Matthew Silva

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Aged mice have enhanced endocortical response and normal periosteal response compared with young-adult mice following 1 week of axial tibial compression
    Michael D Brodt
    Department of Orthopaedic Surgery, Washington University, School of Medicine, St Louis, MO 63110, USA
    J Bone Miner Res 25:2006-15. 2010
  2. pmc Tibial loading increases osteogenic gene expression and cortical bone volume in mature and middle-aged mice
    Matthew J Silva
    Department of Orthopaedic Surgery, Washington University, St Louis, Missouri, United States of America
    PLoS ONE 7:e34980. 2012
  3. pmc Mechanical stimulation of bone formation is normal in the SAMP6 mouse
    Matthew J Silva
    Department of Orthopedic Surgery, Washington University School of Medicine, 1 Barnes Jewish Hospital Plaza, Suite 11300 WP, St Louis, MO 63110, USA
    Calcif Tissue Int 82:489-97. 2008
  4. ncbi request reprint Finite element analysis of the mouse tibia: estimating endocortical strain during three-point bending in SAMP6 osteoporotic mice
    Matthew J Silva
    Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Anat Rec A Discov Mol Cell Evol Biol 283:380-90. 2005
  5. pmc Type 1 diabetes in young rats leads to progressive trabecular bone loss, cessation of cortical bone growth, and diminished whole bone strength and fatigue life
    Matthew J Silva
    Department of Orthopaedic Surgery, Washington University, St Louis, Missouri 63110, USA
    J Bone Miner Res 24:1618-27. 2009
  6. ncbi request reprint Morphological and mechanical properties of caudal vertebrae in the SAMP6 mouse model of senile osteoporosis
    Matthew J Silva
    Orthopaedic Research Laboratories, Department of Orthopaedic Surgery, Barnes Jewish Hospital at Washington University, St Louis, MO 63110, USA
    Bone 35:425-31. 2004
  7. ncbi request reprint Decreased collagen organization and content are associated with reduced strength of demineralized and intact bone in the SAMP6 mouse
    Matthew J Silva
    Department of Orthopaedic Surgery, Barnes Jewish Hospital at Washington University, St Louis, Missouri 63110, USA
    J Bone Miner Res 21:78-88. 2006
  8. ncbi request reprint Bone formation after damaging in vivo fatigue loading results in recovery of whole-bone monotonic strength and increased fatigue life
    Matthew J Silva
    Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Washington University, St Louis, Missouri 63110, USA
    J Orthop Res 25:252-61. 2007
  9. ncbi request reprint Early healing of flexor tendon insertion site injuries: Tunnel repair is mechanically and histologically inferior to surface repair in a canine model
    Matthew J Silva
    Department of Orthopaedic Surgery, Washington University School of Medicine, 1 Barnes Jewish Hospital Plaza, Suite 11300 WP, St Louis, Missouri 63110, USA
    J Orthop Res 24:990-1000. 2006
  10. ncbi request reprint In vivo skeletal imaging of 18F-fluoride with positron emission tomography reveals damage- and time-dependent responses to fatigue loading in the rat ulna
    Matthew J Silva
    Department of Orthopaedic Surgery, Washington University School of Medicine, 1 Barnes Jewish Hospital Plaza, Suite 11300 WP, St Louis, MO 63110, USA
    Bone 39:229-36. 2006

Collaborators

Detail Information

Publications70

  1. pmc Aged mice have enhanced endocortical response and normal periosteal response compared with young-adult mice following 1 week of axial tibial compression
    Michael D Brodt
    Department of Orthopaedic Surgery, Washington University, School of Medicine, St Louis, MO 63110, USA
    J Bone Miner Res 25:2006-15. 2010
    ..We conclude that aging does not limit the short-term anabolic response of cortical bone to mechanical stimulation in our animal model...
  2. pmc Tibial loading increases osteogenic gene expression and cortical bone volume in mature and middle-aged mice
    Matthew J Silva
    Department of Orthopaedic Surgery, Washington University, St Louis, Missouri, United States of America
    PLoS ONE 7:e34980. 2012
    ..We conclude that mechanical loading of the tibia is anabolic for cortical bone in young and middle-aged female BALB/c mice...
  3. pmc Mechanical stimulation of bone formation is normal in the SAMP6 mouse
    Matthew J Silva
    Department of Orthopedic Surgery, Washington University School of Medicine, 1 Barnes Jewish Hospital Plaza, Suite 11300 WP, St Louis, MO 63110, USA
    Calcif Tissue Int 82:489-97. 2008
    ..This finding highlights a limitation of the SAMP6 mouse as a model of senile osteoporosis...
