Michael K Skinner

Summary

Affiliation: Washington State University
Country: USA

Publications

  1. ncbi request reprint Role of transforming growth factor beta in ovarian surface epithelium biology and ovarian cancer
    Eric E Nilsson
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
    Reprod Biomed Online 5:254-8. 2002
  2. ncbi request reprint Seminiferous cord formation and germ-cell programming: epigenetic transgenerational actions of endocrine disruptors
    Michael K Skinner
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
    Ann N Y Acad Sci 1061:18-32. 2005
  3. ncbi request reprint Epigenetic transgenerational toxicology and germ cell disease
    Michael K Skinner
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA, USA
    Int J Androl 30:393-6; discussion 396-7. 2007
  4. ncbi request reprint Endocrine disruptors and epigenetic transgenerational disease etiology
    Michael K Skinner
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Pediatr Res 61:48R-50R. 2007
  5. pmc What is an epigenetic transgenerational phenotype? F3 or F2
    Michael K Skinner
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
    Reprod Toxicol 25:2-6. 2008
  6. ncbi request reprint Epigenetic transgenerational actions of vinclozolin on the development of disease and cancer
    Michael K Skinner
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman WA 99164 4231, USA
    Crit Rev Oncog 13:75-82. 2007
  7. doi request reprint Regulation of granulosa and theca cell transcriptomes during ovarian antral follicle development
    Michael K Skinner
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Mol Reprod Dev 75:1457-72. 2008
  8. ncbi request reprint Regulation of primordial follicle assembly and development
    Michael K Skinner
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
    Hum Reprod Update 11:461-71. 2005
  9. pmc Transgenerational epigenetic programming of the brain transcriptome and anxiety behavior
    Michael K Skinner
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington, USA
    PLoS ONE 3:e3745. 2008
  10. ncbi request reprint Actions of anti-Mullerian hormone on the ovarian transcriptome to inhibit primordial to primary follicle transition
    Eric Nilsson
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Reproduction 134:209-21. 2007

Collaborators

Detail Information

Publications83

  1. ncbi request reprint Role of transforming growth factor beta in ovarian surface epithelium biology and ovarian cancer
    Eric E Nilsson
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
    Reprod Biomed Online 5:254-8. 2002
    ..The regulation of TGFbeta signalling by ovarian steroid hormones may be one mechanism by which the OSE responds to cyclic changes in the underlying follicles...
  2. ncbi request reprint Seminiferous cord formation and germ-cell programming: epigenetic transgenerational actions of endocrine disruptors
    Michael K Skinner
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
    Ann N Y Acad Sci 1061:18-32. 2005
    ..The literature reviewed provides insight into the molecular and cellular control of embryonic testis development, male sex determination, and the programming of the male germ-line...
  3. ncbi request reprint Epigenetic transgenerational toxicology and germ cell disease
    Michael K Skinner
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA, USA
    Int J Androl 30:393-6; discussion 396-7. 2007
    ..g. testicular cancer). A thorough literature review is not provided, rather a perspective is provided on how this epigenetic transgenerational toxicology should be considered in germ cell disease and testicular cancer...
  4. ncbi request reprint Endocrine disruptors and epigenetic transgenerational disease etiology
    Michael K Skinner
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Pediatr Res 61:48R-50R. 2007
    ..This epigenetic transgenerational disease mechanism provides a unique perspective from which to view adult onset disease and ultimately offers new insights into novel diagnostic and therapeutic strategies...
  5. pmc What is an epigenetic transgenerational phenotype? F3 or F2
    Michael K Skinner
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
    Reprod Toxicol 25:2-6. 2008
    ..The ability of an environmental compound (e.g. endocrine disruptor) to promote this reprogramming of the germ-line appears to be the causal factor in the epigenetic transgenerational phenotype...
  6. ncbi request reprint Epigenetic transgenerational actions of vinclozolin on the development of disease and cancer
    Michael K Skinner
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman WA 99164 4231, USA
    Crit Rev Oncog 13:75-82. 2007
    ....
  7. doi request reprint Regulation of granulosa and theca cell transcriptomes during ovarian antral follicle development
    Michael K Skinner
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Mol Reprod Dev 75:1457-72. 2008
    ....
  8. ncbi request reprint Regulation of primordial follicle assembly and development
    Michael K Skinner
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
    Hum Reprod Update 11:461-71. 2005
    ..Elucidation of the molecular and cellular control of primordial follicle assembly and the primordial to primary follicle transition provides therapeutic targets to regulate ovarian function and treat ovarian disease...
