Steven Teitelbaum

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption
    Wei Zou
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Biol 176:877-88. 2007
  2. pmc Osteoclasts; culprits in inflammatory osteolysis
    Steven L Teitelbaum
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8118, St Louis, MO 63110, USA
    Arthritis Res Ther 8:201. 2006
  3. pmc Postmenopausal osteoporosis, T cells, and immune dysfunction
    Steven L Teitelbaum
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 101:16711-2. 2004
  4. ncbi request reprint Osteoclasts and integrins
    Steven L Teitelbaum
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann N Y Acad Sci 1068:95-9. 2006
  5. ncbi request reprint Bone weighs in on obesity
    Clay F Semenkovich
    Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell 130:409-11. 2007
  6. pmc Osteoclasts: what do they do and how do they do it?
    Steven L Teitelbaum
    Department of Pathology and Immunology, Washington University School of Medicine, Campus Box 8118, 660 South Euclid Ave, St Louis, MO 63110, USA
    Am J Pathol 170:427-35. 2007
  7. doi request reprint The osteoclast and its unique cytoskeleton
    Steven L Teitelbaum
    Departments of Pathology and Immunology, and Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Ann N Y Acad Sci 1240:14-7. 2011
  8. doi request reprint Stem cells and osteoporosis therapy
    Steven L Teitelbaum
    Department of Pathology and Immunology, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA
    Cell Stem Cell 7:553-4. 2010
  9. pmc M-CSF mediates TNF-induced inflammatory osteolysis
    Hideki Kitaura
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 115:3418-27. 2005
  10. pmc The HIV protease inhibitor ritonavir blocks osteoclastogenesis and function by impairing RANKL-induced signaling
    Michael W H Wang
    Department of Pathology and Immunology, Washington University School of Medicine, Campus Box 8118, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    J Clin Invest 114:206-13. 2004

Research Grants

  1. CDC 42 BIM AND THE OSTEOCLAST
    Steven L Teitelbaum; Fiscal Year: 2010
  2. MECHANISMS OF AVB3 INTEGRIN MEDIATED BONE RESORPTION
    Steven Teitelbaum; Fiscal Year: 2009
  3. MECHANISMS OF POLARIZED SECRETION BY BONE CELLS
    Steven Teitelbaum; Fiscal Year: 2009
  4. CDC 42 BIM AND THE OSTEOCLAST
    Steven Teitelbaum; Fiscal Year: 2009
  5. Mechanisms of RANKL Mediated Osteoclast Activation
    Steven L Teitelbaum; Fiscal Year: 2010
  6. Mechanisms of RANKL Mediated Osteoclast Activation
    Steven Teitelbaum; Fiscal Year: 2009
  7. MECHANISMS OF POLARIZED SECRETION BY BONE CELLS
    Steven L Teitelbaum; Fiscal Year: 2010
  8. MECHANISMS OF ORTHOPEDIC IMPLANT OSTEOLYSIS
    Steven Teitelbaum; Fiscal Year: 2001
  9. MECHANISMS OF ORTHOPEDIC IMPLANT OSTEOLYSIS
    Steven Teitelbaum; Fiscal Year: 2006
  10. RANK Ligand is a Bone Anabolic Agent
    Steven Teitelbaum; Fiscal Year: 2006

Collaborators

Detail Information

Publications57

  1. pmc Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption
    Wei Zou
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Biol 176:877-88. 2007
    ..Thus, in conjunction with ITAM-bearing proteins, Syk, c-Src, and alpha v beta3 represent an essential signaling complex in the bone-resorbing osteoclast, and, therefore, each is a candidate therapeutic target...
  2. pmc Osteoclasts; culprits in inflammatory osteolysis
    Steven L Teitelbaum
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8118, St Louis, MO 63110, USA
    Arthritis Res Ther 8:201. 2006
    ..Achieving an understanding of the mechanisms by which the three cytokines affect the osteoclast has resulted in a number of active and candidate therapeutic targets...
  3. pmc Postmenopausal osteoporosis, T cells, and immune dysfunction
    Steven L Teitelbaum
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 101:16711-2. 2004
  4. ncbi request reprint Osteoclasts and integrins
    Steven L Teitelbaum
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann N Y Acad Sci 1068:95-9. 2006
    ..Our studies have investigated whether absence of the alphavbeta3 integrin modifies the ability of c-Fms to induce Rho GTPases, and the implications for formation of the osteoclast cytoskeleton...