  4. ncbi request reprint Finite element analysis of the mouse tibia: estimating endocortical strain during three-point bending in SAMP6 osteoporotic mice
    Matthew J Silva
    Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Anat Rec A Discov Mol Cell Evol Biol 283:380-90. 2005
    ..In conclusion, FEA, with supporting strain gauge measurements, has provided unique insight regarding the strain environment throughout the tibia during three-point bending in mice...
  5. pmc Type 1 diabetes in young rats leads to progressive trabecular bone loss, cessation of cortical bone growth, and diminished whole bone strength and fatigue life
    Matthew J Silva
    Department of Orthopaedic Surgery, Washington University, St Louis, Missouri 63110, USA
    J Bone Miner Res 24:1618-27. 2009
    ..Diabetic bone has greatly increased nonenzymatic collagen cross-links but only modestly reduced material properties. The loss of whole bone strength under both monotonic and fatigue loading is attributed mainly to reduced bone size...
  6. ncbi request reprint Morphological and mechanical properties of caudal vertebrae in the SAMP6 mouse model of senile osteoporosis
    Matthew J Silva
    Orthopaedic Research Laboratories, Department of Orthopaedic Surgery, Barnes Jewish Hospital at Washington University, St Louis, MO 63110, USA
    Bone 35:425-31. 2004
    ....
  7. ncbi request reprint Decreased collagen organization and content are associated with reduced strength of demineralized and intact bone in the SAMP6 mouse
    Matthew J Silva
    Department of Orthopaedic Surgery, Barnes Jewish Hospital at Washington University, St Louis, Missouri 63110, USA
    J Bone Miner Res 21:78-88. 2006
    ..The matrix weakness is attributed primarily to poorer organization of collagen fibers and reduced collagen content...
  8. ncbi request reprint Bone formation after damaging in vivo fatigue loading results in recovery of whole-bone monotonic strength and increased fatigue life
    Matthew J Silva
    Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Washington University, St Louis, Missouri 63110, USA
    J Orthop Res 25:252-61. 2007
    ..002). We conclude that woven bone "repair" of a bone damaged by fatigue loading restores whole-bone strength and enhances resistance to further damage by repetitive loading...
  9. ncbi request reprint Early healing of flexor tendon insertion site injuries: Tunnel repair is mechanically and histologically inferior to surface repair in a canine model
    Matthew J Silva
    Department of Orthopaedic Surgery, Washington University School of Medicine, 1 Barnes Jewish Hospital Plaza, Suite 11300 WP, St Louis, Missouri 63110, USA
    J Orthop Res 24:990-1000. 2006
    ..If the results of our animal study extend to healing of the human FDP insertion, they indicate that FDP tendons should be reattached to the distal phalanx by suture to the cortical surface rather than suture in a bone tunnel...
  10. ncbi request reprint In vivo skeletal imaging of 18F-fluoride with positron emission tomography reveals damage- and time-dependent responses to fatigue loading in the rat ulna
    Matthew J Silva
    Department of Orthopaedic Surgery, Washington University School of Medicine, 1 Barnes Jewish Hospital Plaza, Suite 11300 WP, St Louis, MO 63110, USA
    Bone 39:229-36. 2006
    ....
  11. ncbi request reprint Impaired marrow osteogenesis is associated with reduced endocortical bone formation but does not impair periosteal bone formation in long bones of SAMP6 mice
    Matthew J Silva
    Department of Orthopaedic Surgery, Barnes Jewish Hospital at Washington University, St Louis, Missouri 63110, USA
    J Bone Miner Res 20:419-27. 2005
    ..This marrow/endocortical defect did not affect the periosteum, where SAMP6 mice had normal to enhanced bone formation...
  12. pmc Low-magnitude whole-body vibration does not enhance the anabolic skeletal effects of intermittent PTH in adult mice
    Michelle A Lynch
    Department of Orthopaedic Surgery, School of Medicine, Washington University, Saint Louis, Missouri 63110, USA
    J Orthop Res 29:465-72. 2011
    ..Daily exposure to low-magnitude WBV by itself did not improve skeletal properties and did not enhance the PTH effect. No WBV-PTH synergy was found in this preclinical study...
  13. ncbi request reprint Biomechanics of osteoporotic fractures
    Matthew J Silva
    Orthopedic Surgery and Biomedical Engineering, Washington University, Saint Louis, Missouri 63110, USA
    Injury 38:S69-76. 2007
    ..Within this article, I will review data on age-related changes in factors that affect fracture risk. Advanced engineering concepts will not be presented, but a familiarity with basic mechanical principles is assumed...
