Robert Strunk

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Relationship of exhaled nitric oxide to clinical and inflammatory markers of persistent asthma in children
    Robert C Strunk
    Washington University School of Medicine, St Louis, MO, USA
    J Allergy Clin Immunol 112:883-92. 2003
  2. doi request reprint Wheezing symptoms and parental asthma are associated with a physician diagnosis of asthma in children with sickle cell anemia
    Robert C Strunk
    Division of Allergy, Immunology, and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis, Mo Electronic address
    J Pediatr 164:821-826.e1. 2014
  3. pmc Partner randomized controlled trial: study protocol and coaching intervention
    Jane M Garbutt
    Department of Pediatrics, Division of Allergy and Pulmonary Medicine, Washington University, St Louis, MO 63110, USA
    BMC Pediatr 12:42. 2012
  4. ncbi request reprint Defining asthma in the preschool-aged child
    Robert C Strunk
    Washington University School of Medicine, Division of Allergy and Pulmonary Medicine, St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Pediatrics 109:357-61. 2002
  5. pmc Azithromycin or montelukast as inhaled corticosteroid-sparing agents in moderate-to-severe childhood asthma study
    Robert C Strunk
    Department of Pediatrics, Washington University and St Louis Children s Hospital, St Louis, MO 63110, USA
    J Allergy Clin Immunol 122:1138-1144.e4. 2008
  6. pmc Methacholine challenge in children with sickle cell disease: a case series
    Robert C Strunk
    Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Pediatr Pulmonol 43:924-9. 2008
  7. pmc Long-term budesonide or nedocromil treatment, once discontinued, does not alter the course of mild to moderate asthma in children and adolescents
    Robert C Strunk
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, MO 63110, USA
    J Pediatr 154:682-7. 2009
  8. ncbi request reprint Mild to moderate asthma affects lung growth in children and adolescents
    Robert C Strunk
    Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    J Allergy Clin Immunol 118:1040-7. 2006
  9. ncbi request reprint Childhood Asthma Management Program: lessons learned
    Robert C Strunk
    Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, MO 63110, USA
    J Allergy Clin Immunol 119:36-42. 2007
  10. ncbi request reprint Characterization of within-subject responses to fluticasone and montelukast in childhood asthma
    Stanley J Szefler
    Department of Pediatrics, National Jewish Medical and Research Medical Center and University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 115:233-42. 2005

Research Grants

  1. CAMP Continuation Study/Phase 3
    Robert Strunk; Fiscal Year: 2007
  2. CARE Network--St. Louis Center
    Robert Strunk; Fiscal Year: 2007
  3. ASTHMA AND INTERVENTIONS IN THE EMERGENCY DEPARTMENT
    Robert Strunk; Fiscal Year: 2002
  4. Social Support and Education in Asthma Follow-Up
    Robert Strunk; Fiscal Year: 2007

Detail Information

Publications86

  1. ncbi request reprint Relationship of exhaled nitric oxide to clinical and inflammatory markers of persistent asthma in children
    Robert C Strunk
    Washington University School of Medicine, St Louis, MO, USA
    J Allergy Clin Immunol 112:883-92. 2003
    ..Insufficient information is available concerning correlations between eNO and biologic, physiologic, and clinical characteristics of asthma in children currently not taking controller medications...
  2. doi request reprint Wheezing symptoms and parental asthma are associated with a physician diagnosis of asthma in children with sickle cell anemia
    Robert C Strunk
    Division of Allergy, Immunology, and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis, Mo Electronic address
    J Pediatr 164:821-826.e1. 2014
    ..To identify factors associated with asthma associated with increased sickle cell anemia (SCA)...
  3. pmc Partner randomized controlled trial: study protocol and coaching intervention
    Jane M Garbutt
    Department of Pediatrics, Division of Allergy and Pulmonary Medicine, Washington University, St Louis, MO 63110, USA
    BMC Pediatr 12:42. 2012
    ..Effective interventions to improve asthma care such as small group training and care redesign have been difficult to disseminate into office practice...
  4. ncbi request reprint Defining asthma in the preschool-aged child
    Robert C Strunk
    Washington University School of Medicine, Division of Allergy and Pulmonary Medicine, St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Pediatrics 109:357-61. 2002
    ..A chart review of patients presenting consecutively to the Division of Allergy and Pulmonary Medicine provides insight and information on an approach to make an asthma diagnosis for this population...
