W F Stenson

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Reactive hemophagocytic syndrome complicating the treatment of inflammatory bowel disease
    Dustin G James
    Division of Gastroenterology, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Inflamm Bowel Dis 12:573-80. 2006
  2. ncbi request reprint Basic fibroblast growth factor upregulates cyclooxygenase-2 in I407 cells through p38 MAP kinase
    Teresa G Tessner
    Division of Gastroenterology, Washington University, St Louis, Missouri 63110, USA
    Am J Physiol Gastrointest Liver Physiol 284:G269-79. 2003
  3. ncbi request reprint Ionizing radiation up-regulates cyclooxygenase-2 in I407 cells through p38 mitogen-activated protein kinase
    Teresa G Tessner
    Division of Gastroenterology, Washington University School of Medicine, St Louis, MO 63110, USA
    Carcinogenesis 25:37-45. 2004
  4. ncbi request reprint Overexpression of MDR1 in an intestinal cell line results in increased cholesterol uptake from micelles
    T G Tessner
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biochem Biophys Res Commun 267:565-71. 2000
  5. pmc Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation
    Teresa G Tessner
    Division of Gastroenterology, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 114:1676-85. 2004
  6. ncbi request reprint Spontaneous and continuous cyclooxygenase-2-dependent prostaglandin E2 production by stromal cells in the murine small intestine lamina propria: directing the tone of the intestinal immune response
    R D Newberry
    Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
    J Immunol 166:4465-72. 2001
  7. ncbi request reprint Disruption of cyclooxygenase-1 gene results in an impaired response to radiation injury
    C W Houchen
    Division of Gastroenterology, Washington University, Saint Louis, Missouri, USA
    Am J Physiol Gastrointest Liver Physiol 279:G858-65. 2000
  8. pmc Amebic infection in the human colon induces cyclooxygenase-2
    W F Stenson
    Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Infect Immun 69:3382-8. 2001
  9. ncbi request reprint Induction of epithelial arachidonate 12-lipoxygenase at active sites of inflammatory bowel disease
    V R Shannon
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    Am J Physiol 264:G104-11. 1993
  10. ncbi request reprint Sitostanol administered in lecithin micelles potently reduces cholesterol absorption in humans
    R E Ostlund
    Division of Endocrinology, Washington University, St Louis, MO, USA
    Am J Clin Nutr 70:826-31. 1999

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Reactive hemophagocytic syndrome complicating the treatment of inflammatory bowel disease
    Dustin G James
    Division of Gastroenterology, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Inflamm Bowel Dis 12:573-80. 2006
    ..The aims of this study were to describe the clinical and laboratory features of RHS associated with IBD and to review diagnostic criteria, treatment options, and pathogenesis...
  2. ncbi request reprint Basic fibroblast growth factor upregulates cyclooxygenase-2 in I407 cells through p38 MAP kinase
    Teresa G Tessner
    Division of Gastroenterology, Washington University, St Louis, Missouri 63110, USA
    Am J Physiol Gastrointest Liver Physiol 284:G269-79. 2003
    ..Furthermore, they indicate that p38 activity is required at a step distal to arachidonate release, most likely COX-2 upregulation, because exogenous arachidonate did not restore PGE(2) synthesis...
  3. ncbi request reprint Ionizing radiation up-regulates cyclooxygenase-2 in I407 cells through p38 mitogen-activated protein kinase
    Teresa G Tessner
    Division of Gastroenterology, Washington University School of Medicine, St Louis, MO 63110, USA
    Carcinogenesis 25:37-45. 2004
    ..Furthermore, they indicate that p38 activity is required at a step distal to arachidonate release, most probably COX-2 up-regulation, since exogenous arachidonate did not restore PGE2 synthesis...
  4. ncbi request reprint Overexpression of MDR1 in an intestinal cell line results in increased cholesterol uptake from micelles
    T G Tessner
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biochem Biophys Res Commun 267:565-71. 2000
    ..This is also the first demonstration that a multiple drug resistance protein can function in the net uptake, rather than efflux, of a substrate...
  5. pmc Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation
    Teresa G Tessner
    Division of Gastroenterology, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 114:1676-85. 2004
    ....
  6. ncbi request reprint Spontaneous and continuous cyclooxygenase-2-dependent prostaglandin E2 production by stromal cells in the murine small intestine lamina propria: directing the tone of the intestinal immune response
    R D Newberry
    Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
    J Immunol 166:4465-72. 2001
    ....
  7. ncbi request reprint Disruption of cyclooxygenase-1 gene results in an impaired response to radiation injury
    C W Houchen
    Division of Gastroenterology, Washington University, Saint Louis, Missouri, USA
    Am J Physiol Gastrointest Liver Physiol 279:G858-65. 2000
    ..These data suggest that prostaglandins synthesized by Cox-1 regulate multiple steps that determine the fate of crypt epithelial cell after genotoxic or cytotoxic injury...
