Sheng Kwei Song

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Demyelination increases radial diffusivity in corpus callosum of mouse brain
    Sheng Kwei Song
    Department of Radiology, Biomedical MR Laboratory, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroimage 26:132-40. 2005
  2. pmc Diffusion tensor imaging at 3 hours after traumatic spinal cord injury predicts long-term locomotor recovery
    Joong H Kim
    Department of Radiology, Washington University, St Louis, Missouri, USA
    J Neurotrauma 27:587-98. 2010
  3. ncbi request reprint Diffusion tensor imaging predicts hyperacute spinal cord injury severity
    David N Loy
    Department of Radiology, Washington University, Saint Louis, Missouri 63110, USA
    J Neurotrauma 24:979-90. 2007
  4. pmc Rostrocaudal analysis of corpus callosum demyelination and axon damage across disease stages refines diffusion tensor imaging correlations with pathological features
    Mingqiang Xie
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    J Neuropathol Exp Neurol 69:704-16. 2010
  5. ncbi request reprint Noninvasive detection of cuprizone induced axonal damage and demyelination in the mouse corpus callosum
    Shu Wei Sun
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Magn Reson Med 55:302-8. 2006
  6. ncbi request reprint Detecting axon damage in spinal cord from a mouse model of multiple sclerosis
    Joong Hee Kim
    Department of Chemistry, Washington University, St Louis, MO 63110, USA
    Neurobiol Dis 21:626-32. 2006
  7. ncbi request reprint Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia
    Sheng Kwei Song
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroimage 20:1714-22. 2003
  8. pmc Improved in vivo diffusion tensor imaging of human cervical spinal cord
    Junqian Xu
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Neuroimage 67:64-76. 2013
  9. ncbi request reprint Differential sensitivity of in vivo and ex vivo diffusion tensor imaging to evolving optic nerve injury in mice with retinal ischemia
    Shu Wei Sun
    Department of Radiology, Biomedical MR Laboratory, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Neuroimage 32:1195-204. 2006
  10. ncbi request reprint Toward accurate diagnosis of white matter pathology using diffusion tensor imaging
    Matthew D Budde
    Department of Radiology, Washington University, St Louis, Missouri, USA
    Magn Reson Med 57:688-95. 2007

Research Grants

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Demyelination increases radial diffusivity in corpus callosum of mouse brain
    Sheng Kwei Song
    Department of Radiology, Biomedical MR Laboratory, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroimage 26:132-40. 2005
    ..Radial diffusivity offers a specific assessment of demyelination and remyelination, as distinct from acute axonal damage...
  2. pmc Diffusion tensor imaging at 3 hours after traumatic spinal cord injury predicts long-term locomotor recovery
    Joong H Kim
    Department of Radiology, Washington University, St Louis, Missouri, USA
    J Neurotrauma 27:587-98. 2010
    ..Although significant obstacles must still be overcome to derive similar data in human patients, the path to clinical translation is foreseeable and achievable...
  3. ncbi request reprint Diffusion tensor imaging predicts hyperacute spinal cord injury severity
    David N Loy
    Department of Radiology, Washington University, Saint Louis, Missouri 63110, USA
    J Neurotrauma 24:979-90. 2007
    ..Cross-sectional regional measurements of white matter injury severity between dorsal columns and VWM varied with increasing cord displacement in a pattern consistent with spinal cord viscoelastic properties...
  4. pmc Rostrocaudal analysis of corpus callosum demyelination and axon damage across disease stages refines diffusion tensor imaging correlations with pathological features
    Mingqiang Xie
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    J Neuropathol Exp Neurol 69:704-16. 2010
    ....
  5. ncbi request reprint Noninvasive detection of cuprizone induced axonal damage and demyelination in the mouse corpus callosum
    Shu Wei Sun
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Magn Reson Med 55:302-8. 2006
    ..Our results suggest that lambda(parallel) and lambda(perpendicular) may be useful in vivo surrogate markers of axonal and myelin damage in mouse CNS white matter...
  6. ncbi request reprint Detecting axon damage in spinal cord from a mouse model of multiple sclerosis
    Joong Hee Kim
    Department of Chemistry, Washington University, St Louis, MO 63110, USA
    Neurobiol Dis 21:626-32. 2006
    ..Our findings suggest that axonal damage is more widespread than myelin damage in the spinal cord white matter of mice with EAE and that in vivo DTI may provide a sensitive and specific measure of white matter injury...