  5. pmc Azithromycin or montelukast as inhaled corticosteroid-sparing agents in moderate-to-severe childhood asthma study
    Robert C Strunk
    Department of Pediatrics, Washington University and St Louis Children s Hospital, St Louis, MO 63110, USA
    J Allergy Clin Immunol 122:1138-1144.e4. 2008
    ..Clinical trials in children with moderate-to-severe persistent asthma are limited...
  6. pmc Methacholine challenge in children with sickle cell disease: a case series
    Robert C Strunk
    Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Pediatr Pulmonol 43:924-9. 2008
    ..No patient developed a pain or ACS episode within at least 1 month after the challenge. Evaluation of AHR with methacholine challenge in patients with SCD appears to be well tolerated and may elucidate a cause of SCD morbidity...
  7. pmc Long-term budesonide or nedocromil treatment, once discontinued, does not alter the course of mild to moderate asthma in children and adolescents
    Robert C Strunk
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, MO 63110, USA
    J Pediatr 154:682-7. 2009
    ..To determine whether long-term, continuous use of inhaled anti-inflammatory medications affects asthma outcomes in children with mild to moderate asthma after use is discontinued...
  8. ncbi request reprint Mild to moderate asthma affects lung growth in children and adolescents
    Robert C Strunk
    Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    J Allergy Clin Immunol 118:1040-7. 2006
    ..The effect of childhood asthma on lung growth is unclear...
  9. ncbi request reprint Childhood Asthma Management Program: lessons learned
    Robert C Strunk
    Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, MO 63110, USA
    J Allergy Clin Immunol 119:36-42. 2007
    ..A key lesson was absence of a continued effect of inhaled corticosteroid on lung growth during long-term follow-up even as symptoms and airway responsiveness remained improved...
  10. ncbi request reprint Characterization of within-subject responses to fluticasone and montelukast in childhood asthma
    Stanley J Szefler
    Department of Pediatrics, National Jewish Medical and Research Medical Center and University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 115:233-42. 2005
    ..Responses to inhaled corticosteroids (ICSs) and leukotriene receptor antagonists (LTRAs) vary among asthmatic patients...
  11. doi request reprint Impulse oscillometry versus spirometry in a long-term study of controller therapy for pediatric asthma
    Gary L Larsen
    Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 123:861-7.e1. 2009
    ..Determination of the benefits and limitations of specific physiologic tests has not been well studied in long-term clinical pediatric trials...
  12. pmc Effect of long-term corticosteroid use on bone mineral density in children: a prospective longitudinal assessment in the childhood Asthma Management Program (CAMP) study
    H William Kelly
    Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 0001, USA
    Pediatrics 122:e53-61. 2008
    ..Thus, we assessed the effects of multiple short courses of oral corticosteroids and long-term inhaled corticosteroids on bone mineral accretion over a period of years...
  13. pmc Cytokine response after severe respiratory syncytial virus bronchiolitis in early life
    Mario Castro
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    J Allergy Clin Immunol 122:726-733.e3. 2008
    ..Immune response after viral infection usually involves T(H)1-mediated response; however, severe respiratory syncytial virus (RSV) infection appears to be associated with the development of asthma, a T(H)2-predominant phenotype...
  14. pmc Factors associated with asthma exacerbations during a long-term clinical trial of controller medications in children
    Ronina A Covar
    Department of Pediatrics, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 122:741-747.e4. 2008
    ..Asthma exacerbations are a common cause of critical illness in children...
  15. pmc Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma
    Nathan Rabinovitch
    Department of Pediatrics, National Jewish Health and the University of Colorado Denver School of Medicine, Denver, Colo 80206, USA
    J Allergy Clin Immunol 126:545-51.e1-4. 2010
    ..A subset of children with asthma respond better to leukotriene receptor antagonists than to inhaled corticosteroids. Information is needed to identify children with these preferential responses...
  16. ncbi request reprint Response profiles to fluticasone and montelukast in mild-to-moderate persistent childhood asthma
    Robert S Zeiger
    Department of Pediatrics, University of California San Diego, San Diego, CA 92111, USA
    J Allergy Clin Immunol 117:45-52. 2006
    ..Outcome data are needed to base recommendations for controller asthma medication use in school-aged children...
