Research Topics
| Sheng Kwei SongSummaryAffiliation: Washington University School of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
Demyelination increases radial diffusivity in corpus callosum of mouse brainSheng Kwei Song
Department of Radiology, Biomedical MR Laboratory, Washington University School of Medicine, St Louis, MO 63110, USA
Neuroimage 26:132-40. 2005..Radial diffusivity offers a specific assessment of demyelination and remyelination, as distinct from acute axonal damage...- Diffusion tensor imaging predicts hyperacute spinal cord injury severityDavid N Loy
Department of Radiology, Washington University, Saint Louis, Missouri 63110, USA
J Neurotrauma 24:979-90. 2007..Cross-sectional regional measurements of white matter injury severity between dorsal columns and VWM varied with increasing cord displacement in a pattern consistent with spinal cord viscoelastic properties... 
Diffusion tensor imaging at 3 hours after traumatic spinal cord injury predicts long-term locomotor recoveryJoong H Kim
Department of Radiology, Washington University, St Louis, Missouri, USA
J Neurotrauma 27:587-98. 2010..Although significant obstacles must still be overcome to derive similar data in human patients, the path to clinical translation is foreseeable and achievable...- Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemiaSheng Kwei Song
Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Neuroimage 20:1714-22. 2003.... - Rostrocaudal analysis of corpus callosum demyelination and axon damage across disease stages refines diffusion tensor imaging correlations with pathological featuresMingqiang Xie
Department of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
J Neuropathol Exp Neurol 69:704-16. 2010.... - Differential sensitivity of in vivo and ex vivo diffusion tensor imaging to evolving optic nerve injury in mice with retinal ischemiaShu Wei Sun
Department of Radiology, Biomedical MR Laboratory, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
Neuroimage 32:1195-204. 2006..Despite the accurate depiction of the pathology using lambda(||) and lambda( perpendicular) in vivo, the use of ex vivo lambda(||) to extrapolate the status of axonal injury in vivo would require further investigation... - Evolving Wallerian degeneration after transient retinal ischemia in mice characterized by diffusion tensor imagingShu Wei Sun
Department of Radiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
Neuroimage 40:1-10. 2008..The current results suggest that axial and radial diffusivities are capable of reflecting the severity of axonal and myelin damage in mice as assessed using immunohistochemistry... - Toward accurate diagnosis of white matter pathology using diffusion tensor imagingMatthew D Budde
Department of Radiology, Washington University, St Louis, Missouri, USA
Magn Reson Med 57:688-95. 2007..The results suggest that directional diffusivities may reveal abnormalities that are not obvious with SMI-31 and LFB staining, depending on the type of injury... - Noninvasive diffusion tensor imaging of evolving white matter pathology in a mouse model of acute spinal cord injuryJoong Hee Kim
Department of Radiology, Washington University, St Louis, Missouri 63110, USA
Magn Reson Med 58:253-60. 2007..Quantitative measurements of axial and radial diffusivities in VWM showed a trend of acute primary axonal injury followed by delayed, subacute myelin damage at the impact site, with good histological correlation... - Axonal injury detected by in vivo diffusion tensor imaging correlates with neurological disability in a mouse model of multiple sclerosisMatthew D Budde
Department of Radiology, Washington University, St Louis, MO 63110, USA
NMR Biomed 21:589-97. 2008..The results further the notion that axial diffusivity is a non-invasive marker of axonal damage in white matter and could provide the necessary link between pathology and neurological disability... - Full tensor diffusion imaging is not required to assess the white-matter integrity in mouse contusion spinal cord injuryTsang Wei Tu
Department of Mechanical, Aerospace and Structural Engineering, Washington University in St Louis, St Louis, Missouri 63110, USA
