Phillip I Tarr

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome
    Phillip I Tarr
    Division of Gastroenterology, Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, Campus Box 8208, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Lancet 365:1073-86. 2005
  2. pmc Further evidence of constrained radiation in the evolution of pathogenic Escherichia coli O157:H7
    Shana R Leopold
    Washington University School of Medicine, Department of Pediatrics, Saint Louis, MO 63110, USA
    Infect Genet Evol 10:1282-5. 2010
  3. pmc Diarrhea etiology in a pediatric emergency department: a case control study
    Donna M Denno
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA
    Clin Infect Dis 55:897-904. 2012
  4. ncbi request reprint Fim operon variation in the emergence of Enterohemorrhagic Escherichia coli: an evolutionary and functional analysis
    Nurmohammad Shaikh
    Washington University School of Medicine, St Louis, MO 63110, USA
    FEMS Microbiol Lett 273:58-63. 2007
  5. doi request reprint Deer sausage: a newly identified vehicle of transmission of Escherichia coli O157:H7
    Christina K Ahn
    Department of Pediatrics, Division of Gastroenterology and Nutrition, Washington University, Saint Louis, MO 63110, USA
    J Pediatr 155:587-9. 2009
  6. pmc The late 1970s: a lull in the action on kuru
    Phillip I Tarr
    Edward Mallinckrodt Department of Pediatrics, Division of Gastroenterology, Washington University School of Medicine, St Louis, MO 63110, USA
    Philos Trans R Soc Lond B Biol Sci 363:3668-70. 2008
  7. doi request reprint Detection of low-concentration host mRNA transcripts in Malawian children at risk for environmental enteropathy
    Sophia Agapova
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA
    J Pediatr Gastroenterol Nutr 56:66-71. 2013
  8. pmc Obscured phylogeny and possible recombinational dormancy in Escherichia coli
    Shana R Leopold
    Department of Pediatrics, Washington University School of Medicine, Saint Louis, USA
    BMC Evol Biol 11:183. 2011
  9. pmc Use and accuracy of diagnostic imaging by hospital type in pediatric appendicitis
    Jacqueline M Saito
    Division of Pediatric Surgery, Washington University, One Children s Pl, Suite 5S40, St Louis, MO 63110 63110, USA
    Pediatrics 131:e37-44. 2013
  10. pmc Bacterial DNA content in the intestinal wall from infants with necrotizing enterocolitis
    Brian T Bucher
    Division of Pediatric Surgery, Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Pediatr Surg 46:1029-33. 2011

Collaborators

Detail Information

Publications54

  1. ncbi request reprint Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome
    Phillip I Tarr
    Division of Gastroenterology, Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, Campus Box 8208, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Lancet 365:1073-86. 2005
    ..The vascular injury leading to HUS is likely to be well under way by the time infected patients seek medical attention for diarrhoea. The best way to prevent HUS is to prevent primary infection with Shiga-toxin-producing bacteria...
  2. pmc Further evidence of constrained radiation in the evolution of pathogenic Escherichia coli O157:H7
    Shana R Leopold
    Washington University School of Medicine, Department of Pediatrics, Saint Louis, MO 63110, USA
    Infect Genet Evol 10:1282-5. 2010
    ..Our results suggest that successful Cluster 2 strains have radiated on only two branches from their founder; one of these two branches leads to Cluster 3. Constrained radiation appears to be a common theme among this pathogenic clade...
  3. pmc Diarrhea etiology in a pediatric emergency department: a case control study
    Donna M Denno
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA
    Clin Infect Dis 55:897-904. 2012
    ..The etiology of childhood diarrhea is frequently unknown...
  4. ncbi request reprint Fim operon variation in the emergence of Enterohemorrhagic Escherichia coli: an evolutionary and functional analysis
    Nurmohammad Shaikh
    Washington University School of Medicine, St Louis, MO 63110, USA
    FEMS Microbiol Lett 273:58-63. 2007
    ..coli (EHEC) tested. An N135K FimH mutation in the two most evolved O157:H7 clusters is not found in other EHEC. These data refine the evolutionary history of an emerging pathogen...
  5. doi request reprint Deer sausage: a newly identified vehicle of transmission of Escherichia coli O157:H7
    Christina K Ahn
    Department of Pediatrics, Division of Gastroenterology and Nutrition, Washington University, Saint Louis, MO 63110, USA
    J Pediatr 155:587-9. 2009
    ....
