WILLIAM STENSON

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Increased prevalence of celiac disease and need for routine screening among patients with osteoporosis
    William F Stenson
    Divisions of Gastroenterology, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Intern Med 165:393-9. 2005
  2. pmc Amebic infection in the human colon induces cyclooxygenase-2
    W F Stenson
    Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Infect Immun 69:3382-8. 2001
  3. ncbi request reprint Prostaglandins and epithelial response to injury
    William F Stenson
    Division of Gastroenterology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Curr Opin Gastroenterol 23:107-10. 2007
  4. ncbi request reprint TNFR1 mediates the radioprotective effects of lipopolysaccharide in the mouse intestine
    Terrence E Riehl
    Division of Gastroenterology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Gastrointest Liver Physiol 286:G166-73. 2004
  5. pmc Dynamic antagonism between RNA-binding protein CUGBP2 and cyclooxygenase-2-mediated prostaglandin E2 in radiation damage
    Nabendu Murmu
    Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 101:13873-8. 2004
  6. pmc Regulation of colonic epithelial repair in mice by Toll-like receptors and hyaluronic acid
    Ling Zheng
    Division of Gastroenterology, Washington University, St Louis, Missouri, USA
    Gastroenterology 137:2041-51. 2009
  7. pmc Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation
    Teresa G Tessner
    Division of Gastroenterology, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 114:1676-85. 2004
  8. ncbi request reprint Phytosterols that are naturally present in commercial corn oil significantly reduce cholesterol absorption in humans
    Richard E Ostlund
    Division of Endocrinology, Diabetes and Metabolism, Washington University, St Louis, MO 63110, USA
    Am J Clin Nutr 75:1000-4. 2002
  9. pmc Induction of IDO-1 by immunostimulatory DNA limits severity of experimental colitis
    Matthew A Ciorba
    Division of Gastroenterology, Washington University, St Louis, MO 63110, USA
    J Immunol 184:3907-16. 2010
  10. ncbi request reprint Reactive hemophagocytic syndrome complicating the treatment of inflammatory bowel disease
    Dustin G James
    Division of Gastroenterology, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Inflamm Bowel Dis 12:573-80. 2006

Research Grants

  1. MOLECULAR DISSECTION OF E. HISTOLYTICA PATHOGENESIS
    William F Stenson; Fiscal Year: 2010
  2. CELIAC DISEASE IN OSTEOPOROSIS
    WILLIAM STENSON; Fiscal Year: 2004
  3. MEDIATORS OF INFLAMMATION IN INFLAMMATORY BOWEL DISEASE
    WILLIAM STENSON; Fiscal Year: 2006
  4. PROSTAGLANDINS IN EPITHELIAL INJURY
    WILLIAM STENSON; Fiscal Year: 2007
  5. Indoleamine 23-Dioxygnease in Intestinal Inflammation
    WILLIAM STENSON; Fiscal Year: 2007
  6. Mediators of Inflammation in Intestinal Injury
    WILLIAM STENSON; Fiscal Year: 2007
  7. Indoleamine 23-Dioxygnease in Intestinal Inflammation
    William F Stenson; Fiscal Year: 2010
  8. MEDIATORS OF INFLAMMATION IN INFLAMMATORY BOWEL DISEASE
    WILLIAM STENSON; Fiscal Year: 2001
  9. PROSTAGLANDINS IN EPITHELIAL INJURY
    WILLIAM STENSON; Fiscal Year: 2003
  10. PROSTAGLANDINS IN EPITHELIAL INJURY
    William F Stenson; Fiscal Year: 2010

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Increased prevalence of celiac disease and need for routine screening among patients with osteoporosis
    William F Stenson
    Divisions of Gastroenterology, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Intern Med 165:393-9. 2005
    ..However, the relative prevalence of celiac disease among osteoporotic and nonosteoporotic populations is not known, and the benefit of screening the osteoporotic population for celiac disease remains controversial...
  2. pmc Amebic infection in the human colon induces cyclooxygenase-2
    W F Stenson
    Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Infect Immun 69:3382-8. 2001
    ..Moreover, prostaglandins produced through cyclooxygenase-2 participate in the mediation of the neutrophil response to infection and enhance epithelial permeability...
  3. ncbi request reprint Prostaglandins and epithelial response to injury
    William F Stenson
    Division of Gastroenterology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Curr Opin Gastroenterol 23:107-10. 2007
    ..This review will highlight recent studies in the role of prostaglandins in regulating the epithelial response to injury in the gastrointestinal tract...
