Research Topics
| Michael SkinnerSummaryAffiliation: Washington State University Country: USA Publications
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Publications
Environmental epigenetic transgenerational inheritance and somatic epigenetic mitotic stabilityMichael K Skinner
Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA, USA
Epigenetics 6:838-42. 2011....
Role of epigenetics in developmental biology and transgenerational inheritanceMichael K Skinner
Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, 99164 4236, USA
Birth Defects Res C Embryo Today 93:51-5. 2011..This impacts area such as cellular differentiation, tissue development, environmental induced disease etiology, epigenetic transgenerational inheritance, and the general systems biology of organisms and evolution...
Epigenetic transgenerational actions of endocrine disruptorsMichael K Skinner
Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA 99164 4236, United States
Reprod Toxicol 31:337-43. 2011..The current review focuses on the ability of environmental factors such as endocrine disruptors to promote transgenerational phenotypes...- Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclatureMichael K Skinner
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4236, USA
Differentiation 80:1-8. 2010..This phylogenetic and genomic analysis of the bHLH gene family has revealed unique elements of the evolution and functional relationships of the different genes in the bHLH gene family... - Epigenetic transgenerational actions of environmental factors in disease etiologyMichael K Skinner
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4236, USA
Trends Endocrinol Metab 21:214-22. 2010..This review provides an overview of the epigenetics and biology of how environmental factors can promote transgenerational phenotypes and disease... - Environmental epigenomics and disease susceptibilityMichael K Skinner
Center for Reproductive Biology, School of Biological Sciences, Washington State University, USA
EMBO Rep 12:620-2. 2011..The meeting helped to define the developing field of 'environmental epigenetics' and the research presented established its role in disease aetiology and susceptibility... - Actions of anti-Mullerian hormone on the ovarian transcriptome to inhibit primordial to primary follicle transitionEric Nilsson
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
Reproduction 134:209-21. 2007..Analysis of the regulatory factors and cellular pathways altered by AMH provides a better understanding of the molecular control of primordial follicle development... - Transforming growth factor beta (TGFbeta1, TGFbeta2 and TGFbeta3) null-mutant phenotypes in embryonic gonadal developmentMushtaq A Memon
Department of Veterinary Clinical Sciences, Washington State University, Pullman, WA 99164 4234, USA
Mol Cell Endocrinol 294:70-80. 2008..TGFb isoforms appear to have a role in gonadal development, but interactions between the isoforms is speculated to compensate in the different TGFb isoform null-mutant mice... - Regulation of the gonadal transcriptome during sex determination and testis morphogenesis: comparative candidate genesTracy M Clement
School of Molecular Biosciences, Center for Reproductive Biology, Washington State University, Pullman, Washington 99164, USA
Reproduction 134:455-72. 2007..However, the genes and gene network identified influence numerous cellular processes with cellular differentiation, proliferation, focal contact, RNA localization, and development being predominant... - Transgenerational epigenetic programming of the embryonic testis transcriptomeMatthew D Anway
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
Genomics 91:30-40. 2008.... - Epigenetic transgenerational actions of endocrine disruptors and male fertilityMatthew D Anway
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164-4231, USA
Science 308:1466-9. 2005..The ability of an environmental factor (for example, endocrine disruptor) to reprogram the germ line and to promote a transgenerational disease state has significant implications for evolutionary biology and disease etiology... - Transgenerational effects of the endocrine disruptor vinclozolin on the prostate transcriptome and adult onset diseaseMatthew D Anway
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
Prostate 68:517-29. 2008..The ability of an endocrine disruptor exposure during gonadal sex determination to promote a transgenerational prostate disease phenotype was investigated in the current study... - Alterations in the ovarian transcriptome during primordial follicle assembly and developmentPhillip R Kezele
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164-4231, USA
Biol Reprod 72:241-55. 2005.... - Keratinocyte growth factor acts as a mesenchymal factor that promotes ovarian primordial to primary follicle transitionPhillip Kezele