  5. ncbi request reprint Bone weighs in on obesity
    Clay F Semenkovich
    Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell 130:409-11. 2007
    ..In this issue of Cell, Lee et al. (2007) demonstrate in mice that bone regulates the insulin/glucose axis and energy metabolism, providing a new framework for approaching common disorders of bioenergetics...
  6. pmc Osteoclasts: what do they do and how do they do it?
    Steven L Teitelbaum
    Department of Pathology and Immunology, Washington University School of Medicine, Campus Box 8118, 660 South Euclid Ave, St Louis, MO 63110, USA
    Am J Pathol 170:427-35. 2007
    ..This review focuses on these and other molecules that mediate osteoclast differentiation or function and thus serve as candidate anti-osteoporosis therapeutic targets...
  7. doi request reprint The osteoclast and its unique cytoskeleton
    Steven L Teitelbaum
    Departments of Pathology and Immunology, and Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Ann N Y Acad Sci 1240:14-7. 2011
    ..Absence of any component of this signaling pathway compromises osteoclast cytoskeletal organization and abridges bone resorption...
  8. doi request reprint Stem cells and osteoporosis therapy
    Steven L Teitelbaum
    Department of Pathology and Immunology, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA
    Cell Stem Cell 7:553-4. 2010
    ..In this issue of Cell Stem Cell, Wu et al. (2010) demonstrate that this event is mediated by osteoclastic mobilization of active transforming growth factor β1, which is inhibited by a common antiosteoporosis drug...
  9. pmc M-CSF mediates TNF-induced inflammatory osteolysis
    Hideki Kitaura
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 115:3418-27. 2005
    ..M-CSF and its receptor, c-Fms, therefore present as candidate therapeutic targets in states of inflammatory bone erosion...
  10. pmc The HIV protease inhibitor ritonavir blocks osteoclastogenesis and function by impairing RANKL-induced signaling
    Michael W H Wang
    Department of Pathology and Immunology, Washington University School of Medicine, Campus Box 8118, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    J Clin Invest 114:206-13. 2004
    ..Thus, ritonavir may represent a bone-sparing PI capable of preventing development of osteopenia in patients currently on HAART...
  11. pmc IL-1 mediates TNF-induced osteoclastogenesis
    Shi Wei
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 115:282-90. 2005
    ..Thus, IL-1 mediates the osteoclastogenic effect of TNF by enhancing stromal cell expression of RANKL and directly stimulating differentiation of osteoclast precursors...
  12. ncbi request reprint High dose M-CSF partially rescues the Dap12-/- osteoclast phenotype
    Roberta Faccio
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biochem 90:871-83. 2003
    ..Furthermore, the same cells plated onto osteopontin, adhere poorly and fail to phosphorylate c-Src or Pyk2, two kinases central to organization of the osteoclast cytoskeleton...
  13. ncbi request reprint Critical role of beta3 integrin in experimental postmenopausal osteoporosis
    Haibo Zhao
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    J Bone Miner Res 20:2116-23. 2005
    ..Using a lentiviral-based strategy to express beta3 mutants in beta3(-/-) mice, we also show that beta3(S752), but not beta3(Y747/Y759), is important for osteoclastic bone resorption in vivo...
  14. ncbi request reprint Marrow stromal cells and osteoclast precursors differentially contribute to TNF-alpha-induced osteoclastogenesis in vivo
    Hideki Kitaura
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 173:4838-46. 2004
    ....
  15. pmc FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner
    Shuting Bai
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 115:2742-51. 2005
    ..FHL2 is, therefore, an antiosteoclastogenic molecule exerting its effect by attenuating TRAF6-mediated RANK signaling...
  16. ncbi request reprint Unoccupied alpha(v)beta3 integrin regulates osteoclast apoptosis by transmitting a positive death signal
    Haibo Zhao
    Department of Pathology and Immunology, Washington University School of Medicine, Campus Box 8118, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Mol Endocrinol 19:771-80. 2005
    ..Thus, unoccupied alpha(v)beta3 integrin regulates osteoclast apoptosis via a component of the integrin that is different than that regulating resorption...