  7. ncbi request reprint Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia
    Sheng Kwei Song
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroimage 20:1714-22. 2003
    ....
  8. pmc Improved in vivo diffusion tensor imaging of human cervical spinal cord
    Junqian Xu
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Neuroimage 67:64-76. 2013
    ..We also recommend using a mixed-effects model to account for systematic measurement bias depending on cord segment...
  9. ncbi request reprint Differential sensitivity of in vivo and ex vivo diffusion tensor imaging to evolving optic nerve injury in mice with retinal ischemia
    Shu Wei Sun
    Department of Radiology, Biomedical MR Laboratory, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Neuroimage 32:1195-204. 2006
    ..Despite the accurate depiction of the pathology using lambda(||) and lambda( perpendicular) in vivo, the use of ex vivo lambda(||) to extrapolate the status of axonal injury in vivo would require further investigation...
  10. ncbi request reprint Toward accurate diagnosis of white matter pathology using diffusion tensor imaging
    Matthew D Budde
    Department of Radiology, Washington University, St Louis, Missouri, USA
    Magn Reson Med 57:688-95. 2007
    ..The results suggest that directional diffusivities may reveal abnormalities that are not obvious with SMI-31 and LFB staining, depending on the type of injury...
  11. pmc Increased radial diffusivity in spinal cord lesions in neuromyelitis optica compared with multiple sclerosis
    Eric C Klawiter
    Department of Neurology, Washington University School of Medicine, St Louis, USA
    Mult Scler 18:1259-68. 2012
    ..Multiple sclerosis (MS) and neuromyelitis optica (NMO) both affect spinal cord with notable differences in pathology...
  12. pmc Evolving Wallerian degeneration after transient retinal ischemia in mice characterized by diffusion tensor imaging
    Shu Wei Sun
    Department of Radiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Neuroimage 40:1-10. 2008
    ..The current results suggest that axial and radial diffusivities are capable of reflecting the severity of axonal and myelin damage in mice as assessed using immunohistochemistry...
  13. pmc Axonal injury detected by in vivo diffusion tensor imaging correlates with neurological disability in a mouse model of multiple sclerosis
    Matthew D Budde
    Department of Radiology, Washington University, St Louis, MO 63110, USA
    NMR Biomed 21:589-97. 2008
    ..The results further the notion that axial diffusivity is a non-invasive marker of axonal damage in white matter and could provide the necessary link between pathology and neurological disability...
  14. pmc Diffusion tensor imaging detects retinal ganglion cell axon damage in the mouse model of optic nerve crush
    Xu Zhang
    Department of Radiology, Washington University, St Louis, Missouri, USA
    Invest Ophthalmol Vis Sci 52:7001-6. 2011
    ..The authors hypothesized that DTI-derived axonal and myelin injury biomarkers may be used to detect early axonal damage and may be correlated with RGC loss in the mouse model of optic nerve crush (ONC)...
  15. pmc Full tensor diffusion imaging is not required to assess the white-matter integrity in mouse contusion spinal cord injury
    Tsang Wei Tu
    Department of Mechanical, Aerospace and Structural Engineering, Washington University in St Louis, St Louis, Missouri 63110, USA
    J Neurotrauma 27:253-62. 2010
    ..The results suggest that the two-direction DWI derived indices may be used, with significantly reduced imaging time, to estimate accurately spared white matter in mouse SCI...
  16. pmc Quantification of increased cellularity during inflammatory demyelination
    Yong Wang
    Department of Radiology, Washington University, St Louis, MO 63110, USA
    Brain 134:3590-601. 2011
    ..Our findings suggest that diffusion basis spectrum imaging has great potential to provide non-invasive biomarkers for neuroinflammation, axonal injury and demyelination coexisting in multiple sclerosis...
  17. ncbi request reprint Noninvasive diffusion tensor imaging of evolving white matter pathology in a mouse model of acute spinal cord injury
    Joong Hee Kim
    Department of Radiology, Washington University, St Louis, Missouri 63110, USA
    Magn Reson Med 58:253-60. 2007
    ..Quantitative measurements of axial and radial diffusivities in VWM showed a trend of acute primary axonal injury followed by delayed, subacute myelin damage at the impact site, with good histological correlation...
