Steven L Teitelbaum

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Genetic regulation of osteoclast development and function
    Steven L Teitelbaum
    Department of Pathology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8118, St Louis, Missouri 63110, USA
    Nat Rev Genet 4:638-49. 2003
  2. pmc Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by beta3 integrin
    Roberta Faccio
    Department of Pathology, Washington University School of Medicine, 216 South Kingshighway, St Louis, MO 63110, USA
    J Cell Biol 162:499-509. 2003
  3. pmc M-CSF mediates TNF-induced inflammatory osteolysis
    Hideki Kitaura
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 115:3418-27. 2005
  4. ncbi request reprint Critical role of beta3 integrin in experimental postmenopausal osteoporosis
    Haibo Zhao
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    J Bone Miner Res 20:2116-23. 2005
  5. ncbi request reprint M-CSF regulates the cytoskeleton via recruitment of a multimeric signaling complex to c-Fms Tyr-559/697/721
    Roberta Faccio
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 282:18991-9. 2007
  6. pmc IL-1 mediates TNF-induced osteoclastogenesis
    Shi Wei
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 115:282-90. 2005
  7. pmc Oophorectomy-induced bone loss is attenuated in MAGP1-deficient mice
    Clarissa S Craft
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biochem 113:93-9. 2012
  8. pmc Src-like adaptor protein regulates osteoclast generation and survival
    Hyun Ju Kim
    Department of Pathology and Immunology, Washington University in St Louis School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biochem 110:201-9. 2010
  9. pmc The HIV protease inhibitor ritonavir blocks osteoclastogenesis and function by impairing RANKL-induced signaling
    Michael W H Wang
    Department of Pathology and Immunology, Washington University School of Medicine, Campus Box 8118, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    J Clin Invest 114:206-13. 2004
  10. pmc SLP-76 couples Syk to the osteoclast cytoskeleton
    Jennifer L Reeve
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 183:1804-12. 2009

Detail Information

Publications69

  1. ncbi request reprint Genetic regulation of osteoclast development and function
    Steven L Teitelbaum
    Department of Pathology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8118, St Louis, Missouri 63110, USA
    Nat Rev Genet 4:638-49. 2003
    ..The past five years have witnessed important insights into osteoclast formation and function. Many of these discoveries have been made through genetic experiments that involved the rare hereditary disorder osteopetrosis...
  2. pmc Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by beta3 integrin
    Roberta Faccio
    Department of Pathology, Washington University School of Medicine, 216 South Kingshighway, St Louis, MO 63110, USA
    J Cell Biol 162:499-509. 2003
    ..Thus, the beta3 cytoplasmic domain is responsible for activation of specific intracellular signals leading to cytoskeletal reorganization critical for OC function...
  3. pmc M-CSF mediates TNF-induced inflammatory osteolysis
    Hideki Kitaura
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 115:3418-27. 2005
    ..M-CSF and its receptor, c-Fms, therefore present as candidate therapeutic targets in states of inflammatory bone erosion...
  4. ncbi request reprint Critical role of beta3 integrin in experimental postmenopausal osteoporosis
    Haibo Zhao
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    J Bone Miner Res 20:2116-23. 2005
    ..Using a lentiviral-based strategy to express beta3 mutants in beta3(-/-) mice, we also show that beta3(S752), but not beta3(Y747/Y759), is important for osteoclastic bone resorption in vivo...
  5. ncbi request reprint M-CSF regulates the cytoskeleton via recruitment of a multimeric signaling complex to c-Fms Tyr-559/697/721
    Roberta Faccio
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 282:18991-9. 2007
    ..Furthermore, this same add-back approach identifies important roles for Tyr-697 and Tyr-721 in collaborating with Tyr-559 to recruit a multimeric signaling complex that can transduce signals from c-Fms to the actin cytoskeleton...
  6. pmc IL-1 mediates TNF-induced osteoclastogenesis
    Shi Wei
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 115:282-90. 2005
    ..Thus, IL-1 mediates the osteoclastogenic effect of TNF by enhancing stromal cell expression of RANKL and directly stimulating differentiation of osteoclast precursors...