  17. ncbi request reprint Interleukin-4 reversibly inhibits osteoclastogenesis via inhibition of NF-kappa B and mitogen-activated protein kinase signaling
    Shi Wei
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 277:6622-30. 2002
    ....
  18. pmc c-Fms and the alphavbeta3 integrin collaborate during osteoclast differentiation
    Roberta Faccio
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 111:749-58. 2003
    ..Thus, while c-Fms and alpha(v)beta(3) collaborate in the osteoclastogenic process via shared activation of the ERK/c-Fos signaling pathway, the integrin is essential for matrix degradation...
  19. ncbi request reprint Direct inhibition of NF-kappa B blocks bone erosion associated with inflammatory arthritis
    John C Clohisy
    Department of Orthopaedic Research Laboratory, Barnes Jewish Hospital at Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 171:5547-53. 2003
    ..Thus, NF-kappaB appears to be the centerpiece of inflammatory-osteolytic arthritis and direct inhibition of this transcription factor by unique and novel I-kappaB mutant proteins blocks manifestation of the disease...
  20. ncbi request reprint Tyrosines 559 and 807 in the cytoplasmic tail of the macrophage colony-stimulating factor receptor play distinct roles in osteoclast differentiation and function
    Xu Feng
    Departments of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Endocrinology 143:4868-74. 2002
    ..Thus, we have identified specific tyrosine residues in the cytoplasmic tail of c-Fms that are critical for transmitting M-CSF-initiated signals individually required for OC formation or function, respectively...
  21. ncbi request reprint Vav3 regulates osteoclast function and bone mass
    Roberta Faccio
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Med 11:284-90. 2005
    ..Moreover, we provide genetic and biochemical evidence for the role of Syk tyrosine kinase as a crucial upstream regulator of Vav3 in osteoclasts. Thus, Vav3 is a potential new target for antiosteoporosis therapy...
  22. ncbi request reprint SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts
    Sunao Takeshita
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Med 8:943-9. 2002
    ..Thus, SHIP negatively regulates osteoclast formation and function and the absence of this enzyme results in severe osteoporosis...
  23. pmc Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarization
    Yuji Ito
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 120:1981-93. 2010
    ..These data suggest that Cdc42 regulates osteoclast formation and function and may represent a promising therapeutic target for prevention of pathological bone loss...
  24. pmc Microfibril-associated glycoprotein-1, an extracellular matrix regulator of bone remodeling
    Clarissa S Craft
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Biol Chem 285:23858-67. 2010
    ..Together, our findings suggest that MAGP1 is a regulator of bone remodeling, and its absence results in osteopenia associated with an increase in osteoclast number...
  25. ncbi request reprint NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells
    Shuting Bai
    Departments of Pathology and Immunology, Molecular Biology and Pharmacology, and Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Biol Chem 283:6509-18. 2008
    ..These observations raise caution that therapeutic inhibition of NOTCH signaling may adversely accelerate bone loss in humans...
  26. ncbi request reprint SHIP1 negatively regulates proliferation of osteoclast precursors via Akt-dependent alterations in D-type cyclins and p27
    Ping Zhou
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 177:8777-84. 2006
    ..The SHIP1/Akt pathway therefore suppresses bone loss in pathological states associated with an excess of the cytokine...
  27. pmc Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by beta3 integrin
    Roberta Faccio
    Department of Pathology, Washington University School of Medicine, 216 South Kingshighway, St Louis, MO 63110, USA
    J Cell Biol 162:499-509. 2003
    ..Thus, the beta3 cytoplasmic domain is responsible for activation of specific intracellular signals leading to cytoskeletal reorganization critical for OC function...
  28. ncbi request reprint M-CSF regulates the cytoskeleton via recruitment of a multimeric signaling complex to c-Fms Tyr-559/697/721
    Roberta Faccio
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 282:18991-9. 2007
    ..Furthermore, this same add-back approach identifies important roles for Tyr-697 and Tyr-721 in collaborating with Tyr-559 to recruit a multimeric signaling complex that can transduce signals from c-Fms to the actin cytoskeleton...