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
Biol Reprod 73:967-73. 2005..KGF appears to be a mesenchymal factor that promotes the primordial to primary follicle transitions... - Epigenetic transgenerational actions of endocrine disruptorsMatthew D Anway
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164-4231, USA
Endocrinology 147:S43-9. 2006..The biological importance of the epigenetic actions of environmental agents is reviewed in the context of the primordial germ cell and development of epigenetic transgenerational phenotypes... - Epigenetic transgenerational effects of endocrine disruptors on male reproductionCarlos M Guerrero-Bosagna
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
Semin Reprod Med 27:403-8. 2009..An extrinsic epigenetic transgenerational process would involve an epigenetic alteration in a somatic tissue and require exposure at each generation to maintain the transgenerational phenotype... - Profiling gene expression during the differentiation and development of the murine embryonic gonadChristopher L Small
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164, USA
Biol Reprod 72:492-501. 2005..With this study, a large number of transcripts comprising the murine transcriptome can be examined throughout male and female embryonic gonad development and allow for a more complete description of gonad differentiation and development... - Glial-derived neurotrophic factor promotes ovarian primordial follicle development and cell-cell interactions during folliculogenesisGretchen Dole
School of Molecular Biosciences, Center for Reproductive Biology, Washington State University, Pullman, Washington 99164 4231, USA
Reproduction 135:671-82. 2008..In contrast to the testis, ovarian GDNF is predominantly produced by germ cells (oocytes) rather than somatic cells... - Bone morphogenetic protein-4 acts as an ovarian follicle survival factor and promotes primordial follicle developmentEric E Nilsson
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
Biol Reprod 69:1265-72. 2003..Taken together, these data suggest that BMP-4 plays an important role in promoting the survival and development of primordial follicles in the neonatal ovary... - Transgenerational epigenetic programming of the brain transcriptome and anxiety behaviorMichael K Skinner
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington, USA
PLoS ONE 3:e3745. 2008..Observations are discussed in regards to environmental and transgenerational influences on the etiology of brain disease... - Endocrine disruptors and epigenetic transgenerational disease etiologyMichael K Skinner
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
Pediatr Res 61:48R-50R. 2007..This epigenetic transgenerational disease mechanism provides a unique perspective from which to view adult onset disease and ultimately offers new insights into novel diagnostic and therapeutic strategies... - Epigenetic transgenerational toxicology and germ cell diseaseMichael K Skinner
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA, USA
Int J Androl 30:393-6; discussion 396-7. 2007..g. testicular cancer). A thorough literature review is not provided, rather a perspective is provided on how this epigenetic transgenerational toxicology should be considered in germ cell disease and testicular cancer... - What is an epigenetic transgenerational phenotype? F3 or F2Michael K Skinner
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
Reprod Toxicol 25:2-6. 2008..The ability of an environmental compound (e.g. endocrine disruptor) to promote this reprogramming of the germ-line appears to be the causal factor in the epigenetic transgenerational phenotype... - Epigenetic transgenerational actions of vinclozolin on the development of disease and cancerMichael K Skinner
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman WA 99164 4231, USA
Crit Rev Oncog 13:75-82. 2007.... - Role of transforming growth factor beta in ovarian surface epithelium biology and ovarian cancerEric E Nilsson
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
Reprod Biomed Online 5:254-8. 2002..The regulation of TGFbeta signalling by ovarian steroid hormones may be one mechanism by which the OSE responds to cyclic changes in the underlying follicles... - Regulation of granulosa and theca cell transcriptomes during ovarian antral follicle developmentMichael K Skinner
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
Mol Reprod Dev 75:1457-72. 2008.... - Growth and differentiation factor-9 stimulates progression of early primary but not primordial rat ovarian follicle developmentEric E Nilsson
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164-4231, USA
