S L Stanley

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Protective immunity to amebiasis: new insights and new challenges
    S L Stanley
    Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    J Infect Dis 184:504-6. 2001
  2. pmc Progress towards development of a vaccine for amebiasis
    S L Stanley
    Department of Medicine and Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Microbiol Rev 10:637-49. 1997
  3. ncbi request reprint Pathophysiology of amoebiasis
    S L Stanley
    Depts Medicine and Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Trends Parasitol 17:280-5. 2001
  4. ncbi request reprint Microbes and microbial toxins: paradigms for microbial-mucosal interactions. VI. Entamoeba histolytica: parasite-host interactions
    S L Stanley
    Department of Medicine, Washington University School of Medicine, 660 S Euclid, St Louis, Missouri 63110, USA
    Am J Physiol Gastrointest Liver Physiol 280:G1049-54. 2001
  5. ncbi request reprint Amoebiasis
    Samuel L Stanley
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO, St Louis, MO 63110, USA
    Lancet 361:1025-34. 2003
  6. pmc Amebic infection in the human colon induces cyclooxygenase-2
    W F Stenson
    Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Infect Immun 69:3382-8. 2001
  7. pmc Role of the Entamoeba histolytica cysteine proteinase in amebic liver abscess formation in severe combined immunodeficient mice
    S L Stanley
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    Infect Immun 63:1587-90. 1995
  8. ncbi request reprint Vaccines for amoebiasis: barriers and opportunities
    S L Stanley
    Department of Medicine, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Parasitology 133:S81-6. 2006
  9. pmc Complementation of an Escherichia coli adhE mutant by the Entamoeba histolytica EhADH2 gene provides a method for the identification of new antiamebic drugs
    T S Yong
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 93:6464-9. 1996
  10. ncbi request reprint The bifunctional Entamoeba histolytica alcohol dehydrogenase 2 (EhADH2) protein is necessary for amebic growth and survival and requires an intact C-terminal domain for both alcohol dahydrogenase and acetaldehyde dehydrogenase activity
    A Espinosa
    Departments of Medicine, Molecular Microbiology, and Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    J Biol Chem 276:20136-43. 2001