  6. pmc The late 1970s: a lull in the action on kuru
    Phillip I Tarr
    Edward Mallinckrodt Department of Pediatrics, Division of Gastroenterology, Washington University School of Medicine, St Louis, MO 63110, USA
    Philos Trans R Soc Lond B Biol Sci 363:3668-70. 2008
  7. doi request reprint Detection of low-concentration host mRNA transcripts in Malawian children at risk for environmental enteropathy
    Sophia Agapova
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA
    J Pediatr Gastroenterol Nutr 56:66-71. 2013
    ..Our objective was to develop a method for detecting human mRNA suggestive of environmental enteropathy (EE) in feces...
  8. pmc Obscured phylogeny and possible recombinational dormancy in Escherichia coli
    Shana R Leopold
    Department of Pediatrics, Washington University School of Medicine, Saint Louis, USA
    BMC Evol Biol 11:183. 2011
    ..We analyzed single nucleotide polymorphisms in chromosomes of representative strains to reconstruct the topology of its emergence...
  9. pmc Use and accuracy of diagnostic imaging by hospital type in pediatric appendicitis
    Jacqueline M Saito
    Division of Pediatric Surgery, Washington University, One Children s Pl, Suite 5S40, St Louis, MO 63110 63110, USA
    Pediatrics 131:e37-44. 2013
    ..Here, we characterize recent preoperative imaging use and accuracy among pediatric appendectomy subjects...
  10. pmc Bacterial DNA content in the intestinal wall from infants with necrotizing enterocolitis
    Brian T Bucher
    Division of Pediatric Surgery, Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Pediatr Surg 46:1029-33. 2011
    ..The objective of our study was to quantify mucosal bacterial DNA within specimens from neonates undergoing small bowel resection for necrotizing enterocolitis (NEC)...
  11. ncbi request reprint ABO and P1 blood group antigen expression and stx genotype and outcome of childhood Escherichia coli O157:H7 infections
    Srdjan Jelacic
    Division of Gastroenterology, Department of Pediatrics, Children s Hospital and Regional Medical Center, Seattle, WA 98105, USA
    J Infect Dis 185:214-9. 2002
    ..In the present study, ABO antigens and stx genotypes were not major determinants of the outcome of E. coli O157:H7 infections, and P1 expression did not protect against the development of HUS...
  12. pmc A precise reconstruction of the emergence and constrained radiations of Escherichia coli O157 portrayed by backbone concatenomic analysis
    Shana R Leopold
    Department of Pediatrics, Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 106:8713-8. 2009
    ..However, constrained radiations raise the possibility of making false associations between isolates...
  13. ncbi request reprint Platelet-activating factor and Escherichia coliO157:H7 infections
    Jodi M Smith
    Division of Nephrology, Children s Hospital and Regional Medical Center, Department of Pediatrics, University of Washington, Seattle, Washington, USA
    Pediatr Nephrol 17:1047-52. 2002
    ..Thus, elevated plasma PAF levels occur in E. coliO157:H7-infected children, even without HUS, but diminish when HUS develops. The PAF-AH ( G994T) allele does not contribute to the risk of developing HUS...
  14. pmc Metagenomic analysis of human diarrhea: viral detection and discovery
    Stacy R Finkbeiner
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Pathog 4:e1000011. 2008
    ..Using this methodology we detected known enteric viruses as well as multiple sequences from putatively novel viruses with only limited sequence similarity to viruses in GenBank...
  15. pmc The IrgA homologue adhesin Iha is an Escherichia coli virulence factor in murine urinary tract infection
    James R Johnson
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, Campus Box 8208, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Infect Immun 73:965-71. 2005
    ..11). These data suggest that Iha(CFT073) is a virulence factor and might be a target for anti-UTI interventions...
  16. doi request reprint Early volume expansion during diarrhea and relative nephroprotection during subsequent hemolytic uremic syndrome
    Christina A Hickey
    Division of Gastroenterology and Nutrition, Department of Pediatrics, Washington University School of Medicine, 1 Children s Place, St Louis, MO 63110, USA
    Arch Pediatr Adolesc Med 165:884-9. 2011
    ..To determine if interventions during the pre-hemolytic uremic syndrome (HUS) diarrhea phase are associated with maintenance of urine output during HUS...
  17. doi request reprint Enteric infections and diagnostic testing
    William E Bennett
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Curr Opin Gastroenterol 25:1-7. 2009
    ..We aim to provide a clinically pertinent assessment of the current state of our ability to diagnose human gastrointestinal pathogens and describe (and decry) the unsophistication of many current diagnostic methods and strategies...
