Phyllis K Stein

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Caloric restriction may reverse age-related autonomic decline in humans
    Phyllis K Stein
    HRV Laboratory, Washington University School of Medicine, St Louis, MO 63110, USA
    Aging Cell 11:644-50. 2012
  2. doi request reprint Heart rate variability, sleep and sleep disorders
    Phyllis K Stein
    Washington University, School of Medicine HRV Laboratory, 4625 Lindell Boulevard, Suite 402, Saint Louis, MO 63108, USA
    Sleep Med Rev 16:47-66. 2012
  3. pmc Relationship of abnormal heart rate turbulence and elevated CRP to cardiac mortality in low, intermediate, and high-risk older adults
    Phyllis K Stein
    Washington University School of Medicine, St Louis, Missouri, USA
    J Cardiovasc Electrophysiol 22:122-7. 2011
  4. pmc Nighttime heart rate and survival in depressed patients post acute myocardial infarction
    Robert M Carney
    Departments of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Psychosom Med 70:757-63. 2008
  5. ncbi request reprint Cardiac autonomic modulation. Analyzing circadian and ultradian rhythms
    Phyllis K Stein
    Washington University School of Medicine, St Louis, MO 63108, USA
    IEEE Eng Med Biol Mag 26:14-8. 2007
  6. ncbi request reprint Heart rate turbulence, depression, and survival after acute myocardial infarction
    Robert M Carney
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Psychosom Med 69:4-9. 2007
  7. pmc Heart rate variability and its changes over 5 years in older adults
    Phyllis K Stein
    Washington University School of Medicine, St Louis, MO, USA
    Age Ageing 38:212-8. 2009
  8. ncbi request reprint Circadian and ultradian rhythms in heart rate variability
    Phyllis K Stein
    1 Division of Cardiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Biomed Tech (Berl) 51:155-8. 2006
  9. pmc Heart rate variability and markers of inflammation and coagulation in depressed patients with coronary heart disease
    Robert M Carney
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    J Psychosom Res 62:463-7. 2007
  10. ncbi request reprint Low heart rate variability and the effect of depression on post-myocardial infarction mortality
    Robert M Carney
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Arch Intern Med 165:1486-91. 2005