Biol Reprod 67:1018-24. 2002..The actions of GDF-9 on specific stages of follicle development may in part be mediated through altering the expression of KL... - Transgenerational epigenetic imprinting of the male germline by endocrine disruptor exposure during gonadal sex determinationHung-Shu Chang
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164-4231, USA
Endocrinology 147:5524-41. 2006..e. induction of imprinted-like genes/DNA sequences) programming of the male germline, and this is associated with the development of transgenerational disease states... - Leukemia inhibitory factor (LIF) promotes the primordial to primary follicle transition in rat ovariesEric E Nilsson
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164-4231, USA
Mol Cell Endocrinol 188:65-73. 2002..In summary, LIF treatment increased the primordial to primary follicle transition in cultured ovaries and LIF may interact with KL to promote primordial follicle development... - Regulation of primordial follicle assembly and developmentMichael K Skinner
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
Hum Reprod Update 11:461-71. 2005..Elucidation of the molecular and cellular control of primordial follicle assembly and the primordial to primary follicle transition provides therapeutic targets to regulate ovarian function and treat ovarian disease... - Seminiferous cord formation and germ-cell programming: epigenetic transgenerational actions of endocrine disruptorsMichael K Skinner
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
Ann N Y Acad Sci 1061:18-32. 2005..The literature reviewed provides insight into the molecular and cellular control of embryonic testis development, male sex determination, and the programming of the male germ-line... - Kit ligand and basic fibroblast growth factor interactions in the induction of ovarian primordial to primary follicle transitionEric E Nilsson
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
Mol Cell Endocrinol 214:19-25. 2004..Elucidating the cell-cell interactions that mediate this network of specific locally derived growth factors is critical to understanding the physiology of the primordial to primary follicle transition... - Transgenerational effect of the endocrine disruptor vinclozolin on male spermatogenesisMatthew D Anway
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164-4231, USA
J Androl 27:868-79. 2006.... - Comparative anti-androgenic actions of vinclozolin and flutamide on transgenerational adult onset disease and spermatogenesisMatthew D Anway
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4234, USA
Reprod Toxicol 26:100-6. 2008..Although the actions of vinclozolin and flutamide appear similar in the F1 generation males, the transgenerational effects of vinclozolin do not appear to be acting through the same anti-androgenic mechanism as flutamide... - Insulin but not insulin-like growth factor-1 promotes the primordial to primary follicle transitionPhillip R Kezele
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164-4231, USA
Mol Cell Endocrinol 192:37-43. 2002..The significance of the observations in relation to diabetes and female infertility is discussed... - Effect of the anti-androgenic endocrine disruptor vinclozolin on embryonic testis cord formation and postnatal testis development and functionMehmet Uzumcu
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164-4231, USA
Reprod Toxicol 18:765-74. 2004..Observations indicate that transient exposure to an anti-androgenic endocrine disruptor during embryonic development causes delayed effects later in adult life on spermatogenic capacity... - Platelet-derived growth factor modulates the primordial to primary follicle transitionEric E Nilsson
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, 99164-4231, USA
Reproduction 131:1007-15. 2006..These observations provide insight into the cell-cell interactions involved in the regulation of primordial follicle development and can be used in the future development of therapies for some forms of infertility... - Epigenetic programming of the germ line: effects of endocrine disruptors on the development of transgenerational diseaseMatthew D Anway
Centre for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
Reprod Biomed Online 16:23-5. 2008..The epigenetic mechanism involves the alteration of DNA methylation in the germ line that appears to transmit transgenerational adult onset disease, including spermatogenic defects, prostate disease, kidney disease and cancer... - Transgenerational epigenetic effects of the endocrine disruptor vinclozolin on pregnancies and female adult onset diseaseEric E Nilsson
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