  9. pmc Transgenerational epigenetic programming of the brain transcriptome and anxiety behavior
    Michael K Skinner
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington, USA
    PLoS ONE 3:e3745. 2008
    ..Observations are discussed in regards to environmental and transgenerational influences on the etiology of brain disease...
  10. ncbi request reprint Actions of anti-Mullerian hormone on the ovarian transcriptome to inhibit primordial to primary follicle transition
    Eric Nilsson
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Reproduction 134:209-21. 2007
    ..Analysis of the regulatory factors and cellular pathways altered by AMH provides a better understanding of the molecular control of primordial follicle development...
  11. pmc Epigenetic transgenerational inheritance of vinclozolin induced mouse adult onset disease and associated sperm epigenome biomarkers
    Carlos Guerrero-Bosagna
    Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA 99164 4236, United States
    Reprod Toxicol 34:694-707. 2012
    ..Analysis of the F3 generation sperm epigenome identified differential DNA methylation regions that can potentially be utilized as epigenetic biomarkers for transgenerational exposure and disease...
  12. ncbi request reprint Epigenetic transgenerational actions of endocrine disruptors and male fertility
    Matthew D Anway
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
    Science 308:1466-9. 2005
    ..The ability of an environmental factor (for example, endocrine disruptor) to reprogram the germ line and to promote a transgenerational disease state has significant implications for evolutionary biology and disease etiology...
  13. pmc Environmentally induced epigenetic transgenerational inheritance of ovarian disease
    Eric Nilsson
    School of Biological Sciences, Center for Reproductive Biology, Washington State University, Pullman, Washington, USA
    PLoS ONE 7:e36129. 2012
    ..Epigenetic transgenerational inheritance of ovarian disease states was induced by all the different classes of environmental compounds, suggesting a role of environmental epigenetics in ovarian disease etiology...
  14. ncbi request reprint Role of the basic helix-loop-helix transcription factor, scleraxis, in the regulation of Sertoli cell function and differentiation
    Tera Muir
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Mol Endocrinol 19:2164-74. 2005
    ..This is one of the first adult and nontendon/chondrocyte-associated functions described for scleraxis...
  15. pmc Transforming growth factor beta (TGFbeta1, TGFbeta2 and TGFbeta3) null-mutant phenotypes in embryonic gonadal development
    Mushtaq A Memon
    Department of Veterinary Clinical Sciences, Washington State University, Pullman, WA 99164 4234, USA
    Mol Cell Endocrinol 294:70-80. 2008
    ..TGFb isoforms appear to have a role in gonadal development, but interactions between the isoforms is speculated to compensate in the different TGFb isoform null-mutant mice...
  16. ncbi request reprint Role of triptolide as an adjunct chemotherapy for ovarian cancer
    Suzanne D Westfall
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
    Chemotherapy 54:67-76. 2008
    ....
  17. pmc Transgenerational epigenetic programming of the embryonic testis transcriptome
    Matthew D Anway
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
    Genomics 91:30-40. 2008
    ....
  18. doi request reprint SRY induced TCF21 genome-wide targets and cascade of bHLH factors during Sertoli cell differentiation and male sex determination in rats
    Ramji K Bhandari
    Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, Washington, USA
    Biol Reprod 87:131. 2012
    ..The current observations help elucidate the initial molecular events involved in the induction of Sertoli cell differentiation and testis development...
  19. pmc Pesticide and insect repellent mixture (permethrin and DEET) induces epigenetic transgenerational inheritance of disease and sperm epimutations
    Mohan Manikkam
    Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA 99164 4236, United States
    Reprod Toxicol 34:708-19. 2012
    ..Observations demonstrate that a pesticide mixture (permethrin and DEET) can promote epigenetic transgenerational inheritance of adult onset disease and potential sperm epigenetic biomarkers for ancestral environmental exposures...
  20. ncbi request reprint Keratinocyte growth factor acts as a mesenchymal factor that promotes ovarian primordial to primary follicle transition
    Phillip Kezele
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Biol Reprod 73:967-73. 2005
    ..KGF appears to be a mesenchymal factor that promotes the primordial to primary follicle transitions...
