WOJCIECH A SWAT

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi DLGH1 is a negative regulator of T-lymphocyte proliferation
    Linda M Stephenson
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Mol Cell Biol 27:7574-81. 2007
  2. ncbi The Vav family: at the crossroads of signaling pathways
    Wojciech Swat
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunol Res 32:259-65. 2005
  3. ncbi Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter
    Zhen X Mahoney
    Department of Internal Medicine, Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 103:19872-7. 2006
  4. ncbi Vav proteins are necessary for correct differentiation of mouse cecal and colonic enterocytes
    John Y Liu
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Sci 122:324-34. 2009
  5. ncbi Vav proteins regulate the plasma cell program and secretory Ig production
    Linda M Stephenson
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Immunol 177:8620-5. 2006
  6. ncbi Vav/Phospholipase Cgamma2-mediated control of a neutrophil-dependent murine model of rheumatoid arthritis
    Viviana Cremasco
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    Arthritis Rheum 58:2712-22. 2008
  7. ncbi Vav1 controls DAP10-mediated natural cytotoxicity by regulating actin and microtubule dynamics
    Daniel B Graham
    Department of Pathology and Immunology, Washington University School of Medicine and Siteman Cancer Center, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Immunol 177:2349-55. 2006
  8. ncbi Vav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic Guanine nucleotide exchange activity
    Ana V Miletic
    Department of Pathology and Immunology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO, USA
    PLoS ONE 4:e6599. 2009
  9. ncbi Differential requirements for Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicity
    Marina Cella
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    J Exp Med 200:817-23. 2004
  10. ncbi Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes
    Linda M Stephenson
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Autophagy 5:625-35. 2009

Research Grants

  1. Regulation of NK Cell Function by Vav-family Proteins
    Wojciech Swat; Fiscal Year: 2006
  2. Role for Vav Family Proteins in T Lymphocyte Activation
    Wojciech Swat; Fiscal Year: 2007
  3. MECHANISMS OF SIGNALING BY ACTIVATING RECEPTORS IN INNATE IMMUNE SYSTEMS CELLS
    WOJCIECH A SWAT; Fiscal Year: 2010