  18. doi request reprint Acute bloody diarrhea: a medical emergency for patients of all ages
    Lori R Holtz
    Department of Pediatrics, Division of Gastroenterology and Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Gastroenterology 136:1887-98. 2009
    ..These topics are discussed in the context of the medical care that is available to children and adults with bloody diarrhea in most institutions in developed nations...
  19. ncbi request reprint Shiga toxin-producing Escherichia coli in children with diarrhea: a prospective point-of-care study
    Eileen J Klein
    Department of Pediatrics, University of Washington and Children s Hospital and Regional Medical Center, Seattle, Washington, 98105, USA
    J Pediatr 141:172-7. 2002
    ....
  20. ncbi request reprint Cardiac ischemia during hemolytic uremic syndrome
    Meena Thayu
    Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA
    Pediatr Nephrol 18:286-9. 2003
    ..It is possible that myocardial ischemia and secondary arrhythmias account for some sudden deaths that occur during acute HUS...
  21. ncbi request reprint Diarrhea etiology in a Children's Hospital Emergency Department: a prospective cohort study
    Eileen J Klein
    Department of Pediatrics, University of Washington and Children s Hospital and Regional Medical Center, Seattle, WA, USA
    Clin Infect Dis 43:807-13. 2006
    ..We evaluated the frequency of recovery of pathogens from children with diarrhea who presented to a pediatric emergency department and characterized the associated illnesses, to develop guidelines for performing a bacterial enteric culture...
  22. ncbi request reprint Etiology of diarrhea in pediatric outpatient settings
    Donna M Denno
    Department of Pediatrics, University of Washington and Harborview Medical Center, University of Washington and Children s Hospital and Regional Medical Center, Seattle, WA, USA
    Pediatr Infect Dis J 24:142-8. 2005
    ..We attempted to determine the microbiologic etiology of diarrhea in a private pediatric practice (site A) and a clinic serving largely immigrant children (site B) and to establish guidelines for bacterial culture...
  23. doi request reprint Parental management of childhood diarrhea
    Su Ting T Li
    Department of Pediatrics, University of California Davis, Sacramento, California 95817, USA
    Clin Pediatr (Phila) 48:295-303. 2009
    ..Further data on effectiveness of functional foods and education regarding avoidance of potentially harmful medications are needed...
  24. pmc Loop-mediated isothermal amplification assay for rapid detection of common strains of Escherichia coli
    Joshua Hill
    Department of Pediatrics, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    J Clin Microbiol 46:2800-4. 2008
    ..It detected all 36 of 36 E. coli isolates and all 22 urine samples (out of 89 samples tested) that had E. coli. This assay is rapid, low in cost, and simple to perform...
  25. doi request reprint Isolation of patients acutely infected with Escherichia coli O157:H7: low-tech, highly effective prevention of hemolytic uremic syndrome
    Christina K Ahn
    Clin Infect Dis 46:1197-9. 2008
  26. pmc Greater diversity of Shiga toxin-encoding bacteriophage insertion sites among Escherichia coli O157:H7 isolates from cattle than in those from humans
    Thomas E Besser
    Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 7040, USA
    Appl Environ Microbiol 73:671-9. 2007
    ..coli O157:H7 genotypes...
  27. ncbi request reprint Enterohaemorrhagic Escherichia coli in human medicine
    Helge Karch
    Institute for Hygiene, and National Consulting Laboratory on Haemolytic Uraemic Syndrome, University Hospital Munster, Robert Koch Str 41, D 48149 Munster, Germany
    Int J Med Microbiol 295:405-18. 2005
    ..This review will focus on the microbiology, epidemiology, and pathophysiology of EHEC-associated diseases, and illustrate future challenges and opportunities for their control...
  28. ncbi request reprint Relative nephroprotection during Escherichia coli O157:H7 infections: association with intravenous volume expansion
    Julie A Ake
    Department of Medicine, Madigan Army Medical Center, Tacoma, Washington, USA
    Pediatrics 115:e673-80. 2005
    ....
  29. ncbi request reprint Rebuttal to: von Willebrand factor-cleaving protease in childhood diarrhoea-associated haemolytic uraemic syndrome
    Han Mou Tsai
    Thromb Haemost 87:548-9; author's reply 549-50. 2002
  30. ncbi request reprint Escherichia coli O157:H7 infections: discordance between filterable fecal shiga toxin and disease outcome
    Nancy A Cornick
    Department of Veterinary Microbiology and Preventative Medicine, Iowa State University, Ames, Iowa, USA
    J Infect Dis 186:57-63. 2002
    ..These data suggest that therapeutic and diagnostic strategies directed toward binding or identifying intraintestinal fecal Stx may have limited success...
