LARRY TABER

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Computational model for the transition from peristaltic to pulsatile flow in the embryonic heart tube
    Larry A Taber
    Department of Biomedical Engineering, Washington University, Campus Box 1097, St Louis, MO 63130, USA
    J Biomech Eng 129:441-9. 2007
  2. pmc Towards a unified theory for morphomechanics
    Larry A Taber
    Department of Biomedical Engineering, Washington University, Louis, MO 63130, USA
    Philos Transact A Math Phys Eng Sci 367:3555-83. 2009
  3. ncbi request reprint Biophysical mechanisms of cardiac looping
    Larry A Taber
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    Int J Dev Biol 50:323-32. 2006
  4. pmc The role of mechanical forces in the torsional component of cardiac looping
    Larry A Taber
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Ann N Y Acad Sci 1188:103-10. 2010
  5. pmc Theoretical study of Beloussov's hyper-restoration hypothesis for mechanical regulation of morphogenesis
    Larry A Taber
    Department of Biomedical Engineering, Washington University, Campus Box 1097, St Louis, MO 63130, USA
    Biomech Model Mechanobiol 7:427-41. 2008
  6. ncbi request reprint Computational model for early cardiac looping
    Ashok Ramasubramanian
    Department of Biomedical Engineering, Washington University, Campus Box 1097, St Louis, MO 63130, USA
    Ann Biomed Eng 34:1655-69. 2006
  7. ncbi request reprint Material properties and residual stress in the stage 12 chick heart during cardiac looping
    Evan A Zamir
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    J Biomech Eng 126:823-30. 2004
  8. pmc Computational modeling of morphogenesis regulated by mechanical feedback
    Ashok Ramasubramanian
    Department of Biomedical Engineering, Washington University, Campus Box 1097, St Louis, MO 63130, USA
    Biomech Model Mechanobiol 7:77-91. 2008
  9. ncbi request reprint On the effects of residual stress in microindentation tests of soft tissue structures
    Evan A Zamir
    Department of Biomedical Engineering, Washington University, St Louis, MO, USA
    J Biomech Eng 126:276-83. 2004
  10. ncbi request reprint Morphogenetic adaptation of the looping embryonic heart to altered mechanical loads
    Nandan L Nerurkar
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Dev Dyn 235:1822-9. 2006

Collaborators

  • Philip Bayly
  • Nandan L Nerurkar
  • Christopher D Kroenke
  • JAY HUMPHREY
  • L V Wang
  • Igor Efimov
  • Gang Xu
  • Ashok Ramasubramanian
  • Patrick W Alford
  • Dmitry A Voronov
  • Benjamen A Filas
  • Evan A Zamir
  • Mathieu C Rémond
  • Victor D Varner
  • Junjie Yao
  • Andrew K Knutsen
  • Elliot L Elson
  • Kimberly S Latacha
  • Steren Chabert
  • Philip S Kemp
  • Adam M Beagley
  • Yunfei Shi
  • Joyce A Hwu
  • Krikor Dikranian
  • Konstantin I Maslov
  • Kate H Achtien
  • Jessica M Benjamin
  • Kimberley S Latacha
  • Arvind Ravi
  • Judy A Fee
  • Dimtry A Voronov
  • Amy Y Chen
  • Renato Perucchio
  • Varahoor Srinivasan