  17. ncbi request reprint Major gene effect and additive familial pattern of inheritance of asthma exist among families of probands with sickle cell anemia and asthma
    Keydra L Phillips
    Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Hum Biol 20:149-53. 2008
    ....
  18. pmc Low daytime pulse oximetry reading is associated with nocturnal desaturation and obstructive sleep apnea in children with sickle cell anemia
    John F Spivey
    Department of Pediatrics, Washington University School of Medicine St Louis Children s Hospital, St Louis, Missouri, USA
    Pediatr Blood Cancer 50:359-62. 2008
    ..453; P = 0.045). Our results indicate that in children with SCA, a daytime SpO(2) </=94% is a reasonable threshold to recommend a pulmonary evaluation, including a PSG...
  19. ncbi request reprint Socioeconomic status, stress, and immune markers in adolescents with asthma
    Edith Chen
    Washington University, St Louis Children s Hospital, St Louis, MO, USA
    Psychosom Med 65:984-92. 2003
    ..The second objective was to test whether psychological stress and control beliefs could explain these differences...
  20. pmc Acute asthma management by a pediatric after-hours call center
    Kyle A Nelson
    Department of Pediatrics, Division of Emergency Medicine, The University of Pennsylvania School of Medicine, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Telemed J E Health 15:538-45. 2009
    ..This protocol may also be successful in other locations and may improve outcomes, such as reduction in ED visits...
  21. ncbi request reprint Improving follow-up for children with asthma after an acute Emergency Department visit
    Sharon R Smith
    Washington University School of Medicine, St Louis Children s Hospital, Department of Pediatrics, Division of Emergency Medicine, St Louis, Missouri, USA
    J Pediatr 145:772-7. 2004
    ..To improve follow-up with primary care providers after acute Emergency Department (ED) asthma visits for children from low-income urban families...
  22. ncbi request reprint Nocturnal awakening caused by asthma in children with mild-to-moderate asthma in the childhood asthma management program
    Robert C Strunk
    Department of Pediatrics, Washington University School of Medicine, Division of Allergy and Pulmonary Medicine, St Louis Children s Hospital, MO 63110, USA
    J Allergy Clin Immunol 110:395-403. 2002
    ..Nocturnal symptoms of asthma are a cause of significant morbidity and are included as a central feature in the categorization of asthma severity...
  23. ncbi request reprint Refinement of an instrument to evaluate parental attitudes about follow-up care after an acute emergency department visit for asthma
    Sharon R Smith
    Division of Emergency Medicine, St Louis Children s Hospital, Washington University School of Medicine, St Louis, Missouri, USA
    J Asthma 42:587-92. 2005
    ..Prompt follow-up after emergency department (ED) care for asthma allows the primary care provider (PCP) and family to review factors that led to the ED visit, update current care plans, and plan for prevention of future exacerbations...
  24. pmc Painful episodes in children with sickle cell disease and asthma are temporally associated with respiratory symptoms
    Jeffrey Glassberg
    Department of Pediatrics, Division of Allergy and Pulmonary Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Pediatr Hematol Oncol 28:481-5. 2006
    ..We tested the hypothesis that respiratory symptoms either immediately precede or occur concomitantly with painful episodes more frequently in children with SCD and asthma when compared with children with SCD without asthma...
  25. pmc Sibling history of asthma is a risk factor for pain in children with sickle cell anemia
    Joshua J Field
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Hematol 83:855-7. 2008
    ..51, 95% CI= 0.92-2.62; P = 0.12). Further studies are needed to examine genetic and/or environmental risks for asthma as potential contributors to pain in children with SCA...
  26. pmc Home use of albuterol for asthma exacerbations
    Jane M Garbutt
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA
    Ann Allergy Asthma Immunol 102:504-9. 2009
    ..Yet, ED visits for asthma are frequent and often occur several days after onset of increased symptoms, particularly for children from low-income, urban neighborhoods...
  27. ncbi request reprint Asthma and acute chest in sickle-cell disease
    Jessica H Boyd
    Division of Hematology Oncology, Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Pediatr Pulmonol 38:229-32. 2004
    ....
  28. pmc Physician and parent response to the FDA advisory about use of over-the-counter cough and cold medications
    Jane M Garbutt
    Department of Pediatrics, Washington University in St Louis, Missouri 63110, USA
    Acad Pediatr 10:64-9. 2010
    ....