  18. ncbi request reprint Formalin fixation alters water diffusion coefficient magnitude but not anisotropy in infarcted brain
    Shu Wei Sun
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Magn Reson Med 53:1447-51. 2005
    ..However, the sensitivity of water diffusion in detecting tissue injury in vivo is not preserved in fixed tissues...
  19. pmc Diffusion tensor imaging in acute optic neuropathies: predictor of clinical outcomes
    Robert T Naismith
    Department of Neurology, Washington University in St Louis, Campus Box 8111, 660 S Euclid Ave, St Louis, MO 63110, USA
    Arch Neurol 69:65-71. 2012
    ..To evaluate directional diffusivities within the optic nerve in a first event of acute optic neuritis to determine whether decreased axial diffusivity (AD) would predict 6-month visual outcome and optic nerve integrity measures...
  20. ncbi request reprint Remodeling of cardiac fiber structure after infarction in rats quantified with diffusion tensor MRI
    Junjie Chen
    Cardiovascular Magnetic Resonance Laboratories, Cardiovascular Division, Department of Medicine, Washington University, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Am J Physiol Heart Circ Physiol 285:H946-54. 2003
    ..86). These results suggest that DTMRI may provide a valuable tool for defining structural remodeling in diseased myocardium at the cellular and tissue level...
  21. ncbi request reprint Detection of age-dependent brain injury in a mouse model of brain amyloidosis associated with Alzheimer's disease using magnetic resonance diffusion tensor imaging
    Shu Wei Sun
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63130, USA
    Exp Neurol 191:77-85. 2005
    ..This work demonstrates the potential for DTI as a noninvasive modality to detect evolving pathology associated with changes in tissue water diffusion properties in brain tissues...
  22. ncbi request reprint Relative indices of water diffusion anisotropy are equivalent in live and formalin-fixed mouse brains
    Shu Wei Sun
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri
    Magn Reson Med 50:743-8. 2003
    ..The combination of DTI measurements and standard histology may shed light on the microstructural determinants of diffusion anisotropy in normal and disease states...
  23. pmc Radial diffusivity predicts demyelination in ex vivo multiple sclerosis spinal cords
    Eric C Klawiter
    Department of Neurology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Neuroimage 55:1454-60. 2011
    ..Correlation of diffusion tensor imaging (DTI) with histochemical staining for demyelination and axonal damage in multiple sclerosis (MS) ex vivo human cervical spinal cords...
  24. pmc Assessing optic nerve pathology with diffusion MRI: from mouse to human
    Junqian Xu
    Department of Neurology, Washington University in St Louis, St Louis, MO, USA
    NMR Biomed 21:928-40. 2008
    ..From different mouse models of optic nerve injuries to the emerging studies on patients with optic neuritis, directional diffusivities show great potential to be specific biomarkers for axonal and myelin injury...
  25. ncbi request reprint Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water
    Sheng Kwei Song
    Department of Chemistry, Washington University, St Louis, Missouri 63110, USA
    Neuroimage 17:1429-36. 2002
    ..Although further validation is still needed, our finding suggests that changes in lambda(perpendicular) and lambda(parallel) may potentially be used to differentiate myelin loss versus axonal injury...
  26. ncbi request reprint Postmortem delay does not change regional diffusion anisotropy characteristics in mouse spinal cord white matter
    Joong Hee Kim
    Department of Chemistry, Washington University, 4525 Scott Avenue, St Louis, MO 63110, USA
    NMR Biomed 20:352-9. 2007
    ..Regional characteristics of diffusion anisotropy in mouse spinal cord white matter are equivalent in vivo, in situ after death (up to 10 h before fixation), and ex vivo 15 weeks after immersion fixation...
  27. pmc Selective vulnerability of cerebral white matter in a murine model of multiple sclerosis detected using diffusion tensor imaging
    Shu Wei Sun
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurobiol Dis 28:30-8. 2007
    ..The present study demonstrated that the visual pathway is selectively affected in MOG(35-55) induced murine EAE and these injuries are non-invasively detectable using lambda(parallel) and lambda( perpendicular)...
  28. pmc Cell swelling contributes to thickening of low-dose N-methyl-D-aspartate-induced retinal edema
    Junjie Chen
    Department of Medicine, Washington University, St Louis, Missouri 63110, USA
    Invest Ophthalmol Vis Sci 53:2777-85. 2012
    ..The objective of this study was to use in vivo magnetic resonance imaging (MRI) to assess retinal cell swelling in the edematous mouse retina...
