Yvette Sheline

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi Greater loss of 5-HT(2A) receptors in midlife than in late life
    Yvette I Sheline
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Am J Psychiatry 159:430-5. 2002
  2. ncbi Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus
    Yvette I Sheline
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:11020-5. 2010
  3. ncbi Support for the vascular depression hypothesis in late-life depression: results of a 2-site, prospective, antidepressant treatment trial
    Yvette I Sheline
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, Box 8134, St Louis, MO 63110, USA
    Arch Gen Psychiatry 67:277-85. 2010
  4. ncbi Amyloid plaques disrupt resting state default mode network connectivity in cognitively normal elderly
    Yvette I Sheline
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    Biol Psychiatry 67:584-7. 2010
  5. ncbi The default mode network and self-referential processes in depression
    Yvette I Sheline
    Department of Psychiatry, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 106:1942-7. 2009
  6. ncbi Regional white matter hyperintensity burden in automated segmentation distinguishes late-life depressed subjects from comparison subjects matched for vascular risk factors
    Yvette I Sheline
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Psychiatry 165:524-32. 2008
  7. ncbi APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Aβ42
    Yvette I Sheline
    Department of Psychiatry, The Knight Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 30:17035-40. 2010
  8. ncbi Cognitive function in late life depression: relationships to depression severity, cerebrovascular risk factors and processing speed
    Yvette I Sheline
    Department of Psychiatry, Washington University, St Louis, Missouri, USA
    Biol Psychiatry 60:58-65. 2006
  9. ncbi Untreated depression and hippocampal volume loss
    Yvette I Sheline
    Department of Psychiatry, Mallinckrodt Institute of Tadiology, Washington Univeristsy School of Medicine, St Louis, MO 63110, USA
    Am J Psychiatry 160:1516-8. 2003
  10. ncbi Decreased hippocampal 5-HT(2A) receptor binding in older depressed patients using [18F]altanserin positron emission tomography
    Yvette I Sheline
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuropsychopharmacology 29:2235-41. 2004

Research Grants

  1. Neuroimaging in Depression Treatment Studies
    Yvette Sheline; Fiscal Year: 2006
  2. fMRI STUDIES OF EMOTIONAL CIRCUITRY IN DEPRESSION
    Yvette Sheline; Fiscal Year: 2006
  3. Neuroimaging in Depression Treatment Studies
    Yvette Sheline; Fiscal Year: 2007
  4. PET Amyloid Plaque Imaging in Late Life Depression
    Yvette Sheline; Fiscal Year: 2007
  5. Vascular Depression: Longitudinal Followup
    Yvette Sheline; Fiscal Year: 2007
  6. Vascular Depression: Longitudinal Followup
    Yvette Sheline; Fiscal Year: 2009
  7. fMRI STUDIES OF EMOTIONAL CIRCUITRY IN DEPRESSION
    Yvette Sheline; Fiscal Year: 2009
  8. fMRI STUDIES OF EMOTIONAL CIRCUITRY IN DEPRESSION
    Yvette I Sheline; Fiscal Year: 2010
  9. Treatment Outcome of Vascular Depression
    Yvette Sheline; Fiscal Year: 2005
  10. Vascular Depression: Longitudinal Followup
    Yvette I Sheline; Fiscal Year: 2010

