A R Templeton

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Phylogeography of the common vampire bat (Desmodus rotundus): marked population structure, Neotropical Pleistocene vicariance and incongruence between nuclear and mtDNA markers
    Felipe M Martins
    Laboratório de Biologia Evolutiva e Conservação LABEC, Instituto de Biociências USP, Cidade Universitaria, Sao Paulo SP, CEP 05508 900, Brazil
    BMC Evol Biol 9:294. 2009
  2. pmc Tree scanning: a method for using haplotype trees in phenotype/genotype association studies
    Alan R Templeton
    Department of Biology, Washington University, St Louis, Missouri 63130 4899, USA
    Genetics 169:441-53. 2005
  3. pmc Disrupting evolutionary processes: the effect of habitat fragmentation on collared lizards in the Missouri Ozarks
    A R Templeton
    Department of Biology, Washington University, St Louis, MO 63130 4899, USA
    Proc Natl Acad Sci U S A 98:5426-32. 2001
  4. ncbi request reprint Using phylogeographic analyses of gene trees to test species status and processes
    A R Templeton
    Department of Biology, Campus Box 1137, Washington University, St Louis, Missouri 63130 4899, USA
    Mol Ecol 10:779-91. 2001
  5. pmc Cladistic structure within the human Lipoprotein lipase gene and its implications for phenotypic association studies
    A R Templeton
    Department of Biology, Washington University, St Louis, Missouri 63130 4899, USA
    Genetics 156:1259-75. 2000
  6. pmc Recombinational and mutational hotspots within the human lipoprotein lipase gene
    A R Templeton
    Department of Biology, Washington University, St Louis, MO 63130 4899, USA
    Am J Hum Genet 66:69-83. 2000
  7. ncbi request reprint Statistical phylogeography: methods of evaluating and minimizing inference errors
    Alan R Templeton
    Department of Biology, Campus Box 1137, Washington University, St Louis, Missouri 63130 4899, USA
    Mol Ecol 13:789-809. 2004
  8. ncbi request reprint Out of Africa again and again
    Alan Templeton
    Department of Biology, Washington University, St Louis, Missouri 63130 4899, USA
    Nature 416:45-51. 2002
  9. pmc A cladistic analysis of phenotypic associations with haplotypes inferred from restriction endonuclease mapping. IV. Nested analyses with cladogram uncertainty and recombination
    A R Templeton
    Department of Biology, Washington University, St Louis, Missouri 63130
    Genetics 134:659-69. 1993
  10. pmc Empirical tests of some predictions from coalescent theory with applications to intraspecific phylogeny reconstruction
    K A Crandall
    Department of Biology, Washington University, St Louis, Missouri 63130 4899
    Genetics 134:959-69. 1993

Collaborators

Detail Information

Publications38

  1. pmc Phylogeography of the common vampire bat (Desmodus rotundus): marked population structure, Neotropical Pleistocene vicariance and incongruence between nuclear and mtDNA markers
    Felipe M Martins
    Laboratório de Biologia Evolutiva e Conservação LABEC, Instituto de Biociências USP, Cidade Universitaria, Sao Paulo SP, CEP 05508 900, Brazil
    BMC Evol Biol 9:294. 2009
    ....
  2. pmc Tree scanning: a method for using haplotype trees in phenotype/genotype association studies
    Alan R Templeton
    Department of Biology, Washington University, St Louis, Missouri 63130 4899, USA
    Genetics 169:441-53. 2005
    ..Overall, tree scanning is a simple, powerful, and flexible method for using haplotype trees to detect phenotype/genotype associations at candidate loci...
  3. pmc Disrupting evolutionary processes: the effect of habitat fragmentation on collared lizards in the Missouri Ozarks
    A R Templeton
    Department of Biology, Washington University, St Louis, MO 63130 4899, USA
    Proc Natl Acad Sci U S A 98:5426-32. 2001
    ..The general impact of human activities on genetic diversity disrupts or diminishes the capacity for adaptation, speciation, and macroevolutionary change. This impact will ultimately diminish biodiversity at all levels...