Research Grants

  1. HOLTER DERIVED DATA AND OUTCOME IN THE CHS
    Phyllis K Stein; Fiscal Year: 2010

Detail Information

Publications35

  1. pmc Caloric restriction may reverse age-related autonomic decline in humans
    Phyllis K Stein
    HRV Laboratory, Washington University School of Medicine, St Louis, MO 63110, USA
    Aging Cell 11:644-50. 2012
    ....
  2. doi request reprint Heart rate variability, sleep and sleep disorders
    Phyllis K Stein
    Washington University, School of Medicine HRV Laboratory, 4625 Lindell Boulevard, Suite 402, Saint Louis, MO 63108, USA
    Sleep Med Rev 16:47-66. 2012
    ..Evidence also suggests that HRV collected during a PSG can be used in risk stratification models, at least for older adults. Caveats for accurate interpretation of HRV are also presented...
  3. pmc Relationship of abnormal heart rate turbulence and elevated CRP to cardiac mortality in low, intermediate, and high-risk older adults
    Phyllis K Stein
    Washington University School of Medicine, St Louis, Missouri, USA
    J Cardiovasc Electrophysiol 22:122-7. 2011
    ..We examined whether heart rate turbulence (HRT) and C-reactive protein (CRP) add to traditional risk factors for cardiac mortality in older adults at low, intermediate, and high risk...
  4. pmc Nighttime heart rate and survival in depressed patients post acute myocardial infarction
    Robert M Carney
    Departments of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Psychosom Med 70:757-63. 2008
    ..It is also associated with sleep disturbances and with elevated HR, which may be more pronounced at night. Resting and 24-hour HR have been found to predict mortality in patient and community samples...
  5. ncbi request reprint Cardiac autonomic modulation. Analyzing circadian and ultradian rhythms
    Phyllis K Stein
    Washington University School of Medicine, St Louis, MO 63108, USA
    IEEE Eng Med Biol Mag 26:14-8. 2007
  6. ncbi request reprint Heart rate turbulence, depression, and survival after acute myocardial infarction
    Robert M Carney
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Psychosom Med 69:4-9. 2007
    ..e., abnormal turbulence) to premature ventricular contractions (VPCs), and b) whether abnormal HR turbulence accounts for the effect of depression on increased mortality after AMI...
  7. pmc Heart rate variability and its changes over 5 years in older adults
    Phyllis K Stein
    Washington University School of Medicine, St Louis, MO, USA
    Age Ageing 38:212-8. 2009
    ..Purpose: to characterise the association between age, ageing and heart rate variability (HRV) in older individuals, 585 adults age >65 years with two 24-h Holter recordings in the Cardiovascular Health Study were studied...
  8. ncbi request reprint Circadian and ultradian rhythms in heart rate variability
    Phyllis K Stein
    1 Division of Cardiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Biomed Tech (Berl) 51:155-8. 2006
    ..While overall and circadian heart rate (HR) and HRV are well characterized by traditional measures, there is currently no method to measure ultradian cycles of HR and HRV...
  9. pmc Heart rate variability and markers of inflammation and coagulation in depressed patients with coronary heart disease
    Robert M Carney
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    J Psychosom Res 62:463-7. 2007
    ..Cardiac autonomic nervous system (ANS) dysregulation, proinflammatory processes, and procoagulant processes have been suggested as possible explanations...
  10. ncbi request reprint Low heart rate variability and the effect of depression on post-myocardial infarction mortality
    Robert M Carney
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Arch Intern Med 165:1486-91. 2005
    ..Depression is associated with an increased risk for mortality after acute myocardial infarction (MI). The purpose of this study was to determine whether low heart rate variability (HRV) mediates the effect of depression on mortality...
  11. ncbi request reprint Circadian and ultradian rhythms in cardiac autonomic modulation
    Phyllis K Stein
    Washington University School of Medicine, St Louis, MO 63108, USA
    Conf Proc IEEE Eng Med Biol Soc 1:429-32. 2006
    ..We have developed a method for capturing these rhythms during sleep and have now applied it to 24-hour recordings...
  12. pmc Novel measures of heart rate variability predict cardiovascular mortality in older adults independent of traditional cardiovascular risk factors: the Cardiovascular Health Study (CHS)
    Phyllis K Stein
    Washington University School of Medicine, St Louis, Missouri 63108, USA
    J Cardiovasc Electrophysiol 19:1169-74. 2008
    ..Novel HRV Predicts CV Mortality in the Elderly...
  13. pmc Development of more erratic heart rate patterns is associated with mortality post-myocardial infarction
    Phyllis K Stein
    Washington University School of Medicine, Heart Rate Variability Laboratory, St Louis, MO 63121, USA
    J Electrocardiol 41:110-5. 2008
    ..47; 95% confidence interval, 0.39-0.58) were significantly associated with decreased mortality compared with ESR. Quantification of ESR may identify more vulnerable patients or help monitor the effects of pharmacologic treatment...
