Bradley Thach

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Deaths and injuries attributed to infant crib bumper pads
    Bradley T Thach
    Washington University Department of Pediatrics, St Louis, Missouri 63110, USA
    J Pediatr 151:271-4, 274.e1-3. 2007
  2. pmc Sex-specific quantitative trait loci linked to autoresuscitation failure in SWR/J mice
    B T Thach
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Heredity (Edinb) 103:469-75. 2009
  3. doi request reprint Some aspects of clinical relevance in the maturation of respiratory control in infants
    Bradley T Thach
    Edward Mallinckrodt Department of Pediatrics, Washington Univ School of Medicine, St Louis, MO 63110, USA
    J Appl Physiol 104:1828-34. 2008
  4. pmc Tragic and sudden death. Potential and proven mechanisms causing sudden infant death syndrome
    Bradley Thach
    Department of Pediatrics, Washington University in St Louis, MO, USA
    EMBO Rep 9:114-8. 2008
  5. ncbi request reprint The role of respiratory control disorders in SIDS
    Bradley T Thach
    Department of Pediatrics, Washington University School of Medicine, 660 S Euclid, Campus Box 8208, St Louis, MO 63110, USA
    Respir Physiol Neurobiol 149:343-53. 2005
  6. pmc Maturation of cough and other reflexes that protect the fetal and neonatal airway
    Bradley T Thach
    Edward Mallinckrodt Department of Pediatrics, School of Medicine, Washington University, 660 S Euclid Ave, Campus Box 8208, St Louis, MO 63110, USA
    Pulm Pharmacol Ther 20:365-70. 2007
  7. ncbi request reprint Inhibitory effects of hyperthermia on mechanisms involved in autoresuscitation from hypoxic apnea in mice: a model for thermal stress causing SIDS
    Levent Kahraman
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, 660 S Euclid, Campus Box 8208, St Louis, MO 63110, USA
    J Appl Physiol 97:669-74. 2004
  8. ncbi request reprint Characterization of successful and failed autoresuscitation in human infants, including those dying of SIDS
    Raghunathan Sridhar
    Division of Newborn Medicine, Department of Pediatrics, Washington University, St Louis, Missouri 63110, USA
    Pediatr Pulmonol 36:113-22. 2003
  9. ncbi request reprint Influence of sleep position experience on ability of prone-sleeping infants to escape from asphyxiating microenvironments by changing head position
    Dorota A Paluszynska
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63010, USA
    Pediatrics 114:1634-9. 2004
  10. pmc The role of arousal related brainstem reflexes in causing recovery from upper airway occlusion in infants
    Henning Wulbrand
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Sleep 31:833-40. 2008

Research Grants

  1. CONTROL OF BREATHING IN RECOVERY FROM APNEA
    Bradley Thach; Fiscal Year: 2003
  2. CONTROL OF BREATHING IN RECOVERY FROM APNEA
    Bradley Thach; Fiscal Year: 2007
  3. CONTROL OF BREATHING IN RECOVERY FROM APNEA
    Bradley Thach; Fiscal Year: 1980

Collaborators

  • J M Cheverud
  • M Schootman
  • Edwin A Mitchell
  • H F Krous
  • Kathleen A Harris
  • Claudia M Gerard
  • Frances McNamara
  • Henning Wulbrand
  • John M D Thompson
  • Levent Kahraman
  • Joshua R Scheers-Masters
  • Dorota A Paluszynska
  • Benjamin Unger
  • Raghunathan Sridhar
  • Aloka L Patel
  • David M O Becroft
  • Davida Wilkins
  • Terrance Ledbetter
  • Rose Psara
  • Dorota Paluszynska
  • Michael Graham
  • Judith A Henslee
  • Mary Case
  • Dorothy H Kelly
  • James S Kemp
  • Anna S Lijowska