Reproduction 135:713-21. 2008..Observations demonstrate that vinclozolin exposure during gonadal sex determination promotes a transgenerational increase in pregnancy abnormalities and female adult onset disease states... - Progesterone regulation of primordial follicle assembly in bovine fetal ovariesEric E Nilsson
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99163 4231, United States
Mol Cell Endocrinol 313:9-16. 2009..Observations indicate that progesterone affects ovarian primordial follicle assembly in cattle, as it does in rats and mice... - Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiationJeffrey D Stevens
Center for Reproductive Biology, School of Molecular Biosciences, Pullman, WA 99164 4231, USA
Differentiation 76:1006-22. 2008..This phylogenetic and genomic analysis of the bHLH gene family has revealed unique aspects of the evolution and functional relationships of the different genes in the bHLH gene family... - Gene bionetwork analysis of ovarian primordial follicle developmentEric E Nilsson
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington, United States of America
PLoS ONE 5:e11637. 2010..This is one of the first applications of network analysis to a normal developmental process. These observations provide insights into potential therapeutic targets for preventing ovarian disease and promoting female reproduction... - Effect of transient embryonic in vivo exposure to the endocrine disruptor methoxychlor on embryonic and postnatal testis developmentAndrea S Cupp
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164-4231, USA
J Androl 24:736-45. 2003..Therefore, transient embryonic exposure to an endocrine disruptor (methoxychlor) during gestation can influence the germline and fertility in adult males... - Role of the basic helix-loop-helix transcription factor, scleraxis, in the regulation of Sertoli cell function and differentiationTera Muir
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
Mol Endocrinol 19:2164-74. 2005..This is one of the first adult and nontendon/chondrocyte-associated functions described for scleraxis... - Transforming growth factor-beta isoform expression during bovine ovarian antral follicle developmentEric E Nilsson
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
Mol Reprod Dev 66:237-46. 2003..TGF-betas involved in antral follicular growth and development appear to act as paracrine/autocrine signaling molecules having a species-specific pattern of expression... - Regulation of ovarian primordial follicle assembly and development by estrogen and progesterone: endocrine model of follicle assemblyPhillip Kezele
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164-4231, USA
Endocrinology 144:3329-37. 2003..These observations suggest a novel role for steroids and the maternal-fetal endocrine unit in the control of ovarian primordial follicle assembly and early follicular development... - Endocrine disruptor vinclozolin induced epigenetic transgenerational adult-onset diseaseMatthew D Anway
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164-4231, USA
Endocrinology 147:5515-23. 2006..The observations demonstrate that an environmental compound, endocrine disruptor, can induce transgenerational disease states or abnormalities, and this suggests a potential epigenetic etiology and molecular basis of adult onset disease... - Interactions between progesterone and tumor necrosis factor-alpha in the regulation of primordial follicle assemblyEric E Nilsson
School of Molecular Biosciences, Center for Reproductive Biology, Washington State University, Pullman, WA 99164-4231, USA
Reproduction 132:877-86. 2006..Observations provide insight into the hormonal regulation of primordial follicle assembly and lead to novel approaches to potentially manipulate follicle assembly and reproductive capacity... - Embryonic testis cord formation and mesonephric cell migration requires the phosphotidylinositol 3-kinase signaling pathwayMehmet Uzumcu
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman 99164 4231, USA
Biol Reprod 67:1927-35. 2002..Combined observations demonstrate that the PI3K signaling pathway is involved in embryonic testis cord formation and mesonephros cell migration... - Inhibition of platelet-derived growth factor actions in the embryonic testis influences normal cord development and morphologyMehmet Uzumcu
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164-4231, USA
Biol Reprod 66:745-53. 2002..Inhibition of PDGF actions does not inhibit cord formation but does alter normal cord development and morphology. The observations provide insight into the factors involved in male sex differentiation and embryonic testis development... - Cell-cell interactions in primordial follicle assembly and developmentPhillip Kezele
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman WA 99164-4231, USA