Collaborators

Detail Information

Publications19

  1. ncbi DLGH1 is a negative regulator of T-lymphocyte proliferation
    Linda M Stephenson
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Mol Cell Biol 27:7574-81. 2007
    ..These data indicate that, consistent with the known function of Discs large proteins as tumor suppressors and attenuators of cell division, in T lymphocytes, DLGH1 functions as a negative regulator of TCR-induced proliferative responses...
  2. ncbi The Vav family: at the crossroads of signaling pathways
    Wojciech Swat
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunol Res 32:259-65. 2005
    ..Moreover, the three Vav proteins appear to function specifically in distinct signaling pathways emanating from activating receptors of natural killer cells that trigger natural cytotoxicity...
  3. ncbi Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter
    Zhen X Mahoney
    Department of Internal Medicine, Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 103:19872-7. 2006
    ..Our results suggest that (i) besides its well documented role in regulating epithelial polarity, Dlgh1 also regulates smooth muscle orientation, and (ii) human DLG1 mutations may contribute to hereditary forms of hydronephrosis...
  4. ncbi Vav proteins are necessary for correct differentiation of mouse cecal and colonic enterocytes
    John Y Liu
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Sci 122:324-34. 2009
    ..These studies show that Vav proteins are required for enterocytic differentiation and colonic epithelial barrier integrity...
  5. ncbi Vav proteins regulate the plasma cell program and secretory Ig production
    Linda M Stephenson
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Immunol 177:8620-5. 2006
    ..These data indicate a previously unknown role for Vav as an upstream regulator of Blimp-1...
  6. ncbi Vav/Phospholipase Cgamma2-mediated control of a neutrophil-dependent murine model of rheumatoid arthritis
    Viviana Cremasco
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    Arthritis Rheum 58:2712-22. 2008
    ..The aim of this study was to test the hypothesis that Vav and phospholipase Cgamma2 (PLCgamma2), two molecules involved in integrin signaling, are required for arthritis generation and neutrophil activation in a mouse model of arthritis...
  7. ncbi Vav1 controls DAP10-mediated natural cytotoxicity by regulating actin and microtubule dynamics
    Daniel B Graham
    Department of Pathology and Immunology, Washington University School of Medicine and Siteman Cancer Center, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Immunol 177:2349-55. 2006
    ..Based on these findings, we propose a novel model of ITAM-independent signaling by Vav downstream of DAP10 in NK cells...
  8. ncbi Vav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic Guanine nucleotide exchange activity
    Ana V Miletic
    Department of Pathology and Immunology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO, USA
    PLoS ONE 4:e6599. 2009
    ....
  9. ncbi Differential requirements for Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicity
    Marina Cella
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    J Exp Med 200:817-23. 2004
    ..Our results provide evidence that these three Vav proteins function specifically in distinct pathways that trigger NK cell cytotoxicity...
  10. ncbi Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes
    Linda M Stephenson
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Autophagy 5:625-35. 2009
    ..We speculate that, similar to its role in yeast or mammalian liver cells, autophagy is required in T cells for the removal of damaged or aging mitochondria and that this contributes to the cell death of autophagy-deficient T cells...
  11. ncbi Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice
    Daniel B Graham
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    J Clin Invest 117:3445-52. 2007
    ..Taken together, our data indicate that integrin-dependent signals generated during neutrophil adhesion contribute to the activation of NADPH oxidase by a variety of distinct effector pathways, all of which require Vav...
  12. ncbi Green fluorescent protein-glucocorticoid receptor knockin mice reveal dynamic receptor modulation during thymocyte development
    Judson A Brewer
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 169:1309-18. 2002
    ....
  13. ncbi Vav proteins control MyD88-dependent oxidative burst
    Ana V Miletic
    Department of Pathology and Immunology, Washington University School of Medicine and Siteman Cancer Center, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Blood 109:3360-8. 2007
    ..Thus, our data indicate that Vav specifically transduces a subset of signals emanating from MyD88...
  14. ncbi Vav1 acidic region tyrosine 174 is required for the formation of T cell receptor-induced microclusters and is essential in T cell development and activation
    Ana V Miletic
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    J Biol Chem 281:38257-65. 2006
    ....
  15. ncbi Essential role of PI3Kdelta and PI3Kgamma in thymocyte survival
    Wojciech Swat
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Blood 107:2415-22. 2006
    ..Thus, class 1 PI3Ks work in concert to protect developing thymocytes from apoptosis...
  16. ncbi Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells
    Keiko Fujikawa
    660 S Euclid Ave, Dept of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Med 198:1595-608. 2003
    ....
  17. ncbi ITAM signaling in dendritic cells controls T helper cell priming by regulating MHC class II recycling
    Daniel B Graham
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Blood 116:3208-18. 2010
    ..We propose a novel mechanism for control of T helper cell priming...
  18. ncbi The autophagy gene ATG5 plays an essential role in B lymphocyte development
    Brian C Miller
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Autophagy 4:309-14. 2008
    ..In addition, B-1a B cells require ATG5 for their maintenance in the periphery. We conclude that ATG5 is differentially required at discrete stages of development in distinct, but closely related, cell lineages...
  19. ncbi Cytoskeletal remodeling in lymphocyte activation
    Ana V Miletic
    Washington University School of Medicine, Department of Pathology and Immunology, 660 Euclid Avenue, Campus Box 8118, St Louis, MO 63110, USA
    Curr Opin Immunol 15:261-8. 2003
    ..To understand how these complex regulatory networks are wired, a new breed of computational biologists uses mathematical language to reproduce and simulate signaling circuits 'in silico'...

Research Grants8

  1. Regulation of NK Cell Function by Vav-family Proteins
    Wojciech Swat; Fiscal Year: 2006
    ..ITAM-containing adaptors. Here, we propose to use several in vitro and in vivo approaches to determine Vav mechanism in NK cell function and development of natural cytotoxicity against virally-infected and tumor cells. ..
  2. Role for Vav Family Proteins in T Lymphocyte Activation
    Wojciech Swat; Fiscal Year: 2007
    ..abstract_text> ..
  3. MECHANISMS OF SIGNALING BY ACTIVATING RECEPTORS IN INNATE IMMUNE SYSTEMS CELLS
    WOJCIECH A SWAT; Fiscal Year: 2010
    ..abstract_text> ..