Detail Information

Publications21

  1. ncbi request reprint Deaths and injuries attributed to infant crib bumper pads
    Bradley T Thach
    Washington University Department of Pediatrics, St Louis, Missouri 63110, USA
    J Pediatr 151:271-4, 274.e1-3. 2007
    ..To document deaths attributed to bumper pads and injuries from their use that are potentially preventable...
  2. pmc Sex-specific quantitative trait loci linked to autoresuscitation failure in SWR/J mice
    B T Thach
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Heredity (Edinb) 103:469-75. 2009
    ..These results establish a genetic basis for AR failure phenotype in mice, with relevance to Sudden Infant Death Syndrome...
  3. doi request reprint Some aspects of clinical relevance in the maturation of respiratory control in infants
    Bradley T Thach
    Edward Mallinckrodt Department of Pediatrics, Washington Univ School of Medicine, St Louis, MO 63110, USA
    J Appl Physiol 104:1828-34. 2008
    ..Consequently, it also may have a role in causing SIDS. Maturational changes and/or inadequacy of this reflex may be responsible for pulmonary aspiration and infectious pneumonia in both children and adults...
  4. pmc Tragic and sudden death. Potential and proven mechanisms causing sudden infant death syndrome
    Bradley Thach
    Department of Pediatrics, Washington University in St Louis, MO, USA
    EMBO Rep 9:114-8. 2008
  5. ncbi request reprint The role of respiratory control disorders in SIDS
    Bradley T Thach
    Department of Pediatrics, Washington University School of Medicine, 660 S Euclid, Campus Box 8208, St Louis, MO 63110, USA
    Respir Physiol Neurobiol 149:343-53. 2005
    ..In drawing conclusions it is well to recognize that mechanisms leading to death in SIDS are heterogeneous and therefore there is room for several plausible theories for respiratory or circulatory abnormalities contributing to SIDS...
  6. pmc Maturation of cough and other reflexes that protect the fetal and neonatal airway
    Bradley T Thach
    Edward Mallinckrodt Department of Pediatrics, School of Medicine, Washington University, 660 S Euclid Ave, Campus Box 8208, St Louis, MO 63110, USA
    Pulm Pharmacol Ther 20:365-70. 2007
    ..Studies in animal models indicate that with maturation, apnea and swallowing components of the LCR decrease while cough becomes increasingly prominent...
  7. ncbi request reprint Inhibitory effects of hyperthermia on mechanisms involved in autoresuscitation from hypoxic apnea in mice: a model for thermal stress causing SIDS
    Levent Kahraman
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, 660 S Euclid, Campus Box 8208, St Louis, MO 63110, USA
    J Appl Physiol 97:669-74. 2004
    ..This may be due, at least in part, to decreased gasp number and duration as well as to hyperthermia-related asynchrony of reflexes regulating heart and gasping frequencies during attempted AR...
  8. ncbi request reprint Characterization of successful and failed autoresuscitation in human infants, including those dying of SIDS
    Raghunathan Sridhar
    Division of Newborn Medicine, Department of Pediatrics, Washington University, St Louis, Missouri 63110, USA
    Pediatr Pulmonol 36:113-22. 2003
    ..Some SIDS infants appear to be different from infants dying with other diagnoses with respect to efficacy and characteristics of hypoxic gasping...
  9. ncbi request reprint Influence of sleep position experience on ability of prone-sleeping infants to escape from asphyxiating microenvironments by changing head position
    Dorota A Paluszynska
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63010, USA
    Pediatrics 114:1634-9. 2004
    ..We hypothesized that lack of experience in prone sleeping is associated with increased difficulty in changing head position to avoid an asphyxiating sleep environment...
  10. pmc The role of arousal related brainstem reflexes in causing recovery from upper airway occlusion in infants
    Henning Wulbrand
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Sleep 31:833-40. 2008
    ..Lung inflation is not a prerequisite for the reflex to occur...
  11. pmc Spontaneous arousal activity in infants during NREM and REM sleep
    Frances McNamara
    Edward Mallinckrodt Department of Pediatrics Newborn Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Physiol 538:263-9. 2002