  4. ncbi request reprint TNFR1 mediates the radioprotective effects of lipopolysaccharide in the mouse intestine
    Terrence E Riehl
    Division of Gastroenterology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Gastrointest Liver Physiol 286:G166-73. 2004
    ..The immunolocalization of TNFR1 and COX-2 expression to subepithelial fibroblasts following LPS administration suggests that this cell type plays an intermediate role in LPS-induced radioprotection in the intestine...
  5. pmc Dynamic antagonism between RNA-binding protein CUGBP2 and cyclooxygenase-2-mediated prostaglandin E2 in radiation damage
    Nabendu Murmu
    Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 101:13873-8. 2004
    ..Furthermore, CUGBP2 expression is higher in COX-1(-/-) and COX-2(-/-) mice than wild-type controls at basal conditions, which is further increased after IR...
  6. pmc Regulation of colonic epithelial repair in mice by Toll-like receptors and hyaluronic acid
    Ling Zheng
    Division of Gastroenterology, Washington University, St Louis, Missouri, USA
    Gastroenterology 137:2041-51. 2009
    ..TLR4 ligands include bacterial lipopolysaccharide and hyaluronic acid, a component of the extracellular matrix. Our hypothesis is that hyaluronic acid, through TLRs, plays a protective role in the host response to DSS-induced colitis...
  7. pmc Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation
    Teresa G Tessner
    Division of Gastroenterology, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 114:1676-85. 2004
    ....
  8. ncbi request reprint Phytosterols that are naturally present in commercial corn oil significantly reduce cholesterol absorption in humans
    Richard E Ostlund
    Division of Endocrinology, Diabetes and Metabolism, Washington University, St Louis, MO 63110, USA
    Am J Clin Nutr 75:1000-4. 2002
    ..Vegetable oils are the richest dietary source of phytosterols; corn oil contains 0.77% phytosterols by weight...
  9. pmc Induction of IDO-1 by immunostimulatory DNA limits severity of experimental colitis
    Matthew A Ciorba
    Division of Gastroenterology, Washington University, St Louis, MO 63110, USA
    J Immunol 184:3907-16. 2010
    ..These findings support the possibility that targeted induction of IDO-1 is an approach deserving further investigation as a therapeutic strategy for diseases of intestinal inflammation...
  10. ncbi request reprint Reactive hemophagocytic syndrome complicating the treatment of inflammatory bowel disease
    Dustin G James
    Division of Gastroenterology, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Inflamm Bowel Dis 12:573-80. 2006
    ..The aims of this study were to describe the clinical and laboratory features of RHS associated with IBD and to review diagnostic criteria, treatment options, and pathogenesis...
  11. ncbi request reprint Gastrointestinal absorption and plasma kinetics of soy Delta(5)-phytosterols and phytostanols in humans
    Richard E Ostlund
    Division of Endocrinology, Diabetes and Metabolism, Washington University School of Medicine, Missouri 63017, USA
    Am J Physiol Endocrinol Metab 282:E911-6. 2002
    ..We conclude that the efficiency of phytosterol absorption is lower than what was reported previously and is critically dependent on the structure of both sterol nucleus and side chain...
  12. doi request reprint Probiotic therapy in radiation-induced intestinal injury and repair
    Matthew A Ciorba
    Division of Gastroenterology, Washington University in Saint Louis School of Medicine, Saint Louis, MO 63110, USA
    Ann N Y Acad Sci 1165:190-4. 2009
    ..We will review the area with a focus on new developments surrounding probiotic therapy in radiation-induced intestinal injury and repair...
  13. ncbi request reprint Basic fibroblast growth factor upregulates cyclooxygenase-2 in I407 cells through p38 MAP kinase
    Teresa G Tessner
    Division of Gastroenterology, Washington University, St Louis, Missouri 63110, USA
    Am J Physiol Gastrointest Liver Physiol 284:G269-79. 2003
    ..Furthermore, they indicate that p38 activity is required at a step distal to arachidonate release, most likely COX-2 upregulation, because exogenous arachidonate did not restore PGE(2) synthesis...
  14. ncbi request reprint Apobec-1 protects intestine from radiation injury through posttranscriptional regulation of cyclooxygenase-2 expression
    Shrikant Anant
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Gastroenterology 127:1139-49. 2004
    ..This study aimed to determine the role of the RNA binding protein apobec-1 in radioprotection of the intestine...
