S Joshua Swamidass

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi An economic framework to prioritize confirmatory tests after a high-throughput screen
    S Joshua Swamidass
    Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Biomol Screen 15:680-6. 2010
  2. ncbi Utility-aware screening with clique-oriented prioritization
    S Joshua Swamidass
    Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    J Chem Inf Model 52:29-37. 2012
  3. ncbi Mining small-molecule screens to repurpose drugs
    S Joshua Swamidass
    Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Brief Bioinform 12:327-35. 2011
  4. ncbi Automatically detecting workflows in PubChem
    Bradley T Calhoun
    Washington University School of Medicine, 660 S Euclid, St Louis, MO 63108, USA
    J Biomol Screen 17:1071-9. 2012
  5. ncbi Enhancing the rate of scaffold discovery with diversity-oriented prioritization
    S Joshua Swamidass
    Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Bioinformatics 27:2271-8. 2011

Collaborators

  • Bradley T Calhoun
  • Joshua A Bittker
  • Michael R Browning
  • Brian R Chen

Detail Information

Publications5

  1. ncbi An economic framework to prioritize confirmatory tests after a high-throughput screen
    S Joshua Swamidass
    Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Biomol Screen 15:680-6. 2010
    ..Validated with retrospective simulations and prospective experiments, this strategy identified 157 additional actives that had been erroneously labeled inactive in at least one real-world screening experiment...
  2. ncbi Utility-aware screening with clique-oriented prioritization
    S Joshua Swamidass
    Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    J Chem Inf Model 52:29-37. 2012
    ..The utility-aware algorithm used to implement COP is general enough to implement several other important models of screener preferences...
  3. ncbi Mining small-molecule screens to repurpose drugs
    S Joshua Swamidass
    Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Brief Bioinform 12:327-35. 2011
    ..Despite these methods' limitations, it is hopeful that they will accelerate the discovery of new uses for known drugs, but this hope has not yet been realized...
  4. ncbi Automatically detecting workflows in PubChem
    Bradley T Calhoun
    Washington University School of Medicine, 660 S Euclid, St Louis, MO 63108, USA
    J Biomol Screen 17:1071-9. 2012
    ..A Python implementation of the algorithm is available online, and a searchable database of all PubChem workflows is available at http://swami.wustl.edu/flow...
  5. ncbi Enhancing the rate of scaffold discovery with diversity-oriented prioritization
    S Joshua Swamidass
    Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Bioinformatics 27:2271-8. 2011
    ..The number of active scaffolds better reflects the success of the screen than the number of active molecules. Many existing algorithms for deciding which hits should be sent for confirmatory testing neglect this concern...