J Neurotrauma 27:253-62. 2010..The results suggest that the two-direction DWI derived indices may be used, with significantly reduced imaging time, to estimate accurately spared white matter in mouse SCI... - Quantification of increased cellularity during inflammatory demyelinationYong Wang
Department of Radiology, Washington University, St Louis, MO 63110, USA
Brain 134:3590-601. 2011..Our findings suggest that diffusion basis spectrum imaging has great potential to provide non-invasive biomarkers for neuroinflammation, axonal injury and demyelination coexisting in multiple sclerosis... - Diffusion tensor imaging detects retinal ganglion cell axon damage in the mouse model of optic nerve crushXu Zhang
Department of Radiology, Washington University, St Louis, Missouri, USA
Invest Ophthalmol Vis Sci 52:7001-6. 2011..The authors hypothesized that DTI-derived axonal and myelin injury biomarkers may be used to detect early axonal damage and may be correlated with RGC loss in the mouse model of optic nerve crush (ONC)... - Selective vulnerability of cerebral white matter in a murine model of multiple sclerosis detected using diffusion tensor imagingShu Wei Sun
Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Neurobiol Dis 28:30-8. 2007..The present study demonstrated that the visual pathway is selectively affected in MOG(35-55) induced murine EAE and these injuries are non-invasively detectable using lambda(parallel) and lambda( perpendicular)... - Diffusion tensor imaging in acute optic neuropathies: predictor of clinical outcomesRobert T Naismith
Department of Neurology, Washington University in St Louis, Campus Box 8111, 660 S Euclid Ave, St Louis, MO 63110, USA
Arch Neurol 69:65-71. 2012..To evaluate directional diffusivities within the optic nerve in a first event of acute optic neuritis to determine whether decreased axial diffusivity (AD) would predict 6-month visual outcome and optic nerve integrity measures... - Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of waterSheng Kwei Song
Department of Chemistry, Washington University, St Louis, Missouri 63110, USA
Neuroimage 17:1429-36. 2002..Although further validation is still needed, our finding suggests that changes in lambda(perpendicular) and lambda(parallel) may potentially be used to differentiate myelin loss versus axonal injury... - Increased radial diffusivity in spinal cord lesions in neuromyelitis optica compared with multiple sclerosisEric C Klawiter
Department of Neurology, Washington University School of Medicine, St Louis, USA
Mult Scler 18:1259-68. 2012..Multiple sclerosis (MS) and neuromyelitis optica (NMO) both affect spinal cord with notable differences in pathology... - Assessing optic nerve pathology with diffusion MRI: from mouse to humanJunqian Xu
Department of Neurology, Washington University in St Louis, St Louis, MO, USA
NMR Biomed 21:928-40. 2008..From different mouse models of optic nerve injuries to the emerging studies on patients with optic neuritis, directional diffusivities show great potential to be specific biomarkers for axonal and myelin injury... - Radial diffusivity predicts demyelination in ex vivo multiple sclerosis spinal cordsEric C Klawiter
Department of Neurology, Washington University School of Medicine, Saint Louis, MO 63110, USA
Neuroimage 55:1454-60. 2011..Correlation of diffusion tensor imaging (DTI) with histochemical staining for demyelination and axonal damage in multiple sclerosis (MS) ex vivo human cervical spinal cords... - Postmortem delay does not change regional diffusion anisotropy characteristics in mouse spinal cord white matterJoong Hee Kim
Department of Chemistry, Washington University, 4525 Scott Avenue, St Louis, MO 63110, USA
NMR Biomed 20:352-9. 2007..Regional characteristics of diffusion anisotropy in mouse spinal cord white matter are equivalent in vivo, in situ after death (up to 10 h before fixation), and ex vivo 15 weeks after immersion fixation... - Cell swelling contributes to thickening of low-dose N-methyl-D-aspartate-induced retinal edemaJunjie Chen
Department of Medicine, Washington University, St Louis, Missouri 63110, USA
Invest Ophthalmol Vis Sci 53:2777-85. 2012..The objective of this study was to use in vivo magnetic resonance imaging (MRI) to assess retinal cell swelling in the edematous mouse retina... 