  4. ncbi request reprint Using phylogeographic analyses of gene trees to test species status and processes
    A R Templeton
    Department of Biology, Campus Box 1137, Washington University, St Louis, Missouri 63130 4899, USA
    Mol Ecol 10:779-91. 2001
    ..When one or more of the null hypotheses cannot be rejected, this procedure also provides specific guidance for future work that will be needed to judge species status...
  5. pmc Cladistic structure within the human Lipoprotein lipase gene and its implications for phenotypic association studies
    A R Templeton
    Department of Biology, Washington University, St Louis, Missouri 63130 4899, USA
    Genetics 156:1259-75. 2000
    ..Choosing SNPs at random would generally not provide adequate disequilibrium coverage of the sequenced region...
  6. pmc Recombinational and mutational hotspots within the human lipoprotein lipase gene
    A R Templeton
    Department of Biology, Washington University, St Louis, MO 63130 4899, USA
    Am J Hum Genet 66:69-83. 2000
    ..Overall, these results indicate that both recombinational and mutational hotspots have played significant roles in shaping the haplotype variation at the LPL locus...
  7. ncbi request reprint Statistical phylogeography: methods of evaluating and minimizing inference errors
    Alan R Templeton
    Department of Biology, Campus Box 1137, Washington University, St Louis, Missouri 63130 4899, USA
    Mol Ecol 13:789-809. 2004
    ....
  8. ncbi request reprint Out of Africa again and again
    Alan Templeton
    Department of Biology, Washington University, St Louis, Missouri 63130 4899, USA
    Nature 416:45-51. 2002
    ..Second is the ubiquity of genetic interchange between human populations, both in terms of recurrent gene flow constrained by geographical distance and of major population expansion events resulting in interbreeding, not replacement...
  9. pmc A cladistic analysis of phenotypic associations with haplotypes inferred from restriction endonuclease mapping. IV. Nested analyses with cladogram uncertainty and recombination
    A R Templeton
    Department of Biology, Washington University, St Louis, Missouri 63130
    Genetics 134:659-69. 1993
    ..In particular, recombination can be used to assign a physical localization to a given subregion for mutations responsible for significant phenotypic effects...
  10. pmc Empirical tests of some predictions from coalescent theory with applications to intraspecific phylogeny reconstruction
    K A Crandall
    Department of Biology, Washington University, St Louis, Missouri 63130 4899
    Genetics 134:959-69. 1993
    ....
  11. pmc A cladistic analysis of phenotypic associations with haplotypes inferred from restriction endonuclease mapping and DNA sequence data. III. Cladogram estimation
    A R Templeton
    Department of Biology, Washington University, St Louis, Missouri 63130
    Genetics 132:619-33. 1992
    ..We apply this estimation procedure to three data sets to illustrate varying degrees of cladogram ambiguity and recombination...
  12. ncbi request reprint Nested clade analyses of phylogeographic data: testing hypotheses about gene flow and population history
    A R Templeton
    Department of Biology, Washington University, St Louis, Missouri 63130 4899, USA
    Mol Ecol 7:381-97. 1998
    ..Examples are given that illustrate these properties, concentrating on the detection of range expansion events...
  13. ncbi request reprint Out of Africa? What do genes tell us?
    A R Templeton
    Department of Biology, Washington University, St Louis, Missouri 63130 4899, USA
    Curr Opin Genet Dev 7:841-7. 1997
    ..The gene tree analyses instead indicate that genetic interchanges have ensured that all of humanity has evolved as a single evolutionary lineage with no major splits...
  14. ncbi request reprint Abdominal pigmentation variation in drosophila polymorpha: geographic variation in the trait, and underlying phylogeography
    Jennifer A Brisson
    Campus Box 1137, Department of Biology, Washington University, St Louis, Missouri 63130, USA
    Evolution 59:1046-59. 2005
    ..These patterns combined lead us to hypothesize that abdominal pigmentation variation in D. polymorpha is important in mediating the organism's interactions with local ecological factors...
  15. pmc Combining phylogeography with distribution modeling: multiple Pleistocene range expansions in a parthenogenetic gecko from the Australian arid zone
    Jared L Strasburg
    Department of Biology, Washington University, St Louis, Missouri, United States of America
    PLoS ONE 2:e760. 2007
    ....