  14. ncbi request reprint A new selective estrogen receptor modulator, CHF 4227.01, preserves bone mass and microarchitecture in ovariectomized rats
    Reina Armamento-Villareal
    Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    J Bone Miner Res 20:2178-88. 2005
    ..01, given to 6-month-old female rats immediately after ovariectomy, preserved bone mass and bone microarchitecture without affecting uterus weight. It also decreased serum cholesterol and fat mass in estrogen-deficient rats...
  15. pmc Damaging fatigue loading stimulates increases in periosteal vascularity at sites of bone formation in the rat ulna
    Hironori Matsuzaki
    Orthopedic Research Laboratory, Department of Orthopedic Surgery, Washington University, 1 Barnes Jewish Hospital Plaza, Suite 11300 WP, St Louis, MO 63110, USA
    Calcif Tissue Int 80:391-9. 2007
    ..The angiogenic-osteogenic response is spatially coordinated and scaled to the level of the mechanical stimulus...
  16. ncbi request reprint Bone loss following tendon laceration, repair and passive mobilization
    Konstantinos Ditsios
    Department of Orthopaedic Surgery, Barnes Jewish Hospital at Washington University, Suite 11300 WP, 1 Barnes Jewish Plaza, Saint Louis, MO 63110, USA
    J Orthop Res 21:990-6. 2003
    ..This bone loss may impact healing by impeding the restoration of a strong tendon-bone interface...
  17. ncbi request reprint Recent progress in flexor tendon healing
    Matthew J Silva
    Department of Orthopaedic Surgery, Barnes Jewish Hospital at Washington University School of Medicine, One Barnes Jewish Hospital Plaza, Suite 11300 West Pavilion, St Louis, MO 63110, USA
    J Orthop Sci 7:508-14. 2002
    ..Future advances will probably require manipulation of the biological factors that promote healing...
  18. doi request reprint Effect of suture material and bone quality on the mechanical properties of zone I flexor tendon-bone reattachment with bone anchors
    Hironori Matsuzaki
    Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, MO, USA
    J Hand Surg Am 33:709-17. 2008
    ..To compare the initial biomechanical properties of zone I flexor tendon to bone repairs performed using pull-out and anchor techniques and to investigate the effect of bone quality and suture materials on the strength of anchor repairs...
  19. ncbi request reprint Two-portal repair of canine flexor tendon insertion site injuries: histologic and immunohistochemical characterization of healing during the early postoperative period
    Martin I Boyer
    Department of Orthopaedic Surgery, Barnes Jewish Hospital at Washington University School of Medicine, St Louis, MO 63130, USA
    J Hand Surg Am 28:469-74. 2003
    ..The hypothesis was that the tendon-bone interface matures and assumes a progressively more anatomic histologic and immunohistochemical appearance during the first 6 weeks after repair...
  20. pmc Technical and biological modifications for enhanced flexor tendon repair
    H Mike Kim
    Department of Orthopaedic Surgery, Washington University, St Louis, MO 63110, USA
    J Hand Surg Am 35:1031-7; quiz 1038. 2010
    ..In this review, we describe recent efforts to enhance the integrity of the immature repair site. We focus on 2 major areas of advancement: surgical technique modifications and manipulation of the biologic and biochemical environment...
  21. pmc Stress fracture healing: fatigue loading of the rat ulna induces upregulation in expression of osteogenic and angiogenic genes that mimic the intramembranous portion of fracture repair
    Gregory R Wohl
    Department of Orthopaedic Surgery, Washington University, St Louis, Missouri, USA
    Bone 44:320-30. 2009
    ....
  22. ncbi request reprint Role of connexin43 in osteoblast response to physical load
    Susan K Grimston
    Division of Bone and Mineral Diseases, Washington University in St Louis, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Ann N Y Acad Sci 1068:214-24. 2006
    ..Taken together, these results indicate that deficiency of Cx43 in osteoblasts attenuates but does not abolish anabolic responses to mechanical strain...
  23. pmc Age-related changes in bone structure and strength in female and male BALB/c mice
    Mark D Willinghamm
    Department of Orthopedic Surgery, Washington University School of Medicine, 1 Barnes Jewish Hospital Plaza, St Louis, MO 63110, USA
    Calcif Tissue Int 86:470-83. 2010
    ..We conclude that bones from aging female and male BALB/c mice exhibit many of the changes seen in humans and are therefore a clinically relevant model for studies of skeletal aging...