  29. pmc In vivo diffusion tensor MRI of the mouse retina: a noninvasive visualization of tissue organization
    Junjie Chen
    Department of Medicine, Washington University, St Louis, MO 63108, USA
    NMR Biomed 24:447-51. 2011
    ..05 for all comparisons), reflecting the degeneration of photoreceptor cells in rd1 mouse retina. Overall, our findings suggest that in vivo DTI assessment of mouse retina with normal physiology or degenerative pathology is feasible...
  30. ncbi request reprint Regional ventricular wall thickening reflects changes in cardiac fiber and sheet structure during contraction: quantification with diffusion tensor MRI
    Junjie Chen
    Cardiovascular Magnetic Resonance Laboratories, Department of Medicine, Washington University, St Louis, Missouri, USA
    Am J Physiol Heart Circ Physiol 289:H1898-907. 2005
    ..Our results provide direct evidence that sheet reorientation is a primary determinant of myocardial wall thickening...
  31. doi request reprint Noninvasive detection of brainstem and spinal cord axonal degeneration in an amyotrophic lateral sclerosis mouse model
    Joong Hee Kim
    Department of Radiology, Washington University, St Louis, MO 63110, USA
    NMR Biomed 24:163-9. 2011
    ..The present study demonstrates that in vivo diffusion tensor imaging-derived axial diffusivity may be used to accurately evaluate axonal degeneration in an animal model of amyotrophic lateral sclerosis...
  32. pmc Quantitative magnetization transfer measured pool-size ratio reflects optic nerve myelin content in ex vivo mice
    Xiawei Ou
    Department of Radiology, Vanderbilt University Institute of Imaging Science, Nashville, Tennessee 37232 2310, USA
    Magn Reson Med 61:364-71. 2009
    ..This pool size ratio was specific to myelin content only and was not significantly affected by the presence of axon injury in mouse optic nerve 3 days after retinal ischemia...
  33. pmc Impact speed does not determine severity of spinal cord injury in mice with fixed impact displacement
    Joong Hee Kim
    Department of Radiology, Washington University, St Louis, MO 63110, USA
    J Neurotrauma 26:1395-404. 2009
    ..No significant difference in BMS was observed among injury groups of various impact speeds. The present results suggest that injury severity can be reproduced using speeds from 0.1 to 0.4 m/s at the fixed impact displacement...
  34. pmc Diffusion tensor imaging detects axonal injury and demyelination in the spinal cord and cranial nerves of a murine model of globoid cell leukodystrophy
    A Alex Hofling
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    NMR Biomed 22:1100-6. 2009
    ..This first reported application of spinal cord DTI in the setting of GLD holds potential as a noninvasive, quantitative assay of therapeutic efficacy in future treatment studies...
  35. pmc Photoreceptor degeneration changes magnetic resonance imaging features in a mouse model of retinitis pigmentosa
    Qing Wang
    Department of Mechanical Engineering and Materials Science, Washington University, St Louis, Missouri, USA
    Magn Reson Med 65:1793-8. 2011
    ..Together, these data suggest that MRI parameter changes can signature common pathological changes in photoreceptor-degenerated eyes, particularly blood-retinal barrier leakage-induced retinal edema...
  36. ncbi request reprint Improved molecular imaging contrast agent for detection of human thrombus
    Patrick M Winter
    Cardiovascular MR Laboratories, Department of Medicine, Cardiovascular Division, Barnes Jewish Hospital, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Magn Reson Med 50:411-6. 2003
    ..45 +/- 0.02 1/s). These studies demonstrate marked improvement in a fibrin-specific molecular imaging agent that might allow sensitive, early detection of vascular microthrombi, the antecedent to stroke and heart attack...
  37. doi request reprint In vivo quantification of T1, T2, and apparent diffusion coefficient in the mouse retina at 11.74T
    Junjie Chen
    Department of Medicine, Washington University, St Louis, Missouri, USA
    Magn Reson Med 59:731-8. 2008
    ..These MR parameters are expected to be useful in future evaluation of developmental and pathological alterations of retinal cell layers in mice...