Detail Information

Publications27

  1. ncbi request reprint Computational model for the transition from peristaltic to pulsatile flow in the embryonic heart tube
    Larry A Taber
    Department of Biomedical Engineering, Washington University, Campus Box 1097, St Louis, MO 63130, USA
    J Biomech Eng 129:441-9. 2007
    ..This study illustrates the interrelationship between form and function in the early embryonic heart...
  2. pmc Towards a unified theory for morphomechanics
    Larry A Taber
    Department of Biomedical Engineering, Washington University, Louis, MO 63130, USA
    Philos Transact A Math Phys Eng Sci 367:3555-83. 2009
    ..g. the heart, arteries and brain), wound healing and sea urchin gastrulation. Understanding the fundamental principles of tissue construction can help engineers design new strategies for creating replacement tissues and organs in vitro...
  3. ncbi request reprint Biophysical mechanisms of cardiac looping
    Larry A Taber
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    Int J Dev Biol 50:323-32. 2006
    ..Understanding morphogenetic mechanisms would facilitate research devoted to preventing and treating congenital heart malformations caused by looping abnormalities...
  4. pmc The role of mechanical forces in the torsional component of cardiac looping
    Larry A Taber
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Ann N Y Acad Sci 1188:103-10. 2010
    ..For each perturbation, the models predict the correct qualitative response. These studies provide new insight into the mechanisms that drive and regulate cardiac looping...
  5. pmc Theoretical study of Beloussov's hyper-restoration hypothesis for mechanical regulation of morphogenesis
    Larry A Taber
    Department of Biomedical Engineering, Washington University, Campus Box 1097, St Louis, MO 63130, USA
    Biomech Model Mechanobiol 7:427-41. 2008
    ..Other processes, however, may require secondary mechanisms or perturbations to proceed to completion...
  6. ncbi request reprint Computational model for early cardiac looping
    Ashok Ramasubramanian
    Department of Biomedical Engineering, Washington University, Campus Box 1097, St Louis, MO 63130, USA
    Ann Biomed Eng 34:1655-69. 2006
    ..The model was tested further in studies that perturbed normal cardiac morphogenesis. The model, taken together with the new experimental data, supports our hypothesis for the mechanisms that drive early looping...
  7. ncbi request reprint Material properties and residual stress in the stage 12 chick heart during cardiac looping
    Evan A Zamir
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    J Biomech Eng 126:823-30. 2004
    ..These results should be useful for computational models of the looping heart...
  8. pmc Computational modeling of morphogenesis regulated by mechanical feedback
    Ashok Ramasubramanian
    Department of Biomedical Engineering, Washington University, Campus Box 1097, St Louis, MO 63130, USA
    Biomech Model Mechanobiol 7:77-91. 2008
    ..Results presented for bending of bilayered beams and invagination of cylindrical and spherical shells provide insight into some of the mechanical aspects that must be considered in studying morphogenetic mechanisms...
  9. ncbi request reprint On the effects of residual stress in microindentation tests of soft tissue structures
    Evan A Zamir
    Department of Biomedical Engineering, Washington University, St Louis, MO, USA
    J Biomech Eng 126:276-83. 2004
    ..This method may not be as useful, however, for structures that behave as a beam on a foundation...
  10. ncbi request reprint Morphogenetic adaptation of the looping embryonic heart to altered mechanical loads
    Nandan L Nerurkar
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Dev Dyn 235:1822-9. 2006
    ..These results suggest that the looping embryonic heart has the ability to adapt to changes in the mechanical environment, which may play a regulatory role during morphogenesis...
  11. ncbi request reprint Mechanical asymmetry in the embryonic chick heart during looping
    Evan A Zamir
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    Ann Biomed Eng 31:1327-36. 2003
    ..A second model shows that a relatively stiff IC may facilitate bending of the heart tube during looping...
  12. pmc Axons pull on the brain, but tension does not drive cortical folding
    Gang Xu
    Department of Biomedical Engineering, Washington University, Saint Louis, MO 63130, USA
    J Biomech Eng 132:071013. 2010
    ..This study shows that a combination of experimental and computational mechanics can be used to evaluate competing hypotheses of morphogenesis, and illuminate the biomechanics of cortical folding...
  13. ncbi request reprint Regional epicardial strain in the embryonic chick heart during the early looping stages
    Patrick W Alford
    Department of Biomedical Engineering, Washington University, Campus Box 1097, St Louis, MO 63130, USA
    J Biomech 36:1135-41. 2003
    ....
  14. pmc On modeling morphogenesis of the looping heart following mechanical perturbations
    Ashok Ramasubramanian
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    J Biomech Eng 130:061018. 2008
    ..In each simulation, the model predicts the correct response. Hence, these models provide new insight into the mechanical mechanisms that drive and regulate cardiac looping...
  15. ncbi request reprint Cardiac looping in experimental conditions: effects of extraembryonic forces
    Dmitry A Voronov
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Dev Dyn 224:413-21. 2002
    ..Our results show that both tensions can affect looping, with surface tension potentially having a much greater effect. Moreover, we show that surface tension can alter results in one classic looping experiment...
  16. pmc A new method for measuring deformation of folding surfaces during morphogenesis
    Benjamen A Filas
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    J Biomech Eng 130:061010. 2008
    ..In these examples, microspheres are tracked using optical coherence tomography. This technique provides a new tool that can be used in studies of the mechanics of morphogenesis...
  17. pmc Growth and remodeling in a thick-walled artery model: effects of spatial variations in wall constituents
    Patrick W Alford
    Department of Biomedical Engineering, Washington University, Campus Box 1097, St Louis, MO 63130, USA
    Biomech Model Mechanobiol 7:245-62. 2008
    ..These results provide a better understanding of the determinants of residual stress in arteries and could lend insight into the importance of constituent distributions in both natural and tissue-engineered blood vessels...
  18. ncbi request reprint Optical coherence tomography as a tool for measuring morphogenetic deformation of the looping heart
    Benjamen A Filas
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Anat Rec (Hoboken) 290:1057-68. 2007
    ..These results illustrate the potential of OCT as a tool in studies of morphogenesis, as well as provide a better understanding of the mechanical forces that drive cardiac looping...
  19. ncbi request reprint Intramyocardial pressure measurements in the stage 18 embryonic chick heart
    Steren Chabert
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Am J Physiol Heart Circ Physiol 282:H1248-54. 2002
    ..Measured pressures likely correspond to regional variations in wall stress that may influence morphogenesis and function in the embryonic heart...
  20. ncbi request reprint The role of mechanical forces in dextral rotation during cardiac looping in the chick embryo
    Dmitry A Voronov
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    Dev Biol 272:339-50. 2004
    ..The results of this study may help investigators searching for the link between gene expression and the mechanical processes that drive looping...
  21. pmc Opening angles and material properties of the early embryonic chick brain
    Gang Xu
    Department of Biomedical Engineering, Washington University, Saint Louis, MO 63130, USA
    J Biomech Eng 132:011005. 2010
    ..Information on the regional material properties of the early embryonic brain will help illuminate the process of early brain morphogenesis...
  22. ncbi request reprint Myosin-based contraction is not necessary for cardiac c-looping in the chick embryo
    Mathieu C Rémond
    Department of Biomedical Engineering, Washington University, Campus Box 1097, St Louis, MO 63130, USA
    Anat Embryol (Berl) 211:443-54. 2006
    ..None of these drugs significantly affected looping during the studied stages. These results suggest that active contraction is not required for normal c-looping of the embryonic chick heart between stages 10 and 12...
  23. pmc Computational study of growth and remodelling in the aortic arch
    Patrick W Alford
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    Comput Methods Biomech Biomed Engin 11:525-38. 2008
    ..The models also suggest that the slow turnover rate of elastin limits longitudinal growth. These results should promote increased understanding of the causes of residual stress in arteries...
  24. doi request reprint Residual stress in the adult mouse brain
    Gang Xu
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130 4899, USA
    Biomech Model Mechanobiol 8:253-62. 2009
    ..The models show that the observed deformation after cutting can be caused by more growth in the gray matter than in the white matter, with the estimated tensile stress in the white matter being on the order of 100-1,000 Pa...
  25. pmc Mechanics of head fold formation: investigating tissue-level forces during early development
    Victor D Varner
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    Development 137:3801-11. 2010
    ..Taken together, the results suggest that the proposed morphogenetic mechanisms provide the main tissue-level forces that drive HF formation...
  26. ncbi request reprint Role of actin polymerization in bending of the early heart tube
    Kimberly S Latacha
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Dev Dyn 233:1272-86. 2005
    ..Taken together, these data suggest that ongoing actin polymerization is required for the bending component of cardiac c-looping, and we speculate that polymerization-driven myocardial cell shape changes cause this deformation...
  27. pmc In vivo photoacoustic imaging of transverse blood flow by using Doppler broadening of bandwidth
    Junjie Yao
    Department of Biomedical Engineering, Washington University in St Louis, St Louis, Missouri 63130, USA
    Opt Lett 35:1419-21. 2010
    ..By measuring bovine blood flowing through a plastic tube, the linear dependence of the broadening on the flow speed was validated. The blood flow of the microvasculature in a mouse ear and a chicken embryo (stage 16) was also studied...