  24. pmc Healing of non-displaced fractures produced by fatigue loading of the mouse ulna
    Mario D Martinez
    Department of Orthopaedic Surgery, Washington University, St Louis, Missouri, USA
    Bone 46:1604-12. 2010
    ..In the future, the fatigue loading approach can be used create non-displaced bone fractures in transgenic and knockout mice to study the mechanisms by which the skeleton rapidly repairs damage...
  25. pmc Constrained tibial vibration does not produce an anabolic bone response in adult mice
    Blaine A Christiansen
    Department of Orthopaedic Surgery, Washington University in St Louis, St Louis, MO, USA
    Bone 45:750-9. 2009
    ..We conclude that direct vibrational loading of bone in anesthetized, adult mice is not anabolic...
  26. ncbi request reprint SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts
    Sunao Takeshita
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Med 8:943-9. 2002
    ..Thus, SHIP negatively regulates osteoclast formation and function and the absence of this enzyme results in severe osteoporosis...
  27. pmc Skeletal effects of whole-body vibration in adult and aged mice
    Michelle A Lynch
    Department of Orthopaedic Surgery, Washington University, St Louis, Missouri 63110, USA
    J Orthop Res 28:241-7. 2010
    ..05). In summary, 5 weeks of daily exposure to low-amplitude WBV had no skeletal effects in aged male mice. The potential of WBV to enhance bone mass in age-related osteoporosis is not supported in this preclinical study...
  28. ncbi request reprint Flexor digitorum profundus tendon to bone tunnel repair: a vascularization and histologic study in canines
    Thomas T Dovan
    Department of Orthopaedic Surgery, Barnes Jewish Hospital at Washington University, St Louis, MO, USA
    J Hand Surg Am 30:246-57. 2005
    ..The purpose of this study was to analyze the histologic and vascular anatomic properties of the FDP insertion site after transection and repair in a bone tunnel within the distal phalanx...
  29. pmc bFGF and PDGF-BB for tendon repair: controlled release and biologic activity by tendon fibroblasts in vitro
    Stavros Thomopoulos
    Department of Orthopaedic Surgery, Washington University, 660 South Euclid, Campus Box 8233, St Louis, MO 63110, USA
    Ann Biomed Eng 38:225-34. 2010
    ..Both growth factors may be effective in enhancing tendon healing in vivo...
  30. pmc Microfibril-associated glycoprotein-1, an extracellular matrix regulator of bone remodeling
    Clarissa S Craft
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Biol Chem 285:23858-67. 2010
    ..Together, our findings suggest that MAGP1 is a regulator of bone remodeling, and its absence results in osteopenia associated with an increase in osteoclast number...
  31. ncbi request reprint Nanoindentation and whole-bone bending estimates of material properties in bones from the senescence accelerated mouse SAMP6
    Matthew J Silva
    Orthopaedic Research Laboratories, Department of Orthopaedic Surgery, Barnes Jewish Hospital at Washington University, 1 Barnes Jewish Plaza, Suite 11300 WP, Saint Louis, MO 63110, USA
    J Biomech 37:1639-46. 2004
    ....
  32. pmc The effects of exogenous basic fibroblast growth factor on intrasynovial flexor tendon healing in a canine model
    Stavros Thomopoulos
    Department of Orthopaedic Surgery, Washington University, 660 South Euclid, Campus Box 8233, St Louis, MO 63110
    J Bone Joint Surg Am 92:2285-93. 2010
    ..The application of growth factors holds promise for improving the tendon-repair response and obviating failure in the initial three weeks...
  33. ncbi request reprint Bone loss after temporarily induced muscle paralysis by Botox is not fully recovered after 12 weeks
    Susan K Grimston
    Division of Bone and Mineral Diseases, Washington University in Saint Louis, St Louis, MO 63110, USA
    Ann N Y Acad Sci 1116:444-60. 2007
    ..These results underscore the significance of normal muscle function in the maintenance of bone mass...
  34. pmc Attenuated response to in vivo mechanical loading in mice with conditional osteoblast ablation of the connexin43 gene (Gja1)
    Susan K Grimston
    Division of Bone and Mineral Disease, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Bone Miner Res 23:879-86. 2008
    ..We tested this hypothesis in vivo in a model of genetic deficiency of the Cx43 gene (Gja1)...
  35. pmc In vivo static creep loading of the rat forelimb reduces ulnar structural properties at time-zero and induces damage-dependent woven bone formation
    Jennifer A Lynch
    Department of Orthopedics, Washington University, St Louis, Missouri 63110, USA
    Bone 42:942-9. 2008
    ..We conclude that bone damage created without dynamic strain triggers a woven bone response, and thus infer that the woven bone response reported after fatigue loading and in stress fractures is in large part a response to bone damage...