    ..The spontaneous arousal responses occur periodically but with a high level of irregularity and the level of activity is affected by sleep state...
  12. ncbi request reprint Occurrence and mechanisms of sudden oxygen desaturation in infants who sleep face down
    Aloka L Patel
    St Louis Children s Hospital and the Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Pediatrics 111:e328-32. 2003
    ....
  13. ncbi request reprint Physiologic studies on swaddling: an ancient child care practice, which may promote the supine position for infant sleep
    Claudia M Gerard
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA
    J Pediatr 141:398-403. 2002
    ..Swaddle tightness was increased in 13 infants, simulating traditional swaddles. Respiratory variables-respiratory rate, tidal volume, oxygen saturation, heart rate, sigh rate, and "grunting"-were measured...
  14. ncbi request reprint Spontaneous arousals in supine infants while swaddled and unswaddled during rapid eye movement and quiet sleep
    Claudia M Gerard
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA
    Pediatrics 110:e70. 2002
    ..Arousal is initiated in brainstem centers and manifests as a sequence of reflexes: from sighs to startles and then to thrashing movements. Such "brainstem arousals" may progress to full arousal, but most do not...
  15. ncbi request reprint Racial disparity and modifiable risk factors among infants dying suddenly and unexpectedly
    Benjamin Unger
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Pediatrics 111:E127-31. 2003
    ..Death rates attributable to AS and UD are also higher in African Americans (AAs) than in other races (non-AA). The potential contribution of unsafe sleep practices to this overall disparity in death rates is uncertain...
  16. ncbi request reprint Heat stress and sudden infant death syndrome incidence: a United States population epidemiologic study
    Joshua R Scheers-Masters
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Pediatrics 113:e586-92. 2004
    ..To determine the role of heat stress in sudden infant death syndrome (SIDS) by examining the SIDS rates during periods of extreme environmental temperatures in a period when most infants were placed prone for sleep...
  17. ncbi request reprint The brainstem and vulnerability to sudden infant death syndrome
    Bradley T Thach
    Neurology 61:1170-1. 2003
  18. ncbi request reprint Aspiration of gastric contents in sudden infant death syndrome without cardiopulmonary resuscitation
    Henry F Krous
    Department of Pathology, Rady Children s Hospital, San Diego, California 92123, USA
    J Pediatr 150:241-6. 2007
    ....
  19. ncbi request reprint Sudden infant death syndrome: risk factors for infants found face down differ from other SIDS cases
    John M D Thompson
    Department of Pediatrics, University of Auckland, New Zealand
    J Pediatr 149:630-633. 2006
    ..To test the hypothesis that infants with sudden infant death syndrome (SIDS) found face down (FD) would have SIDS risk factors different from those found in other positions (non-face-down position, NFD)...
  20. ncbi request reprint Can we breathe and swallow at the same time?
    Bradley T Thach
    J Appl Physiol 99:1633. 2005
  21. ncbi request reprint Where should baby be put back to sleep?
    Bradley T Thach
    J Pediatr 147:6-7. 2005

Research Grants21

  1. CONTROL OF BREATHING IN RECOVERY FROM APNEA
    Bradley Thach; Fiscal Year: 2003
    ..Finally, we will study development of the infant's ability to avoid potentially suffocating environments during sleep, and determine the potential role of the infant's past experience on this development. ..
  2. CONTROL OF BREATHING IN RECOVERY FROM APNEA
    Bradley Thach; Fiscal Year: 2007
    ..Finally, we will study Medical Examiner's records (St. Louis, MO.) of infants dying suddenly and unexpectedly to determine if post mortem body temperature indicates involvement of overheating or disorders of thermoregulation in SIDS. ..
  3. CONTROL OF BREATHING IN RECOVERY FROM APNEA
    Bradley Thach; Fiscal Year: 1980
    ..These studies are viewed as relevant to the maturation and development of respiratory control in man and to the clinical syndromes of apnea of prematurity, sleep obstructive apnea and Sudden Infant Death Syndrome (S.I.D.S.)...