  7. pmc Oophorectomy-induced bone loss is attenuated in MAGP1-deficient mice
    Clarissa S Craft
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biochem 113:93-9. 2012
    ..These studies provide support for increased RANKL expression associated with MAGP1 deficiency and provide a link to altered TGF-β signaling as a possible causative signaling pathway regulating RANKL expression in MAGP1Δ osteoblasts...
  8. pmc Src-like adaptor protein regulates osteoclast generation and survival
    Hyun Ju Kim
    Department of Pathology and Immunology, Washington University in St Louis School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biochem 110:201-9. 2010
    ..These counterbalancing events yield indistinguishable bones of WT and SLAP-/- mice which contain equal numbers of osteoclasts in basal and stimulated conditions...
  9. pmc The HIV protease inhibitor ritonavir blocks osteoclastogenesis and function by impairing RANKL-induced signaling
    Michael W H Wang
    Department of Pathology and Immunology, Washington University School of Medicine, Campus Box 8118, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    J Clin Invest 114:206-13. 2004
    ..Thus, ritonavir may represent a bone-sparing PI capable of preventing development of osteopenia in patients currently on HAART...
  10. pmc SLP-76 couples Syk to the osteoclast cytoskeleton
    Jennifer L Reeve
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 183:1804-12. 2009
    ..Finally, c-Fms-activated Syk also exerts its OC cytoskeleton-organizing effect in a SLP-76/Vav3-dependent manner...
  11. pmc Talin1 and Rap1 are critical for osteoclast function
    Wei Zou
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Mol Cell Biol 33:830-44. 2013
    ..Thus, talin1 and Rap1 are critical for resorptive function, and their selective inhibition in mature osteoclasts retards pathological bone loss...
  12. pmc Syk tyrosine 317 negatively regulates osteoclast function via the ubiquitin-protein isopeptide ligase activity of Cbl
    Wei Zou
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 284:18833-9. 2009
    ..Consequently, Syk(Y317F) abolishes M-CSF- and integrin-stimulated Syk ubiquitination. Thus, Cbl/Syk(Y317) association negatively regulates OC function and therefore is essential for maintenance of skeletal homeostasis...
  13. ncbi request reprint c-Fms tyrosine 559 is a major mediator of M-CSF-induced proliferation of primary macrophages
    Sunao Takeshita
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 282:18980-90. 2007
    ..Using specific small molecule inhibitors we find that a combination of the Src family kinase, phosphatidylinositol 3-kinase/Akt, phospholipase C, and ERK pathways mediates macrophage proliferation in response to M-CSF...
  14. pmc Tumor necrosis factor receptor-associated factor 6 is an intranuclear transcriptional coactivator in osteoclasts
    Shuting Bai
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 283:30861-7. 2008
    ....
  15. ncbi request reprint SHIP1 negatively regulates proliferation of osteoclast precursors via Akt-dependent alterations in D-type cyclins and p27
    Ping Zhou
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 177:8777-84. 2006
    ..The SHIP1/Akt pathway therefore suppresses bone loss in pathological states associated with an excess of the cytokine...
  16. ncbi request reprint Dexamethsone suppresses bone formation via the osteoclast
    Hyun Ju Kim
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Adv Exp Med Biol 602:43-6. 2007
    ..Consequently, pathologically or pharmacologically inhibited resorption eventuates in arrested osteoblast activity...
  17. pmc c-Src links a RANK/αvβ3 integrin complex to the osteoclast cytoskeleton
    Takashi Izawa
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Mol Cell Biol 32:2943-53. 2012
    ..Thus, activated RANK prompts two distinct signaling pathways; one promotes osteoclast formation, and the other, in collaboration with c-Src-mediated linkage to αvβ3, organizes the cell's cytoskeleton...
  18. ncbi request reprint Marrow stromal cells and osteoclast precursors differentially contribute to TNF-alpha-induced osteoclastogenesis in vivo
    Hideki Kitaura
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 173:4838-46. 2004
    ....
  19. pmc DAP12 couples c-Fms activation to the osteoclast cytoskeleton by recruitment of Syk
    Wei Zou
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cell 31:422-31. 2008
    ..Our data provide genetic and biochemical evidence that uncovers an epistatic signaling pathway linking the receptor tyrosine kinase c-Fms to the immune adaptor DAP12 and the cytoskeleton...
