C E Suarez

Summary

Affiliation: Washington State University
Country: USA

Publications

  1. Suarez C, Alzan H, Silva M, Rathinasamy V, Poole W, Cooke B. Unravelling the cellular and molecular pathogenesis of bovine babesiosis: is the sky the limit?. Int J Parasitol. 2019;: pubmed publisher
  2. Gallego Lopez G, Lau A, Brown W, Johnson W, Ueti M, Suarez C. Spherical Body Protein 2 truncated copy 11 as a specific Babesia bovis attenuation marker. Parasit Vectors. 2018;11:169 pubmed publisher
  3. request reprint
    Suarez C, Norimine J, Lacy P, McElwain T. Characterization and gene expression of Babesia bovis elongation factor-1alpha. Int J Parasitol. 2006;36:965-73 pubmed
    ..Interestingly, in contrast to other related intra-erythrocytic apicomplexans, the ef-1alpha locus of B. bovis contains a 160 bp intron in the 5' untranslated region. ..
  4. Suarez C, Johnson W, Herndon D, Laughery J, Davis W. Integration of a transfected gene into the genome of Babesia bovis occurs by legitimate homologous recombination mechanisms. Mol Biochem Parasitol. 2015;202:23-8 pubmed publisher
    ..Use of legitimate homologous recombination mechanisms in transfected B. bovis supports the future use of transfection methods for developing efficient gene function assignment experiments using gene knockout techniques. ..
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    Suarez C, McElwain T. Transient transfection of purified Babesia bovis merozoites. Exp Parasitol. 2008;118:498-504 pubmed
    ..bovis merozoites using either nucleofection or conventional electroporation. However, nucleofection is significantly more efficient when transfecting either circular or restriction digested DNA in the 2-10 microg range. ..
  6. Suarez C, McElwain T. Transfection systems for Babesia bovis: a review of methods for the transient and stable expression of exogenous genes. Vet Parasitol. 2010;167:205-15 pubmed publisher
    ..bovis strains. Further development of these transfection systems will facilitate functional analysis of B. bovis genes and will improve our understanding of the biology of and immunological response to this parasite. ..
  7. Hussein H, Scoles G, Ueti M, Suarez C, Adham F, Guerrero F, et al. Targeted silencing of the Aquaporin 2 gene of Rhipicephalus (Boophilus) microplus reduces tick fitness. Parasit Vectors. 2015;8:618 pubmed publisher
    ..microplus and tick-borne parasites. ..
  8. Mahmoud M, Kandil O, Nasr S, Hendawy S, Habeeb S, Mabrouk D, et al. Serological and molecular diagnostic surveys combined with examining hematological profiles suggests increased levels of infection and hematological response of cattle to babesiosis infections compared to native buffaloes in Egypt. Parasit Vectors. 2015;8:319 pubmed publisher
    ..Infected bovine, but not buffalo, populations often present hematological disorders compatible with intravascular hemolysis and thrombocytopenia. ..
  9. G Silva M, Knowles D, Antunes S, Domingos A, Esteves M, Suarez C. Inhibition of the in vitro growth of Babesia bigemina, Babesia caballi and Theileria equi parasites by trifluralin analogues. Ticks Tick Borne Dis. 2017;8:593-597 pubmed publisher
    ..and Theileria equi, and their lack of toxic effects on erythrocytes supports further in vivo testing and eventually their development as novel alternatives for the treatment of babesiosis and theileriosis. ..

More Information

Publications17

  1. Alzan H, Silva M, Davis W, Herndon D, Schneider D, Suarez C. Geno- and phenotypic characteristics of a transfected Babesia bovis 6-Cys-E knockout clonal line. Parasit Vectors. 2017;10:214 pubmed publisher
    ..Further investigation is underway to determine if the 6-Cys E protein is required for replication and sexual stage development of B. bovis during tick stages. ..
  2. Kappmeyer L, Thiagarajan M, Herndon D, Ramsay J, Caler E, Djikeng A, et al. Comparative genomic analysis and phylogenetic position of Theileria equi. BMC Genomics. 2012;13:603 pubmed publisher
    ..equi relative to sequenced apicomplexan parasites...
  3. Suarez C, NOH S. Emerging perspectives in the research of bovine babesiosis and anaplasmosis. Vet Parasitol. 2011;180:109-25 pubmed publisher
  4. Suarez C, Florin Christensen M, Hines S, Palmer G, Brown W, McElwain T. Characterization of allelic variation in the Babesia bovis merozoite surface antigen 1 (MSA-1) locus and identification of a cross-reactive inhibition-sensitive MSA-1 epitope. Infect Immun. 2000;68:6865-70 pubmed
  5. request reprint
    Suarez C, Palmer G, Hotzel I, McElwain T. Structure, sequence, and transcriptional analysis of the Babesia bovis rap-1 multigene locus. Mol Biochem Parasitol. 1998;93:215-24 pubmed
    ..bigemina versus B. bovis are reflected in the marked structural and antigenic polymorphism in the B. bigemina RAP-1 molecules as compared with the essentially monomorphic RAP-1 in B. bovis...
  6. Suarez C, Laughery J, Schneider D, Sondgeroth K, McElwain T. Acute and persistent infection by a transfected Mo7 strain of Babesia bovis. Mol Biochem Parasitol. 2012;185:52-7 pubmed publisher
    ..Together, the data demonstrates that exogenous B. bovis transgenes can be expressed and remain stable throughout acute and persistent infection in calves...
  7. Suarez C, Bishop R, Alzan H, Poole W, Cooke B. Advances in the application of genetic manipulation methods to apicomplexan parasites. Int J Parasitol. 2017;47:701-710 pubmed publisher
  8. Suarez C, McElwain T. Stable expression of a GFP-BSD fusion protein in Babesia bovis merozoites. Int J Parasitol. 2009;39:289-97 pubmed publisher
    ..bovis, one of the three major tick-borne parasites that limit global livestock production...