  36. pmc Age-related changes in bone morphology are accelerated in group VIA phospholipase A2 (iPLA2beta)-null mice
    Sasanka Ramanadham
    Washington University School of Medicine, Department of Internal Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Am J Pathol 172:868-81. 2008
    ....
  37. pmc The effect of muscle loading on flexor tendon-to-bone healing in a canine model
    Stavros Thomopoulos
    Department of Orthopedic Surgery, Washington University, One Barnes Jewish Hospital Plaza, Suite 11300, Campus Box 8233, St Louis, Missouri 63110, USA
    J Orthop Res 26:1611-7. 2008
    ..Complete removal of load by proximal transection resulted in tendon-to-bone repairs with less range of motion and lower biomechanical properties compared to repairs in which the muscle-tendon-bone unit was left intact...
  38. pmc Comparing histological, vascular and molecular responses associated with woven and lamellar bone formation induced by mechanical loading in the rat ulna
    Jennifer A McKenzie
    Department of Orthopedics, Washington University, St Louis, MO 63110, USA
    Bone 48:250-8. 2011
    ....
  39. pmc Use of a magnesium-based bone adhesive for flexor tendon-to-bone healing
    Stavros Thomopoulos
    Department of Orthopaedic Surgery, Washington University, St Louis, MO 63110, USA
    J Hand Surg Am 34:1066-73. 2009
    ..Therefore, we hypothesized that magnesium-based bone adhesive (MBA) will improve the tendon-to-bone biomechanical properties initially and in the early period after repair...
  40. ncbi request reprint Long bones from the senescence accelerated mouse SAMP6 have increased size but reduced whole-bone strength and resistance to fracture
    Matthew J Silva
    Department of Orthopaedic Surgery, Barnes Jewish Hospital at Washington University, St Louis, Missouri 63110, USA
    J Bone Miner Res 17:1597-603. 2002
    ..These findings extend the previous descriptions of the SAMP6 mouse and identify key mechanical features that further validate its relevance as a unique and functionally relevant model of senile osteoporosis...
  41. pmc Enhanced flexor tendon healing through controlled delivery of PDGF-BB
    Stavros Thomopoulos
    Department of Orthopaedic Surgery, Washington University, St Louis, Missouri, USA
    J Orthop Res 27:1209-15. 2009
    ..In conclusion, PDGF-BB treatment consistently improved the functional but not the structural properties of sutured intrasynovial tendons through 42 days following repair...
  42. ncbi request reprint The rigidity of repaired flexor tendons increases following ex vivo cyclic loading
    Konstantinos T Ditsios
    Department of Orthopaedic Surgery, Washington University, Suite 11300, 1 Barnes Jewish Plaza, St Louis, MO 63100, USA
    J Biomech 35:853-6. 2002
    ....
  43. ncbi request reprint A method for delivering variable impact stresses to the articular cartilage of rabbit knees
    Joseph Borrelli
    Department of Orthopaedic Surgery, School of Medicine, Washington University, St Louis, Missouri 63110, USA
    J Orthop Trauma 16:182-8. 2002
    ..To develop a method by which a single impact force of controlled magnitude and rate could be applied uniformly to an area on the posterior aspect of the medial femoral condyle of adult rabbits...
  44. ncbi request reprint Tendon injury response: assessment of biomechanical properties, tissue morphology and viability following flexor digitorum profundus tendon transection
    Matthew J Silva
    Orthopaedic Research Laboratories, Department of Orthopaedic Surgery, Barnes Jewish Hospital at Washington University, 1 Barnes Jewish Plaza, Suite 1100 WP, St Louis, MO 63110, USA
    J Orthop Res 22:990-7. 2004
    ..This leads to increased tendon size and enhanced resistance to suture pullout. These findings offer a scientific rationale supporting the clinical practice of surgical re-attachment within the first 3 weeks after injury...
  45. ncbi request reprint What's new in orthopaedic research
    Matthew J Silva
    Department of Orthopaedic Surgery, Washington University School of Medicine at Barnes Jewish Hospital, St Louis, MO 63110, USA
    J Bone Joint Surg Am 84:1490-6. 2002
  46. ncbi request reprint Zone I flexor digitorum profundus repair: an ex vivo biomechanical analysis of tendon to bone repair in cadavera
    Thomas T Dovan
    Department of Orthopaedic Surgery, Barnes Jewish Hospital at Washington University, St Louis, MO, USA
    J Hand Surg Am 30:258-66. 2005
    ..The purpose of this study was to evaluate the ex vivo biomechanical properties of 2 new repair techniques in comparison with the standard FDP tendon to distal phalanx cortical surface repair...