  21. doi request reprint Glial-derived neurotrophic factor promotes ovarian primordial follicle development and cell-cell interactions during folliculogenesis
    Gretchen Dole
    School of Molecular Biosciences, Center for Reproductive Biology, Washington State University, Pullman, Washington 99164 4231, USA
    Reproduction 135:671-82. 2008
    ..In contrast to the testis, ovarian GDNF is predominantly produced by germ cells (oocytes) rather than somatic cells...
  22. ncbi request reprint Inhibition of phosphatidylinositol 3-kinase sensitizes ovarian cancer cells to carboplatin and allows adjunct chemotherapy treatment
    Suzanne D Westfall
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
    Mol Cancer Ther 4:1764-71. 2005
    ..g., LY294002) as an adjunct platinum-based drug therapy for treatment of ovarian cancer...
  23. pmc Profiling gene expression during the differentiation and development of the murine embryonic gonad
    Christopher L Small
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164, USA
    Biol Reprod 72:492-501. 2005
    ..With this study, a large number of transcripts comprising the murine transcriptome can be examined throughout male and female embryonic gonad development and allow for a more complete description of gonad differentiation and development...
  24. ncbi request reprint Role of the basic helix-loop-helix protein ITF2 in the hormonal regulation of Sertoli cell differentiation
    Terla Muir
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Mol Reprod Dev 73:491-500. 2006
    ..Observations suggest ITF2 can enhance FSH actions through suppressing the inhibitory actions of the Id family of proteins and increasing the actions of stimulatory bHLH proteins (i.e., scleraxis) in Sertoli cells...
  25. ncbi request reprint Regulation of the gonadal transcriptome during sex determination and testis morphogenesis: comparative candidate genes
    Tracy M Clement
    School of Molecular Biosciences, Center for Reproductive Biology, Washington State University, Pullman, Washington 99164, USA
    Reproduction 134:455-72. 2007
    ..However, the genes and gene network identified influence numerous cellular processes with cellular differentiation, proliferation, focal contact, RNA localization, and development being predominant...
  26. pmc Inhibitory actions of Anti-Müllerian Hormone (AMH) on ovarian primordial follicle assembly
    Eric E Nilsson
    Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, Washington, United States of America
    PLoS ONE 6:e20087. 2011
    ....
  27. ncbi request reprint Alterations in the ovarian transcriptome during primordial follicle assembly and development
    Phillip R Kezele
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Biol Reprod 72:241-55. 2005
    ....
  28. pmc Environmentally induced epigenetic transgenerational inheritance of altered Sertoli cell transcriptome and epigenome: molecular etiology of male infertility
    Carlos Guerrero-Bosagna
    Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, Washington, United States of America
    PLoS ONE 8:e59922. 2013
    ..The environmentally induced epigenetic transgenerational inheritance of testis disease appears to be a component of the molecular etiology of male infertility...
  29. pmc Hydrocarbons (jet fuel JP-8) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations
    Rebecca Tracey
    Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA 99164 4236, United States
    Reprod Toxicol 36:104-16. 2013
    ..Observations demonstrate hydrocarbons can promote epigenetic transgenerational inheritance of disease and sperm epimutations, potential biomarkers for ancestral exposures...
  30. pmc Basic helix-loop-helix transcription factor TCF21 is a downstream target of the male sex determining gene SRY
    Ramji K Bhandari
    Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, Washington, United States of America
    PLoS ONE 6:e19935. 2011
    ..Therefore, SRY acts directly on the Tcf21 promoter to in part initiate a cascade of events associated with Sertoli cell differentiation and embryonic testis development...
  31. ncbi request reprint Growth and differentiation factor-9 stimulates progression of early primary but not primordial rat ovarian follicle development
    Eric E Nilsson
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Biol Reprod 67:1018-24. 2002
    ..The actions of GDF-9 on specific stages of follicle development may in part be mediated through altering the expression of KL...
  32. ncbi request reprint Bone morphogenetic protein-4 acts as an ovarian follicle survival factor and promotes primordial follicle development
    Eric E Nilsson
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Biol Reprod 69:1265-72. 2003
    ..Taken together, these data suggest that BMP-4 plays an important role in promoting the survival and development of primordial follicles in the neonatal ovary...
  33. ncbi request reprint Interactions between progesterone and tumor necrosis factor-alpha in the regulation of primordial follicle assembly
    Eric E Nilsson
    School of Molecular Biosciences, Center for Reproductive Biology, Washington State University, Pullman, WA 99164 4231, USA
    Reproduction 132:877-86. 2006
    ..Observations provide insight into the hormonal regulation of primordial follicle assembly and lead to novel approaches to potentially manipulate follicle assembly and reproductive capacity...
