Research Topics
Genomes and Genes | A R TempletonSummaryAffiliation: Washington University School of Medicine Country: USA Publications
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Detail Information
Publications
Phylogeography of the common vampire bat (Desmodus rotundus): marked population structure, Neotropical Pleistocene vicariance and incongruence between nuclear and mtDNA markersFelipe M Martins
Laboratório de Biologia Evolutiva e Conservação LABEC, Instituto de Biociências USP, Cidade Universitaria, Sao Paulo SP, CEP 05508 900, Brazil
BMC Evol Biol 9:294. 2009....- Tree scanning: a method for using haplotype trees in phenotype/genotype association studiesAlan R Templeton
Department of Biology, Washington University, St Louis, Missouri 63130 4899, USA
Genetics 169:441-53. 2005..Overall, tree scanning is a simple, powerful, and flexible method for using haplotype trees to detect phenotype/genotype associations at candidate loci... - Disrupting evolutionary processes: the effect of habitat fragmentation on collared lizards in the Missouri OzarksA R Templeton
Department of Biology, Washington University, St Louis, MO 63130 4899, USA
Proc Natl Acad Sci U S A 98:5426-32. 2001..The general impact of human activities on genetic diversity disrupts or diminishes the capacity for adaptation, speciation, and macroevolutionary change. This impact will ultimately diminish biodiversity at all levels... - Using phylogeographic analyses of gene trees to test species status and processesA R Templeton
Department of Biology, Campus Box 1137, Washington University, St Louis, Missouri 63130 4899, USA
Mol Ecol 10:779-91. 2001..When one or more of the null hypotheses cannot be rejected, this procedure also provides specific guidance for future work that will be needed to judge species status... - Cladistic structure within the human Lipoprotein lipase gene and its implications for phenotypic association studiesA R Templeton
Department of Biology, Washington University, St Louis, Missouri 63130 4899, USA
Genetics 156:1259-75. 2000..Choosing SNPs at random would generally not provide adequate disequilibrium coverage of the sequenced region... - Recombinational and mutational hotspots within the human lipoprotein lipase geneA R Templeton
Department of Biology, Washington University, St Louis, MO 63130 4899, USA
Am J Hum Genet 66:69-83. 2000..Overall, these results indicate that both recombinational and mutational hotspots have played significant roles in shaping the haplotype variation at the LPL locus... - Statistical phylogeography: methods of evaluating and minimizing inference errorsAlan R Templeton
Department of Biology, Campus Box 1137, Washington University, St Louis, Missouri 63130 4899, USA
Mol Ecol 13:789-809. 2004.... - Out of Africa again and againAlan Templeton
Department of Biology, Washington University, St Louis, Missouri 63130 4899, USA
Nature 416:45-51. 2002..Second is the ubiquity of genetic interchange between human populations, both in terms of recurrent gene flow constrained by geographical distance and of major population expansion events resulting in interbreeding, not replacement... - A cladistic analysis of phenotypic associations with haplotypes inferred from restriction endonuclease mapping. IV. Nested analyses with cladogram uncertainty and recombinationA R Templeton
Department of Biology, Washington University, St Louis, Missouri 63130
Genetics 134:659-69. 1993..In particular, recombination can be used to assign a physical localization to a given subregion for mutations responsible for significant phenotypic effects... - Empirical tests of some predictions from coalescent theory with applications to intraspecific phylogeny reconstructionK A Crandall
Department of Biology, Washington University, St Louis, Missouri 63130 4899
Genetics 134:959-69. 1993.... - A cladistic analysis of phenotypic associations with haplotypes inferred from restriction endonuclease mapping and DNA sequence data. III. Cladogram estimationA R Templeton
Department of Biology, Washington University, St Louis, Missouri 63130
Genetics 132:619-33. 1992..We apply this estimation procedure to three data sets to illustrate varying degrees of cladogram ambiguity and recombination... - Nested clade analyses of phylogeographic data: testing hypotheses about gene flow and population historyA R Templeton
Department of Biology, Washington University, St Louis, Missouri 63130 4899, USA