  8. pmc Amebic infection in the human colon induces cyclooxygenase-2
    W F Stenson
    Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Infect Immun 69:3382-8. 2001
    ..Moreover, prostaglandins produced through cyclooxygenase-2 participate in the mediation of the neutrophil response to infection and enhance epithelial permeability...
  9. ncbi request reprint Induction of epithelial arachidonate 12-lipoxygenase at active sites of inflammatory bowel disease
    V R Shannon
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    Am J Physiol 264:G104-11. 1993
    ....
  10. ncbi request reprint Sitostanol administered in lecithin micelles potently reduces cholesterol absorption in humans
    R E Ostlund
    Division of Endocrinology, Washington University, St Louis, MO, USA
    Am J Clin Nutr 70:826-31. 1999
    ..Phytosterol feeding in human clinical trials has had generally small and inconsistent effects on serum cholesterol concentrations, raising doubts about the importance of phytosterols in natural diets and supplements...
  11. pmc COX-1(+/-)COX-2(-/-) genotype in mice is associated with shortened time to carotid artery occlusion through increased PAI-1
    T E Riehl
    Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Thromb Haemost 9:350-60. 2011
    ..The cyclooxygenase products thromboxane A(2) and prostacyclin are important in the regulation of coagulation but their role in fibrinolysis is largely unexplored. PAI-1 blocks fibrinolysis by inhibiting plasminogen activator...
  12. ncbi request reprint Analysis of mucosal gene expression in inflammatory bowel disease by parallel oligonucleotide arrays
    B K Dieckgraefe
    Division of Gastroenterology, Department of Surgical Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Physiol Genomics 4:1-11. 2000
    ....
  13. ncbi request reprint Prosurvival and antiapoptotic effects of PGE2 in radiation injury are mediated by EP2 receptor in intestine
    Courtney W Houchen
    Department of Medicine, Division of Gastroenterology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Am J Physiol Gastrointest Liver Physiol 284:G490-8. 2003
    ..The effects of PGE(2) on both crypt epithelial apoptosis and intestinal crypt stem cell survival are mediated through the EP(2) receptor...
  14. ncbi request reprint Prostaglandins and epithelial response to injury
    William F Stenson
    Division of Gastroenterology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Curr Opin Gastroenterol 23:107-10. 2007
    ..This review will highlight recent studies in the role of prostaglandins in regulating the epithelial response to injury in the gastrointestinal tract...
  15. pmc Myd88-dependent positioning of Ptgs2-expressing stromal cells maintains colonic epithelial proliferation during injury
    Sarah L Brown
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 117:258-69. 2007
    ....
  16. ncbi request reprint Rapid transient absorption and biliary secretion of enantiomeric cholesterol in hamsters
    Emily J Westover
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Lipid Res 47:2374-81. 2006
    ..These findings suggest that cholesterol absorption is structurally specific and likely to be mediated by enantiospecific cellular proteins...
  17. ncbi request reprint Differential role of tumor necrosis factor receptors in TNBS colitis
    Dawn R Ebach
    Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Washington University, St Louis, Missouri, USA
    Inflamm Bowel Dis 11:533-40. 2005
    ..Tumor necrosis factor alpha (TNFalpha) plays a central role in the pathology of T helper 1-mediated colitis such as Crohn's disease; however, the role of its 2 receptors in mediating pathology has not been fully explored...
  18. ncbi request reprint Increased prevalence of celiac disease and need for routine screening among patients with osteoporosis
    William F Stenson
    Divisions of Gastroenterology, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Intern Med 165:393-9. 2005
    ..However, the relative prevalence of celiac disease among osteoporotic and nonosteoporotic populations is not known, and the benefit of screening the osteoporotic population for celiac disease remains controversial...
  19. ncbi request reprint Apobec-1 protects intestine from radiation injury through posttranscriptional regulation of cyclooxygenase-2 expression
    Shrikant Anant
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Gastroenterology 127:1139-49. 2004
    ..This study aimed to determine the role of the RNA binding protein apobec-1 in radioprotection of the intestine...
  20. pmc Dynamic antagonism between RNA-binding protein CUGBP2 and cyclooxygenase-2-mediated prostaglandin E2 in radiation damage
    Nabendu Murmu
    Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 101:13873-8. 2004
    ..Furthermore, CUGBP2 expression is higher in COX-1(-/-) and COX-2(-/-) mice than wild-type controls at basal conditions, which is further increased after IR...