  34. doi request reprint Neurotrophin NT3 promotes ovarian primordial to primary follicle transition
    Eric Nilsson
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4234, USA
    Reproduction 138:697-707. 2009
    ..Observations indicate that the neurotrophin NT3, acting through the NTRK3 receptor in oocytes, promotes the primordial to primary follicle transition...
  35. doi request reprint Comparative anti-androgenic actions of vinclozolin and flutamide on transgenerational adult onset disease and spermatogenesis
    Matthew D Anway
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4234, USA
    Reprod Toxicol 26:100-6. 2008
    ..Although the actions of vinclozolin and flutamide appear similar in the F1 generation males, the transgenerational effects of vinclozolin do not appear to be acting through the same anti-androgenic mechanism as flutamide...
  36. ncbi request reprint Platelet-derived growth factor modulates the primordial to primary follicle transition
    Eric E Nilsson
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, 99164 4231, USA
    Reproduction 131:1007-15. 2006
    ..These observations provide insight into the cell-cell interactions involved in the regulation of primordial follicle development and can be used in the future development of therapies for some forms of infertility...
  37. pmc Alterations in the developing testis transcriptome following embryonic vinclozolin exposure
    Tracy M Clement
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4236, USA
    Reprod Toxicol 30:353-64. 2010
    ..Specific cellular process and pathway analyses suggest the involvement of Wnt and calcium signaling, vascular development and epigenetic mechanisms as potential mediators of the direct F1 generation actions of vinclozolin...
  38. ncbi request reprint The helix-loop-helix inhibitor of differentiation (ID) proteins induce post-mitotic terminally differentiated Sertoli cells to re-enter the cell cycle and proliferate
    Jaideep Chaudhary
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Biol Reprod 72:1205-17. 2005
    ..The observations are discussed in regards to potential future applications in model systems of terminally differentiated cell types such as neurons or myocytes...
  39. pmc Environmentally induced epigenetic transgenerational inheritance of phenotype and disease
    Carlos Guerrero-Bosagna
    Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA 99164 4236, USA
    Mol Cell Endocrinol 354:3-8. 2012
    ..This environmental epigenetic transgenerational inheritance of phenotype and disease is reviewed with a systems biology perspective...
  40. doi request reprint Transgenerational effects of the endocrine disruptor vinclozolin on the prostate transcriptome and adult onset disease
    Matthew D Anway
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Prostate 68:517-29. 2008
    ..The ability of an endocrine disruptor exposure during gonadal sex determination to promote a transgenerational prostate disease phenotype was investigated in the current study...
  41. doi request reprint Integration of CREB and bHLH transcriptional signaling pathways through direct heterodimerization of the proteins: role in muscle and testis development
    Tera Muir
    Center for Reproductive Biology, Washington State University, Pullman, Washington 99164 4231, USA
    Mol Reprod Dev 75:1637-52. 2008
    ..The observations suggest a mechanism for direct cross-talk between cAMP induced and bHLH controlled cellular differentiation...
  42. ncbi request reprint Insulin but not insulin-like growth factor-1 promotes the primordial to primary follicle transition
    Phillip R Kezele
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
    Mol Cell Endocrinol 192:37-43. 2002
    ..The significance of the observations in relation to diabetes and female infertility is discussed...
  43. ncbi request reprint Embryonic testis cord formation and mesonephric cell migration requires the phosphotidylinositol 3-kinase signaling pathway
    Mehmet Uzumcu
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman 99164 4231, USA
    Biol Reprod 67:1927-35. 2002
    ..Combined observations demonstrate that the PI3K signaling pathway is involved in embryonic testis cord formation and mesonephros cell migration...
  44. doi request reprint Transgenerational epigenetic effects of the endocrine disruptor vinclozolin on pregnancies and female adult onset disease
    Eric E Nilsson
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Reproduction 135:713-21. 2008
    ..Observations demonstrate that vinclozolin exposure during gonadal sex determination promotes a transgenerational increase in pregnancy abnormalities and female adult onset disease states...
  45. pmc Epigenetic transgenerational effects of endocrine disruptors on male reproduction
    Carlos M Guerrero-Bosagna
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Semin Reprod Med 27:403-8. 2009
    ..An extrinsic epigenetic transgenerational process would involve an epigenetic alteration in a somatic tissue and require exposure at each generation to maintain the transgenerational phenotype...