Mol Ecol 7:381-97. 1998..Examples are given that illustrate these properties, concentrating on the detection of range expansion events... - Out of Africa? What do genes tell us?A R Templeton
Department of Biology, Washington University, St Louis, Missouri 63130 4899, USA
Curr Opin Genet Dev 7:841-7. 1997..The gene tree analyses instead indicate that genetic interchanges have ensured that all of humanity has evolved as a single evolutionary lineage with no major splits... - Abdominal pigmentation variation in drosophila polymorpha: geographic variation in the trait, and underlying phylogeographyJennifer A Brisson
Campus Box 1137, Department of Biology, Washington University, St Louis, Missouri 63130, USA
Evolution 59:1046-59. 2005..These patterns combined lead us to hypothesize that abdominal pigmentation variation in D. polymorpha is important in mediating the organism's interactions with local ecological factors... - Combining phylogeography with distribution modeling: multiple Pleistocene range expansions in a parthenogenetic gecko from the Australian arid zoneJared L Strasburg
Department of Biology, Washington University, St Louis, Missouri, United States of America
PLoS ONE 2:e760. 2007.... - On transferability of genome-wide tagSNPsC Charles Gu
Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110, USA
Genet Epidemiol 32:89-97. 2008..We present a review of the literature about where and why tagSNP transferability may become a problem and suggest research directions that may help the resolution... - Nested clade analysis: an extensively validated method for strong phylogeographic inferenceAlan R Templeton
Department of Biology, Washington University, St Louis, Missouri 63130-4899, USA
Mol Ecol 17:1877-80. 2008 - Coherent and incoherent inference in phylogeography and human evolutionAlan R Templeton
Department of Biology, Washington University, St Louis, MO 63130, USA
Proc Natl Acad Sci U S A 107:6376-81. 2010.... - The reality and importance of founder speciation in evolutionAlan R Templeton
Department of Biology, Washington University, St Louis, Missouri 63130 4899, USA
Bioessays 30:470-9. 2008..Founder speciation also interacts with other speciation mechanisms such that a speciation event is not a one-dimensional process due to either selection alone or drift alone... - Statistical hypothesis testing in intraspecific phylogeography: nested clade phylogeographical analysis vs. approximate Bayesian computationAlan R Templeton
Department of Biology, Washington University, St Louis, MO 63130 4899, USA
Mol Ecol 18:319-31. 2009..Accordingly, ABC should not be used for hypothesis testing, but simulation approaches are valuable when used in conjunction with NCPA or other methods that do not rely on highly parameterized models... - Why does a method that fails continue to be used? The answerAlan R Templeton
Department of Biology, Campus Box 1137, Washington University, St Louis, Missouri 63130, USA
Evolution 63:807-12. 2009..Hence, researchers can choose to use NCPA based upon objective critical validation that shows that NCPA delivers what it promises... - Multiple-infection and recombination in HIV-1 within a longitudinal cohort of womenAlan R Templeton
Department of Biology, Washington University, St Louis, Missouri, USA
Retrovirology 6:54. 2009.... - The diverse applications of cladistic analysis of molecular evolution, with special reference to nested clade analysisAlan R Templeton
Department of Biology, Washington University, St Louis, MO 63130 4899, USA E Mail Tel 1 314 935 6868
Int J Mol Sci 11:124-39. 2010.... - Genetics and recent human evolutionAlan R Templeton
Department of Biology, Campus Box 1137, Washington University, St Louis, Missouri 63130, USA
Evolution 61:1507-19. 2007..As more and more loci became available, genetics will undoubtedly offer additional insights and resolutions of human evolution... - Haplotype trees and modern human originsAlan R Templeton
Department of Biology, Washington University, St Louis, Missouri 63130 4899, USA
Am J Phys Anthropol . 2005..Genetics provides many insights into human evolution, but those insights need to be integrated with fossil and archaeological data to yield a fuller picture of the origin of modern humans... - Beta-2 adrenergic receptor genotypes and haplotypes in different ethnic groupsTaylor J Maxwell
Department of Biology, Washington University in St Louis, St Louis, MO 63110 1093, USA