  15. ncbi request reprint Inhibition of indoleamine 2,3-dioxygenase augments trinitrobenzene sulfonic acid colitis in mice
    Gregory J Gurtner
    Division of Gastroenteroloyg, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Gastroenterology 125:1762-73. 2003
    ..IDO is highly expressed in the mammalian intestine. We sought to determine whether IDO played a regulatory role in the T-cell helper 1 (Th1)-mediated trinitrobenzene sulfonic acid (TNBS) model of colitis...
  16. ncbi request reprint Ionizing radiation up-regulates cyclooxygenase-2 in I407 cells through p38 mitogen-activated protein kinase
    Teresa G Tessner
    Division of Gastroenterology, Washington University School of Medicine, St Louis, MO 63110, USA
    Carcinogenesis 25:37-45. 2004
    ..Furthermore, they indicate that p38 activity is required at a step distal to arachidonate release, most probably COX-2 up-regulation, since exogenous arachidonate did not restore PGE2 synthesis...
  17. ncbi request reprint Inhibition of cholesterol absorption by phytosterol-replete wheat germ compared with phytosterol-depleted wheat germ
    Richard E Ostlund
    Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Washington University, St Louis, MO 63110, USA
    Am J Clin Nutr 77:1385-9. 2003
    ..Low-fat vegetable foods contain phytosterols, but it is not known whether they are in biologically active forms or whether their concentrations are high enough to reduce cholesterol absorption and favorably affect lipid metabolism...
  18. ncbi request reprint Prosurvival and antiapoptotic effects of PGE2 in radiation injury are mediated by EP2 receptor in intestine
    Courtney W Houchen
    Department of Medicine, Division of Gastroenterology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Am J Physiol Gastrointest Liver Physiol 284:G490-8. 2003
    ..The effects of PGE(2) on both crypt epithelial apoptosis and intestinal crypt stem cell survival are mediated through the EP(2) receptor...
  19. pmc Myd88-dependent positioning of Ptgs2-expressing stromal cells maintains colonic epithelial proliferation during injury
    Sarah L Brown
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 117:258-69. 2007
    ....
  20. pmc Growth factor regulation of prostaglandin-endoperoxide synthase 2 (Ptgs2) expression in colonic mesenchymal stem cells
    Monica R Walker
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 285:5026-39. 2010
    ..These studies suggest that Fgf9 is an important factor in the regulation of Ptgs2 in colonic MSCs and may be a factor involved in its constitutive expression in vivo...
  21. ncbi request reprint Safety of selective cyclooxygenase-2-inhibitors in inflammatory bowel disease
    William F Stenson
    Department of Gastroenterology, Washington University School of Medicine, Saint Louis, Missouri, USA
    Inflamm Bowel Dis 8:429-30. 2002
  22. ncbi request reprint Rapid transient absorption and biliary secretion of enantiomeric cholesterol in hamsters
    Emily J Westover
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Lipid Res 47:2374-81. 2006
    ..These findings suggest that cholesterol absorption is structurally specific and likely to be mediated by enantiospecific cellular proteins...
  23. ncbi request reprint Opposing effects of tumor necrosis factor receptor 1 and 2 in sepsis due to cecal ligation and puncture
    Dawn R Ebach
    Division of Pediatric Gastroenterology, Department of Pediatrics, Washington University, St Louis, Missouri 63110, USA
    Shock 23:311-8. 2005
    ..These data suggest that in sepsis, TNFR1 mediates much of the TNF-alpha-induced pathology, whereas TNFR2 mediates protective effects...
  24. ncbi request reprint Effects of trace components of dietary fat on cholesterol metabolism: phytosterols, oxysterols, and squalene
    Richard E Ostlund
    Division of Endocrinology, Diabetes, and Metabolism, Washington University, St Louis, MO 63110, USA
    Nutr Rev 60:349-59. 2002
    ....
  25. pmc Characterization of enantiomeric bile acid-induced apoptosis in colon cancer cell lines
    Bryson W Katona
    Department of Developmental Biology, Division of Gastroenterology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Biol Chem 284:3354-64. 2009
    ..This suggests that LCA/ent-LCA induce apoptosis enantioselectively through CD95 activation, likely because of increased reactive oxygen species generation, with resulting procaspase-8 cleavage...
  26. pmc CD46-induced immunomodulatory CD4+ T cells express the adhesion molecule and chemokine receptor pattern of intestinal T cells
    Shannon K Alford
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 181:2544-55. 2008
    ..These data suggest that CD46-induced Tregs might play a role in intestinal immune homeostasis where they could dampen unwanted effector T cell responses through local IL-10/granzyme B production...