  29. ncbi request reprint Parental impressions of the benefits (pros) and barriers (cons) of follow-up care after an acute emergency department visit for children with asthma
    Sharon R Smith
    Division of Emergency Medicine, Department of Pediatrics, St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Pediatrics 110:323-30. 2002
    ..Follow-up care after ED visits is infrequent. We developed and evaluated an instrument that describes the parental benefits (pros) and barriers (cons) of obtaining follow-up care for interventions to promote follow-up...
  30. ncbi request reprint Hospital readmissions for childhood asthma: a 10-year metropolitan study
    Gordon R Bloomberg
    Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Respir Crit Care Med 167:1068-76. 2003
    ..Prior admission was a more specific indicator of readmission with greater positive predictive value than ethnicity or insurance status or their combination...
  31. doi request reprint Growth of lung function in children with sickle cell anemia
    Joshua J Field
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Pediatr Pulmonol 43:1061-6. 2008
    ..We conclude that growth of lung function is reduced in children with HbSS compared to children in the general population. Gender may influence the risk of developing abnormal lung function and airway obstruction in children with HbSS...
  32. ncbi request reprint Recruitment into a long-term pediatric asthma study during emergency department visits
    Sharon R Smith
    Divisions of Emergency Medicine and Allergy and Pulmonary Medicine, St Louis Children s Hospital, St Louis, Missouri 63110 1077, USA
    J Asthma 41:477-84. 2004
    ..The purpose of this manuscript is to describe the recruitment process and the results of our recruitment in soliciting children and their parents to participate in an ED-based asthma research study...
  33. ncbi request reprint Pediatric asthma admissions: chronic severity and acute exacerbations
    Arnon Elizur
    Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, MO 63110, USA
    J Asthma 44:285-9. 2007
    ..Children with different chronic asthma severities had comparable severities of acute exacerbation. In conclusion, acute asthma exacerbations dissociate in severity from chronic asthma and are under-treated with systemic corticosteroids...
  34. ncbi request reprint Asthma is associated with increased mortality in individuals with sickle cell anemia
    Jessica H Boyd
    Department of Pediatrics, Division of Allergy and Pulmonary Medicine, Washington University School of Medicine, St Louis, MO 63108, USA
    Haematologica 92:1115-8. 2007
    ..After controlling for established risk factors, individuals with SCA and asthma had a more than two-fold higher risk of mortality (hazard ratio 2.36, 95% CI 1.21 to 4.62, p=0.01). To summarize, asthma is a risk factor for death in SCA...
  35. pmc Effects of time, albuterol, and budesonide on the shape of the flow-volume loop in children with asthma
    Anand C Patel
    Division of Allergy Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, and St Louis Children s Hospital, St Louis, MO 63110, USA
    J Allergy Clin Immunol 122:781-787.e8. 2008
    ..Assessment of asthma through spirometric analysis in children is challenging because of often normal FEV(1) values...
  36. doi request reprint Urinary cysteinyl leukotriene E(4) is associated with increased risk for pain and acute chest syndrome in adults with sickle cell disease
    Joshua J Field
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Hematol 84:158-60. 2009
    ..1, 95% CI 1.8-27.5, P = 0.005; ACS: risk ratio 12.2, 95% CI 2.1-69.8, P = 0.005)...
  37. pmc Lower airway obstruction is associated with increased morbidity in children with sickle cell disease
    Jessica H Boyd
    Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Pediatr Pulmonol 44:290-6. 2009
    ..Our objective was to study the relationship between abnormalities in pulmonary function and morbidity as represented by the rate of hospitalizations for pain or acute chest syndrome (ACS) in children with SCD...
  38. pmc Patient characteristics associated with improved outcomes with use of an inhaled corticosteroid in preschool children at risk for asthma
    Leonard B Bacharier
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, MO 63017, USA
    J Allergy Clin Immunol 123:1077-82, 1082.e1-5. 2009
    ..However, determination of baseline features associated with ICS responsiveness may identify children most likely to benefit from ICS treatment...
  39. pmc Longitudinal analysis of pulmonary function in adults with sickle cell disease
    Joshua J Field
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Hematol 83:574-6. 2008
    ..Further studies are needed to identify factors which impact the rate of lung function decline in adults with SCD...