In vivo diffusion tensor MRI of the mouse retina: a noninvasive visualization of tissue organizationJunjie Chen
Department of Medicine, Washington University, St Louis, MO 63108, USA
NMR Biomed 24:447-51. 2011..05 for all comparisons), reflecting the degeneration of photoreceptor cells in rd1 mouse retina. Overall, our findings suggest that in vivo DTI assessment of mouse retina with normal physiology or degenerative pathology is feasible...- In vivo quantification of T1, T2, and apparent diffusion coefficient in the mouse retina at 11.74TJunjie Chen
Department of Medicine, Washington University, St Louis, Missouri, USA
Magn Reson Med 59:731-8. 2008..These MR parameters are expected to be useful in future evaluation of developmental and pathological alterations of retinal cell layers in mice... - Photoreceptor degeneration changes magnetic resonance imaging features in a mouse model of retinitis pigmentosaQing Wang
Department of Mechanical Engineering and Materials Science, Washington University, St Louis, Missouri, USA
Magn Reson Med 65:1793-8. 2011..Together, these data suggest that MRI parameter changes can signature common pathological changes in photoreceptor-degenerated eyes, particularly blood-retinal barrier leakage-induced retinal edema... - Impact speed does not determine severity of spinal cord injury in mice with fixed impact displacementJoong Hee Kim
Department of Radiology, Washington University, St Louis, MO 63110, USA
J Neurotrauma 26:1395-404. 2009..No significant difference in BMS was observed among injury groups of various impact speeds. The present results suggest that injury severity can be reproduced using speeds from 0.1 to 0.4 m/s at the fixed impact displacement... - Quantitative magnetization transfer measured pool-size ratio reflects optic nerve myelin content in ex vivo miceXiawei Ou
Department of Radiology, Vanderbilt University Institute of Imaging Science, Nashville, Tennessee 37232 2310, USA
Magn Reson Med 61:364-71. 2009..This pool size ratio was specific to myelin content only and was not significantly affected by the presence of axon injury in mouse optic nerve 3 days after retinal ischemia... - Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid depositionSheng Kwei Song
Department of Chemistry, Washington University, St Louis, MO 63130, USA
Neurobiol Dis 15:640-7. 2004..Our results suggest that as amyloid beta (Abeta) deposition and levels increase over time in PDAPP mice, these changes lead to primary or secondary white matter injury that can be detected by DTI... - Noninvasive detection of brainstem and spinal cord axonal degeneration in an amyotrophic lateral sclerosis mouse modelJoong Hee Kim
Department of Radiology, Washington University, St Louis, MO 63110, USA
NMR Biomed 24:163-9. 2011..The present study demonstrates that in vivo diffusion tensor imaging-derived axial diffusivity may be used to accurately evaluate axonal degeneration in an animal model of amyotrophic lateral sclerosis... - Diffusion tensor imaging detects axonal injury and demyelination in the spinal cord and cranial nerves of a murine model of globoid cell leukodystrophyA Alex Hofling
Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
NMR Biomed 22:1100-6. 2009..This first reported application of spinal cord DTI in the setting of GLD holds potential as a noninvasive, quantitative assay of therapeutic efficacy in future treatment studies... - CXCR7 antagonism prevents axonal injury during experimental autoimmune encephalomyelitis as revealed by in vivo axial diffusivityLillian Cruz-Orengo
Department of Internal Medicine, Washington University School of Medicine, 660 S, Euclid Ave, St Louis, MO 63110, USA
J Neuroinflammation 8:170. 2011..Because functional recovery reflects axonal integrity, we utilized diffusion tensor imaging (DTI) to evaluate axonal injury in CXCR7 antagonist- versus vehicle-treated mice after recovery from EAE... - Comprehensive locomotor outcomes correlate to hyperacute diffusion tensor measures after spinal cord injury in the adult ratJoong H Kim
Department of Radiology, Washington University, St Louis, MO 63110, USA
Exp Neurol 235:188-96. 2012..These observations suggest that acute DTI should be useful to provide functional predictions for spared white matter following contusive spinal cord injuries clinically... - Neuropathologic correlates for diffusion tensor imaging in postinfectious encephalopathyChin I Chen
Department of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
Pediatr Neurol 44:389-93. 2011..In conclusion, diffusion tensor parameters can potentially depict more microstructural changes than conventional magnetic resonance imaging in postinfectious encephalopathy in children... - Automatic segmentation of rodent spinal cord diffusion MR imagesVanessa K Tidwell
Department of Electrical and Systems Engineering, Washington University in St Louis, St Louis, Missouri 63130, USA
Magn Reson Med 64:893-901. 2010..The algorithm is shown to remain accurate for whole spinal cord, white matter, and hemorrhage segmentation in the presence of significant injury. The results of the method are shown to be at least on par with expert manual segmentation... - Improved magnetic resonance imaging detection of prostate cancer in a transgenic mouse modelSheng Kwei Song
Biomedical MR Laboratory, Department of Chemistry, Washington University, St Louis, Missouri 63110, USA