Int J Mol Med 16:573-80. 2005..Further studies are needed to see if functional relationships are the same across populations... - Population genetics of the developmental gene optomotor-blind (omb) in Drosophila polymorpha: evidence for a role in abdominal pigmentation variationJennifer A Brisson
Department of Biology, Washington University, Saint Louis, Missouri 63130, USA
Genetics 168:1999-2010. 2004..Selection at this locus is expected if omb contributes to variation in abdominal pigmentation, since this trait is likely of ecological importance... - Evolutionary implications of developmental instability in parthenogenetic drosophila mercatorum. I. Comparison of several strains with different genotypesMelissa G Kramer
Department of Biology, Washington University, St Louis, MO 63130, USA
Evol Dev 4:223-33. 2002.... - Evolutionary implications of developmental instability in parthenogenetic Drosophila mercatorum. II. Comparison of two strains with identical genotypes, but different modes of reproductionMelissa G Kramer
Department of Biology, Washington University, St Louis, MO 63130, USA
Evol Dev 4:234-41. 2002.... - Life-history changes that accompany the transition from sexual to parthenogenetic reproduction in Drosophila mercatorumM G Kramer
Department of Biology, Washington University, St Louis, Missouri 63130, USA
Evolution 55:748-61. 2001..These results support the theory of Stalker (1956) that parthenogenesis is favored in environments in which sexual reproduction is difficult or impossible... - Contingency tests of neutrality using intra/interspecific gene trees: the rejection of neutrality for the evolution of the mitochondrial cytochrome oxidase II gene in the hominoid primatesA R Templeton
Department of Biology, Washington University, St Louis, Missouri 63130 4899, USA
Genetics 144:1263-70. 1996..Finally, the detected deleterious selection causes lowered inbreeding effective sizes, so arguments for small effective sizes in recent human evolutionary history based upon mitochondrial DNA may be invalid... - Selection in context: patterns of natural selection in the glycoprotein 120 region of human immunodeficiency virus 1 within infected individualsAlan R Templeton
Department of Biology, Washington University, St Louis, Missouri 63130 4899, USA
Genetics 167:1547-61. 2004..Finally, the transition between NSI and SI forms is associated with a burst of evolutionary change due to strong positive selection at sites other than those that define the NSI/SI phenotypes... - How frugal is Mother Nature with haplotypes?Sharlee Climer
Department of Computer Science and Engineering, Washington University, St Louis, MO, USA
Bioinformatics 25:68-74. 2009..At a higher level, and with broad applicability, this article illustrates the power of combinatorial methods to tease out imperfections in a given biological model... - The role of nuclear genes in intraspecific evolutionary inference: genealogy of the transferrin gene in the brown troutAgostinho Antunes
Centre de Investigação em Biodiversidade e Recursos Genéticos CIBIO UP, Campus Agrário de Vairão, Vairao, Portugal
Mol Biol Evol 19:1272-87. 2002.... - Race and genomicsScott M Williams
N Engl J Med 348:2581-2; author reply 2581-2. 2003 - TreeScan: a bioinformatic application to search for genotype/phenotype associations using haplotype treesDavid Posada
Variagenics, Inc, Cambridge, MA 02139, USA
Bioinformatics 21:2130-2. 2005..AVAILABILITY: The program is available free of charge, under the GNU General Public License. A package including C source code, a Makefile, and Windows (DOS) and Macintosh binaries, can be downloaded from http://darwin.uvigo.es.. - Postglacial dispersal of the European rabbit (Oryctolagus cuniculus) on the Iberian peninsula reconstructed from nested clade and mismatch analyses of mitochondrial DNA genetic variationMadalena Branco
, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France
Evolution Int J Org Evolution 56:792-803. 2002..Nonetheless, climatic oscillations of this period, although certainly milder than in northern Europe, were sufficient to affect the range distributions of Iberian organisms... - The association of DNA sequence variation at the MAOA genetic locus with quantitative behavioural traits in normal malesShai Rosenberg
Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa, Israel
Hum Genet 120:447-59. 2006..This study is used to address the validation, interpretation and limitation of genetic association studies of quantitative behavioural traits...