  46. pmc Progesterone regulation of primordial follicle assembly in bovine fetal ovaries
    Eric E Nilsson
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99163 4231, United States
    Mol Cell Endocrinol 313:9-16. 2009
    ..Observations indicate that progesterone affects ovarian primordial follicle assembly in cattle, as it does in rats and mice...
  47. pmc Global genome analysis of the downstream binding targets of testis determining factor SRY and SOX9
    Ramji K Bhandari
    Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, Washington, United States of America
    PLoS ONE 7:e43380. 2012
    ..The specific DNA sequence binding site motifs for both SRY and SOX9 were identified. Observations provide insights into the molecular control of male gonadal sex determination...
  48. pmc Dioxin (TCDD) induces epigenetic transgenerational inheritance of adult onset disease and sperm epimutations
    Mohan Manikkam
    Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, Washington, USA
    PLoS ONE 7:e46249. 2012
    ..Observations demonstrate dioxin exposure of a gestating female promotes epigenetic transgenerational inheritance of adult onset disease and sperm epimutations...
  49. pmc SRY directly regulates the neurotrophin 3 promoter during male sex determination and testis development in rats
    Tracy M Clement
    Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA, USA
    Biol Reprod 85:277-84. 2011
    ..Observations suggest that SRY physically interacts with the Ntf3 promoter during male sex determination to coordinate cell migration in the testis to form testis cords...
  50. ncbi request reprint Epigenetic transgenerational actions of endocrine disruptors
    Matthew D Anway
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Endocrinology 147:S43-9. 2006
    ..The biological importance of the epigenetic actions of environmental agents is reviewed in the context of the primordial germ cell and development of epigenetic transgenerational phenotypes...
  51. pmc Epigenetic transgenerational actions of endocrine disruptors
    Michael K Skinner
    Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA 99164 4236, United States
    Reprod Toxicol 31:337-43. 2011
    ..The current review focuses on the ability of environmental factors such as endocrine disruptors to promote transgenerational phenotypes...
  52. ncbi request reprint Endocrine disruptor vinclozolin induced epigenetic transgenerational adult-onset disease
    Matthew D Anway
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Endocrinology 147:5515-23. 2006
    ..The observations demonstrate that an environmental compound, endocrine disruptor, can induce transgenerational disease states or abnormalities, and this suggests a potential epigenetic etiology and molecular basis of adult onset disease...
  53. ncbi request reprint Transgenerational effect of the endocrine disruptor vinclozolin on male spermatogenesis
    Matthew D Anway
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
    J Androl 27:868-79. 2006
    ....
  54. ncbi request reprint Kit ligand and basic fibroblast growth factor interactions in the induction of ovarian primordial to primary follicle transition
    Eric E Nilsson
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
    Mol Cell Endocrinol 214:19-25. 2004
    ..Elucidating the cell-cell interactions that mediate this network of specific locally derived growth factors is critical to understanding the physiology of the primordial to primary follicle transition...
  55. ncbi request reprint Leukemia inhibitory factor (LIF) promotes the primordial to primary follicle transition in rat ovaries
    Eric E Nilsson
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
    Mol Cell Endocrinol 188:65-73. 2002
    ..In summary, LIF treatment increased the primordial to primary follicle transition in cultured ovaries and LIF may interact with KL to promote primordial follicle development...
  56. ncbi request reprint Effect of the anti-androgenic endocrine disruptor vinclozolin on embryonic testis cord formation and postnatal testis development and function
    Mehmet Uzumcu
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
    Reprod Toxicol 18:765-74. 2004
    ..Observations indicate that transient exposure to an anti-androgenic endocrine disruptor during embryonic development causes delayed effects later in adult life on spermatogenic capacity...
  57. ncbi request reprint Regulation of ovarian primordial follicle assembly and development by estrogen and progesterone: endocrine model of follicle assembly
    Phillip Kezele
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Endocrinology 144:3329-37. 2003
    ..These observations suggest a novel role for steroids and the maternal-fetal endocrine unit in the control of ovarian primordial follicle assembly and early follicular development...
  58. ncbi request reprint Transgenerational epigenetic imprinting of the male germline by endocrine disruptor exposure during gonadal sex determination
    Hung Shu Chang
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Endocrinology 147:5524-41. 2006
    ..e. induction of imprinted-like genes/DNA sequences) programming of the male germline, and this is associated with the development of transgenerational disease states...