  21. ncbi request reprint Safety of selective cyclooxygenase-2-inhibitors in inflammatory bowel disease
    William F Stenson
    Department of Gastroenterology, Washington University School of Medicine, Saint Louis, Missouri, USA
    Inflamm Bowel Dis 8:429-30. 2002
  22. ncbi request reprint Fat-free foods supplemented with soy stanol-lecithin powder reduce cholesterol absorption and LDL cholesterol
    Curtis A Spilburg
    Lifeline Technologies, Chesterfield, MO 63017, USA
    J Am Diet Assoc 103:577-81. 2003
    ..The objective of this work was to show that fat-free, lecithin-formulated soy stanols lower cholesterol absorption and serum LDL cholesterol...
  23. ncbi request reprint Inhibition of cholesterol absorption by phytosterol-replete wheat germ compared with phytosterol-depleted wheat germ
    Richard E Ostlund
    Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Washington University, St Louis, MO 63110, USA
    Am J Clin Nutr 77:1385-9. 2003
    ..Low-fat vegetable foods contain phytosterols, but it is not known whether they are in biologically active forms or whether their concentrations are high enough to reduce cholesterol absorption and favorably affect lipid metabolism...
  24. ncbi request reprint Phytosterols that are naturally present in commercial corn oil significantly reduce cholesterol absorption in humans
    Richard E Ostlund
    Division of Endocrinology, Diabetes and Metabolism, Washington University, St Louis, MO 63110, USA
    Am J Clin Nutr 75:1000-4. 2002
    ..Vegetable oils are the richest dietary source of phytosterols; corn oil contains 0.77% phytosterols by weight...
  25. ncbi request reprint Gastrointestinal absorption and plasma kinetics of soy Delta(5)-phytosterols and phytostanols in humans
    Richard E Ostlund
    Division of Endocrinology, Diabetes and Metabolism, Washington University School of Medicine, Missouri 63017, USA
    Am J Physiol Endocrinol Metab 282:E911-6. 2002
    ..We conclude that the efficiency of phytosterol absorption is lower than what was reported previously and is critically dependent on the structure of both sterol nucleus and side chain...
  26. ncbi request reprint Inhibition of indoleamine 2,3-dioxygenase augments trinitrobenzene sulfonic acid colitis in mice
    Gregory J Gurtner
    Division of Gastroenteroloyg, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Gastroenterology 125:1762-73. 2003
    ..IDO is highly expressed in the mammalian intestine. We sought to determine whether IDO played a regulatory role in the T-cell helper 1 (Th1)-mediated trinitrobenzene sulfonic acid (TNBS) model of colitis...
  27. ncbi request reprint TNFR1 mediates the radioprotective effects of lipopolysaccharide in the mouse intestine
    Terrence E Riehl
    Division of Gastroenterology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Gastrointest Liver Physiol 286:G166-73. 2004
    ..The immunolocalization of TNFR1 and COX-2 expression to subepithelial fibroblasts following LPS administration suggests that this cell type plays an intermediate role in LPS-induced radioprotection in the intestine...
  28. ncbi request reprint Celecoxib versus naproxen and diclofenac in osteoarthritis patients: SUCCESS-I Study
    Gurkirpal Singh
    Department of Medicine, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, Calif 94301, USA
    Am J Med 119:255-66. 2006
    ..To evaluate the efficacy and upper gastrointestinal (UGI) safety of celecoxib, compared with nonspecific nonsteroidal anti-inflammatory drugs (NSAIDs), among patients with osteoarthritis...
  29. ncbi request reprint Opposing effects of tumor necrosis factor receptor 1 and 2 in sepsis due to cecal ligation and puncture
    Dawn R Ebach
    Division of Pediatric Gastroenterology, Department of Pediatrics, Washington University, St Louis, Missouri 63110, USA
    Shock 23:311-8. 2005
    ..These data suggest that in sepsis, TNFR1 mediates much of the TNF-alpha-induced pathology, whereas TNFR2 mediates protective effects...
  30. ncbi request reprint Effects of trace components of dietary fat on cholesterol metabolism: phytosterols, oxysterols, and squalene
    Richard E Ostlund
    Division of Endocrinology, Diabetes, and Metabolism, Washington University, St Louis, MO 63110, USA
    Nutr Rev 60:349-59. 2002
    ....
  31. doi request reprint Challenges in IBD research: Assessing progress and rethinking the research agenda
    William F Stenson
    Washington University, St Louis, Missouri, USA
    Inflamm Bowel Dis 14:687-708. 2008
  32. doi request reprint Toll-like receptors and intestinal epithelial repair
    William F Stenson
    Curr Opin Gastroenterol 24:103-7. 2008
  33. pmc CD46-induced immunomodulatory CD4+ T cells express the adhesion molecule and chemokine receptor pattern of intestinal T cells
    Shannon K Alford
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 181:2544-55. 2008
    ..These data suggest that CD46-induced Tregs might play a role in intestinal immune homeostasis where they could dampen unwanted effector T cell responses through local IL-10/granzyme B production...