Detail Information

Publications27

  1. ncbi Greater loss of 5-HT(2A) receptors in midlife than in late life
    Yvette I Sheline
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Am J Psychiatry 159:430-5. 2002
    ..In this study the authors used positron emission tomography (PET) and [(18)F]altanserin, a ligand with high affinity for the 5-HT(2A) receptor, to examine the relationship between 5-HT(2A) receptor density and age in more detail...
  2. ncbi Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus
    Yvette I Sheline
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:11020-5. 2010
    ....
  3. ncbi Support for the vascular depression hypothesis in late-life depression: results of a 2-site, prospective, antidepressant treatment trial
    Yvette I Sheline
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, Box 8134, St Louis, MO 63110, USA
    Arch Gen Psychiatry 67:277-85. 2010
    ..Research on vascular depression has used 2 approaches to subtype late-life depression, based on executive dysfunction or white matter hyperintensity severity...
  4. ncbi Amyloid plaques disrupt resting state default mode network connectivity in cognitively normal elderly
    Yvette I Sheline
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    Biol Psychiatry 67:584-7. 2010
    ....
  5. ncbi The default mode network and self-referential processes in depression
    Yvette I Sheline
    Department of Psychiatry, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 106:1942-7. 2009
    ..These findings provide a brain network framework within which to consider the pathophysiology of depression...
  6. ncbi Regional white matter hyperintensity burden in automated segmentation distinguishes late-life depressed subjects from comparison subjects matched for vascular risk factors
    Yvette I Sheline
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Psychiatry 165:524-32. 2008
    ..Correlations between neuropsychological performance and whole brain-segmented white matter hyperintensities and white and gray matter volumes were also examined...
  7. ncbi APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Aβ42
    Yvette I Sheline
    Department of Psychiatry, The Knight Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 30:17035-40. 2010
    ....
  8. ncbi Cognitive function in late life depression: relationships to depression severity, cerebrovascular risk factors and processing speed
    Yvette I Sheline
    Department of Psychiatry, Washington University, St Louis, Missouri, USA
    Biol Psychiatry 60:58-65. 2006
    ....
  9. ncbi Untreated depression and hippocampal volume loss
    Yvette I Sheline
    Department of Psychiatry, Mallinckrodt Institute of Tadiology, Washington Univeristsy School of Medicine, St Louis, MO 63110, USA
    Am J Psychiatry 160:1516-8. 2003
    ..The purpose of this study was to investigate the effect of antidepressant treatment on hippocampal volumes in patients with major depression...
  10. ncbi Decreased hippocampal 5-HT(2A) receptor binding in older depressed patients using [18F]altanserin positron emission tomography
    Yvette I Sheline
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuropsychopharmacology 29:2235-41. 2004
    ..04) than previously treated subjects (n = 10). It may be that prior medication treatment provides a compensatory upregulation of the 5-HT(2A) receptor...
  11. ncbi Decreased hippocampal 5-HT2A receptor binding in major depressive disorder: in vivo measurement with [18F]altanserin positron emission tomography
    Mark A Mintun
    Department of Radiology, Mallinckrodt Institute of Radiology, Box 8225, Washington University School of Medicine, 510 South Kingshighway Boulevard, St Louis, MO 63110, USA
    Biol Psychiatry 55:217-24. 2004
    ..Postmortem and positron emission tomography studies have reported both increased and decreased 5-HT(2A) receptor binding in different limbic and paralimbic regions...
  12. ncbi Altered emotional interference processing in affective and cognitive-control brain circuitry in major depression
    Christina L Fales
    Department of Psychology, Washington University in St Louis, St Louis, Missouri 63110, USA
    Biol Psychiatry 63:377-84. 2008
    ....
  13. ncbi Antidepressant treatment normalizes hypoactivity in dorsolateral prefrontal cortex during emotional interference processing in major depression
    Christina L Fales
    Department of Psychology, Washington University in St Louis, St Louis, Missouri 63110, United States
    J Affect Disord 112:206-11. 2009
    ..The purpose of this study was to examine the effects of antidepressant treatment on anomalous neural activity in cognitive-control and emotion-processing circuitry...
  14. ncbi Cerebral blood flow changes during vagus nerve stimulation for depression
    Charles R Conway
    Department of Psychiatry, Saint Louis University School of Medicine, 1221 South Grand Boulevard, St Louis, MO 63104, USA
    Psychiatry Res 146:179-84. 2006
    ..Decreases were found in the bilateral temporal cortex and right parietal area. Regions of change were consistent with brain structures associated with depression and the afferent pathways of the vagus nerve...
  15. ncbi Psychiatric comorbidity, health, and function in epilepsy
    Frank Gilliam
    Department of Neurology, Washington University, St Louis, MO, USA
    Epilepsy Behav 4:S26-30. 2003
    ..Further research is needed to increase understanding of the mechanisms of psychiatric illness in epilepsy, the effects of depression and anxiety on long-term clinical outcomes, and the most effective treatments...
  16. ncbi Late life depression with cognitive impairment: evaluation and treatment
    Consuelo H Wilkins
    Department of Medicine Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, MO 63108, USA
    Clin Interv Aging 4:51-7. 2009
    ..Both antidepressants and psychotherapy can be effective in treating LLD. Subsequent evaluations following treatment should also reassess cognition...
  17. ncbi Vitamin D deficiency is associated with worse cognitive performance and lower bone density in older African Americans
    Consuelo H Wilkins
    Department of Medicine, Division of Geriatrics and Nutritional Science, Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, Missouri 63108, USA
    J Natl Med Assoc 101:349-54. 2009
    ..The detrimental effects of vitamin D deficiency on the bone are widely known; however, recent data suggest that vitamin D deficiency may contribute to other disorders, including low mood, cognitive impairment, and impaired mobility...
  18. ncbi Cerebral perfusion response to successful treatment of depression with different serotoninergic agents
    Andrei Vlassenko
    Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA
    J Neuropsychiatry Clin Neurosci 16:360-3. 2004
    ..Amesergide differs from SSRIs in that it is also a highly selective 5-HT antagonist, which may in part account for differences in cerebral blood flow response to treatment...
  19. ncbi Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory
    Randy L Buckner
    Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63105, USA
    J Neurosci 25:7709-17. 2005
    ..These cortical regions may be part of a network with the medial temporal lobe whose disruption contributes to memory impairment...
  20. ncbi Vitamin D deficiency is associated with low mood and worse cognitive performance in older adults
    Consuelo H Wilkins
    Department of Medicine, Division of Geriatrics and Nutritional Science, Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, MO 63108, USA
    Am J Geriatr Psychiatry 14:1032-40. 2006
    ..This study examined the relationship among vitamin D status, cognitive performance, mood, and physical performance in older adults...
  21. ncbi Antidepressant efficacy of olanzapine as monotherapy in major depressive disorder, without psychosis: a pilot study
    Jose Mathews
    Department of Psychiatry, Washington University School of Medicine, Box 8134, 660 S. Euclid, St. Louis, MO 63110, USA
    Psychiatry Res 146:149-55. 2006
    ..Half the patients (n=6) showed > or =50% reduction in their HAMD17 scores. This study points to the potential of olanzapine as a therapeutic agent for the treatment of major depressive disorder without psychosis...
  22. ncbi Diffuse microstructural abnormalities of normal-appearing white matter in late life depression: a diffusion tensor imaging study
    Joshua S Shimony
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    Biol Psychiatry 66:245-52. 2009
    ..However, no study of LLD to date has examined the integrity of white matter outside of WMH (i.e., in normal-appearing white matter)...
  23. ncbi Neuroimaging studies of mood disorder effects on the brain
    Yvette I Sheline
    Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    Biol Psychiatry 54:338-52. 2003
    ..Mechanisms proposed to explain volume loss in depression include glucocorticoid neurotoxicity, decreased brain-derived growth factor, decreased neurogenesis, and loss of plasticity...
  24. ncbi Working memory and prefrontal cortex dysfunction: specificity to schizophrenia compared with major depression
    Deanna M Barch
    Department of Psychology, Washington University, St. Louis, Missouri, USA
    Biol Psychiatry 53:376-84. 2003
    ....
  25. ncbi Mechanisms of depression in epilepsy from a clinical perspective
    Hrvoje Hecimovic
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Epilepsy Behav 4:S25-30. 2003
    ....
  26. ncbi Evaluation of 5-ethynyl-2'-deoxyuridine staining as a sensitive and reliable method for studying cell proliferation in the adult nervous system
    Chenbo Zeng
    Department of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63110, USA
    Brain Res 1319:21-32. 2010
    ..for tracking the two populations of neurons generated at different time points. In conclusion, our results suggest that EdU staining is a fast, sensitive and reproducible method to study cell proliferation in the central nervous system...
  27. ncbi Childhood adversity predicts earlier onset of major depression but not reduced hippocampal volume
    Shannon N Lenze
    Department of Psychology, University of Pittsburgh, 3rd Floor Sennott Square, Pittsburgh, PA 15260, USA
    Psychiatry Res 162:39-49. 2008
    ..Further research is needed to more fully understand the interrelationships among childhood adversity, hippocampal morphology, neuroendocrine regulation, and other genetic and environmental factors influencing vulnerability to depression...