  38. pmc CXCR7 antagonism prevents axonal injury during experimental autoimmune encephalomyelitis as revealed by in vivo axial diffusivity
    Lillian Cruz-Orengo
    Department of Internal Medicine, Washington University School of Medicine, 660 S, Euclid Ave, St Louis, MO 63110, USA
    J Neuroinflammation 8:170. 2011
    ..Because functional recovery reflects axonal integrity, we utilized diffusion tensor imaging (DTI) to evaluate axonal injury in CXCR7 antagonist- versus vehicle-treated mice after recovery from EAE...
  39. pmc Comprehensive locomotor outcomes correlate to hyperacute diffusion tensor measures after spinal cord injury in the adult rat
    Joong H Kim
    Department of Radiology, Washington University, St Louis, MO 63110, USA
    Exp Neurol 235:188-96. 2012
    ..These observations suggest that acute DTI should be useful to provide functional predictions for spared white matter following contusive spinal cord injuries clinically...
  40. pmc Neuropathologic correlates for diffusion tensor imaging in postinfectious encephalopathy
    Chin I Chen
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    Pediatr Neurol 44:389-93. 2011
    ..In conclusion, diffusion tensor parameters can potentially depict more microstructural changes than conventional magnetic resonance imaging in postinfectious encephalopathy in children...
  41. pmc Automatic segmentation of rodent spinal cord diffusion MR images
    Vanessa K Tidwell
    Department of Electrical and Systems Engineering, Washington University in St Louis, St Louis, Missouri 63130, USA
    Magn Reson Med 64:893-901. 2010
    ..The algorithm is shown to remain accurate for whole spinal cord, white matter, and hemorrhage segmentation in the presence of significant injury. The results of the method are shown to be at least on par with expert manual segmentation...
  42. ncbi request reprint Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid deposition
    Sheng Kwei Song
    Department of Chemistry, Washington University, St Louis, MO 63130, USA
    Neurobiol Dis 15:640-7. 2004
    ..Our results suggest that as amyloid beta (Abeta) deposition and levels increase over time in PDAPP mice, these changes lead to primary or secondary white matter injury that can be detected by DTI...
  43. ncbi request reprint Improved magnetic resonance imaging detection of prostate cancer in a transgenic mouse model
    Sheng Kwei Song
    Biomedical MR Laboratory, Department of Chemistry, Washington University, St Louis, Missouri 63110, USA
    Cancer Res 62:1555-8. 2002
    ..00001). Clinical application of DWI may offer advantages over current T2-weighted magnetic resonance imaging methods...
  44. pmc Use of ethylene glycol to evaluate gradient performance in gradient-intensive diffusion MR sequences
    William M Spees
    Department of Radiology, Washington University, St Louis, Missouri 63110, USA
    Magn Reson Med 68:319-24. 2012
    ..The high viscosity of ethylene glycol makes it well-suited for assessing gradient performance in demanding diffusion-weighted imaging and spectroscopy sequences...
  45. pmc The validation of complete Fourier direct MR method for diffusion MRI via biological and numerical phantoms
    Alpay Ozcan
    Mallinckrodt Institute of Radiology, Washington University in Saint Louis, School of Medicine, St Louis, MO 63110, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:3756-9. 2011
    ..CFD-MR's ability to estimate accurately and fully spin diffusion properties demonstrated here, provides the experimental validation of the theoretical CFD-MR model...
  46. pmc Bone marrow transplantation augments the effect of brain- and spinal cord-directed adeno-associated virus 2/5 gene therapy by altering inflammation in the murine model of globoid-cell leukodystrophy
    Adarsh S Reddy
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 31:9945-57. 2011
    ..These data suggest that the efficacy of AAV2/5-mediated gene therapy is limited by the associated inflammatory response and BMT synergizes with AAV2/5 by modulating inflammation...
  47. pmc Diffusion tensor imaging of mouse brain stem and cervical spinal cord
    Joong Hee Kim
    Department of Radiology, Washington University, St Louis, MO 63110, USA
    J Neurosci Methods 176:186-91. 2009
    ..The results may serve as a reference for future inter-lab comparison in mouse brain stem and cervical spine diffusion measurements...
  48. pmc White-matter diffusion fMRI of mouse optic nerve
    William M Spees
    Biomedical MR Laboratory, Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroimage 65:209-15. 2013
    ..The experimental results strongly suggest that osmotic after-effects of nerve impulses through the axonal fibers are responsible for the observed ADC decrease...
