Research Topics
Genomes and GenesSpecies | Paul J ShawSummaryAffiliation: Washington University School of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
Stress response genes protect against lethal effects of sleep deprivation in DrosophilaPaul J Shaw
The Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, California 92121, USA
Nature 417:287-91. 2002..These data represent the first step in identifying the molecular mechanisms that constitute the sleep homeostat...- Perchance to dream: solving the mystery of sleep through genetic analysisPaul J Shaw
The Neurosciences Institute, 10640 John J Hopkins Dr, San Diego, California 92121, USA
J Neurobiol 54:179-202. 2003..In this article we will review recent studies that have used genetic techniques to evaluate sleep in the fruit fly and the mouse... 
Neurological disorders: towards a mechanistic understanding of restless legs syndromePaul J Shaw
Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Ave Campus Box 8108, St Louis, MO 63110, USA
Curr Biol 22:R485-6. 2012..A new study has found that Drosophila mutants in the fly homologue of a human gene, BTBD9, that has been implicated as a risk factor for restless legs display important features of the syndrome...
Drosophila aging 2006/2007Paul Shaw
Department of Anatomy and Neurobiology, Washington University, School of Medicine, St Louis, MO 63110, USA
Exp Gerontol 43:5-10. 2008..An important emerging theme is determining the age-dependent alterations that occur at the organ level and how this functional senescence is regulated by different tissues...- Notch signaling modulates sleep homeostasis and learning after sleep deprivation in DrosophilaLaurent Seugnet
Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8108, St Louis, MO 63110, USA
Curr Biol 21:835-40. 2011..These data highlight the emerging role of neuron-glia interactions in regulating both sleep and learning impairments associated with sleep loss... - Identifying sleep regulatory genes using a Drosophila model of insomniaLaurent Seugnet
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Neurosci 29:7148-57. 2009..Together, these data indicate that the ins-l flies are a useful tool that can be used to identify molecules important for sleep regulation and may provide insights into both the causes and long-term consequences of insomnia... - Inducing sleep by remote control facilitates memory consolidation in DrosophilaJeffrey M Donlea
Department of Anatomy and Neurobiology, Washington University in St Louis, St Louis, MO 63110, USA
Science 332:1571-6. 2011..Activating the dorsal FB in the absence of sleep did not result in the formation of LTM after massed training... - Changes in gene expression with sleepMatthew S Thimgan
Department of Anatomy and Neurobiology, Washington University in St Louis, St Louis, MO 63110, USA
J Clin Sleep Med 7:S26-7. 2011..Thus, we have exploited genetic and pharmacological tools in the model organism Drosophila melanogaster to more fully characterize the behavior of the most exciting candidate biomarkers... - Persistent short-term memory defects following sleep deprivation in a drosophila model of Parkinson diseaseLaurent Seugnet
Washington University School of Medicine, St Louis, MO 63110, USA
Sleep 32:984-92. 2009..Thus we investigated the long-term consequences of sleep deprivation on shortterm memory using a Drosophila model of Parkinson disease... - Use-dependent plasticity in clock neurons regulates sleep need in DrosophilaJeffrey M Donlea
Department of Anatomy and Neurobiology, Washington University in St Louis, 660 South Euclid Avenue, St Louis, Missouri, USA
Science 324:105-8. 2009..The number of synaptic terminals was reduced during sleep and this decline was prevented by sleep deprivation... - Sleep deprivation during early-adult development results in long-lasting learning deficits in adult DrosophilaLaurent Seugnet
Washington University School of Medicine, Anatomy and Neurobiology, 660 S Euclid Avenue, St Louis, MO 63110, USA
Sleep 34:137-46. 2011.... - D1 receptor activation in the mushroom bodies rescues sleep-loss-induced learning impairments in DrosophilaLaurent Seugnet
Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Curr Biol 18:1110-7. 2008..However, the underlying molecular mechanisms triggered by extended waking and restored by sleep are unknown. Moreover, the neuronal circuits that depend on sleep for optimal learning remain unidentified... - Sleeping together using social interactions to understand the role of sleep in plasticityJeffrey M Donlea
Department of Anatomy and Neurobiology, Washington University School of Medicine, Campus Box 8108, St Louis, Missouri, USA
Adv Genet 68:57-81. 2009..2006). In this review, we discuss the plastic mechanisms that are induced in response to social experience and how social enrichment can provide insight into the biological functions of sleep... - Foraging alters resilience/vulnerability to sleep disruption and starvation in DrosophilaJEFFREY DONLEA
Department of Anatomy and Neurobiology, Washington University in St Louis, MO 63104, USA
Proc Natl Acad Sci U S A 109:2613-8. 2012..Understanding how these tradeoffs confer resilience or vulnerability to specific environmental challenges may provide additional clues as to why an evolutionary alternative to sleep has not emerged... - Identification of a biomarker for sleep drive in flies and humansLaurent Seugnet
Anatomy and Neurobiology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8108, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 103:19913-8. 2006..These data indicate that the fly is relevant for human sleep research and represents a first step in developing an effective method for detecting sleepiness in vulnerable populations... - Waking experience affects sleep need in DrosophilaIndrani Ganguly-Fitzgerald
Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92101, USA
Science 313:1775-81. 2006..Furthermore, this experience-dependent plasticity in sleep need is subserved by the dopaminergic and adenosine 3',5'-monophosphate signaling pathways and a particular subset of 17 long-term memory genes...
Research Grants
- SELECTING BIOMARKERS FOR THE MOLECULAR DIAGNOSIS OF SLEEPINESSPaul Shaw; Fiscal Year: 2007..Developing tools for the molecular diagnosis of sleepiness will assist with the identification and treatment of sleepiness in the general population and in critical patient populations. ..
- Functional Analysis of Sleep Homeostasis in DrosophilaPaul Shaw; Fiscal Year: 2009....
- Functional Analysis of Sleep Homeostasis in DrosophilaPaul J Shaw; Fiscal Year: 2010..Identifying pathways that are degraded during waking and restored during sleep may enhance our ability to understand neuronal processes during both health and disease. ..