Sheila Stewart

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi Alternative lengthening of telomeres (ALT) and chromatin: is there a connection?
    Thalia Nittis
    Department of Cell Biology and Physiology, Washington University, St Louis, MO 63110, USA
    Biochimie 90:5-12. 2008
  2. ncbi Senescence: does it all happen at the ends?
    Sheila A Stewart
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, MA 02142, USA
    Oncogene 21:627-30. 2002
  3. ncbi Telomerase maintains telomere structure in normal human cells
    Kenkichi Masutomi
    Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Cell 114:241-53. 2003
  4. ncbi Telomeres: cancer to human aging
    Sheila A Stewart
    Departments of Cell Biology and Physiology and of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Annu Rev Cell Dev Biol 22:531-57. 2006
  5. ncbi Telomere maintenance and tumorigenesis: an "ALT"ernative road
    Sheila A Stewart
    Departments of Cell Biology and Physiology and Medicine, Washington University, 660 S Euclid Ave, St Louis, MO 63110, USA
    Curr Mol Med 5:253-7. 2005
  6. doi Senescence: the good the bad and the dysfunctional
    Ermira Pazolli
    Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Curr Opin Genet Dev 18:42-7. 2008
  7. ncbi Multiple levels of telomerase regulation
    Sheila A Stewart
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Mol Interv 2:481-3. 2002
  8. pmc Telomerase contributes to tumorigenesis by a telomere length-independent mechanism
    Sheila A Stewart
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 99:12606-11. 2002
  9. ncbi Prospects for anti-neoplastic therapies based on telomere biology
    Sheila A Stewart
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Curr Cancer Drug Targets 2:1-17. 2002
  10. ncbi Erosion of the telomeric single-strand overhang at replicative senescence
    Sheila A Stewart
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Nat Genet 33:492-6. 2003

Research Grants

Collaborators

  • Robert Weinberg
  • William Hahn
  • Thalia Nittis
  • Ermira Pazolli
  • Lionel Guittat
  • Abhishek Saharia
  • Kenkichi Masutomi
  • Mary W Brooks
  • Ante S Lundberg
  • Martin Steffen
  • Adeline Lim
  • Sandra Crocker
  • Shashikant Kulkarni
  • Shuichi Kaneko
  • Seishi Murakami
  • Evan Y Yu
  • Jennifer L Currier
  • James A DeCaprio
  • Geoffrey B Metz
  • Ittai Ben-Porath
  • Shilagardy Khurts
  • Brian Elenbaas
  • Kimberly A Hartwell
  • Mark D Fleming
  • Scott H Randell
  • John C Olsen
  • Scott W Miller

Detail Information

Publications12

  1. ncbi Alternative lengthening of telomeres (ALT) and chromatin: is there a connection?
    Thalia Nittis
    Department of Cell Biology and Physiology, Washington University, St Louis, MO 63110, USA
    Biochimie 90:5-12. 2008
    ..In this review we focus on these recent advances and their implications in telomere maintenance...
  2. ncbi Senescence: does it all happen at the ends?
    Sheila A Stewart
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, MA 02142, USA
    Oncogene 21:627-30. 2002
    ..In this review, we highlight some of the salient points of basic telomere biology and relate them to the current controversies surrounding the role of telomeres and telomerase in cellular senescence...
  3. ncbi Telomerase maintains telomere structure in normal human cells
    Kenkichi Masutomi
    Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Cell 114:241-53. 2003
    ..Together, these observations support the view that telomerase and telomere structure are dynamically regulated in normal human cells and that telomere length alone is unlikely to trigger entry into replicative senescence...
  4. ncbi Telomeres: cancer to human aging
    Sheila A Stewart
    Departments of Cell Biology and Physiology and of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Annu Rev Cell Dev Biol 22:531-57. 2006
    ..Here we discuss how telomeres are monitored and maintained and how loss of a functional telomere influences biological functions as diverse as aging and carcinogenesis...
  5. ncbi Telomere maintenance and tumorigenesis: an "ALT"ernative road
    Sheila A Stewart
    Departments of Cell Biology and Physiology and Medicine, Washington University, 660 S Euclid Ave, St Louis, MO 63110, USA
    Curr Mol Med 5:253-7. 2005
    ..For these reasons a detailed understanding of the ALT pathway is critical to the future design of anti-neoplastic therapies...
  6. doi Senescence: the good the bad and the dysfunctional
    Ermira Pazolli
    Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Curr Opin Genet Dev 18:42-7. 2008
    ..This added level of complexity suggests that senescence functions as a biological 'double edged sword.'..
  7. ncbi Multiple levels of telomerase regulation
    Sheila A Stewart
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Mol Interv 2:481-3. 2002
    ..The sequestration of telomerase thus imposes a newly identified level of regulation on telomerase activity, implicating telomerase localization as a potentially useful target for pharmacotherapy...
  8. pmc Telomerase contributes to tumorigenesis by a telomere length-independent mechanism
    Sheila A Stewart
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 99:12606-11. 2002
    ..These studies indicate that hTERT confers an additional function that is required for tumorigenesis but does not depend on its ability to maintain telomeres...
  9. ncbi Prospects for anti-neoplastic therapies based on telomere biology
    Sheila A Stewart
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Curr Cancer Drug Targets 2:1-17. 2002
    ..Understanding telomerase biology may eventually lead to several types of clinically effective, telomerase-based therapies for neoplastic disease...
  10. ncbi Erosion of the telomeric single-strand overhang at replicative senescence
    Sheila A Stewart
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Nat Genet 33:492-6. 2003
    ..We thus provide evidence for a specific molecular alteration in telomere structure at senescence and suggest that this change, rather than overall telomere length, serves to trigger this state...
  11. ncbi Immortalization and transformation of primary human airway epithelial cells by gene transfer
    Ante S Lundberg
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Oncogene 21:4577-86. 2002
    ....
  12. pmc Flap endonuclease 1 contributes to telomere stability
    Abhishek Saharia
    Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Curr Biol 18:496-500. 2008
    ..Given FEN1's role in lagging-strand DNA replication and reinitiation of stalled replication forks, we propose that FEN1 contributes to telomere stability by ensuring efficient telomere replication...

Research Grants3

  1. THE ROLE OF FIBROBLAST-DERIVED OSTEOPONTIN IN TUMORIGENESIS
    Sheila A Stewart; Fiscal Year: 2010
    ..To this end, we will study a molecule (osteopontin) elevated in aged, tumor promoting cells and determine how it promotes the development of cancer. ..
  2. Cellular Lifespan and the Telomere Proteome
    Sheila Stewart; Fiscal Year: 2005
    ..For these reasons, a detailed understanding of the molecular mechanisms governing cellular senescence is critical. ..
  3. THE ROLE OF FIBROBLAST-DERIVED OSTEOPONTIN IN TUMORIGENESIS
    Sheila Stewart; Fiscal Year: 2009
    ..To this end, we will study a molecule (osteopontin) elevated in aged, tumor promoting cells and determine how it promotes the development of cancer. ..