Michael Skinner


Affiliation: Washington State University
Country: USA


  1. Klukovich R, Nilsson E, Sadler Riggleman I, Beck D, Xie Y, Yan W, et al. Environmental Toxicant Induced Epigenetic Transgenerational Inheritance of Prostate Pathology and Stromal-Epithelial Cell Epigenome and Transcriptome Alterations: Ancestral Origins of Prostate Disease. Sci Rep. 2019;9:2209 pubmed publisher
  2. Ben Maamar M, Nilsson E, Sadler Riggleman I, Beck D, McCarrey J, Skinner M. Developmental origins of transgenerational sperm DNA methylation epimutations following ancestral DDT exposure. Dev Biol. 2019;445:280-293 pubmed publisher
  3. Skinner M. Environmental Epigenetics and a Unified Theory of the Molecular Aspects of Evolution: A Neo-Lamarckian Concept that Facilitates Neo-Darwinian Evolution. Genome Biol Evol. 2015;7:1296-302 pubmed publisher
    ..Neo-Lamarckian concept can facilitate neo-Darwinian evolution. A unified theory of evolution is presented to describe the integration of environmental epigenetic and genetic aspects of evolution. ..
  4. Ben Maamar M, Sadler Riggleman I, Beck D, Skinner M. Epigenetic Transgenerational Inheritance of Altered Sperm Histone Retention Sites. Sci Rep. 2018;8:5308 pubmed publisher
  5. Haque M, Nilsson E, Holder L, Skinner M. Genomic Clustering of differential DNA methylated regions (epimutations) associated with the epigenetic transgenerational inheritance of disease and phenotypic variation. BMC Genomics. 2016;17:418 pubmed publisher
    ..Observations suggest these clustered DMR within an ECR may be susceptible to epigenetic reprogramming and dramatically influence genome activity. ..
  6. Skinner M, Ben Maamar M, Sadler Riggleman I, Beck D, Nilsson E, McBirney M, et al. Alterations in sperm DNA methylation, non-coding RNA and histone retention associate with DDT-induced epigenetic transgenerational inheritance of disease. Epigenetics Chromatin. 2018;11:8 pubmed publisher
    ..Observations demonstrate all three epigenetic processes are involved in transgenerational inheritance. The different epigenetic processes appear to be integrated in mediating the epigenetic transgenerational inheritance phenomenon. ..
  7. Skinner M, Savenkova M, Zhang B, Gore A, Crews D. Gene bionetworks involved in the epigenetic transgenerational inheritance of altered mate preference: environmental epigenetics and evolutionary biology. BMC Genomics. 2014;15:377 pubmed publisher
    ..Combined observations elucidate the potential molecular control of mate preference behavior and suggests environmental epigenetics can have a role in evolutionary biology. ..
  8. Guillette L, Parrott B, Nilsson E, Haque M, Skinner M. Epigenetic programming alterations in alligators from environmentally contaminated lakes. Gen Comp Endocrinol. 2016;238:4-12 pubmed publisher
    ..The epigenetic alterations may provide biomarkers to assess the environmental exposures and health impacts on these populations of alligators. ..
  9. Skinner M, Gurerrero Bosagna C, Haque M, Nilsson E, Koop J, Knutie S, et al. Epigenetics and the evolution of Darwin's Finches. Genome Biol Evol. 2014;6:1972-89 pubmed publisher
    ..As environmental factors are known to result in heritable changes in the epigenome, it is possible that epigenetic changes contribute to the molecular basis of the evolution of Darwin's finches. ..

More Information


  1. Nilsson E, Skinner M. Environmentally Induced Epigenetic Transgenerational Inheritance of Reproductive Disease. Biol Reprod. 2015;93:145 pubmed publisher
    ..Environmentally induced epigenetic transgenerational inheritance appears to be an important contributing factor to reproductive disease in many organisms, including humans. ..
  2. Nilsson E, Zhang B, Skinner M. Gene bionetworks that regulate ovarian primordial follicle assembly. BMC Genomics. 2013;14:496 pubmed publisher
    ..This systems biology approach has helped elucidate the molecular control of primordial follicle assembly and provided potential therapeutic targets for the treatment of ovarian disease. ..
  3. Skinner M, Guerrero Bosagna C. Role of CpG deserts in the epigenetic transgenerational inheritance of differential DNA methylation regions. BMC Genomics. 2014;15:692 pubmed publisher
    ..Observations suggest a potential regulatory role for lower density CpG regions termed "CpG deserts". The potential evolutionary origins of these regions is also discussed. ..
  4. Skinner M, Manikkam M, Guerrero Bosagna C. Epigenetic transgenerational actions of environmental factors in disease etiology. Trends Endocrinol Metab. 2010;21:214-22 pubmed publisher
    ..This review provides an overview of the epigenetics and biology of how environmental factors can promote transgenerational phenotypes and disease. ..
  5. Nilsson E, Larsen G, Skinner M. Roles of Gremlin 1 and Gremlin 2 in regulating ovarian primordial to primary follicle transition. Reproduction. 2014;147:865-74 pubmed publisher
    ..Insights into the regulatory networks affecting the pool of primordial follicles are important to understand the molecular basis for reproductive diseases such as primary ovarian insufficiency. ..
  6. Skinner M, Manikkam M, Tracey R, Guerrero Bosagna C, Haque M, Nilsson E. Ancestral dichlorodiphenyltrichloroethane (DDT) exposure promotes epigenetic transgenerational inheritance of obesity. BMC Med. 2013;11:228 pubmed publisher
    ..The etiology of disease such as obesity may be in part due to environmentally induced epigenetic transgenerational inheritance. ..
  7. McNew S, Beck D, Sadler Riggleman I, Knutie S, Koop J, Clayton D, et al. Epigenetic variation between urban and rural populations of Darwin's finches. BMC Evol Biol. 2017;17:183 pubmed publisher
    ..In summary, our study documents local population epigenetic variation within each of two species of Darwin's finches. ..
  8. Thorson J, Smithson M, Beck D, Sadler Riggleman I, Nilsson E, Dybdahl M, et al. Epigenetics and adaptive phenotypic variation between habitats in an asexual snail. Sci Rep. 2017;7:14139 pubmed publisher
    ..This provides a potential explanation for the capacity of this asexual snail to spread by adaptive evolution or plasticity to different environments. ..
  9. Skinner M, Guerrero Bosagna C, Haque M, Nilsson E, Bhandari R, McCarrey J. Environmentally induced transgenerational epigenetic reprogramming of primordial germ cells and the subsequent germ line. PLoS ONE. 2013;8:e66318 pubmed publisher
    ..Insights into the molecular control of germline transmitted epigenetic inheritance are provided. ..
  10. Skinner M. Environmental epigenetic transgenerational inheritance and somatic epigenetic mitotic stability. Epigenetics. 2011;6:838-42 pubmed
  11. Skinner M. Role of epigenetics in developmental biology and transgenerational inheritance. Birth Defects Res C Embryo Today. 2011;93:51-5 pubmed publisher
    ..This impacts area such as cellular differentiation, tissue development, environmental induced disease etiology, epigenetic transgenerational inheritance, and the general systems biology of organisms and evolution...
  12. Skinner M, Rawls A, Wilson Rawls J, Roalson E. Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature. Differentiation. 2010;80:1-8 pubmed publisher
    ..This phylogenetic and genomic analysis of the bHLH gene family has revealed unique elements of the evolution and functional relationships of the different genes in the bHLH gene family. ..