  16. ncbi request reprint On transferability of genome-wide tagSNPs
    C Charles Gu
    Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110, USA
    Genet Epidemiol 32:89-97. 2008
    ..We present a review of the literature about where and why tagSNP transferability may become a problem and suggest research directions that may help the resolution...
  17. pmc Nested clade analysis: an extensively validated method for strong phylogeographic inference
    Alan R Templeton
    Department of Biology, Washington University, St Louis, Missouri 63130 4899, USA
    Mol Ecol 17:1877-80. 2008
  18. pmc Coherent and incoherent inference in phylogeography and human evolution
    Alan R Templeton
    Department of Biology, Washington University, St Louis, MO 63130, USA
    Proc Natl Acad Sci U S A 107:6376-81. 2010
    ....
  19. doi request reprint The reality and importance of founder speciation in evolution
    Alan R Templeton
    Department of Biology, Washington University, St Louis, Missouri 63130 4899, USA
    Bioessays 30:470-9. 2008
    ..Founder speciation also interacts with other speciation mechanisms such that a speciation event is not a one-dimensional process due to either selection alone or drift alone...
  20. pmc Statistical hypothesis testing in intraspecific phylogeography: nested clade phylogeographical analysis vs. approximate Bayesian computation
    Alan R Templeton
    Department of Biology, Washington University, St Louis, MO 63130 4899, USA
    Mol Ecol 18:319-31. 2009
    ..Accordingly, ABC should not be used for hypothesis testing, but simulation approaches are valuable when used in conjunction with NCPA or other methods that do not rely on highly parameterized models...
  21. pmc Why does a method that fails continue to be used? The answer
    Alan R Templeton
    Department of Biology, Campus Box 1137, Washington University, St Louis, Missouri 63130, USA
    Evolution 63:807-12. 2009
    ..Hence, researchers can choose to use NCPA based upon objective critical validation that shows that NCPA delivers what it promises...
  22. pmc Multiple-infection and recombination in HIV-1 within a longitudinal cohort of women
    Alan R Templeton
    Department of Biology, Washington University, St Louis, Missouri, USA
    Retrovirology 6:54. 2009
    ....
  23. pmc The diverse applications of cladistic analysis of molecular evolution, with special reference to nested clade analysis
    Alan R Templeton
    Department of Biology, Washington University, St Louis, MO 63130 4899, USA E Mail Tel 1 314 935 6868
    Int J Mol Sci 11:124-39. 2010
    ....
  24. ncbi request reprint Genetics and recent human evolution
    Alan R Templeton
    Department of Biology, Campus Box 1137, Washington University, St Louis, Missouri 63130, USA
    Evolution 61:1507-19. 2007
    ..As more and more loci became available, genetics will undoubtedly offer additional insights and resolutions of human evolution...
  25. ncbi request reprint Haplotype trees and modern human origins
    Alan R Templeton
    Department of Biology, Washington University, St Louis, Missouri 63130 4899, USA
    Am J Phys Anthropol . 2005
    ..Genetics provides many insights into human evolution, but those insights need to be integrated with fossil and archaeological data to yield a fuller picture of the origin of modern humans...
  26. ncbi request reprint Beta-2 adrenergic receptor genotypes and haplotypes in different ethnic groups
    Taylor J Maxwell
    Department of Biology, Washington University in St Louis, St Louis, MO 63110 1093, USA
    Int J Mol Med 16:573-80. 2005
    ..Further studies are needed to see if functional relationships are the same across populations...
  27. pmc Population genetics of the developmental gene optomotor-blind (omb) in Drosophila polymorpha: evidence for a role in abdominal pigmentation variation
    Jennifer A Brisson
    Department of Biology, Washington University, Saint Louis, Missouri 63130, USA
    Genetics 168:1999-2010. 2004
    ..Selection at this locus is expected if omb contributes to variation in abdominal pigmentation, since this trait is likely of ecological importance...
