Research Topics
| Phyllis K SteinSummaryAffiliation: Washington University School of Medicine Country: USA Publications
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Detail Information
Publications
Caloric restriction may reverse age-related autonomic decline in humansPhyllis K Stein
HRV Laboratory, Washington University School of Medicine, St Louis, MO 63110, USA
Aging Cell 11:644-50. 2012....
Heart rate variability, sleep and sleep disordersPhyllis K Stein
Washington University, School of Medicine HRV Laboratory, 4625 Lindell Boulevard, Suite 402, Saint Louis, MO 63108, USA
Sleep Med Rev 16:47-66. 2012..Evidence also suggests that HRV collected during a PSG can be used in risk stratification models, at least for older adults. Caveats for accurate interpretation of HRV are also presented...
Relationship of abnormal heart rate turbulence and elevated CRP to cardiac mortality in low, intermediate, and high-risk older adultsPhyllis K Stein
Washington University School of Medicine, St Louis, Missouri, USA
J Cardiovasc Electrophysiol 22:122-7. 2011..We examined whether heart rate turbulence (HRT) and C-reactive protein (CRP) add to traditional risk factors for cardiac mortality in older adults at low, intermediate, and high risk...
Nighttime heart rate and survival in depressed patients post acute myocardial infarctionRobert M Carney
Departments of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Psychosom Med 70:757-63. 2008..It is also associated with sleep disturbances and with elevated HR, which may be more pronounced at night. Resting and 24-hour HR have been found to predict mortality in patient and community samples...
Cardiac autonomic modulation. Analyzing circadian and ultradian rhythmsPhyllis K Stein
Washington University School of Medicine, St. Louis, MO 63108, USA
IEEE Eng Med Biol Mag 26:14-8. 2007
Heart rate turbulence, depression, and survival after acute myocardial infarctionRobert M Carney
Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
Psychosom Med 69:4-9. 2007..e., abnormal turbulence) to premature ventricular contractions (VPCs), and b) whether abnormal HR turbulence accounts for the effect of depression on increased mortality after AMI...
Heart rate variability and its changes over 5 years in older adultsPhyllis K Stein
Washington University School of Medicine, St Louis, MO, USA
Age Ageing 38:212-8. 2009..Purpose: to characterise the association between age, ageing and heart rate variability (HRV) in older individuals, 585 adults age >65 years with two 24-h Holter recordings in the Cardiovascular Health Study were studied...
Circadian and ultradian rhythms in heart rate variabilityPhyllis K Stein
1. Division of Cardiology, Washington University School of Medicine, St. Louis, MO 63110, USA
Biomed Tech (Berl) 51:155-8. 2006..Quantification of ultradian patterns of HRV is feasible and could provide new insights into autonomic physiology...
Heart rate variability and markers of inflammation and coagulation in depressed patients with coronary heart diseaseRobert M Carney
Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
J Psychosom Res 62:463-7. 2007..Cardiac autonomic nervous system (ANS) dysregulation, proinflammatory processes, and procoagulant processes have been suggested as possible explanations...
Low heart rate variability and the effect of depression on post-myocardial infarction mortalityRobert M Carney
Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
Arch Intern Med 165:1486-91. 2005..Depression is associated with an increased risk for mortality after acute myocardial infarction (MI). The purpose of this study was to determine whether low heart rate variability (HRV) mediates the effect of depression on mortality...
Circadian and ultradian rhythms in cardiac autonomic modulationPhyllis K Stein
Washington University School of Medicine, St Louis, MO 63108, USA
Conf Proc IEEE Eng Med Biol Soc 1:429-32. 2006..We have developed a method for capturing these rhythms during sleep and have now applied it to 24-hour recordings...
Novel measures of heart rate variability predict cardiovascular mortality in older adults independent of traditional cardiovascular risk factors: the Cardiovascular Health Study (CHS)Phyllis K Stein
Washington University School of Medicine, St Louis, Missouri 63108, USA
J Cardiovasc Electrophysiol 19:1169-74. 2008..Novel HRV Predicts CV Mortality in the Elderly...
Development of more erratic heart rate patterns is associated with mortality post-myocardial infarctionPhyllis K Stein
Washington University School of Medicine, Heart Rate Variability Laboratory, St Louis, MO 63121, USA
J Electrocardiol 41:110-5. 2008..47; 95% confidence interval, 0.39-0.58) were significantly associated with decreased mortality compared with ESR. Quantification of ESR may identify more vulnerable patients or help monitor the effects of pharmacologic treatment...