Research Grants

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Protective immunity to amebiasis: new insights and new challenges
    S L Stanley
    Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    J Infect Dis 184:504-6. 2001
    ..Theses findings indicate that immunity to amebiasis can develop in some children after intestinal infection, but protective immunity may be transient, and its importance in preventing disease remains to be established...
  2. pmc Progress towards development of a vaccine for amebiasis
    S L Stanley
    Department of Medicine and Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Microbiol Rev 10:637-49. 1997
    ....
  3. ncbi request reprint Pathophysiology of amoebiasis
    S L Stanley
    Depts Medicine and Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Trends Parasitol 17:280-5. 2001
    ..histolytica and human intestine, and between E. histolytica and hepatocytes, and discuss what these studies tell us about the role of inflammation and programmed cell death in the pathogenesis of amoebiasis...
  4. ncbi request reprint Microbes and microbial toxins: paradigms for microbial-mucosal interactions. VI. Entamoeba histolytica: parasite-host interactions
    S L Stanley
    Department of Medicine, Washington University School of Medicine, 660 S Euclid, St Louis, Missouri 63110, USA
    Am J Physiol Gastrointest Liver Physiol 280:G1049-54. 2001
    ..The host response is also an important factor in the outcome of infection, and neutrophils may play a key role in contributing to the tissue damage seen in amebiasis and in controlling amebic infection...
  5. ncbi request reprint Amoebiasis
    Samuel L Stanley
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO, St Louis, MO 63110, USA
    Lancet 361:1025-34. 2003
    ..New models of disease have linked E histolytica induction of intestinal inflammation and hepatocyte programmed cell death to the pathogenesis of amoebic colitis and amoebic liver abscess...
  6. pmc Amebic infection in the human colon induces cyclooxygenase-2
    W F Stenson
    Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Infect Immun 69:3382-8. 2001
    ..Moreover, prostaglandins produced through cyclooxygenase-2 participate in the mediation of the neutrophil response to infection and enhance epithelial permeability...
  7. pmc Role of the Entamoeba histolytica cysteine proteinase in amebic liver abscess formation in severe combined immunodeficient mice
    S L Stanley
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    Infect Immun 63:1587-90. 1995
    ..Our study suggests an important role for a functional cysteine proteinase in amebic liver abscess formation...
  8. ncbi request reprint Vaccines for amoebiasis: barriers and opportunities
    S L Stanley
    Department of Medicine, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Parasitology 133:S81-6. 2006
    ..In addition, there are strong economic barriers to developing an amoebiasis vaccine and questions about how and where an effective vaccine would be utilized...
  9. pmc Complementation of an Escherichia coli adhE mutant by the Entamoeba histolytica EhADH2 gene provides a method for the identification of new antiamebic drugs
    T S Yong
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 93:6464-9. 1996
    ..Using bacteria to bypass the need for parasite culture in the initial screening process for anti-parasitic agents could greatly simplify and reduce the cost of identifying new therapeutic agents effective against parasitic diseases...
  10. ncbi request reprint The bifunctional Entamoeba histolytica alcohol dehydrogenase 2 (EhADH2) protein is necessary for amebic growth and survival and requires an intact C-terminal domain for both alcohol dahydrogenase and acetaldehyde dehydrogenase activity
    A Espinosa
    Departments of Medicine, Molecular Microbiology, and Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    J Biol Chem 276:20136-43. 2001
    ..histolytica growth and survival and that the C-terminal ADH domain of the enzyme functions as a separate entity. However, ALDH activity requires residues in both the N- and C-terminal halves of the molecule...
  11. pmc Innate immunity to amebic liver abscess is dependent on gamma interferon and nitric oxide in a murine model of disease
    K B Seydel
    Departments of Medicine and Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Infect Immun 68:400-2. 2000
    ....
  12. pmc Shigella infection in a SCID mouse-human intestinal xenograft model: role for neutrophils in containing bacterial dissemination in human intestine
    Z Zhang
    Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    Infect Immun 69:3240-7. 2001
    ..Our studies establish the SCID-HU-INT mouse as a viable model for studying the interactions between shigella and human intestine and indicate that neutrophils are important for controlling the invasion of human intestine by shigella...
  13. doi request reprint Estimating gene signals from noisy microarray images
    P Sarder
    Department of Electrical and Systems Engineering, Washington University, St Louis, MO 63130, USA
    IEEE Trans Nanobioscience 7:142-53. 2008
    ..In a realistic example using our method, we show that the gene-signal fluctuations on the estimated foreground are better observed for the input noisy images with relatively higher undesired bindings...
  14. pmc Blockade of caspases inhibits amebic liver abscess formation in a mouse model of disease
    L Yan
    Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    Infect Immun 69:7911-4. 2001
    ..These data indicate that apoptosis plays a significant but not an exclusive role in amebic liver abscess formation in the mouse model...
  15. pmc A severe combined immunodeficient (SCID) mouse model for infection with Entamoeba histolytica
    P R Cieslak
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    J Exp Med 176:1605-9. 1992
    ..histolytica antibody can protect against amebic infection in this system. The SCID mouse may provide a powerful model for studying the components of protective immunity to invasive amebiasis...
  16. pmc Tumor necrosis factor alpha is a key mediator of gut inflammation seen in amebic colitis in human intestine in the SCID mouse-human intestinal xenograft model of disease
    Zhi Zhang
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Infect Immun 71:5355-9. 2003
    ..We found that blockade of TNF-alpha reduced inflammation and intestinal damage in amebic infection, while inhibition of IL-1 reduced cytokine production but had less marked effects on inflammation and disease...
  17. pmc Antibody responses to vaccinia membrane proteins after smallpox vaccination