  47. ncbi request reprint Effect of several growth factors on canine flexor tendon fibroblast proliferation and collagen synthesis in vitro
    Stavros Thomopoulos
    Department of Orthopaedic Research, Washington University, St Louis, MO, USA
    J Hand Surg Am 30:441-7. 2005
    ..Our second hypothesis was that there would be a positive effect from the combination of PDGF-BB and bFGF...
  48. ncbi request reprint Use of the rat forelimb compression model to create discrete levels of bone damage in vivo
    Brian A Uthgenannt
    Department of Orthopaedic Surgery, Barnes Jewish Hospital at Washington University, 1 Barnes Jewish Hospital Place, Ste 11300 WP, St Louis, MO 63110, USA
    J Biomech 40:317-24. 2007
    ..This loading model will be useful for examining biological responses to a range of sub-fracture damage levels in future experiments...
  49. ncbi request reprint Lack of OH in nanocrystalline apatite as a function of degree of atomic order: implications for bone and biomaterials
    Jill Dill Pasteris
    Department of Earth and Planetary Sciences, Washington University, Campus Box 1169, St Louis, MO 63130 4899, USA
    Biomaterials 25:229-38. 2004
    ....
  50. ncbi request reprint The insertion site of the canine flexor digitorum profundus tendon heals slowly following injury and suture repair
    Matthew J Silva
    Department of Orthopaedic Surgery, Barnes Jewish Hospital, Washington University, St Louis, MO 63110, USA
    J Orthop Res 20:447-53. 2002
    ..While these findings may be limited to the particular repair method we used, they demonstrate a need for devising new treatment strategies to improve healing of flexor tendon insertion site injuries...
  51. ncbi request reprint The effect of varying magnitudes of whole-body vibration on several skeletal sites in mice
    Blaine A Christiansen
    Department of Orthopaedic Surgery, University in St Louis, 1 Barnes Jewish Hospital Plaza Campus Box 8233, St Louis, MO 63110, USA
    Ann Biomed Eng 34:1149-56. 2006
    ..05). The 0.1 g and 1.0 g groups also had higher BV/TV than the 0.3 g loaded group. If this non-dose-dependent phenomenon is verified by future studies, it suggests that a range of magnitudes should be examined for each application of WBV...
  52. ncbi request reprint PDGF-BB released in tendon repair using a novel delivery system promotes cell proliferation and collagen remodeling
    Stavros Thomopoulos
    Department of Orthopaedics, Washington University, St Louis, Missouri 63110, USA
    J Orthop Res 25:1358-68. 2007
    ..Sustained delivery of growth factors may be achieved using a novel fibrin-based delivery system. PDGF-BB delivery increased cell proliferation and matrix remodeling and thus may accelerate flexor tendon healing...
  53. ncbi request reprint The early effects of sustained platelet-derived growth factor administration on the functional and structural properties of repaired intrasynovial flexor tendons: an in vivo biomechanic study at 3 weeks in canines
    Richard H Gelberman
    Department of Orthopaedic Surgery, Barnes Jewish Hospital at Washington University, St Louis, MO 63110, USA
    J Hand Surg Am 32:373-9. 2007
    ..We hypothesized that PDGF-BB administered in this manner would improve the sutured tendon's functional and structural properties 3 weeks after repair...
  54. ncbi request reprint Alendronate prevents bone loss and improves tendon-to-bone repair strength in a canine model
    Stavros Thomopoulos
    Department of Orthopaedic Surgery, Washington University, 1 Barnes Jewish Hospital Plaza, Suite 11300, Campus Box 8233, St Louis, Missouri 63110, USA
    J Orthop Res 25:473-9. 2007
    ..These initial short-term data demonstrate the potential for a clinical treatment that could enhance tendon-to-bone healing...
  55. ncbi request reprint Characteristics of the rat supraspinatus tendon during tendon-to-bone healing after acute injury
    Leesa M Galatz
    Department of Orthopaedic Research, Washington University School of Medicine, Barnes Jewish Hospital, 660 S Euclid Avenue, Campus Box 8233, St Louis, Missouri 63110, USA
    J Orthop Res 24:541-50. 2006
    ..Repair sites remained unorganized histologically and biomechanically inferior in comparison to previously described uninjured insertion sites...