Traditional and nonlinear heart rate variability are each independently associated with mortality after myocardial infarctionPhyllis K Stein
Washington University School of Medicine, St Louis, Missouri 63108, USA
J Cardiovasc Electrophysiol 16:13-20. 2005..Traditional HRV predicts mortality in patients with a range of times post-MI, but the association of nonlinear HRV and outcome in this population is unknown...
Effect of omega-3 fatty acids on heart rate variability in depressed patients with coronary heart diseaseRobert M Carney
Behavioral Medicine Center, Department of Psychiatry, Washington University School of Medicine, 4320 Forest Park Avenue, Suite 301, St Louis, MO 63108, USA
Psychosom Med 72:748-54. 2010..Low intake of omega-3 FAs is associated with depression and with low HRV, and all three are associated with an increased risk of death in patients with CHD...
Ambulatory ECG-based T-wave alternans predicts sudden cardiac death in high-risk post-MI patients with left ventricular dysfunction in the EPHESUS studyPhyllis K Stein
Washington University School of Medicine HRV Lab, 4625 Lindell Blvd, Suite 402, St Louis, Missouri, 63108, USA
J Cardiovasc Electrophysiol 19:1037-42. 2008..TWA can be measured from ambulatory ECGs (AECGs) using modified moving average (MMA) method. Whether MMA TWA from AECGs predicts SCD in post-MI patients with left ventricular dysfunction (LVD) is unknown...
Sometimes higher heart rate variability is not better heart rate variability: results of graphical and nonlinear analysesPhyllis K Stein
Washington University School of Medicine, St Louis, Missouri 63108, USA
J Cardiovasc Electrophysiol 16:954-9. 2005..To determine the prevalence and effect on traditional heart rate variability (HRV) indices of abnormal HRV patterns in the elderly...
Association of Holter-based measures including T-wave alternans with risk of sudden cardiac death in the community-dwelling elderly: the Cardiovascular Health StudyPhyllis K Stein
Washington University School of Medicine, 4625 Lindell Blvd, St Louis, MO 63108, USA
J Electrocardiol 43:251-9. 2010..Sudden cardiac death (SCD) can be the first manifestation of cardiovascular disease. Development of screening methods for higher/lower risk is critical...
Higher levels of inflammation factors and greater insulin resistance are independently associated with higher heart rate and lower heart rate variability in normoglycemic older individuals: the Cardiovascular Health StudyPhyllis K Stein
Cardiovascular Division, Washington University School of Medicine, St Louis, Missouri 63108, USA
J Am Geriatr Soc 56:315-21. 2008..To explore the relationship between (1) insulin resistance and inflammation factors with (2) higher heart rate (HR) and lower heart rate variability (HRV) in normoglycemic older adults...
Including patients with diabetes mellitus or coronary artery bypass grafting decreases the association between heart rate variability and mortality after myocardial infarctionPhyllis K Stein
Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St Louis, MO 63108, USA
Am Heart J 147:309-16. 2004..Decreased heart rate variability (HRV) is often assumed to be associated with mortality in all patients after myocardial infarction (MI), independent of clinical factors or time after MI...
Demonstration of circadian rhythm in heart rate turbulence using novel application of correlator functionsMari A Watanabe
Department of Internal Medicine, St Louis University, St Louis, Missouri 63110, USA
Heart Rhythm 4:292-300. 2007..Demonstration of a circadian rhythm in two parameters of heart rate turbulence--turbulence onset (TO) and turbulence slope (TS)--has been difficult...
Depression and obstructive sleep apnea in patients with coronary heart diseaseRobert M Carney
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
Psychosom Med 68:443-8. 2006..Obstructive sleep apnea/hypopnea syndrome (OSAHS) is frequently comorbid with depression and is also a risk factor for cardiac events. Undetected OSAHS could help explain the increased risk associated with depression...
Heart rate variability: measurement and clinical utilityRobert E Kleiger
Washington University School of Medicine, St. Louis, MO, USA
Ann Noninvasive Electrocardiol 10:88-101. 2005..g., exercise or drugs. RR interval variability is useful for assessing risk of cardiovascular death or arrhythmic events, especially when combined with other tests, e.g., left ventricular ejection fraction or ventricular arrhythmias...