  14. ncbi request reprint Traditional and nonlinear heart rate variability are each independently associated with mortality after myocardial infarction
    Phyllis K Stein
    Washington University School of Medicine, St Louis, Missouri 63108, USA
    J Cardiovasc Electrophysiol 16:13-20. 2005
    ..Traditional HRV predicts mortality in patients with a range of times post-MI, but the association of nonlinear HRV and outcome in this population is unknown...
  15. pmc Effect of omega-3 fatty acids on heart rate variability in depressed patients with coronary heart disease
    Robert M Carney
    Behavioral Medicine Center, Department of Psychiatry, Washington University School of Medicine, 4320 Forest Park Avenue, Suite 301, St Louis, MO 63108, USA
    Psychosom Med 72:748-54. 2010
    ..Low intake of omega-3 FAs is associated with depression and with low HRV, and all three are associated with an increased risk of death in patients with CHD...
  16. doi request reprint Ambulatory ECG-based T-wave alternans predicts sudden cardiac death in high-risk post-MI patients with left ventricular dysfunction in the EPHESUS study
    Phyllis K Stein
    Washington University School of Medicine HRV Lab, 4625 Lindell Blvd, Suite 402, St Louis, Missouri, 63108, USA
    J Cardiovasc Electrophysiol 19:1037-42. 2008
    ..TWA can be measured from ambulatory ECGs (AECGs) using modified moving average (MMA) method. Whether MMA TWA from AECGs predicts SCD in post-MI patients with left ventricular dysfunction (LVD) is unknown...
  17. ncbi request reprint Sometimes higher heart rate variability is not better heart rate variability: results of graphical and nonlinear analyses
    Phyllis K Stein
    Washington University School of Medicine, St Louis, Missouri 63108, USA
    J Cardiovasc Electrophysiol 16:954-9. 2005
    ..To determine the prevalence and effect on traditional heart rate variability (HRV) indices of abnormal HRV patterns in the elderly...
  18. pmc Association of Holter-based measures including T-wave alternans with risk of sudden cardiac death in the community-dwelling elderly: the Cardiovascular Health Study
    Phyllis K Stein
    Washington University School of Medicine, 4625 Lindell Blvd, St Louis, MO 63108, USA
    J Electrocardiol 43:251-9. 2010
    ..Sudden cardiac death (SCD) can be the first manifestation of cardiovascular disease. Development of screening methods for higher/lower risk is critical...
  19. doi request reprint Higher levels of inflammation factors and greater insulin resistance are independently associated with higher heart rate and lower heart rate variability in normoglycemic older individuals: the Cardiovascular Health Study
    Phyllis K Stein
    Cardiovascular Division, Washington University School of Medicine, St Louis, Missouri 63108, USA
    J Am Geriatr Soc 56:315-21. 2008
    ..To explore the relationship between (1) insulin resistance and inflammation factors with (2) higher heart rate (HR) and lower heart rate variability (HRV) in normoglycemic older adults...
  20. ncbi request reprint Including patients with diabetes mellitus or coronary artery bypass grafting decreases the association between heart rate variability and mortality after myocardial infarction
    Phyllis K Stein
    Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St Louis, MO 63108, USA
    Am Heart J 147:309-16. 2004
    ..Decreased heart rate variability (HRV) is often assumed to be associated with mortality in all patients after myocardial infarction (MI), independent of clinical factors or time after MI...
  21. ncbi request reprint Demonstration of circadian rhythm in heart rate turbulence using novel application of correlator functions
    Mari A Watanabe
    Department of Internal Medicine, St Louis University, St Louis, Missouri 63110, USA
    Heart Rhythm 4:292-300. 2007
    ..Demonstration of a circadian rhythm in two parameters of heart rate turbulence--turbulence onset (TO) and turbulence slope (TS)--has been difficult...
  22. ncbi request reprint Depression and obstructive sleep apnea in patients with coronary heart disease
    Robert M Carney
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    Psychosom Med 68:443-8. 2006
    ..Obstructive sleep apnea/hypopnea syndrome (OSAHS) is frequently comorbid with depression and is also a risk factor for cardiac events. Undetected OSAHS could help explain the increased risk associated with depression...
  23. ncbi request reprint Heart rate variability: measurement and clinical utility
    Robert E Kleiger
    Washington University School of Medicine, St Louis, MO, USA
    Ann Noninvasive Electrocardiol 10:88-101. 2005
    ..g., exercise or drugs. RR interval variability is useful for assessing risk of cardiovascular death or arrhythmic events, especially when combined with other tests, e.g., left ventricular ejection fraction or ventricular arrhythmias...
  24. ncbi request reprint A simple method to identify sleep apnea using Holter recordings
    Phyllis K Stein
    Cardiovascular Division, Washington University School of Medicine, St Louis, Missouri 63108, USA