  31. pmc Molecular characterization of a serotype O121:H19 clone, a distinct Shiga toxin-producing clone of pathogenic Escherichia coli
    Cheryl L Tarr
    Microbial Evolution Laboratory, National Food Safety and Toxicology Center, Michigan State University, East Lansing 48824, USA
    Infect Immun 70:6853-9. 2002
    ..On the basis of sequencing analysis with 13 housekeeping genes, the O121:H19 clone did not fall into any of the four classical EHEC and enteropathogenic E. coli groups but instead was closely related to two eae-negative STEC strains...
  32. ncbi request reprint Risk of hemolytic uremic syndrome from antibiotic treatment of Escherichia coli O157:H7 colitis
    Phillip I Tarr
    JAMA 288:3111-2; author reply 3112. 2002
  33. ncbi request reprint Shiga toxin-producing Escherichia coli in Montana: bacterial genotypes and clinical profiles
    Jill K Jelacic
    University of Washington School of Medicine, Seattle, Washington, USA
    J Infect Dis 188:719-29. 2003
    ..033). Non-O157:H7 STEC are more heterogeneous and cause bloody diarrhea less frequently than do E. coli O157:H7. Bloody diarrhea cannot be attributed simply to the stx genotype of the infecting organism...
  34. ncbi request reprint Prothrombotic coagulation abnormalities preceding the hemolytic-uremic syndrome
    Wayne L Chandler
    Department of Laboratory Medicine, University of Washington School of Medicine, Seattle 98105, USA
    N Engl J Med 346:23-32. 2002
    ..The hemolytic-uremic syndrome is a thrombotic complication of Escherichia coli O157:H7 infection. It is not known whether the coagulation abnormalities precede, and potentially cause, this disorder...
  35. ncbi request reprint Reducing stunting among children: the potential contribution of diagnostics
    Karen A Ricci
    RAND Corporation, 1776 Main Street, PO Box 2138, Santa Monica, California 90407 2138, USA
    Nature 444:29-38. 2006
  36. ncbi request reprint Thrombotic microangiopathies
    Phillip I Tarr
    N Engl J Med 347:2171-3; author reply 2171-3. 2002
  37. pmc Using antibiotics in suspected haemolytic-uraemic syndrome: antibiotics should not be used in Escherichia coli O157:H7 infection
    Stephanie Dundas
    BMJ 330:1209; author reply 1209. 2005
  38. ncbi request reprint StcE, a metalloprotease secreted by Escherichia coli O157:H7, specifically cleaves C1 esterase inhibitor
    Wyndham W Lathem
    Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, WI 53706, USA
    Mol Microbiol 45:277-88. 2002
    ..Cleavage of C1-INH by StcE could plausibly cause localized pro-inflammatory and coagulation responses resulting in tissue damage, intestinal oedema and thrombotic abnormalities...
  39. pmc Expression of putative virulence factors of Escherichia coli O157:H7 differs in bovine and human infections
    Rebecca A Rashid
    Department of Microbiology, University of Washington, 1959 N E Pacific St, Mail Stop 357242, Seattle, WA 98195, USA
    Infect Immun 74:4142-8. 2006
    ..Our results support the hypothesis that some virulence-associated genes of O157:H7 are differentially expressed in a host-specific manner...
  40. pmc Proteomics-based expression library screening (PELS): a novel method for rapidly defining microbial immunoproteomes
    Indira T Kudva
    Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Mol Cell Proteomics 5:1514-9. 2006
    ..In this report, we demonstrate "proof-of-principle" by identifying 207 proteins of the Escherichia coli O157:H7 immunome in bovine reservoirs in only 3 weeks...
  41. pmc Analysis of urinary Escherichia coli isolates for ability to produce Shiga toxin
    James R Johnson
    Medical Service, VA Medical Center, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA
    J Clin Microbiol 40:2247-8. 2002
    ..We tested 597 urinary E. coli isolates by Stx immunoassay and found no STEC. The routine screening of urinary E. coli for the ability to produce Stx is not warranted...
  42. pmc Lipopolysaccharide from enterohemorrhagic Escherichia coli binds to platelets through TLR4 and CD62 and is detected on circulating platelets in patients with hemolytic uremic syndrome
    Anne lie Ståhl
    Department of Pediatrics, Clinical Sciences Lund, the Institute of Laboratory Medicine, Section for Microbiology, Immunology and Glycobiology, Lund University, 22185 Lund, Sweden
    Blood 108:167-76. 2006
    ..These data suggest that O157LPS on platelets might contribute to platelet consumption in HUS...