  20. pmc Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation
    Matthew J Hilton
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Med 14:306-14. 2008
    ..Thus, mesenchymal progenitors may be expanded in vitro by activating the Notch pathway, whereas bone formation in vivo may be enhanced by transiently suppressing this pathway...
  21. pmc Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarization
    Yuji Ito
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 120:1981-93. 2010
    ..These data suggest that Cdc42 regulates osteoclast formation and function and may represent a promising therapeutic target for prevention of pathological bone loss...
  22. pmc FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner
    Shuting Bai
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 115:2742-51. 2005
    ..FHL2 is, therefore, an antiosteoclastogenic molecule exerting its effect by attenuating TRAF6-mediated RANK signaling...
  23. pmc c-Fms and the alphavbeta3 integrin collaborate during osteoclast differentiation
    Roberta Faccio
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 111:749-58. 2003
    ..Thus, while c-Fms and alpha(v)beta(3) collaborate in the osteoclastogenic process via shared activation of the ERK/c-Fos signaling pathway, the integrin is essential for matrix degradation...
  24. ncbi request reprint The LIM protein, Limd1, regulates AP-1 activation through an interaction with Traf6 to influence osteoclast development
    Yunfeng Feng
    Department of Medicine, Washington University, St Louis, Missouri 63110, USA
    J Biol Chem 282:39-48. 2007
    ..These results implicate Limd1 as a potentially important regulator of osteoclast development under conditions of stress...
  25. ncbi request reprint High dose M-CSF partially rescues the Dap12-/- osteoclast phenotype
    Roberta Faccio
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biochem 90:871-83. 2003
    ..Furthermore, the same cells plated onto osteopontin, adhere poorly and fail to phosphorylate c-Src or Pyk2, two kinases central to organization of the osteoclast cytoskeleton...
  26. doi request reprint The osteoclast and its unique cytoskeleton
    Steven L Teitelbaum
    Departments of Pathology and Immunology, and Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Ann N Y Acad Sci 1240:14-7. 2011
    ..Absence of any component of this signaling pathway compromises osteoclast cytoskeletal organization and abridges bone resorption...
  27. pmc Microfibril-associated glycoprotein-1, an extracellular matrix regulator of bone remodeling
    Clarissa S Craft
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Biol Chem 285:23858-67. 2010
    ..Together, our findings suggest that MAGP1 is a regulator of bone remodeling, and its absence results in osteopenia associated with an increase in osteoclast number...
  28. pmc Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption
    Wei Zou
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Biol 176:877-88. 2007
    ..Thus, in conjunction with ITAM-bearing proteins, Syk, c-Src, and alpha v beta3 represent an essential signaling complex in the bone-resorbing osteoclast, and, therefore, each is a candidate therapeutic target...
  29. pmc Defects in osteoblast function but no changes in long-term repopulating potential of hematopoietic stem cells in a mouse chronic inflammatory arthritis model
    Yunglin D Ma
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Blood 114:4402-10. 2009
    ..Therefore, the bone-forming capacity of osteoblasts is distinct from their ability to maintain hematopoietic stem cells in chronic inflammatory conditions...
  30. pmc Noninvasive imaging of osteoclasts in parathyroid hormone-induced osteolysis using a 64Cu-labeled RGD peptide
    Jennifer E Sprague
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 48:311-8. 2007
    ..We proposed that radiolabeled RGD peptides could be used to detect osteoclasts in lytic bone lesions...
  31. ncbi request reprint Vav3 regulates osteoclast function and bone mass
    Roberta Faccio
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Med 11:284-90. 2005
    ..Moreover, we provide genetic and biochemical evidence for the role of Syk tyrosine kinase as a crucial upstream regulator of Vav3 in osteoclasts. Thus, Vav3 is a potential new target for antiosteoporosis therapy...
  32. pmc Zap70 inhibits Syk-mediated osteoclast function
    Wei Zou
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biochem 114:1871-8. 2013
    ..Such inhibition requires Zap70 kinase activity, as it is abolished by mutation of the Zap70 kinase domain. Thus, while the kinase domain of Syk is uniquely required for OC function that of Zap70 inhibits it...