  27. ncbi request reprint Celecoxib versus naproxen and diclofenac in osteoarthritis patients: SUCCESS-I Study
    Gurkirpal Singh
    Department of Medicine, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, Calif 94301, USA
    Am J Med 119:255-66. 2006
    ..To evaluate the efficacy and upper gastrointestinal (UGI) safety of celecoxib, compared with nonspecific nonsteroidal anti-inflammatory drugs (NSAIDs), among patients with osteoarthritis...
  28. ncbi request reprint Fat-free foods supplemented with soy stanol-lecithin powder reduce cholesterol absorption and LDL cholesterol
    Curtis A Spilburg
    Lifeline Technologies, Chesterfield, MO 63017, USA
    J Am Diet Assoc 103:577-81. 2003
    ..The objective of this work was to show that fat-free, lecithin-formulated soy stanols lower cholesterol absorption and serum LDL cholesterol...
  29. ncbi request reprint Differential role of tumor necrosis factor receptors in TNBS colitis
    Dawn R Ebach
    Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Washington University, St Louis, Missouri, USA
    Inflamm Bowel Dis 11:533-40. 2005
    ..Tumor necrosis factor alpha (TNFalpha) plays a central role in the pathology of T helper 1-mediated colitis such as Crohn's disease; however, the role of its 2 receptors in mediating pathology has not been fully explored...
  30. doi request reprint Toll-like receptors and intestinal epithelial repair
    William F Stenson
    Curr Opin Gastroenterol 24:103-7. 2008
  31. doi request reprint Challenges in IBD research: Assessing progress and rethinking the research agenda
    William F Stenson
    Washington University, St Louis, Missouri, USA
    Inflamm Bowel Dis 14:687-708. 2008

Research Grants39

  1. MOLECULAR DISSECTION OF E. HISTOLYTICA PATHOGENESIS
    William F Stenson; Fiscal Year: 2010
    ..Jr. The name of the principal investigator/programdirector must be provided at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OFCONTENTS Page Numbers Face Page 1 Description, ..
  2. CELIAC DISEASE IN OSTEOPOROSIS
    WILLIAM STENSON; Fiscal Year: 2004
    ..At the end of the year of therapy, bone mass indices will be repeated and the response to the therapy of the two groups will be compared. ..
  3. MEDIATORS OF INFLAMMATION IN INFLAMMATORY BOWEL DISEASE
    WILLIAM STENSON; Fiscal Year: 2006
    ..Manipulation of the epithelial response to radiation could lead to agents that protect normal epithelial cells during radiation therapy. ..
  4. PROSTAGLANDINS IN EPITHELIAL INJURY
    WILLIAM STENSON; Fiscal Year: 2007
    ..In vivo growth studies of Cox-1-/- and Cox-2-/- sarcomas in WT and Rag-1-/- mice suggest that suppression of the host immune response by tumor PGE2 markedly enhances tumor growth. ..
  5. Indoleamine 23-Dioxygnease in Intestinal Inflammation
    WILLIAM STENSON; Fiscal Year: 2007
    ..The long term goal of this project is to determine if there is a role for pharmacologic agents that increase IDO expression in the management of human inflammatory bowel disease. ..
  6. Mediators of Inflammation in Intestinal Injury
    WILLIAM STENSON; Fiscal Year: 2007
    ..2) To define the mechanisms by which DSS induces cell cycle arrest and by which PGE2 rescues this arrest. 3) To define the mechanism for the increased radiation induced apoptosis in Myd88-/- mice and the rescue by PGE2. ..
  7. Indoleamine 23-Dioxygnease in Intestinal Inflammation
    William F Stenson; Fiscal Year: 2010
    ..The long term goal of this project is to determine if there is a role for pharmacologic agents that increase IDO expression in the management of human inflammatory bowel disease. ..
  8. MEDIATORS OF INFLAMMATION IN INFLAMMATORY BOWEL DISEASE
    WILLIAM STENSON; Fiscal Year: 2001
    ....
  9. PROSTAGLANDINS IN EPITHELIAL INJURY
    WILLIAM STENSON; Fiscal Year: 2003
    ..To determine the role of prostaglandins and/or apoptosis in the effects of other radioprotective (LPS, IL-1, IL-11, TGF-beta3), or radiosensitizing (IL-12) agents. ..
  10. PROSTAGLANDINS IN EPITHELIAL INJURY
    William F Stenson; Fiscal Year: 2010
    ..This proposal is also relevant to any disease that involves the host response to injuries to the intestinal epithelium including inflammatory bowel disease and enteric infections. ..