Front Biosci 7:d1990-6. 2002..The studies reviewed regarding the control of primordial follicle assembly and the primordial to primary follicle transition help elucidate these poorly understood aspects of ovarian biology... - Role of basic helix-loop-helix (bHLH) and CREB transcription factors in the regulation of Sertoli cell androgen-binding protein expressionMelissa A Saxlund
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
Mol Reprod Dev 68:269-78. 2004..Combined observations of the ABP promoter and artificial promoter provide insight into a common mechanism for gene regulation in differentiated Sertoli cells involving a role for both the bHLH and CREB family of transcription factors... - Chemotactic role of neurotropin 3 in the embryonic testis that facilitates male sex determinationAndrea S Cupp
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
Biol Reprod 68:2033-7. 2003.... - Integration of CREB and bHLH transcriptional signaling pathways through direct heterodimerization of the proteins: role in muscle and testis developmentTera Muir
Center for Reproductive Biology, Washington State University, Pullman, Washington 99164 4231, USA
Mol Reprod Dev 75:1637-52. 2008..The observations suggest a mechanism for direct cross-talk between cAMP induced and bHLH controlled cellular differentiation... - The helix-loop-helix inhibitor of differentiation (ID) proteins induce post-mitotic terminally differentiated Sertoli cells to re-enter the cell cycle and proliferateJaideep Chaudhary
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
Biol Reprod 72:1205-17. 2005..The observations are discussed in regards to potential future applications in model systems of terminally differentiated cell types such as neurons or myocytes... - Inhibition of phosphatidylinositol 3-kinase sensitizes ovarian cancer cells to carboplatin and allows adjunct chemotherapy treatmentSuzanne D Westfall
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164-4231, USA
Mol Cancer Ther 4:1764-71. 2005..g., LY294002) as an adjunct platinum-based drug therapy for treatment of ovarian cancer... - Identification of a novel Sertoli cell gene product SERT that influences follicle stimulating hormone actionsJaideep Chaudhary
Center for Reproductive Biology School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
Gene 324:79-88. 2004..g. FSH) actions in Sertoli cells... - Identification of a novel gene product, Sertoli cell gene with a zinc finger domain, that is important for FSH activation of testicular Sertoli cellsJaideep Chaudhary
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
Endocrinology 143:426-35. 2002..Translation of SERZ may give rise to two gene products; however, the SERZ-beta containing the zinc finger domain is probably the principal product of the SERZ gene... - Role of the basic helix-loop-helix protein ITF2 in the hormonal regulation of Sertoli cell differentiationTerla Muir
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
Mol Reprod Dev 73:491-500. 2006..Observations suggest ITF2 can enhance FSH actions through suppressing the inhibitory actions of the Id family of proteins and increasing the actions of stimulatory bHLH proteins (i.e., scleraxis) in Sertoli cells... - An in vivo mouse reporter gene (human secreted alkaline phosphatase) model to monitor ovarian tumor growth and response to therapeuticsEric E Nilsson
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164-4231, USA
Cancer Chemother Pharmacol 49:93-100. 2002..Future studies will utilize this model to investigate novel chemotherapeutic approaches to treating ovarian cancer... - Role of triptolide as an adjunct chemotherapy for ovarian cancerSuzanne D Westfall
Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
Chemotherapy 54:67-76. 2008....
Research Grants
- CELL-CELL INTERACTIONS IN TESTIS DEVELOPMENTMichael Skinner; Fiscal Year: 2007..It is anticipated that the observations will lead to the design of future: therapeutic treatments for male infertility. ..
- Ovarian Primordial Follicle DevelopmentMichael Skinner; Fiscal Year: 2007....
- EPIGENETIC TRANSGENERATIONAL ENDOCRINE DISRUPTOR ACTIONSMichael Skinner; Fiscal Year: 2007..The proposed research will thoroughly establish this phenomenon and elucidate the molecular mechanisms involved. ..
- Ovarian Primordial Follicle DevelopmentMichael K Skinner; Fiscal Year: 2010..abstract_text> ..
- SERTOLI CELL DIFFERENTIATION AND TESTIS DEVELOPMENTMichael Skinner; Fiscal Year: 2002..Therefore, observations from the current proposal on transcriptional regulation of Sertoli cell differentiation will provide a better understanding of normal and abnormal testis development and function. ..
- EPIGENETIC TRANSGENERATIONAL ENDOCRINE DISRUPTOR ACTIONSMichael K Skinner; Fiscal Year: 2010..The proposed research will more thoroughly investigate this phenomenon and elucidate the molecular mechanisms involved. ..