  40. doi request reprint Telephone coaching for parents of children with asthma: impact and lessons learned
    Jane M Garbutt
    Department of Medicine, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Arch Pediatr Adolesc Med 164:625-30. 2010
    ..To determine whether an asthma coaching program can improve parent and child asthma-related quality of life (QOL) and reduce urgent care events...
  41. doi request reprint Urinary cysteinyl leukotriene E4 significantly increases during pain in children and adults with sickle cell disease
    Joshua J Field
    Division of Hematology, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Hematol 84:231-3. 2009
    ..36 pg/mg creatinine at baseline to 162.81 pg/mg creatinine during a painful episode (P < 0.001). These data further support a contribution of CysLTs to the process of vaso-occlusion...
  42. pmc Asthma prevalence in low-income urban elementary school students in St. Louis, 1992 and 2004
    Kyle A Nelson
    Division of Emergency Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA
    J Pediatr 154:111-5. 2009
    ..We reexamined asthma prevalence in urban public elementary school children after 12 years, during which time poverty had worsened...
  43. pmc Signs and symptoms that precede wheezing in children with a pattern of moderate-to-severe intermittent wheezing
    Katherine Rivera-Spoljaric
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110 1077, USA
    J Pediatr 154:877-81.e4. 2009
    ..To examine parent-reported signs and symptoms as antecedents of wheezing in preschool children with previous moderate to severe wheezing episodes, and to determine the predictive capacity of these symptom patterns for wheezing events...
  44. pmc Episodic use of an inhaled corticosteroid or leukotriene receptor antagonist in preschool children with moderate-to-severe intermittent wheezing
    Leonard B Bacharier
    Department of Pediatrics, Washington University and St Louis Children s Hospital, St Louis, MO 63110, USA
    J Allergy Clin Immunol 122:1127-1135.e8. 2008
    ..Acute wheezing illnesses in preschoolers require better management strategies to reduce morbidity...
  45. ncbi request reprint Age-related changes in the asthmatic phenotype in children
    Caroline C Horner
    Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, 1 Children s Place, St Louis, MO 63110, USA
    Curr Opin Pediatr 19:295-9. 2007
    ..To review the changes in the asthma phenotype as children progress from childhood into young adulthood...
  46. ncbi request reprint Severe intermittent wheezing in preschool children: a distinct phenotype
    Leonard B Bacharier
    Department of Pediatrics, Washington University, St Louis Children s Hospital, St Louis, MOO 63110, USA
    J Allergy Clin Immunol 119:604-10. 2007
    ....
  47. ncbi request reprint Long-term effect of budesonide on hypothalamic-pituitary-adrenal axis function in children with mild to moderate asthma
    Leonard B Bacharier
    Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Pediatrics 113:1693-9. 2004
    ..To determine the safety of long-term (36 months) administration of an inhaled corticosteroid (budesonide) on hypothalamic-pituitary-adrenal (HPA) axis function in children with mild to moderate asthma...
  48. ncbi request reprint Classifying asthma severity in children: mismatch between symptoms, medication use, and lung function
    Leonard B Bacharier
    Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, One Children s Place, St Louis, MO 63110, USA
    Am J Respir Crit Care Med 170:426-32. 2004
    ..FEV(1) is generally normal, even in severe persistent childhood asthma, whereas FEV(1)/FVC declines as asthma severity increases...
  49. ncbi request reprint Pets and childhood asthma--how should the pediatrician respond to new information that pets may prevent asthma?
    Leonard B Bacharier
    Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, MO 63110, USA
    Pediatrics 112:974-6. 2003
  50. ncbi request reprint Growth and bone density in children with mild-moderate asthma: a cross-sectional study in children entering the Childhood Asthma Management Program (CAMP)
    H William Kelly
    Department of Pediatrics, School of Medicine, and the College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131 5311, USA
    J Pediatr 142:286-91. 2003
    ..We sought to determine whether mild-moderate persistent asthma sufficient to produce a decrease in baseline lung function is associated with an adverse effect on growth and bone mineral density (BMD) in children...
  51. pmc Elevated urinary leukotriene E4 levels are associated with hospitalization for pain in children with sickle cell disease
    Jeanine E Jennings
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Hematol 83:640-3. 2008
    ..52 episodes per 100 patient-years, P = 0.038). LTE(4) levels are elevated in children with SCD when compared with controls. LTE(4) levels are associated with an increased rate of hospitalizations for pain...