  59. pmc Transgenerational actions of environmental compounds on reproductive disease and identification of epigenetic biomarkers of ancestral exposures
    Mohan Manikkam
    Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, Washington, United States of America
    PLoS ONE 7:e31901. 2012
    ..Exposure-specific epigenetic biomarkers were identified that may allow for the assessment of ancestral environmental exposures associated with adult onset disease...
  60. ncbi request reprint Epigenetic programming of the germ line: effects of endocrine disruptors on the development of transgenerational disease
    Matthew D Anway
    Centre for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
    Reprod Biomed Online 16:23-5. 2008
    ..The epigenetic mechanism involves the alteration of DNA methylation in the germ line that appears to transmit transgenerational adult onset disease, including spermatogenic defects, prostate disease, kidney disease and cancer...
  61. pmc Epigenetic transgenerational actions of environmental factors in disease etiology
    Michael K Skinner
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4236, USA
    Trends Endocrinol Metab 21:214-22. 2010
    ..This review provides an overview of the epigenetics and biology of how environmental factors can promote transgenerational phenotypes and disease...
  62. ncbi request reprint Role of basic helix-loop-helix (bHLH) and CREB transcription factors in the regulation of Sertoli cell androgen-binding protein expression
    Melissa A Saxlund
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Mol Reprod Dev 68:269-78. 2004
    ..Combined observations of the ABP promoter and artificial promoter provide insight into a common mechanism for gene regulation in differentiated Sertoli cells involving a role for both the bHLH and CREB family of transcription factors...
  63. pmc Gene bionetwork analysis of ovarian primordial follicle development
    Eric E Nilsson
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington, United States of America
    PLoS ONE 5:e11637. 2010
    ..This is one of the first applications of network analysis to a normal developmental process. These observations provide insights into potential therapeutic targets for preventing ovarian disease and promoting female reproduction...
  64. ncbi request reprint Effect of transient embryonic in vivo exposure to the endocrine disruptor methoxychlor on embryonic and postnatal testis development
    Andrea S Cupp
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
    J Androl 24:736-45. 2003
    ..Therefore, transient embryonic exposure to an endocrine disruptor (methoxychlor) during gestation can influence the germline and fertility in adult males...
  65. pmc Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature
    Michael K Skinner
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4236, USA
    Differentiation 80:1-8. 2010
    ..This phylogenetic and genomic analysis of the bHLH gene family has revealed unique elements of the evolution and functional relationships of the different genes in the bHLH gene family...
  66. ncbi request reprint Transforming growth factor-beta isoform expression during bovine ovarian antral follicle development
    Eric E Nilsson
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Mol Reprod Dev 66:237-46. 2003
    ..TGF-betas involved in antral follicular growth and development appear to act as paracrine/autocrine signaling molecules having a species-specific pattern of expression...
  67. ncbi request reprint Chemotactic role of neurotropin 3 in the embryonic testis that facilitates male sex determination
    Andrea S Cupp
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Biol Reprod 68:2033-7. 2003
    ....
  68. pmc Induction of ovarian primordial follicle assembly by connective tissue growth factor CTGF
    Ryan Schindler
    Center for Reproductive Biology, School Biological Sciences, Washington State University, Pullman, Washington, United States of America
    PLoS ONE 5:e12979. 2010
    ..These observations suggest the possibility of manipulating primordial follicle pool size and influencing female reproductive lifespan...
  69. ncbi request reprint Environmental epigenetic transgenerational inheritance and somatic epigenetic mitotic stability
    Michael K Skinner
    Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA, USA
    Epigenetics 6:838-42. 2011
    ....
  70. ncbi request reprint Identification of a novel Sertoli cell gene product SERT that influences follicle stimulating hormone actions
    Jaideep Chaudhary
    Center for Reproductive Biology School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
    Gene 324:79-88. 2004
    ..g. FSH) actions in Sertoli cells...
  71. pmc Environmental epigenomics and disease susceptibility
    Michael K Skinner
    Center for Reproductive Biology, School of Biological Sciences, Washington State University, USA
    EMBO Rep 12:620-2. 2011
    ..The meeting helped to define the developing field of 'environmental epigenetics' and the research presented established its role in disease aetiology and susceptibility...