  33. ncbi request reprint Tyrosines 559 and 807 in the cytoplasmic tail of the macrophage colony-stimulating factor receptor play distinct roles in osteoclast differentiation and function
    Xu Feng
    Departments of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Endocrinology 143:4868-74. 2002
    ..Thus, we have identified specific tyrosine residues in the cytoplasmic tail of c-Fms that are critical for transmitting M-CSF-initiated signals individually required for OC formation or function, respectively...
  34. pmc Fyn promotes proliferation, differentiation, survival and function of osteoclast lineage cells
    Hyun Ju Kim
    Department of Pathology and Immunology, Washington University in St Louis School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biochem 111:1107-13. 2010
    ..Thus, Fyn is a pro-resorptive SFK, which exerts its effects by prompting proliferation and differentiation while attenuating apoptosis of OC lineage cells...
  35. pmc Osteoclasts: what do they do and how do they do it?
    Steven L Teitelbaum
    Department of Pathology and Immunology, Washington University School of Medicine, Campus Box 8118, 660 South Euclid Ave, St Louis, MO 63110, USA
    Am J Pathol 170:427-35. 2007
    ..This review focuses on these and other molecules that mediate osteoclast differentiation or function and thus serve as candidate anti-osteoporosis therapeutic targets...
  36. pmc The Src family kinase, Lyn, suppresses osteoclastogenesis in vitro and in vivo
    Hyun Ju Kim
    Department of Pathology and Immunology, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 106:2325-30. 2009
    ..The most pragmatic aspect of our findings is that successful therapeutic inhibition of c-Src, in the context of the osteoclast, will require its stringent targeting...
  37. pmc Synaptotagmin VII regulates bone remodeling by modulating osteoclast and osteoblast secretion
    Haibo Zhao
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Dev Cell 14:914-25. 2008
    ..Therefore, synaptotagmin VII plays an important role in bone remodeling and homeostasis by modulating secretory pathways functionally important in osteoclasts and osteoblasts...
  38. ncbi request reprint NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells
    Shuting Bai
    Departments of Pathology and Immunology, Molecular Biology and Pharmacology, and Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Biol Chem 283:6509-18. 2008
    ..These observations raise caution that therapeutic inhibition of NOTCH signaling may adversely accelerate bone loss in humans...
  39. pmc Paxillin contracts the osteoclast cytoskeleton
    Wei Zou
    Department of Pathology and Immunology, School of Medicine, Washington University, St Louis, MO 63110, USA
    J Bone Miner Res 27:2490-500. 2012
    ..Thus, in response to RANKL, paxillin associates with myosin IIA to contract the osteoclast cytoskeleton, thereby promoting its bone-degrading capacity...
  40. pmc The IkappaB function of NF-kappaB2 p100 controls stimulated osteoclastogenesis
    Deborah Veis Novack
    Washington University School of Medicine, 660 S Euclid Ave, Box 8301, St Louis, MO 63110, USA
    J Exp Med 198:771-81. 2003
    ..These data demonstrate a novel, biologically relevant means of regulating NF-kappaB signaling, with upstream control and kinetics distinct from the classical IkappaBalpha pathway...
  41. pmc Glucocorticoids suppress bone formation via the osteoclast
    Hyun Ju Kim
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 116:2152-60. 2006
    ..Consistent with osteoclasts modulating the osteoblast-suppressive effect of DEX, GRoc-/- mice are protected from the steroid's inhibition of bone formation...
  42. ncbi request reprint Glucocorticoids and the osteoclast
    Hyun Ju Kim
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann N Y Acad Sci 1116:335-9. 2007
    ..Consistent with osteoclasts modulating the osteoblast-suppressive effect of dexamethasone, GC receptor-deficient mice are protected from the steroid's inhibition of bone formation...
  43. pmc Type I phosphotidylinosotol 4-phosphate 5-kinase γ regulates osteoclasts in a bifunctional manner
    Tingting Zhu
    Department of Pathology and Immunology, Washington University in St Louis School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 288:5268-77. 2013
    ..Thus, optimal PIP5KIγ and PI(4,5)P(2) expression, by osteoclasts, are essential for skeletal homeostasis...
  44. pmc IL-17 mediates estrogen-deficient osteoporosis in an Act1-dependent manner
    Carl J DeSelm
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biochem 113:2895-902. 2012
    ..Estrogen deprivation, therefore, promotes RANKL expression and bone resorption in association with upregulation of the IL-17 effector, Act1, supporting the concept that post-menopausal osteoporosis is a disorder of innate immunity...