  52. ncbi request reprint Asthma coaching in the pediatric emergency department
    Sharon R Smith
    Division of Emergency Medicine, Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, MO, USA
    Acad Emerg Med 13:835-9. 2006
    ..The authors performed a randomized, controlled trial of an intervention combining asthma coaching during an emergency department (ED) visit for asthma, and monetary incentive to improve follow-up with primary care providers (PCP)...
  53. ncbi request reprint Predictors of repeat hospitalizations in children with asthma: the role of psychosocial and socioenvironmental factors
    Edith Chen
    Department of Psychology, Washington University, Campus Box 1125, One Brookings Drive, St Louis, Missouri 63130, USA
    Health Psychol 22:12-8. 2003
    ..These findings could help guide future interventions targeted at the subgroup of children who represent a high proportion of asthma hospitalizations...
  54. ncbi request reprint Hospitalization for asthma: atopic, pulmonary function, and psychological correlates among participants in the Childhood Asthma Management Program
    Leonard B Bacharier
    Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Pediatrics 112:e85-92. 2003
    ..Sensitization and exposure to inhalant allergens have been identified as risk factors for asthma hospitalization...
  55. ncbi request reprint Severity of respiratory syncytial virus bronchiolitis is affected by cigarette smoke exposure and atopy
    Joseph P Bradley
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Pediatrics 115:e7-14. 2005
    ..Little is known about what determines the severity of RSV bronchiolitis, which may be helpful in the initial assessment of these children...
  56. ncbi request reprint Use of high-dose ibuprofen in a pediatric cystic fibrosis center
    Preston Blain Fennell
    Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, United States
    J Cyst Fibros 6:153-8. 2007
    ..Neither use of high-dose ibuprofen nor its cessation resulted in a significant change in the rate of decline in pulmonary function or influenced hospitalization rates...
  57. ncbi request reprint Predictors of protocol adherence in a pediatric asthma clinical trial
    Robert C Strunk
    Department of Pediatrics, Division of Allergy and Pulmonary Medicine, Washington University School of Medicine, St Louis Children s Hospital, 1 Children s Place, St Louis, MO 63110, USA
    J Allergy Clin Immunol 110:596-602. 2002
    ..Declining protocol adherence can threaten the validity of a clinical trial...
  58. ncbi request reprint Omalizumab for asthma
    Robert C Strunk
    Department of Pediatrics, Washington University School of Medicine, St Louis, USA
    N Engl J Med 354:2689-95. 2006
  59. pmc Effect of elevated exhaled nitric oxide levels on the risk of respiratory tract illness in preschool-aged children with moderate-to-severe intermittent wheezing
    Avraham Beigelman
    Department of Pediatrics, Washington University and St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Ann Allergy Asthma Immunol 103:108-13. 2009
    ..The fractional concentration of exhaled nitric oxide (FeNO) is a noninvasive marker for airway inflammation but requires further study in preschool-aged children to determine its clinical relevance...
  60. pmc Prevalence of daily medication adherence among children with sickle cell disease: a 1-year retrospective cohort analysis
    Niti G Patel
    St Louis College of Pharmacy, St Louis, Missouri, USA
    Pediatr Blood Cancer 55:554-6. 2010
    ..A total of 93 children were studied. The average refill prescription rate was 58.4%. More formal strategies are required to identify barriers to prescription refills among children with SCD...
  61. pmc Asthma is associated with acute chest syndrome and pain in children with sickle cell anemia
    Jessica H Boyd
    Department of Pediatrics, Division of Allergy and Pulmonary Medicine, Washington University School of Medicine in St Louis, Patient Oriented Research Unit, 4444 Forest Park Blvd, CB 8519, St Louis, MO 63108, USA
    Blood 108:2923-7. 2006
    ..39 vs 0.47 events per patient year, P < .001). In conclusion, in children with SCA, asthma is associated with an increased incidence of sickle cell disease-related morbidity, including ACS and painful episodes...
  62. ncbi request reprint Community Asthma Program improves appropriate prescribing in moderate to severe asthma
    Sheniz A Moonie
    Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, Campus Box 8052, 660 S Euclid Ave, St Louis, MO 63110 1093, USA
    J Asthma 42:281-9. 2005
    ..Use of the CAP over time aided PCPs in appropriately medicating patients with moderate to severe asthma in accordance with guidelines...