  29. pmc Defects in osteoblast function but no changes in long-term repopulating potential of hematopoietic stem cells in a mouse chronic inflammatory arthritis model
    Yunglin D Ma
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Blood 114:4402-10. 2009
    ..Therefore, the bone-forming capacity of osteoblasts is distinct from their ability to maintain hematopoietic stem cells in chronic inflammatory conditions...
  30. pmc Synaptotagmin VII regulates bone remodeling by modulating osteoclast and osteoblast secretion
    Haibo Zhao
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Dev Cell 14:914-25. 2008
    ..Therefore, synaptotagmin VII plays an important role in bone remodeling and homeostasis by modulating secretory pathways functionally important in osteoclasts and osteoblasts...
  31. ncbi request reprint The osteoclast: friend or foe?
    Deborah V Novack
    Department of Pathology and Immunology, Division of Bone and Mineral Diseases, Washington University School of Medicine, St Louis, MO 63110, USA
    Annu Rev Pathol 3:457-84. 2008
    ..In these diseases, osteoclast activity causes bone loss that leads to pain, deformity, and fracture. Thus, osteoclasts are critical for normal bone function, but their activity must be controlled...
  32. pmc Noninvasive imaging of osteoclasts in parathyroid hormone-induced osteolysis using a 64Cu-labeled RGD peptide
    Jennifer E Sprague
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 48:311-8. 2007
    ..We proposed that radiolabeled RGD peptides could be used to detect osteoclasts in lytic bone lesions...
  33. ncbi request reprint Genetic regulation of osteoclast development and function
    Steven L Teitelbaum
    Department of Pathology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8118, St Louis, Missouri 63110, USA
    Nat Rev Genet 4:638-49. 2003
    ..The past five years have witnessed important insights into osteoclast formation and function. Many of these discoveries have been made through genetic experiments that involved the rare hereditary disorder osteopetrosis...
  34. pmc The IkappaB function of NF-kappaB2 p100 controls stimulated osteoclastogenesis
    Deborah Veis Novack
    Washington University School of Medicine, 660 S Euclid Ave, Box 8301, St Louis, MO 63110, USA
    J Exp Med 198:771-81. 2003
    ..These data demonstrate a novel, biologically relevant means of regulating NF-kappaB signaling, with upstream control and kinetics distinct from the classical IkappaBalpha pathway...
  35. pmc RANKing c-Jun in osteoclast development
    Steven L Teitelbaum
    Department of Pathology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Clin Invest 114:463-5. 2004
  36. ncbi request reprint alphavbeta3 and macrophage colony-stimulating factor: partners in osteoclast biology
    F Patrick Ross
    Washington University School of Medicine, St Louis, MO 63110, USA
    Immunol Rev 208:88-105. 2005
    ..Signals from alphavbeta3 and/or c-Fms activate Syk and Vav3, originally defined by their function in lymphoid cells. Genetic depletion of either protein generates a strong bone phenotype, underscoring the promise of osteoimmunobiology...
  37. doi request reprint Integrins, growth factors, and the osteoclast cytoskeleton
    Wei Zou
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Ann N Y Acad Sci 1192:27-31. 2010
    ..Integrin/bone recognition also promotes formation of actin rings, which surround the ruffled border, thereby isolating the focus of skeletal degradation from the general extracellular space...
  38. pmc Src-like adaptor protein regulates osteoclast generation and survival
    Hyun Ju Kim
    Department of Pathology and Immunology, Washington University in St Louis School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biochem 110:201-9. 2010
    ..These counterbalancing events yield indistinguishable bones of WT and SLAP-/- mice which contain equal numbers of osteoclasts in basal and stimulated conditions...
  39. pmc The Src family kinase, Lyn, suppresses osteoclastogenesis in vitro and in vivo
    Hyun Ju Kim
    Department of Pathology and Immunology, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 106:2325-30. 2009
    ..The most pragmatic aspect of our findings is that successful therapeutic inhibition of c-Src, in the context of the osteoclast, will require its stringent targeting...
  40. pmc SLP-76 couples Syk to the osteoclast cytoskeleton
    Jennifer L Reeve
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 183:1804-12. 2009
    ..Finally, c-Fms-activated Syk also exerts its OC cytoskeleton-organizing effect in a SLP-76/Vav3-dependent manner...