  56. ncbi request reprint Medial collateral ligament healing in macrophage metalloelastase (MMP-12)-deficient mice
    Rick W Wright
    Department of Orthopaedic Surgery, Washington University School of Medicine at Barnes Jewish Hospital, St Louis, Missouri, USA
    J Orthop Res 24:2106-13. 2006
    ..05 by Tukey post hoc test). We conclude MME is important in the multifactorial cascade of knee MCL injury healing, showing significant differences in both the early inflammatory and in the matrix tissue synthesis phases...
  57. pmc Short-term low-strain vibration enhances chemo-transport yet does not stimulate osteogenic gene expression or cortical bone formation in adult mice
    Akhilesh A Kotiya
    Department of Orthopaedic Surgery, Washington University in St Louis, St Louis, MO, USA
    Bone 48:468-75. 2011
    ..We conclude that short-term, low-strain vibration results in increased chemo-transport, yet does not stimulate an increase in mechano-responsive or osteogenic gene expression, and cortical bone formation in tibias of adult mice...
  58. ncbi request reprint Repair of flexor digitorum profundus tendon avulsions from bone: an ex vivo biomechanical analysis
    Martin I Boyer
    Department of Orthopaedic Surgery, Barnes Jewish Hospital at Washington University, One Barnes Jewish Hospital, Suite 11300 West Pavilion, St Louis, MO 63110, USA
    J Hand Surg Am 27:594-8. 2002
    ..Neither suture caliber nor repair technique had a notable effect on strain at 20-N force, suggesting that early gap formation at the tendon-bone repair site may occur regardless of technique...
  59. ncbi request reprint Smoking and mouse MCL healing
    Rick Wright
    Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, Missouri 63131, USA
    J Knee Surg 23:193-9. 2010
    ..However, our findings did not support a dose-dependent effect of cigarette exposure on the tensile mechanical properties of ligaments...
  60. ncbi request reprint Neovascularization of the flexor digitorum profundus tendon after avulsion injury: an in vivo canine study
    Konstantinos Ditsios
    Department of Orthopaedic Surgery, Barnes Jewish Hospital at Washington University School of Medicine, St Louis, MO 63110, USA
    J Hand Surg Am 28:231-6. 2003
    ..Our objective was to determine both the time course and the source of neovascularization of the tendon stump in an in vivo canine model of flexor digitorum profundus (FDP) avulsion after a clinically relevant delay in diagnosis...
  61. ncbi request reprint Effect of hemorrhage on medial collateral ligament healing in a mouse model
    Rick W Wright
    Department of Orthopaedic Surgery, Washington University School of Medicine at Barnes Jewish Hospital, St Louis, Missouri 63110, USA
    Am J Sports Med 31:660-6. 2003
    ..Medial collateral ligament injuries heal by a scar response...
  62. ncbi request reprint Mechanical properties of bioabsorbable meniscal arrows as a function of tear location: an ex vivo experimental study
    Mihir M Jani
    Washington University, Department of Orthopaedic Surgery, St Louis, Missouri 63110, USA
    Am J Sports Med 32:666-74. 2004
    ..Ex vivo studies have established that arrow fixation of meniscal tears is inferior to vertical sutures and is dependent on arrow length, although the influence of tear location is not known...
  63. ncbi request reprint Marrow stromal cells and osteoclast precursors differentially contribute to TNF-alpha-induced osteoclastogenesis in vivo
    Hideki Kitaura
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 173:4838-46. 2004
    ....
  64. pmc Constrained tibial vibration in mice: a method for studying the effects of vibrational loading of bone
    Blaine A Christiansen
    Department of Orthopaedic Surgery, and Department of Biomedical Engineering, Washington University in St Louis, Campus Box 8233, St Louis, MO 63110, USA
    J Biomech Eng 130:044502. 2008
    ..This model will be used in future in vivo studies and will potentially become an important tool for understanding the response of bone to vibrational loading...
  65. pmc Genetic relationships between obesity and osteoporosis in LGXSM recombinant inbred mice
    Michael S Reich
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Genet Res (Camb) 90:433-44. 2008
    ..Our results support the use of the LG/J-by-SM/J mouse intercross populations as models for normal, complex genetic variation in obesity, bone properties and their interrelationship...
  66. doi request reprint Single high-energy impact load causes posttraumatic OA in young rabbits via a decrease in cellular metabolism
    Joseph Borrelli
    Department of Orthopaedic Surgery, Washington University School of Medicine, Barnes Jewish Hospital, St Louis, Missouri, USA
    J Orthop Res 27:347-52. 2009
    ..These findings confirm that a single high-energy impact load can cause the development of PTA by disrupting the extracellular matrix and by causing a decrease in chondrocyte metabolism...