  63. pmc Hospital admission for acute painful episode following methacholine challenge in an adolescent with sickle cell disease
    Jessica E Knight-Perry
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Pediatr Pulmonol 44:728-30. 2009
    ....
  64. doi request reprint Wheezing in children with sickle cell disease
    Jeffrey A Glassberg
    aEmergency Medicine, Hematology and Medical Oncology, Mount Sinai School of Medicine, New York bWashington University School of Medicine in St Louis, St Louis, Missouri cVanderbilt Meharry Center of Excellence in Sickle Cell Disease, Monroe Carell Jr Children s Hospital, Vanderbilt, Nashville, Tennessee, USA
    Curr Opin Pediatr 26:9-18. 2014
    ....
  65. pmc Detection and home management of worsening asthma symptoms
    Jane Garbutt
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Ann Allergy Asthma Immunol 103:469-73. 2009
    ..Asthma guidelines recommend early home treatment of exacerbations. However, home treatment is often suboptimal and delayed...
  66. ncbi request reprint Community organization to reduce the need for acute care for asthma among African American children in low-income neighborhoods: the Neighborhood Asthma Coalition
    Edwin B Fisher
    Department of Psychology, Washington University, St Louis, Missouri 63108, USA
    Pediatrics 114:116-23. 2004
    ..Low-income African Americans exhibit disproportionate prevalences, morbidity rates, and mortality rates for asthma...
  67. ncbi request reprint Reducing disparities in asthma care: priorities for research--National Heart, Lung, and Blood Institute workshop report
    Robert C Strunk
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63108, USA
    J Allergy Clin Immunol 109:229-37. 2002
    ..Research is encouraged to identify strategies that improve cultural adaptation and adoption of proven programs in a variety of populations...
  68. pmc Airway hyperresponsiveness in children with sickle cell anemia
    Joshua J Field
    Department of Medicine, Division of Allergy and Immunology, Box 8116, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO, 63110, USA
    Chest 139:563-8. 2011
    ..The high prevalence of airway hyperresponsiveness (AHR) among children with sickle cell anemia (SCA) remains unexplained...
  69. ncbi request reprint Bronchodilation and bronchoconstriction: predictors of future lung function in childhood asthma
    Kelan G Tantisira
    Channing Laboratory, Pulmonary Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Allergy Clin Immunol 117:1264-71. 2006
    ..Persistently low levels of lung function are associated with subsequent symptoms in patients with asthma as children...
  70. ncbi request reprint The Prevention of Early Asthma in Kids study: design, rationale and methods for the Childhood Asthma Research and Education network
    Theresa W Guilbert
    Division of Pediatric Pulmonary Medicine, Arizona Respiratory Center, University of Arizona, 1501 N Campbell Avenue, PO Box 245073, Tucson, AZ 85724, USA
    Control Clin Trials 25:286-310. 2004
    ..These measures were chosen to reflect the progression of the disease from intermittent wheezing to persistent asthma and measurement of the extent of airflow limitation and airway reactivity...
  71. ncbi request reprint Developing measures of symptom perception for children with asthma
    Edith Chen
    J Allergy Clin Immunol 119:248-50. 2007
  72. pmc Histopathology of experimentally induced asthma in a murine model of sickle cell disease
    Sandhya D Nandedkar
    Department of Surgery, Division of Pediatric Surgery, Medical College of Wisconsin, Blood Research Institute, Children s Research Institute, Cardiovascular Center, Milwaukee, WI 53226, USA
    Blood 112:2529-38. 2008
    ..Our findings indicate SCD mice with experimentally induced asthma are more susceptible to death and pulmonary inflammation compared with control mice, suggesting that asthma contributes significantly to morbidity and mortality in SCD...
  73. pmc Airway responsiveness in mild to moderate childhood asthma: sex influences on the natural history
    Kelan G Tantisira
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 178:325-31. 2008
    ..Airway responsiveness is a prognostic marker for asthma symptoms in later life. Objectives: To evaluate characteristics responsible for persistence of airway responsiveness in children with asthma...
  74. ncbi request reprint Long-term inhaled corticosteroids in preschool children at high risk for asthma
    Theresa W Guilbert
    Division of Pediatric Pulmonary Medicine, Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724, USA
    N Engl J Med 354:1985-97. 2006
    ..It is unknown whether inhaled corticosteroids can modify the subsequent development of asthma in preschool children at high risk for asthma...