  43. ncbi request reprint Basic fibroblast growth factor and Shiga toxin-O157:H7-associated hemolytic uremic syndrome
    Phillip I Tarr
    J Am Soc Nephrol 13:817-20. 2002
  44. pmc Single multiplex polymerase chain reaction to detect diverse loci associated with diarrheagenic Escherichia coli
    Catalina Lopez-Saucedo
    Dpto de Biomedicina Molecular, CINVESTAV IPN, Mexico D F, Mexico
    Emerg Infect Dis 9:127-31. 2003
    ..Because of its simplicity, economy, and efficiency, this protocol warrants further evaluation in large, prospective studies of polymicrobial substances...
  45. ncbi request reprint Hemolytic uremic syndrome in association with typhoid fever
    Ali Albaqali
    Department of Internal Medicine, Salmaniya Medical Complex, Manama, Bahrain
    Am J Kidney Dis 41:709-13. 2003
    ..The authors report on a patient with typhoid fever in whom HUS and myocarditis developed during the course of his illness and in whom there was no evidence of a Shiga-toxin (Stx)-producing organism...
  46. pmc Shiga toxin gene loss and transfer in vitro and in vivo during enterohemorrhagic Escherichia coli O26 infection in humans
    Martina Bielaszewska
    Institute for Hygiene and the National Consulting Laboratory on Hemolytic Uremic Syndrome, University of Munster, Germany
    Appl Environ Microbiol 73:3144-50. 2007
    ..The suggested occurrence of this process in the human intestine has diagnostic, clinical, epidemiological, and evolutionary implications...
  47. ncbi request reprint Confirmation of an old adage: you find what you seek
    Philip M Sherman
    J Pediatr 146:11-3. 2005
  48. ncbi request reprint Explaining unexplained diarrhea and associating risks and infections
    Donna M Denno
    Department of Health Services, University of Washington School of Medicine, Seattle, WA, USA
    Anim Health Res Rev 8:69-80. 2007
    ..By filling these gaps in our knowledge it should be possible to formulate rational prevention mechanisms for human gastrointestinal illnesses...
  49. pmc Phenotypic and molecular analysis of tellurite resistance among enterohemorrhagic Escherichia coli O157:H7 and sorbitol-fermenting O157:NM clinical isolates
    Martina Bielaszewska
    Institut fur Hygiene, Universitatsklinikum Munster, Robert Koch Str 41, 48149 Munster, Germany
    J Clin Microbiol 43:452-4. 2005
    ..5%) of 86 sorbitol-fermenting (SF) EHEC O157:NM strains had Te MICs of </=4 microg/ml, did not grow on Te-containing media, and lacked ter genes. Optimal detection of SF EHEC O157:NM strains requires Te-independent strategies...
  50. pmc Shiga toxin antigen detection should not replace sorbitol MacConkey agar screening of stool specimens
    Eileen J Klein
    J Clin Microbiol 42:4416; author reply 4416-7. 2004
  51. pmc Use of in vivo-induced antigen technology for identification of Escherichia coli O157:H7 proteins expressed during human infection
    Manohar John
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA
    Infect Immun 73:2665-79. 2005
    ..Also, such proteins may be exploited as markers of O157 infection in stool specimens...
  52. pmc Expression of the Escherichia coli IrgA homolog adhesin is regulated by the ferric uptake regulation protein
    Rebecca A Rashid
    Department of Microbiology, University of Washington, 1959 NE Pacific St Mailstop 357242, Seattle, WA 98195, USA
    Microb Pathog 41:207-17. 2006
    ..We identified strain-dependent differences in iha expression and determined that single nucleotide polymorphisms upstream of the iha promoter, in particular position -85, contribute to differences in expression levels...
  53. pmc Escherichia coli O157:H7 Shiga toxin-encoding bacteriophages: integrations, excisions, truncations, and evolutionary implications
    Nurmohammad Shaikh
    Children s Hospital and the University of Washington, Seattle, Washington, USA
    J Bacteriol 185:3596-605. 2003
    ....
  54. ncbi request reprint Intestinal infections and environmental enteropathy: Working Group report of the second World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition
    Eduardo Salazar-Lindo
    J Pediatr Gastroenterol Nutr 39:S662-9. 2004