A simple method to identify sleep apnea using Holter recordingsPhyllis K Stein
Cardiovascular Division, Washington University School of Medicine, St Louis, Missouri 63108, USA
J Cardiovasc Electrophysiol 14:467-73. 2003....
Usefulness of abnormal heart rate turbulence to predict cardiovascular mortality in high-risk patients with acute myocardial infarction and left ventricular dysfunction (from the EPHESUS study)Phyllis K Stein
Washington University School of Medicine, St Louis, Missouri, USA
Am J Cardiol 103:1495-9. 2009..037) independently predicted cardiovascular death. In conclusion, HRT is an independent predictor of cardiovascular death in a high-risk population after AMI, with a possibly higher optimal cutpoint for HRT slope than previously reported...
Effect of cognitive behavioral therapy on heart rate variability during REM sleep in female rape victims with PTSDPallavi Nishith
Center for Trauma Recovery, University of Missouri St Louis, St Louis, Missouri 63121, USA
J Trauma Stress 16:247-50. 2003..The noncompleter remained unchanged. Thus a remission in PTSD symptoms following CBT accompanied a reduction in the HRV indicator of sympathetic predominance in REM sleep...
Sex effects on heart rate variability in fibromyalgia and Gulf War illnessPhyllis K Stein
Washington University School of Medicine, St Louis, MO 63108, USA
Arthritis Rheum 51:700-8. 2004..To investigate autonomic abnormalities in male and female fibromyalgia (FM) and Gulf War illness (GWI) patients by comparing heart rate variability (HRV) with that of age- and sex-matched healthy controls...
Genetic vulnerability and phenotypic expression of depression and risk for ischemic heart disease in the Vietnam era twin study of agingHong Xian
Research Service, St Louis Veterans Affairs Medical Center, St Louis, Missouri 63103, USA
Psychosom Med 72:370-5. 2010..To determine if depression contributes to incident heart disease after accounting for genetic, behavioral, and medical factors associated with both conditions...
New York Heart Association functional class influences the impact of diabetes on cardiac autonomic functionPhyllis K Stein
Washington University School of Medicine, St Louis, MO 63108, USA
J Electrocardiol 43:379-84. 2010..Diabetes (D) and heart failure (HF) are associated with abnormal heart rate variability (HRV). It is unclear whether the HRV effect of having both is cumulative...
Diastolic dysfunction and autonomic abnormalities in patients with systolic heart failurePhyllis K Stein
Washington University School of Medicine, St Louis, MO 63108, USA
Eur J Heart Fail 9:364-9. 2007..Patients with systolic heart failure (SHF) often have concomitant diastolic dysfunction (DD). SHF is associated with decreased heart rate variability (HRV), but the impact of degree of DD on HRV in SHF is unclear...
Assessing heart rate variability from real-world Holter reportsPhyllis K Stein
Cardiovascular Division, Washington University School of Medicine, St Louis, Missouri, USA
Card Electrophysiol Rev 6:239-44. 2002..However, graphical power spectral plots can provide additional information about whether the HRV pattern is normal and can also identify some patients with obstructive sleep apnea...
Circadian rhythm in the cardiovascular system: considerations in non-invasive electrophysiologyYi Fang Guo
Cardiovascular Division, Washington University School of Medicine, St Louis, Missouri, USA
Card Electrophysiol Rev 6:267-72. 2002..These characteristics of the cardiovascular system require us keep in mind the "time" factor any time we analyze electrophysiological results and make clinical decisions...
Autonomic nervous system responses during sedative infusions of dexmedetomidineCharles W Hogue
Department of Anesthesiology and Cardiovascular Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
Anesthesiology 97:592-8. 2002..The purpose of this study was to determine the effects of dexmedetomidine on systemic and cardiac autonomic reflex responses during rest and during thermal stress...
Heart rate variability in critical illness and critical careTimothy G Buchman
Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
Curr Opin Crit Care 8:311-5. 2002..The reviewers' opinion is that real-time analysis of HRV in critical illness may provide caregivers with additional information about patient status, effects of intervention, and prognosis...
Effects of depression on QT interval variability after myocardial infarctionRobert M Carney
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
Psychosom Med 65:177-80. 2003..The purpose of this study was to determine whether depression is associated with increased QT variability in patients recovering from myocardial infarction...
Research Grants
- HOLTER DERIVED DATA AND OUTCOME IN THE CHSPhyllis K Stein; Fiscal Year: 2010....
