aortic aneurysm (AAA) repair...
  37. ncbi request reprint Altered patterns of gene expression distinguishing ascending aortic aneurysms from abdominal aortic aneurysms: complementary DNA expression profiling in the molecular characterization of aortic disease
    Tarek S Absi
    Departments of Surgery, Sections of Cardiac and Vascular Surgery, Washington University School of Medicine, 9901 Wohl Hospital, 4960 Children s Place, St Louis, MO 63110, USA
    J Thorac Cardiovasc Surg 126:344-57; discission 357. 2003
    ..The purpose of this study was to profile altered patterns of gene expression that characterize degenerative ascending thoracic aortic aneurysms and to compare these patterns with those observed for infrarenal abdominal aortic aneurysms...
  38. ncbi request reprint Abdominal aortic aneurysms: basic mechanisms and clinical implications
    Robert W Thompson
    Department of Surgery Section of Vascular Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Curr Probl Surg 39:110-230. 2002
  39. ncbi request reprint Treatment of embolizing arterial lesions with endoluminally placed stent grafts
    Murray L Shames
    Division of Vascular Surgery, Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Ann Vasc Surg 16:608-12. 2002
    ..Long-term follow-up will be necessary to assess the durability of this approach to embolizing arterial lesions...
  40. ncbi request reprint Pharmacological targets in the treatment of abdominal aortic aneurysms
    Michel P Bergoeing
    Washington University in Saint Louis, Department of Surgery, Section of Vascular Surgery, 660 S Euclid Avenue, Campus Box 8109, St Louis, MO 63110, USA
    Expert Opin Ther Targets 10:547-59. 2006
    ..The future of AAA therapy, however, may belong to agents which can induce aneurysm regression and to delivery methods which specifically target affected arterial tissue...
  41. ncbi request reprint Abdominal aortic aneurysms. Surgical treatment
    Murray L Shames
    Section of Vascular Surgery, Washington University School of Medicine, 9901 Wohl Hospital, 4960 Children s Place, St Louis, MO 63110, USA
    Cardiol Clin 20:563-78, vi. 2002
    ....
  42. ncbi request reprint Matrix metalloproteinases in peripheral vascular disease
    Mark J Hobeika
    Department of Surgery, New York University School of Medicine, New York, NY, USA
    J Vasc Surg 45:849-57. 2007
    ..In addition, the importance of MMPs in the future diagnosis and treatment of peripheral vascular disease is discussed...
  43. ncbi request reprint Detection and management of small aortic aneurysms
    Robert W Thompson
    N Engl J Med 346:1484-6. 2002
  44. doi request reprint Comprehensive surgical management of the competitive athlete with effort thrombosis of the subclavian vein (Paget-Schroetter syndrome)
    Spencer J Melby
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Vasc Surg 47:809-820; discussion 821. 2008
    ..The results of treatment for subclavian vein effort thrombosis were assessed in a series of competitive athletes...
  45. pmc Cationic amino acid transporter-2 regulates immunity by modulating arginase activity
    Robert W Thompson
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Pathog 4:e1000023. 2008
    ..Thus, by controlling NOS2 and arginase activity, CAT2 functions as a potent regulator of immunity...
  46. pmc The IL-21 receptor augments Th2 effector function and alternative macrophage activation
    John Pesce
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Invest 116:2044-55. 2006
    ..Collectively, these results illustrate an essential function for the IL-21R in the development of pathogen-induced Th2 responses, which may have relevance in therapies for both inflammatory and chronic fibrotic diseases...
  47. ncbi request reprint Transient exposure to elastase induces mouse aortic wall smooth muscle cell production of MCP-1 and RANTES during development of experimental aortic aneurysm
    Jamie S Colonnello
    Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Vasc Surg 38:138-46. 2003
    ....
  48. pmc Adaptive cellular immunity in aortic aneurysms: cause, consequence, or context?
    John A Curci
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 114:168-71. 2004
    ..It is expected that these surprising findings will stimulate further efforts to clarify whether adaptive cellular immunity in aneurysm disease is detrimental or potentially beneficial...
  49. ncbi request reprint Increased MMP-9 expression and activity by aortic smooth muscle cells after nitric oxide synthase inhibition is associated with increased nuclear factor-kappaB and activator protein-1 activity
    Brian S Knipp
    Jobst Vascular Research Laboratories, Section of Vascular Surgery, Ann Arbor, Michigan 48109 0329, USA
    J Surg Res 116:70-80. 2004
    ..To determine the mechanism underlying increased expression and activity of matrix metalloproteinase 9 (MMP-9) by rat aortic smooth muscle cells (RA-SMC) after inhibition of inducible nitric oxide synthase (iNOS)...