  41. ncbi request reprint c-Fms tyrosine 559 is a major mediator of M-CSF-induced proliferation of primary macrophages
    Sunao Takeshita
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 282:18980-90. 2007
    ..Using specific small molecule inhibitors we find that a combination of the Src family kinase, phosphatidylinositol 3-kinase/Akt, phospholipase C, and ERK pathways mediates macrophage proliferation in response to M-CSF...
  42. pmc Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation
    Matthew J Hilton
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Med 14:306-14. 2008
    ..Thus, mesenchymal progenitors may be expanded in vitro by activating the Notch pathway, whereas bone formation in vivo may be enhanced by transiently suppressing this pathway...
  43. ncbi request reprint The LIM protein, Limd1, regulates AP-1 activation through an interaction with Traf6 to influence osteoclast development
    Yunfeng Feng
    Department of Medicine, Washington University, St Louis, Missouri 63110, USA
    J Biol Chem 282:39-48. 2007
    ..These results implicate Limd1 as a potentially important regulator of osteoclast development under conditions of stress...
  44. pmc DAP12 couples c-Fms activation to the osteoclast cytoskeleton by recruitment of Syk
    Wei Zou
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cell 31:422-31. 2008
    ..Our data provide genetic and biochemical evidence that uncovers an epistatic signaling pathway linking the receptor tyrosine kinase c-Fms to the immune adaptor DAP12 and the cytoskeleton...
  45. pmc Syk tyrosine 317 negatively regulates osteoclast function via the ubiquitin-protein isopeptide ligase activity of Cbl
    Wei Zou
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 284:18833-9. 2009
    ..Consequently, Syk(Y317F) abolishes M-CSF- and integrin-stimulated Syk ubiquitination. Thus, Cbl/Syk(Y317) association negatively regulates OC function and therefore is essential for maintenance of skeletal homeostasis...
  46. ncbi request reprint Tumor necrosis factor-alpha mediates polymethylmethacrylate particle-induced NF-kappaB activation in osteoclast precursor cells
    John C Clohisy
    Department of Orthopaedic Surgery, Barnes Jewish Hospital at Washington University School of Medicine, St Louis, MO 63110, USA
    J Orthop Res 20:174-81. 2002
    ..Thus, PMMA particle activation of NF-kappaB is a secondary event resulting from enhanced TNF expression and is independent of LPS contamination...
  47. ncbi request reprint Dexamethsone suppresses bone formation via the osteoclast
    Hyun Ju Kim
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Adv Exp Med Biol 602:43-6. 2007
    ..Consequently, pathologically or pharmacologically inhibited resorption eventuates in arrested osteoblast activity...
  48. pmc Tumor necrosis factor receptor-associated factor 6 is an intranuclear transcriptional coactivator in osteoclasts
    Shuting Bai
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 283:30861-7. 2008
    ....
  49. pmc Glucocorticoids suppress bone formation via the osteoclast
    Hyun Ju Kim
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 116:2152-60. 2006
    ..Consistent with osteoclasts modulating the osteoblast-suppressive effect of DEX, GRoc-/- mice are protected from the steroid's inhibition of bone formation...
  50. pmc Dissection of platelet and myeloid cell defects by conditional targeting of the beta3-integrin subunit
    Elizabeth A Morgan
    Department of Medicine, Mallinkrodt Institute of Radiology, St Louis, Missouri, USA
    FASEB J 24:1117-27. 2010
    ..Hurchla, M. A., Deng, H., Floyd, D., Berdy, A., Prior, J. L., Piwnica-Worms, D., Teitelbaum, S. L., Ross, F. P., Weilbaecher, K. N. Dissection of platelet and myeloid cell defects by conditional targeting of the beta3-integrin subunit...
  51. doi request reprint Bone turnover in bone biopsies of patients with low-energy cortical fractures receiving bisphosphonates: a case series
    Reina Armamento-Villareal
    Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, Campus Box 8301, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Calcif Tissue Int 85:37-44. 2009
    ..Considering the widespread use of bisphosphonates, it appears that the overall risk of cortical fractures is low. However, there may be a subset of as yet unidentified patients who could be predisposed to this complication...
  52. doi request reprint How do bone cells secrete proteins?