  75. ncbi request reprint Association of hypothalamic-pituitary-adrenal axis function with neuropsychological performance in children with mild/moderate asthma
    Robert D Annett
    University of New Mexico Health Sciences Center, Pediatrics, Albuquerque, NM 87131, USA
    Child Neuropsychol 11:333-48. 2005
    ..In contrast, cortisol production was not associated with child reports of psychological functioning. Limitations to the methods employed in this study are discussed...
  76. ncbi request reprint Atopic characteristics of children with recurrent wheezing at high risk for the development of childhood asthma
    Theresa W Guilbert
    Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724, USA
    J Allergy Clin Immunol 114:1282-7. 2004
    ....
  77. pmc The role of the social environment in children and adolescents with asthma
    Edith Chen
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada
    Am J Respir Crit Care Med 176:644-9. 2007
    ..Biopsychosocial models of asthma have been proposed in the literature, but few empirical tests of social factors at various levels of influence have been conducted...
  78. ncbi request reprint Prevalence of asthma: is the answer in our differences?
    Gordon R Bloomberg
    Ann Allergy Asthma Immunol 89:348-9. 2002
  79. ncbi request reprint The outcomes of sickle cell disease in adulthood are clear, but the origins and progression of sickle cell anemia-induced problems in the heart and lung in childhood are not
    Jessica H Boyd
    J Pediatr 149:3-4. 2006
  80. ncbi request reprint Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: the Pediatric Asthma Controller Trial
    Christine A Sorkness
    Clinical Science Center, University of Wisconsin, Madison, WI 53792, USA
    J Allergy Clin Immunol 119:64-72. 2007
    ..More evidence is needed on which to base recommendations for treatment of mild-moderate persistent asthma in school-aged children...
  81. ncbi request reprint Choice of a medication to treat asthma: is an improvement in symptoms sufficient for deciding?
    Robert C Strunk
    J Allergy Clin Immunol 110:832-3. 2002
  82. ncbi request reprint Effect of peak expiratory flow rate measurement on exhaled nitric oxide levels in children with asthma
    Kyle A Nelson
    J Allergy Clin Immunol 119:245-6. 2007
  83. pmc Chronic traffic-related air pollution and stress interact to predict biologic and clinical outcomes in asthma
    Edith Chen
    Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada
    Environ Health Perspect 116:970-5. 2008
    ..Previous research has documented effects of both physical and social environmental exposures on childhood asthma. However, few studies have considered how these two environments might interact to affect asthma...
  84. ncbi request reprint Symptom perception in childhood asthma: the role of anxiety and asthma severity
    Edith Chen
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada
    Health Psychol 25:389-95. 2006
    ..These results suggest that anxiety plays a role when children's symptoms are mild, whereas medical variables such as severity play a role in perception of changes in asthma symptomatology as bronchoconstriction worsens...
  85. ncbi request reprint Feasibility of a national fatal asthma registry: more evidence of IRB variation in evaluation of a standard protocol
    Sunday Clark
    Massachusetts General Hospital, Boston, MA, USA
    J Asthma 43:19-23. 2006
    ..The project was revived in 2004 when a standard protocol was submitted to Institutional Review Boards (IRBs) in four different states...
  86. ncbi request reprint Retrospective and prospective parental reports of sleep in children with asthma
    Bruce G Bender
    J Allergy Clin Immunol 114:985-8. 2004

Research Grants12

  1. CAMP Continuation Study/Phase 3
    Robert Strunk; Fiscal Year: 2007
    ..End of Abstract.) ..
  2. CARE Network--St. Louis Center
    Robert Strunk; Fiscal Year: 2007
    ..End of abstract.) ..
  3. ASTHMA AND INTERVENTIONS IN THE EMERGENCY DEPARTMENT
    Robert Strunk; Fiscal Year: 2002
    ..The intent to treat model will be used, as primary outcome can be obtained after consent even if not contact cannot be made at 2 week and 6 month phone calls. ..
  4. Social Support and Education in Asthma Follow-Up
    Robert Strunk; Fiscal Year: 2007
    ..05 to detect a reduction of ED visits of 20%. Because the primary outcome can be obtained from medical records after consent even if phone contact cannot be maintained, intent to treat model will be used for analyses. ..