  50. ncbi request reprint Screening for abdominal aortic aneurysm: a consensus statement
    K Craig Kent
    Division of Vascular Surgery, New York Presbyterian Hospital, Weill Medical College of Cornell University, 525 E 68th Street, Room P 707, New York, NY 10021, USA
    J Vasc Surg 39:267-9. 2004
  51. ncbi request reprint Immunopathogenesis of schistosomiasis
    Thomas A Wynn
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Immunol Rev 201:156-67. 2004
    ..mansoni infection, and succumb to the disease at an accelerated rate; thus, identifying the 'decoy' IL-13 receptor as a critical life sustaining 'off' switch for tissue damaging egg-induced inflammation...
  52. pmc IL-13 receptor alpha 2 down-modulates granulomatous inflammation and prolongs host survival in schistosomiasis
    Margaret M Mentink-Kane
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:586-90. 2004
    ..Here, we show that the IL-13 receptor alpha 2 (IL-13R alpha 2) is a critical mediator of immune down-modulation, identifying the receptor as a life-sustaining off signal for chronic and pernicious inflammation in schistosomiasis...
  53. pmc Treatment with simvastatin suppresses the development of experimental abdominal aortic aneurysms in normal and hypercholesterolemic mice
    Eric F Steinmetz
    Department of Surgery Section of Vascular Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Ann Surg 241:92-101. 2005
    ..To determine if treatment with hydroxymethylglutaryl-coenzyme A reductase inhibitors (statins) can influence the development of experimental abdominal aortic aneurysms (AAAs)...
  54. ncbi request reprint Matrix metalloproteinases in ascending aortic aneurysms: bicuspid versus trileaflet aortic valves
    Scott A LeMaire
    Division of Cardiothoracic Surgery, Michael E DeBakey Department of Surgery, Baylor College of Medicine and The Methodist DeBakey Heart Center, Houston, Texas, USA
    J Surg Res 123:40-8. 2005
    ....
  55. ncbi request reprint Neutrophil depletion inhibits experimental abdominal aortic aneurysm formation
    Jonathan L Eliason
    Jobst Vascular Research Laboratories, Department of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, USA
    Circulation 112:232-40. 2005
    ..The purpose of this investigation was to test the hypothesis that neutrophil depletion would limit experimental AAA formation by altering one or both of these enzymes...
  56. ncbi request reprint Decreased expression of fibulin-5 correlates with reduced elastin in thoracic aortic dissection
    Xinwen Wang
    Section of Adult Cardiac Surgery, the Texas Heart Institute at St Luke s Episcopal Hospital, The Division of Cardiothoracic Surgery, Baylor College of Medicine, Houston 77030, USA
    Surgery 138:352-9. 2005
    ..In this study, we examined whether thoracic aortic dissection (TAD) is associated with abnormal fibulin-5 expression...
  57. ncbi request reprint Aneurysm treatments expand
    Robert W Thompson
    Nat Med 11:1279-81. 2005
  58. pmc A single nucleotide polymorphism in the matrix metalloproteinase 9 gene (-8202A/G) is associated with thoracic aortic aneurysms and thoracic aortic dissection
    Li Chen
    Cardiovascular Surgery Service, the Texas Heart Institute at St Luke s Episcopal Hospital, and the Division of Cardiothoracic Surgery, Baylor College of Medicine, Houston, Tex, USA
    J Thorac Cardiovasc Surg 131:1045-52. 2006
    ..The purpose of this study was to determine whether 3 single nucleotide polymorphisms in the matrix metalloproteinase 9 gene are associated with thoracic aortic aneurysms and dissection...
  59. doi request reprint Elastic fiber depletion in the supporting ligaments of the gastroesophageal junction: a structural basis for the development of hiatal hernia
    John A Curci
    Washington University Institute for Minimally Invasive Surgery and the Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Am Coll Surg 207:191-6. 2008
    ..The purpose of this study was to characterize and compare the histology of these ligaments in patients with gastroesophageal reflux disease (GERD) and hiatal hernia (HH) versus GERD alone, with emphasis on the elastin morphology...