Cancer Res 62:1555-8. 2002..00001). Clinical application of DWI may offer advantages over current T2-weighted magnetic resonance imaging methods... - Use of ethylene glycol to evaluate gradient performance in gradient-intensive diffusion MR sequencesWilliam M Spees
Department of Radiology, Washington University, St Louis, Missouri 63110, USA
Magn Reson Med 68:319-24. 2012..The high viscosity of ethylene glycol makes it well-suited for assessing gradient performance in demanding diffusion-weighted imaging and spectroscopy sequences... - The validation of complete Fourier direct MR method for diffusion MRI via biological and numerical phantomsAlpay Ozcan
Mallinckrodt Institute of Radiology, Washington University in Saint Louis, School of Medicine, St Louis, MO 63110, USA
Conf Proc IEEE Eng Med Biol Soc 2011:3756-9. 2011..CFD-MR's ability to estimate accurately and fully spin diffusion properties demonstrated here, provides the experimental validation of the theoretical CFD-MR model... - Bone marrow transplantation augments the effect of brain- and spinal cord-directed adeno-associated virus 2/5 gene therapy by altering inflammation in the murine model of globoid-cell leukodystrophyAdarsh S Reddy
Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Neurosci 31:9945-57. 2011..These data suggest that the efficacy of AAV2/5-mediated gene therapy is limited by the associated inflammatory response and BMT synergizes with AAV2/5 by modulating inflammation... - Diffusion tensor imaging of mouse brain stem and cervical spinal cordJoong Hee Kim
Department of Radiology, Washington University, St Louis, MO 63110, USA
J Neurosci Methods 176:186-91. 2009..The results may serve as a reference for future inter-lab comparison in mouse brain stem and cervical spine diffusion measurements... - Axial diffusivity is the primary correlate of axonal injury in the experimental autoimmune encephalomyelitis spinal cord: a quantitative pixelwise analysisMatthew D Budde
Department of Radiology, Washington University, St Louis, Missouri 63110, USA
J Neurosci 29:2805-13. 2009..The results demonstrate a strong, quantitative relationship between axial diffusivity and axonal damage and show that anisotropy is not specific for axonal damage after inflammatory demyelination... - Magnetic resonance diffusion characteristics of histologically defined prostate cancer in humansJunqian Xu
Department of Chemistry, Washington University, St Louis, Missouri 63110, USA
Magn Reson Med 61:842-50. 2009..PCa identified in volume rendered MR images qualitatively correlates well with histologically determined PCa foci... - The MT pool size ratio and the DTI radial diffusivity may reflect the myelination in shiverer and control miceXiawei Ou
Department of Radiology, Vanderbilt University Institute of Imaging Science, Nashville, TN 37232, USA
NMR Biomed 22:480-7. 2009..Our findings support the view that qMT may be used for estimating myelin integrity... - MRI detection of early bone metastases in b16 mouse melanoma modelsKaren M Gauvain
Department of Pediatrics, Division of Hematology Oncology, Washington University School of Medicine, One Children s Place, Box 8116, St Louis, MO 63110, USA
Clin Exp Metastasis 22:403-11. 2005..0001) and can be used as a marker of early bone metastases. These studies demonstrate that MR imaging can detect bone marrow metastases in small animals prior to development of cortical bone loss identified by X-ray... - In vivo imaging in a murine model of glioblastomaSarah C Jost
Department of Neurosurgery, Washington University, School of Medicine, St Louis, Missouri 63110, USA
Neurosurgery 60:360-70; discussion 370-1. 2007.... - White-matter diffusion fMRI of mouse optic nerveWilliam M Spees
Biomedical MR Laboratory, Department of Radiology, Washington University School of Medicine, St Louis, MO, USA Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA Electronic address
Neuroimage 65:209-15. 2013..The experimental results strongly suggest that osmotic after-effects of nerve impulses through the axonal fibers are responsible for the observed ADC decrease...
Research Grants
- Noninvasive Quantification of Axon Damage in EAE and MSSheng Kwei Song; Fiscal Year: 2010..In both strains, the extent of axonal damage will closely relate to the duration of the acute peaking of neurological deficits - presumably caused by acute inflammatory responses. ..
- Noninvasive Quantification of Axon Damage in EAE and MSSheng Kwei Song; Fiscal Year: 2009..In both strains, the extent of axonal damage will closely relate to the duration of the acute peaking of neurological deficits - presumably caused by acute inflammatory responses. ..
- Noninvasive Quantification of Axon Damage in EAE and MSSheng Kwei Song; Fiscal Year: 2007..In both strains, the extent of axonal damage will closely relate to the duration of the acute peaking of neurological deficits - presumably caused by acute inflammatory responses. ..
- Evaluation of Spinal Cord White Matter Injury Using DTISheng Kwei Song; Fiscal Year: 2007..In vivo DTI findings will be validated by histological analysis including myelin staining, axonal staining, and transmission electron microscopy (EM). ..
- Evaluation of Spinal Cord White Matter Injury Using DTISheng Kwei Song; Fiscal Year: 2010..The successful application of the proposed in vivo diffusion tensor imaging biomarker of white matter in the proposed studies will offer a more accurate prognostication and improved treatment stratification for SCI patients. ..