    J Cardiovasc Electrophysiol 14:467-73. 2003
    ....
  25. doi request reprint Usefulness of abnormal heart rate turbulence to predict cardiovascular mortality in high-risk patients with acute myocardial infarction and left ventricular dysfunction (from the EPHESUS study)
    Phyllis K Stein
    Washington University School of Medicine, St Louis, Missouri, USA
    Am J Cardiol 103:1495-9. 2009
    ..037) independently predicted cardiovascular death. In conclusion, HRT is an independent predictor of cardiovascular death in a high-risk population after AMI, with a possibly higher optimal cutpoint for HRT slope than previously reported...
  26. ncbi request reprint Effect of cognitive behavioral therapy on heart rate variability during REM sleep in female rape victims with PTSD
    Pallavi Nishith
    Center for Trauma Recovery, University of Missouri St Louis, St Louis, Missouri 63121, USA
    J Trauma Stress 16:247-50. 2003
    ..The noncompleter remained unchanged. Thus a remission in PTSD symptoms following CBT accompanied a reduction in the HRV indicator of sympathetic predominance in REM sleep...
  27. ncbi request reprint Sex effects on heart rate variability in fibromyalgia and Gulf War illness
    Phyllis K Stein
    Washington University School of Medicine, St Louis, MO 63108, USA
    Arthritis Rheum 51:700-8. 2004
    ..To investigate autonomic abnormalities in male and female fibromyalgia (FM) and Gulf War illness (GWI) patients by comparing heart rate variability (HRV) with that of age- and sex-matched healthy controls...
  28. pmc Genetic vulnerability and phenotypic expression of depression and risk for ischemic heart disease in the Vietnam era twin study of aging
    Hong Xian
    Research Service, St Louis Veterans Affairs Medical Center, St Louis, Missouri 63103, USA
    Psychosom Med 72:370-5. 2010
    ..To determine if depression contributes to incident heart disease after accounting for genetic, behavioral, and medical factors associated with both conditions...
  29. doi request reprint New York Heart Association functional class influences the impact of diabetes on cardiac autonomic function
    Phyllis K Stein
    Washington University School of Medicine, St Louis, MO 63108, USA
    J Electrocardiol 43:379-84. 2010
    ..Diabetes (D) and heart failure (HF) are associated with abnormal heart rate variability (HRV). It is unclear whether the HRV effect of having both is cumulative...
  30. ncbi request reprint Diastolic dysfunction and autonomic abnormalities in patients with systolic heart failure
    Phyllis K Stein
    Washington University School of Medicine, St Louis, MO 63108, USA
    Eur J Heart Fail 9:364-9. 2007
    ..Patients with systolic heart failure (SHF) often have concomitant diastolic dysfunction (DD). SHF is associated with decreased heart rate variability (HRV), but the impact of degree of DD on HRV in SHF is unclear...
  31. ncbi request reprint Assessing heart rate variability from real-world Holter reports
    Phyllis K Stein
    Cardiovascular Division, Washington University School of Medicine, St Louis, Missouri, USA
    Card Electrophysiol Rev 6:239-44. 2002
    ..However, graphical power spectral plots can provide additional information about whether the HRV pattern is normal and can also identify some patients with obstructive sleep apnea...
  32. ncbi request reprint Circadian rhythm in the cardiovascular system: considerations in non-invasive electrophysiology
    Yi Fang Guo
    Cardiovascular Division, Washington University School of Medicine, St Louis, Missouri, USA
    Card Electrophysiol Rev 6:267-72. 2002
    ..These characteristics of the cardiovascular system require us keep in mind the "time" factor any time we analyze electrophysiological results and make clinical decisions...
  33. ncbi request reprint Autonomic nervous system responses during sedative infusions of dexmedetomidine
    Charles W Hogue
    Department of Anesthesiology and Cardiovascular Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Anesthesiology 97:592-8. 2002
    ..The purpose of this study was to determine the effects of dexmedetomidine on systemic and cardiac autonomic reflex responses during rest and during thermal stress...
  34. ncbi request reprint Heart rate variability in critical illness and critical care
    Timothy G Buchman
    Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Curr Opin Crit Care 8:311-5. 2002
    ..The reviewers' opinion is that real-time analysis of HRV in critical illness may provide caregivers with additional information about patient status, effects of intervention, and prognosis...
  35. ncbi request reprint Effects of depression on QT interval variability after myocardial infarction
    Robert M Carney
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    Psychosom Med 65:177-80. 2003
    ..The purpose of this study was to determine whether depression is associated with increased QT variability in patients recovering from myocardial infarction...

Research Grants1

  1. HOLTER DERIVED DATA AND OUTCOME IN THE CHS
    Phyllis K Stein; Fiscal Year: 2010
    ....