Research Grants24

  1. Neuroimaging in Depression Treatment Studies
    Yvette Sheline; Fiscal Year: 2006
    ..abstract_text> ..
  2. fMRI STUDIES OF EMOTIONAL CIRCUITRY IN DEPRESSION
    Yvette Sheline; Fiscal Year: 2006
    ..The proposed study has the potential to substantially advance our understanding of the precise nature and mechanisms underlying cognitive-emotional dysregulation in major depression. ..
  3. Neuroimaging in Depression Treatment Studies
    Yvette Sheline; Fiscal Year: 2007
    ..K24 support will provide the applicant with protected time to continue to carry out depression studies in late life depression and to increase the mentoring of beginning clinical investigators in neuroimaging studies in depression. ..
  4. PET Amyloid Plaque Imaging in Late Life Depression
    Yvette Sheline; Fiscal Year: 2007
    ..Successful completion of this study will allow effect size and power calculations critical in designing a definitive study to determine whether LLD is associated with increased numbers of PIB+ patients. ..
  5. Vascular Depression: Longitudinal Followup
    Yvette Sheline; Fiscal Year: 2007
    ..The proposal will provide important new data on neuroradiologic and neuropsychological factors contributing to recurrent or chronic depression in older individuals. ..
  6. Vascular Depression: Longitudinal Followup
    Yvette Sheline; Fiscal Year: 2009
    ..The proposal will provide important new data on neuroradiologic and neuropsychological factors contributing to recurrent or chronic depression in older individuals. ..
  7. fMRI STUDIES OF EMOTIONAL CIRCUITRY IN DEPRESSION
    Yvette Sheline; Fiscal Year: 2009
    ..Brain activity will be compared before and after treatment for these tasks in both CBT and antidepressant medication. This will add to our understanding of treatment mechanisms for major depression. ..
  8. fMRI STUDIES OF EMOTIONAL CIRCUITRY IN DEPRESSION
    Yvette I Sheline; Fiscal Year: 2010
    ..Brain activity will be compared before and after treatment for these tasks in both CBT and antidepressant medication. This will add to our understanding of treatment mechanisms for major depression. ..
  9. Treatment Outcome of Vascular Depression
    Yvette Sheline; Fiscal Year: 2005
    ..The proposed trial will provide information of value to the practitioner and also provide data to build a more comprehensive model of the prognostic impact of frontal-subcortical brain changes on the outcome of late-life depression. ..
  10. Vascular Depression: Longitudinal Followup
    Yvette I Sheline; Fiscal Year: 2010
    ..The proposal will provide important new data on neuroradiologic and neuropsychological factors contributing to recurrent or chronic depression in older individuals. ..