  72. ncbi request reprint Cell-cell interactions in primordial follicle assembly and development
    Phillip Kezele
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman WA 99164 4231, USA
    Front Biosci 7:d1990-6. 2002
    ..The studies reviewed regarding the control of primordial follicle assembly and the primordial to primary follicle transition help elucidate these poorly understood aspects of ovarian biology...
  73. doi request reprint Role of epigenetics in developmental biology and transgenerational inheritance
    Michael K Skinner
    Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, 99164 4236, USA
    Birth Defects Res C Embryo Today 93:51-5. 2011
    ..This impacts area such as cellular differentiation, tissue development, environmental induced disease etiology, epigenetic transgenerational inheritance, and the general systems biology of organisms and evolution...
  74. doi request reprint Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation
    Jeffrey D Stevens
    Center for Reproductive Biology, School of Molecular Biosciences, Pullman, WA 99164 4231, USA
    Differentiation 76:1006-22. 2008
    ..This phylogenetic and genomic analysis of the bHLH gene family has revealed unique aspects of the evolution and functional relationships of the different genes in the bHLH gene family...
  75. ncbi request reprint An in vivo mouse reporter gene (human secreted alkaline phosphatase) model to monitor ovarian tumor growth and response to therapeutics
    Eric E Nilsson
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
    Cancer Chemother Pharmacol 49:93-100. 2002
    ..The SEAP protein is detectable in small blood samples so that animals can be repeatedly sampled over the trial period to monitor the course of tumor progression...
  76. ncbi request reprint Inhibition of platelet-derived growth factor actions in the embryonic testis influences normal cord development and morphology
    Mehmet Uzumcu
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Biol Reprod 66:745-53. 2002
    ..Inhibition of PDGF actions does not inhibit cord formation but does alter normal cord development and morphology. The observations provide insight into the factors involved in male sex differentiation and embryonic testis development...
  77. ncbi request reprint Identification of a novel gene product, Sertoli cell gene with a zinc finger domain, that is important for FSH activation of testicular Sertoli cells
    Jaideep Chaudhary
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Endocrinology 143:426-35. 2002
    ..Translation of SERZ may give rise to two gene products; however, the SERZ-beta containing the zinc finger domain is probably the principal product of the SERZ gene...
  78. ncbi request reprint Environmental epigenomics and disease susceptibility
    Randy L Jirtle
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Rev Genet 8:253-62. 2007
    ..Methods are now becoming available to investigate the relevance of these phenomena to human disease...
  79. pmc Transgenerational epigenetic imprints on mate preference
    David Crews
    Section of Integrative Biology, University of Texas, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 104:5942-6. 2007
    ..Our observations provide direct experimental evidence for a role of epigenetics as a determinant factor in evolution...
  80. ncbi request reprint Testis developmental phenotypes in neurotropin receptor trkA and trkC null mutations: role in formation of seminiferous cords and germ cell survival
    Andrea S Cupp
    Neural Development Group, Mouse Cancer Genetics Program, National Cancer Institute, Fredrick, Maryland 21701, USA
    Biol Reprod 66:1838-45. 2002
    ..The current study demonstrates that both trkA and trkC neurotropin receptors influence germ cell numbers during testis development and events such as seminiferous cord formation...
  81. ncbi request reprint Characterization of a rat in vitro ovarian culture system to study the ovarian toxicant 4-vinylcyclohexene diepoxide
    Patrick J Devine
    Department of Physiology, The University of Arizona, Tucson 85724, USA
    Toxicol Appl Pharmacol 184:107-15. 2002
    ..The similarities between VCD's effects in vitro and in vivo demonstrate the usefulness of this system for future mechanistic studies related to ovarian follicle loss induced by VCD or other ovotoxic chemicals...
  82. pmc Age-dependent loss of sperm production in mice via impaired lysophosphatidic acid signaling
    Xiaoqin Ye
    Department of Molecular Biology, The Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, La Jolla, California 92037, USA
    Biol Reprod 79:328-36. 2008
    ..Germ cell apoptosis led to a reduction in germ cell proliferation. These data demonstrate a novel in vivo function for LPA signaling as a germ cell survival factor during spermatogenesis...
  83. ncbi request reprint Developmentally distinct in vivo effects of FSH on proliferation and apoptosis during testis maturation
    Sarah J Meachem
    Prince Henry s Institute of Medical Research, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria, 3168, Australia
    J Endocrinol 186:429-46. 2005
    ..This model has enabled identification of candidate genes that contribute to the FSH-mediated pathway by which Sertoli cells support germ cells...