  28. ncbi request reprint Evolutionary implications of developmental instability in parthenogenetic drosophila mercatorum. I. Comparison of several strains with different genotypes
    Melissa G Kramer
    Department of Biology, Washington University, St Louis, MO 63130, USA
    Evol Dev 4:223-33. 2002
    ....
  29. ncbi request reprint Evolutionary implications of developmental instability in parthenogenetic Drosophila mercatorum. II. Comparison of two strains with identical genotypes, but different modes of reproduction
    Melissa G Kramer
    Department of Biology, Washington University, St Louis, MO 63130, USA
    Evol Dev 4:234-41. 2002
    ....
  30. ncbi request reprint Life-history changes that accompany the transition from sexual to parthenogenetic reproduction in Drosophila mercatorum
    M G Kramer
    Department of Biology, Washington University, St Louis, Missouri 63130, USA
    Evolution 55:748-61. 2001
    ..These results support the theory of Stalker (1956) that parthenogenesis is favored in environments in which sexual reproduction is difficult or impossible...
  31. pmc Contingency tests of neutrality using intra/interspecific gene trees: the rejection of neutrality for the evolution of the mitochondrial cytochrome oxidase II gene in the hominoid primates
    A R Templeton
    Department of Biology, Washington University, St Louis, Missouri 63130 4899, USA
    Genetics 144:1263-70. 1996
    ..Finally, the detected deleterious selection causes lowered inbreeding effective sizes, so arguments for small effective sizes in recent human evolutionary history based upon mitochondrial DNA may be invalid...
  32. pmc Selection in context: patterns of natural selection in the glycoprotein 120 region of human immunodeficiency virus 1 within infected individuals
    Alan R Templeton
    Department of Biology, Washington University, St Louis, Missouri 63130 4899, USA
    Genetics 167:1547-61. 2004
    ..Finally, the transition between NSI and SI forms is associated with a burst of evolutionary change due to strong positive selection at sites other than those that define the NSI/SI phenotypes...
  33. pmc How frugal is Mother Nature with haplotypes?
    Sharlee Climer
    Department of Computer Science and Engineering, Washington University, St Louis, MO, USA
    Bioinformatics 25:68-74. 2009
    ..The first, and most critical step, is the ascertainment of a biologically sound model to be optimized. Many models that have been proposed rely partially or entirely on reducing the number of unique haplotypes in the solution...
  34. ncbi request reprint The role of nuclear genes in intraspecific evolutionary inference: genealogy of the transferrin gene in the brown trout
    Agostinho Antunes
    Centre de Investigação em Biodiversidade e Recursos Genéticos CIBIO UP, Campus Agrário de Vairão, Vairao, Portugal
    Mol Biol Evol 19:1272-87. 2002
    ....
  35. ncbi request reprint Race and genomics
    Scott M Williams
    N Engl J Med 348:2581-2; author reply 2581-2. 2003
  36. ncbi request reprint TreeScan: a bioinformatic application to search for genotype/phenotype associations using haplotype trees
    David Posada
    Variagenics, Inc, Cambridge, MA 02139, USA
    Bioinformatics 21:2130-2. 2005
    ..We present the software implementation of the tree scanning method to detect associations between genetic haplotypes and quantitative traits, utilizing the evolutionary history of the haplotypes, in samples of unrelated individuals...
  37. ncbi request reprint Postglacial dispersal of the European rabbit (Oryctolagus cuniculus) on the Iberian peninsula reconstructed from nested clade and mismatch analyses of mitochondrial DNA genetic variation
    Madalena Branco
    Centre de Genetique Moleculaire, Centre National de la Recherche Scientifique, Gif sur Yvette, France
    Evolution 56:792-803. 2002
    ..Nonetheless, climatic oscillations of this period, although certainly milder than in northern Europe, were sufficient to affect the range distributions of Iberian organisms...
  38. ncbi request reprint The association of DNA sequence variation at the MAOA genetic locus with quantitative behavioural traits in normal males
    Shai Rosenberg
    Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa, Israel
    Hum Genet 120:447-59. 2006
    ..This study is used to address the validation, interpretation and limitation of genetic association studies of quantitative behavioural traits...