    Steven J Lawrence
    Division of Infectious Diseases, Washington University School of Medicine, St Louis, MO 63110, USA
    J Infect Dis 196:220-9. 2007
    ..Vaccinia virus (VV) membrane proteins are candidates for orthopoxvirus subunit vaccines and potential targets for therapeutic antibodies. Human antibody responses to these proteins after VV vaccination have not been well characterized...
  18. ncbi request reprint The immunogenetics of smallpox vaccination
    Samuel L Stanley
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Infect Dis 196:212-9. 2007
    ....
  19. pmc Expression of amoebapores is required for full expression of Entamoeba histolytica virulence in amebic liver abscess but is not necessary for the induction of inflammation or tissue damage in amebic colitis
    Xiaochun Zhang
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Infect Immun 72:678-83. 2004
    ..These data are consistent with the concept that tissue damage may proceed by different mechanisms in amebic liver abscess compared to amebic colitis...
  20. ncbi request reprint The need for continuing vigilance: addressing the threat for transmission of blood-borne infectious disease
    Samuel L Stanley
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Semin Hematol 43:S17-22. 2006
    ..The proactive devotion of appropriate resources to infectious disease containment and prevention prior to an epidemic should be perceived as both essential public health policy and cost effective...
  21. pmc The Entamoeba histolytica genome: something old, something new, something borrowed and sex too?
    Samuel L Stanley
    Department of Medicine, Midwest Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Trends Parasitol 21:451-3. 2005
    ....
  22. pmc Identification of a family of BspA like surface proteins of Entamoeba histolytica with novel leucine rich repeats
    Paul H Davis
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Biochem Parasitol 145:111-6. 2006
  23. ncbi request reprint Differences in complement-mediated killing of Entamoeba histolytica between men and women--an explanation for the increased susceptibility of men to invasive amebiasis?
    Margaret Snow
    Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Am J Trop Med Hyg 78:922-3. 2008
    ..histolytica trophozoites than serum from men, and this killing was complement dependent. Our results provide a possible explanation for the differential susceptibility of men and women to amebic liver abscess and amebic colitis...
  24. ncbi request reprint Stereotypic and specific elements of the human colonic response to Entamoeba histolytica and Shigella flexneri
    Zhi Zhang
    Department of Medicine, Washington University School of Medicine, USA
    Cell Microbiol 6:535-54. 2004
    ..The responses to amoeba and Shigella were not identical however, and we found unique elements in each response that may provide new insights into the distinct pathogenic mechanisms of E. histolytica and S. flexneri...
  25. ncbi request reprint Entamoeba histolytica alcohol dehydrogenase 2 (EhADH2) as a target for anti-amoebic agents
    Avelina Espinosa
    Departments of Molecular Microbiology, and Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Antimicrob Chemother 54:56-9. 2004
    ..The current use of metronidazole as an anti-amoebic agent causes significant side-effects. The purpose of this study was to identify alternative compounds with which to treat amoebiasis...
  26. pmc Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model
    Samuel G Melendez-Lopez
    Department of Pathology, University of California, San Diego, San Diego, California 92103 8416, USA
    Eukaryot Cell 6:1130-6. 2007
    ..The resultant dramatic inhibition of invasion by both inhibitors in this human colonic model of amebiasis strongly suggests a significant role of secreted amebic proteinases, such as EhCP1, in the pathogenesis of amebiasis...
  27. pmc A monoclonal antibody to the amebic lipophosphoglycan-proteophosphoglycan antigens can prevent disease in human intestinal xenografts infected with Entamoeba histolytica
    Zhi Zhang
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Infect Immun 70:5873-6. 2002
    ..histolytica colonic infection...
  28. ncbi request reprint Transcriptomic comparison of two Entamoeba histolytica strains with defined virulence phenotypes identifies new virulence factor candidates and key differences in the expression patterns of cysteine proteases, lectin light chains, and calmodulin
    Paul H Davis
    Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    Mol Biochem Parasitol 151:118-28. 2007
    ..histolytica HM-1:IMSS genome. We find extensive differences between the two strains, including distinct patterns of gene expression of cysteine proteinases, AIG family members, and lectin light chains...
  29. ncbi request reprint Structural analysis of the acetaldehyde dehydrogenase activity of Entamoeba histolytica alcohol dehydrogenase 2 (EhADH2), a member of the ADHE enzyme family
    Minghe Chen
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Biochem Parasitol 137:201-5. 2004
    ..In addition, we show, using site directed mutagenesis, that the catalytic mechanism for the ALDH activity appears to be similar to that described for other members of the ALDH extended family...
  30. ncbi request reprint Co-ordinate but disproportionate activation of apoptotic, regenerative and inflammatory pathways characterizes the liver response to acute amebic infection
    Lorraine C Pelosof
    Department of Medicine, Division of Infectious Diseases, Campus Box 8051, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Microbiol 8:508-22. 2006
    ..E. histolytica infection of the liver simultaneously activates inflammatory, regenerative and apoptotic pathways, but the sum of these early responses is biased towards programmed cell death...
  31. ncbi request reprint Comparative proteomic analysis of two Entamoeba histolytica strains with different virulence phenotypes identifies peroxiredoxin as an important component of amoebic virulence
    Paul H Davis
    Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    Mol Microbiol 61:1523-32. 2006
    ..Our data indicate that there are definable molecular differences between Rahman and HM-1:IMSS that may explain the phenotypic differences, and identify peroxiredoxin as an important component of virulence in amoebic colitis...

Research Grants1

  1. MRCE for Biodefense and Emerging Infectious Diseases
    Samuel Stanley; Fiscal Year: 2007
    ..The MRCE is uniquely positioned to serve Region VII and the nation through an exceptional program that addresses the most immediate and urgent national biodefense needs. ..