  49. ncbi request reprint Diffusion tensor imaging of the mouse brainstem and cervical spinal cord
    Joong Hee Kim
    Department of Radiology, Washington University, St Louis, Missouri, USA
    Nat Protoc 8:409-17. 2013
    ..7-T horizontal small animal imaging scanner equipped with an actively shielded gradient coil capable of pulsed gradient strengths up to 18 G cm(−1) with a gradient rise time of ≤295 μs...
  50. pmc Axial diffusivity is the primary correlate of axonal injury in the experimental autoimmune encephalomyelitis spinal cord: a quantitative pixelwise analysis
    Matthew D Budde
    Department of Radiology, Washington University, St Louis, Missouri 63110, USA
    J Neurosci 29:2805-13. 2009
    ..The results demonstrate a strong, quantitative relationship between axial diffusivity and axonal damage and show that anisotropy is not specific for axonal damage after inflammatory demyelination...
  51. pmc The MT pool size ratio and the DTI radial diffusivity may reflect the myelination in shiverer and control mice
    Xiawei Ou
    Department of Radiology, Vanderbilt University Institute of Imaging Science, Nashville, TN 37232, USA
    NMR Biomed 22:480-7. 2009
    ..Our findings support the view that qMT may be used for estimating myelin integrity...
  52. pmc Magnetic resonance diffusion characteristics of histologically defined prostate cancer in humans
    Junqian Xu
    Department of Chemistry, Washington University, St Louis, Missouri 63110, USA
    Magn Reson Med 61:842-50. 2009
    ..PCa identified in volume rendered MR images qualitatively correlates well with histologically determined PCa foci...
  53. pmc Simultaneous and noninvasive imaging of cerebral oxygen metabolic rate, blood flow and oxygen extraction fraction in stroke mice
    Xiao Hong Zhu
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Neuroimage 64:437-47. 2013
    ....
  54. ncbi request reprint In vivo imaging in a murine model of glioblastoma
    Sarah C Jost
    Department of Neurosurgery, Washington University, School of Medicine, St Louis, Missouri 63110, USA
    Neurosurgery 60:360-70; discussion 370-1. 2007
    ....
  55. pmc MRI detection of early bone metastases in b16 mouse melanoma models
    Karen M Gauvain
    Department of Pediatrics, Division of Hematology Oncology, Washington University School of Medicine, One Children s Place, Box 8116, St Louis, MO 63110, USA
    Clin Exp Metastasis 22:403-11. 2005
    ..0001) and can be used as a marker of early bone metastases. These studies demonstrate that MR imaging can detect bone marrow metastases in small animals prior to development of cortical bone loss identified by X-ray...
  56. doi request reprint Diffusion tensor imaging of the mouse brainstem and cervical spinal cord
    Joong Hee Kim
    Department of Radiology, Washington University, St Louis, Missouri, USA
    Nat Protoc 8:409-17. 2013
    ..7-T horizontal small animal imaging scanner equipped with an actively shielded gradient coil capable of pulsed gradient strengths up to 18 G cm(-1) with a gradient rise time of ≤295 μs...

Research Grants11

  1. Noninvasive Quantification of Axon Damage in EAE and MS
    Sheng Kwei Song; Fiscal Year: 2010
    ..In both strains, the extent of axonal damage will closely relate to the duration of the acute peaking of neurological deficits - presumably caused by acute inflammatory responses. ..
  2. Noninvasive Quantification of Axon Damage in EAE and MS
    Sheng Kwei Song; Fiscal Year: 2009
    ..In both strains, the extent of axonal damage will closely relate to the duration of the acute peaking of neurological deficits - presumably caused by acute inflammatory responses. ..
  3. Noninvasive Quantification of Axon Damage in EAE and MS
    Sheng Kwei Song; Fiscal Year: 2007
    ..In both strains, the extent of axonal damage will closely relate to the duration of the acute peaking of neurological deficits - presumably caused by acute inflammatory responses. ..
  4. Evaluation of Spinal Cord White Matter Injury Using DTI
    Sheng Kwei Song; Fiscal Year: 2007
    ..In vivo DTI findings will be validated by histological analysis including myelin staining, axonal staining, and transmission electron microscopy (EM). ..
  5. Evaluation of Spinal Cord White Matter Injury Using DTI
    Sheng Kwei Song; Fiscal Year: 2010
    ..The successful application of the proposed in vivo diffusion tensor imaging biomarker of white matter in the proposed studies will offer a more accurate prognostication and improved treatment stratification for SCI patients. ..