  45. pmc Cytoskeletal dysfunction dominates in DAP12-deficient osteoclasts
    Wei Zou
    Pathology and Immunology, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA
    J Cell Sci 123:2955-63. 2010
    ..The failure of osteoblasts to normalize Dap12(-/-) osteoclasts indicates that functionally relevant quantities of OSCAR ligand do not reside in bone-forming cells...
  46. ncbi request reprint Unoccupied alpha(v)beta3 integrin regulates osteoclast apoptosis by transmitting a positive death signal
    Haibo Zhao
    Department of Pathology and Immunology, Washington University School of Medicine, Campus Box 8118, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Mol Endocrinol 19:771-80. 2005
    ..Thus, unoccupied alpha(v)beta3 integrin regulates osteoclast apoptosis via a component of the integrin that is different than that regulating resorption...
  47. pmc Halofuginone prevents estrogen-deficient osteoporosis in mice
    Carl J DeSelm
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Biochem 113:3086-92. 2012
    ..Thus, halofuginone, which is presently FDA-approved for treatment of scleroderma, is a candidate therapeutic for post-menopausal osteoporosis...
  48. doi request reprint How do bone cells secrete proteins?
    Haibo Zhao
    Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Adv Exp Med Biol 658:105-9. 2010
    ..Thus, SytVII-deficient mice experience suppressed bone resorption and formation with the latter deficiency predominant thereby yielding osteoporosis characterized by attenuated remodeling...
  49. ncbi request reprint alphavbeta3 and macrophage colony-stimulating factor: partners in osteoclast biology
    F Patrick Ross
    Washington University School of Medicine, St Louis, MO 63110, USA
    Immunol Rev 208:88-105. 2005
    ..Signals from alphavbeta3 and/or c-Fms activate Syk and Vav3, originally defined by their function in lymphoid cells. Genetic depletion of either protein generates a strong bone phenotype, underscoring the promise of osteoimmunobiology...
  50. pmc RANKing c-Jun in osteoclast development
    Steven L Teitelbaum
    Department of Pathology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Clin Invest 114:463-5. 2004
  51. pmc Rac deletion in osteoclasts causes severe osteopetrosis
    Monica Croke
    Department of Pathology and Immunology, Washington University in St Louis, School of Medicine, St Louis, MO 63110, USA
    J Cell Sci 124:3811-21. 2011
    ..Thus, Rac1 and Rac2 are mutually compensatory. Unlike Cdc42 deficiency, their combined absence does not impact upon differentiation but promotes severe osteopetrosis by dysregulating the osteoclast cytoskeleton...
  52. ncbi request reprint Direct inhibition of NF-kappa B blocks bone erosion associated with inflammatory arthritis
    John C Clohisy
    Department of Orthopaedic Research Laboratory, Barnes Jewish Hospital at Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 171:5547-53. 2003
    ..Thus, NF-kappaB appears to be the centerpiece of inflammatory-osteolytic arthritis and direct inhibition of this transcription factor by unique and novel I-kappaB mutant proteins blocks manifestation of the disease...
  53. pmc Osteoclasts; culprits in inflammatory osteolysis
    Steven L Teitelbaum
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8118, St Louis, MO 63110, USA
    Arthritis Res Ther 8:201. 2006
    ..Achieving an understanding of the mechanisms by which the three cytokines affect the osteoclast has resulted in a number of active and candidate therapeutic targets...
  54. doi request reprint Integrins, growth factors, and the osteoclast cytoskeleton
    Wei Zou
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Ann N Y Acad Sci 1192:27-31. 2010
    ..Integrin/bone recognition also promotes formation of actin rings, which surround the ruffled border, thereby isolating the focus of skeletal degradation from the general extracellular space...
  55. ncbi request reprint SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts
    Sunao Takeshita
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Med 8:943-9. 2002
    ..Thus, SHIP negatively regulates osteoclast formation and function and the absence of this enzyme results in severe osteoporosis...