  67. pmc Skeletal self-repair: stress fracture healing by rapid formation and densification of woven bone
    Brian A Uthgenannt
    Department of Orthopaedic Surgery, Washington University, St Louis, Missouri 63110, USA
    J Bone Miner Res 22:1548-56. 2007
    ..Periosteal woven bone formed in proportion to the level of bone damage, resulting in the rapid recovery of whole bone strength independent of stress fracture severity...
  68. ncbi request reprint Vascular anatomy of the human flexor digitorum profundus tendon insertion
    Fraser J Leversedge
    Department of Orthopaedic Surgery, Barnes Jewish Hospital, Washington University School of Medicine, St Louis, MO 63110, USA
    J Hand Surg Am 27:806-12. 2002
    ....
  69. ncbi request reprint In vivo fatigue loading of the rat ulna induces both bone formation and resorption and leads to time-related changes in bone mechanical properties and density
    Yeou Fang Hsieh
    Department of Experimental Surgery, Istituti Ortopedici Rizzoli, Bologna, Italy
    J Orthop Res 20:764-71. 2002
    ..In summary, our findings demonstrate the remarkable ability of the adult skeleton to rapidly form periosteal woven bone and thereby offset the negative structural effects of acute fatigue damage and subsequent intracortical resorption...
  70. ncbi request reprint Biomechanical evaluation of 2 techniques for ulnar collateral ligament reconstruction of the elbow
    George A Paletta
    Center for the Athlete s Shoulder and Elbow at the Orthopaedic Center of St Louis, Chesterfield, Missouri, USA
    Am J Sports Med 34:1599-603. 2006
    ..Testing of this construct has not demonstrated that the biomechanical parameters of the native ligament are restored. A more recent construct, the docking technique, may more reliably reproduce these factors...

Research Grants14

  1. RESPONSE OF THE OSTEOPOROTIC SKELETON TO IN VIVO LOADING
    Matthew Silva; Fiscal Year: 2001
    ..abstract_text> ..
  2. RESPONSE OF THE OSTEOPOROTIC SKELETON TO IN VIVO LOADING
    Matthew Silva; Fiscal Year: 2009
    ....
  3. OSTEOGENIC AND ANGIOGENIC RESPONSE TO SKELETAL LOADING
    Matthew Silva; Fiscal Year: 2009
    ..The goal of this project is to understand the biological pathways that control bone formation following mechanical stimulation. This information may lead to future strategies to increase bone mass and reduce skeletal fragility. ..
  4. RESPONSE OF THE OSTEOPOROTIC SKELETON TO IN VIVO LOADING
    Matthew Silva; Fiscal Year: 2007
    ....
  5. RESPONSE OF THE OSTEOPOROTIC SKELETON TO IN VIVO LOADING
    Matthew Silva; Fiscal Year: 2006
    ....
  6. OSTEOGENIC AND ANGIOGENIC RESPONSE TO SKELETAL LOADING
    Matthew Silva; Fiscal Year: 2006
    ....
  7. OSTEOGENIC AND ANGIOGENIC RESPONSE TO SKELETAL LOADING
    Matthew Silva; Fiscal Year: 2005
    ....
  8. OSTEOGENIC AND ANGIOGENIC RESPONSE TO SKELETAL LOADING
    Matthew Silva; Fiscal Year: 2004
    ....
  9. RESPONSE OF THE OSTEOPOROTIC SKELETON TO IN VIVO LOADING
    Matthew Silva; Fiscal Year: 2004
    ..abstract_text> ..
  10. OSTEOGENIC AND ANGIOGENIC RESPONSE TO SKELETAL LOADING
    Matthew Silva; Fiscal Year: 2003
    ....
  11. RESPONSE OF THE OSTEOPOROTIC SKELETON TO IN VIVO LOADING
    Matthew Silva; Fiscal Year: 2003
    ..abstract_text> ..
  12. RESPONSE OF THE OSTEOPOROTIC SKELETON TO IN VIVO LOADING
    Matthew Silva; Fiscal Year: 2002
    ..abstract_text> ..
  13. OSTEOGENIC AND ANGIOGENIC RESPONSE TO SKELETAL LOADING
    Matthew J Silva; Fiscal Year: 2010
    ..The goal of this project is to understand the biological pathways that control bone formation following mechanical stimulation. This information may lead to future strategies to increase bone mass and reduce skeletal fragility. ..