Research Grants13

  1. Computational and Experimental Study of Early Cardiac Morphogenesis
    LARRY TABER; Fiscal Year: 2009
    ..In addition, the computational model created during the course of our research may someday lead to advanced models of the developing human heart, which is not amenable to direct experimental study. ..
  2. Computational Modeling of Developmental Processes
    LARRY TABER; Fiscal Year: 2009
    ..This software will open up new avenues for studying the mechanics of development in the cardiovascular, nervous, and other systems composed of soft tissue. ..
  3. Computational Modeling of Developmental Processes
    LARRY TABER; Fiscal Year: 2007
    ..This software will open up new avenues for studying the mechanics of development in the cardiovascular, nervous, and other systems composed of soft tissue. ..
  4. Computational and Experimental Study of Early Cardiac Morphogenesis
    LARRY TABER; Fiscal Year: 2007
    ..In addition, the computational model created during the course of our research may someday lead to advanced models of the developing human heart, which is not amenable to direct experimental study. ..
  5. BIOMECHANICS OF LOOPING IN THE EMBRYONIC HEART
    LARRY TABER; Fiscal Year: 2003
    ..Defining the biomechanical forces involved in looping would provide insight into this morphogenetic process and thereby help researchers searching for the link between gene expression and looping morphology. ..
  6. MECHANICS OF EARLY BRAIN AND EYE DEVELOPMENT
    Larry A Taber; Fiscal Year: 2010
    ..Prevention and treatment of these maladies requires understanding their root cause. This project will provide important new understanding of the morphogenetic mechanisms that create the embryonic brain and eye. ..