    Haibo Zhao
    Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Adv Exp Med Biol 658:105-9. 2010
    ..Thus, SytVII-deficient mice experience suppressed bone resorption and formation with the latter deficiency predominant thereby yielding osteoporosis characterized by attenuated remodeling...
  53. ncbi request reprint Glucocorticoids and the osteoclast
    Hyun Ju Kim
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann N Y Acad Sci 1116:335-9. 2007
    ..Consistent with osteoclasts modulating the osteoblast-suppressive effect of dexamethasone, GC receptor-deficient mice are protected from the steroid's inhibition of bone formation...
  54. ncbi request reprint Mice lacking the integrin beta5 subunit have accelerated osteoclast maturation and increased activity in the estrogen-deficient state
    Nancy E Lane
    Department of Medicine, University of California at San Francisco, San Francisco, California 94143, USA
    J Bone Miner Res 20:58-66. 2005
    ..These preliminary data suggest alphavbeta5 integrin's presence on osteoclast precursors may inhibit of osteoclast formation...
  55. pmc Rab3D regulates a novel vesicular trafficking pathway that is required for osteoclastic bone resorption
    Nathan J Pavlos
    Unit of Orthopaedics, School of Surgery and Pathology, University of Western Australia, 2nd Floor M Block, QEII Medical Centre, Nedlands, Perth, Western Australia 6009, Australia
    Mol Cell Biol 25:5253-69. 2005
    ..Collectively, our data suggest that Rab3D modulates a post-TGN trafficking step that is required for osteoclastic bone resorption...
  56. ncbi request reprint Osteopetrosis
    Jakub Tolar
    Program in Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis 55455, USA
    N Engl J Med 351:2839-49. 2004
  57. ncbi request reprint Osteoporosis and integrins
    Steven L Teitelbaum
    J Clin Endocrinol Metab 90:2466-8. 2005

Research Grants38

  1. CDC 42 BIM AND THE OSTEOCLAST
    Steven L Teitelbaum; Fiscal Year: 2010
    ..abstract_text> ..
  2. MECHANISMS OF AVB3 INTEGRIN MEDIATED BONE RESORPTION
    Steven Teitelbaum; Fiscal Year: 2009
    ..abstract_text> ..
  3. MECHANISMS OF POLARIZED SECRETION BY BONE CELLS
    Steven Teitelbaum; Fiscal Year: 2009
    ..We propose to identify the mechanisms by which these two proteins control bone mass, with the view of generating novel drugs to treat diseases such as osteoporosis. ..
  4. CDC 42 BIM AND THE OSTEOCLAST
    Steven Teitelbaum; Fiscal Year: 2009
    ..abstract_text> ..
  5. Mechanisms of RANKL Mediated Osteoclast Activation
    Steven L Teitelbaum; Fiscal Year: 2010
    ..The purpose of this proposal is to gain insight into the mechanism by which RANKL activates osteoclasts and to design candidate drugs which will inhibit this event and consequently, prevent pathological bone loss. ..
  6. Mechanisms of RANKL Mediated Osteoclast Activation
    Steven Teitelbaum; Fiscal Year: 2009
    ..Information garnered from the supplemental Specific Aim may add to our armamentarium of potential anti-bone resorption therapeutic targets. ..
  7. MECHANISMS OF POLARIZED SECRETION BY BONE CELLS
    Steven L Teitelbaum; Fiscal Year: 2010
    ..We propose to identify the mechanisms by which these two proteins control bone mass, with the view of generating novel drugs to treat diseases such as osteoporosis. ..
  8. MECHANISMS OF ORTHOPEDIC IMPLANT OSTEOLYSIS
    Steven Teitelbaum; Fiscal Year: 2001
    ....
  9. MECHANISMS OF ORTHOPEDIC IMPLANT OSTEOLYSIS
    Steven Teitelbaum; Fiscal Year: 2006
    ....
  10. RANK Ligand is a Bone Anabolic Agent
    Steven Teitelbaum; Fiscal Year: 2006
    ..abstract_text> ..
  11. MECHANISMS OF AVB3 INTEGRIN MEDIATED BONE RESORPTION
    Steven Teitelbaum; Fiscal Year: 2004
    ..abstract_text> ..