  56. pmc Autophagy proteins regulate the secretory component of osteoclastic bone resorption
    Carl J DeSelm
    Department of Pathology, Washington University Medical School, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Dev Cell 21:966-74. 2011
    ..These findings are in keeping with a putative link between autophagy genes and human skeletal homeostasis...
  57. pmc Dissection of platelet and myeloid cell defects by conditional targeting of the beta3-integrin subunit
    Elizabeth A Morgan
    Department of Medicine, Mallinkrodt Institute of Radiology, St Louis, Missouri, USA
    FASEB J 24:1117-27. 2010
    ..Hurchla, M. A., Deng, H., Floyd, D., Berdy, A., Prior, J. L., Piwnica-Worms, D., Teitelbaum, S. L., Ross, F. P., Weilbaecher, K. N. Dissection of platelet and myeloid cell defects by conditional targeting of the beta3-integrin subunit...
  58. doi request reprint Stem cells and osteoporosis therapy
    Steven L Teitelbaum
    Department of Pathology and Immunology, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA
    Cell Stem Cell 7:553-4. 2010
    ..In this issue of Cell Stem Cell, Wu et al. (2010) demonstrate that this event is mediated by osteoclastic mobilization of active transforming growth factor β1, which is inhibited by a common antiosteoporosis drug...
  59. ncbi request reprint The osteoclast: friend or foe?
    Deborah V Novack
    Department of Pathology and Immunology, Division of Bone and Mineral Diseases, Washington University School of Medicine, St Louis, MO 63110, USA
    Annu Rev Pathol 3:457-84. 2008
    ..In these diseases, osteoclast activity causes bone loss that leads to pain, deformity, and fracture. Thus, osteoclasts are critical for normal bone function, but their activity must be controlled...
  60. ncbi request reprint Osteoclasts and integrins
    Steven L Teitelbaum
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann N Y Acad Sci 1068:95-9. 2006
    ..Our studies have investigated whether absence of the alphavbeta3 integrin modifies the ability of c-Fms to induce Rho GTPases, and the implications for formation of the osteoclast cytoskeleton...
  61. pmc RANKL employs distinct binding modes to engage RANK and the osteoprotegerin decoy receptor
    Christopher A Nelson
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110 1093, USA
    Structure 20:1971-82. 2012
    ..These results suggest cytokine plasticity may help to fine-tune specific tumor necrosis factor (TNF)-family cytokine/receptor pair selectivity...
  62. ncbi request reprint Interleukin-4 reversibly inhibits osteoclastogenesis via inhibition of NF-kappa B and mitogen-activated protein kinase signaling
    Shi Wei
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 277:6622-30. 2002
    ....
  63. pmc Postmenopausal osteoporosis, T cells, and immune dysfunction
    Steven L Teitelbaum
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 101:16711-2. 2004
  64. ncbi request reprint Bone weighs in on obesity
    Clay F Semenkovich
    Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell 130:409-11. 2007
    ..In this issue of Cell, Lee et al. (2007) demonstrate in mice that bone regulates the insulin/glucose axis and energy metabolism, providing a new framework for approaching common disorders of bioenergetics...
  65. ncbi request reprint Osteopetrosis
    Jakub Tolar
    Program in Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis 55455, USA
    N Engl J Med 351:2839-49. 2004
  66. ncbi request reprint Mice lacking the integrin beta5 subunit have accelerated osteoclast maturation and increased activity in the estrogen-deficient state
    Nancy E Lane
    Department of Medicine, University of California at San Francisco, San Francisco, California 94143, USA
    J Bone Miner Res 20:58-66. 2005
    ..These preliminary data suggest alphavbeta5 integrin's presence on osteoclast precursors may inhibit of osteoclast formation...
  67. pmc Rab3D regulates a novel vesicular trafficking pathway that is required for osteoclastic bone resorption
    Nathan J Pavlos
    Unit of Orthopaedics, School of Surgery and Pathology, University of Western Australia, 2nd Floor M Block, QEII Medical Centre, Nedlands, Perth, Western Australia 6009, Australia
    Mol Cell Biol 25:5253-69. 2005
    ..Collectively, our data suggest that Rab3D modulates a post-TGN trafficking step that is required for osteoclastic bone resorption...
  68. ncbi request reprint Osteoporosis and integrins
    Steven L Teitelbaum
    J Clin Endocrinol Metab 90:2466-8. 2005