Paul J Shaw

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Stress response genes protect against lethal effects of sleep deprivation in Drosophila
    Paul J Shaw
    The Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, California 92121, USA
    Nature 417:287-91. 2002
  2. ncbi request reprint Perchance to dream: solving the mystery of sleep through genetic analysis
    Paul J Shaw
    The Neurosciences Institute, 10640 John J Hopkins Dr, San Diego, California 92121, USA
    J Neurobiol 54:179-202. 2003
  3. pmc Neurological disorders: towards a mechanistic understanding of restless legs syndrome
    Paul J Shaw
    Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Ave Campus Box 8108, St Louis, MO 63110, USA
    Curr Biol 22:R485-6. 2012
  4. pmc Drosophila aging 2006/2007
    Paul Shaw
    Department of Anatomy and Neurobiology, Washington University, School of Medicine, St Louis, MO 63110, USA
    Exp Gerontol 43:5-10. 2008
  5. pmc Notch signaling modulates sleep homeostasis and learning after sleep deprivation in Drosophila
    Laurent Seugnet
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8108, St Louis, MO 63110, USA
    Curr Biol 21:835-40. 2011
  6. pmc Identifying sleep regulatory genes using a Drosophila model of insomnia
    Laurent Seugnet
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 29:7148-57. 2009
  7. pmc Sleep deprivation during early-adult development results in long-lasting learning deficits in adult Drosophila
    Laurent Seugnet
    Washington University School of Medicine, Anatomy and Neurobiology, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Sleep 34:137-46. 2011
  8. doi request reprint Inducing sleep by remote control facilitates memory consolidation in Drosophila
    Jeffrey M Donlea
    Department of Anatomy and Neurobiology, Washington University in St Louis, St Louis, MO 63110, USA
    Science 332:1571-6. 2011
  9. pmc Persistent short-term memory defects following sleep deprivation in a drosophila model of Parkinson disease
    Laurent Seugnet
    Washington University School of Medicine, St Louis, MO 63110, USA
    Sleep 32:984-92. 2009
  10. pmc Changes in gene expression with sleep
    Matthew S Thimgan
    Department of Anatomy and Neurobiology, Washington University in St Louis, St Louis, MO 63110, USA
    J Clin Sleep Med 7:S26-7. 2011

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Stress response genes protect against lethal effects of sleep deprivation in Drosophila
    Paul J Shaw
    The Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, California 92121, USA
    Nature 417:287-91. 2002
    ..These data represent the first step in identifying the molecular mechanisms that constitute the sleep homeostat...
  2. ncbi request reprint Perchance to dream: solving the mystery of sleep through genetic analysis
    Paul J Shaw
    The Neurosciences Institute, 10640 John J Hopkins Dr, San Diego, California 92121, USA
    J Neurobiol 54:179-202. 2003
    ..In this article we will review recent studies that have used genetic techniques to evaluate sleep in the fruit fly and the mouse...
  3. pmc Neurological disorders: towards a mechanistic understanding of restless legs syndrome
    Paul J Shaw
    Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Ave Campus Box 8108, St Louis, MO 63110, USA
    Curr Biol 22:R485-6. 2012
    ..A new study has found that Drosophila mutants in the fly homologue of a human gene, BTBD9, that has been implicated as a risk factor for restless legs display important features of the syndrome...
  4. pmc Drosophila aging 2006/2007
    Paul Shaw
    Department of Anatomy and Neurobiology, Washington University, School of Medicine, St Louis, MO 63110, USA
    Exp Gerontol 43:5-10. 2008
    ..An important emerging theme is determining the age-dependent alterations that occur at the organ level and how this functional senescence is regulated by different tissues...
  5. pmc Notch signaling modulates sleep homeostasis and learning after sleep deprivation in Drosophila
    Laurent Seugnet
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8108, St Louis, MO 63110, USA
    Curr Biol 21:835-40. 2011
    ..These data highlight the emerging role of neuron-glia interactions in regulating both sleep and learning impairments associated with sleep loss...
  6. pmc Identifying sleep regulatory genes using a Drosophila model of insomnia
    Laurent Seugnet
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 29:7148-57. 2009
    ..Together, these data indicate that the ins-l flies are a useful tool that can be used to identify molecules important for sleep regulation and may provide insights into both the causes and long-term consequences of insomnia...
  7. pmc Sleep deprivation during early-adult development results in long-lasting learning deficits in adult Drosophila
    Laurent Seugnet
    Washington University School of Medicine, Anatomy and Neurobiology, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Sleep 34:137-46. 2011
    ....
  8. doi request reprint Inducing sleep by remote control facilitates memory consolidation in Drosophila
    Jeffrey M Donlea
    Department of Anatomy and Neurobiology, Washington University in St Louis, St Louis, MO 63110, USA
    Science 332:1571-6. 2011
    ..Activating the dorsal FB in the absence of sleep did not result in the formation of LTM after massed training...
  9. pmc Persistent short-term memory defects following sleep deprivation in a drosophila model of Parkinson disease
    Laurent Seugnet
    Washington University School of Medicine, St Louis, MO 63110, USA
    Sleep 32:984-92. 2009
    ..Thus we investigated the long-term consequences of sleep deprivation on shortterm memory using a Drosophila model of Parkinson disease...
  10. pmc Changes in gene expression with sleep
    Matthew S Thimgan
    Department of Anatomy and Neurobiology, Washington University in St Louis, St Louis, MO 63110, USA
    J Clin Sleep Med 7:S26-7. 2011
    ..Thus, we have exploited genetic and pharmacological tools in the model organism Drosophila melanogaster to more fully characterize the behavior of the most exciting candidate biomarkers...
  11. pmc Use-dependent plasticity in clock neurons regulates sleep need in Drosophila
    Jeffrey M Donlea
    Department of Anatomy and Neurobiology, Washington University in St Louis, 660 South Euclid Avenue, St Louis, Missouri, USA
    Science 324:105-8. 2009
    ..The number of synaptic terminals was reduced during sleep and this decline was prevented by sleep deprivation...
  12. pmc D1 receptor activation in the mushroom bodies rescues sleep-loss-induced learning impairments in Drosophila
    Laurent Seugnet
    Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Curr Biol 18:1110-7. 2008
    ..However, the underlying molecular mechanisms triggered by extended waking and restored by sleep are unknown. Moreover, the neuronal circuits that depend on sleep for optimal learning remain unidentified...
  13. pmc Sleeping together using social interactions to understand the role of sleep in plasticity
    Jeffrey M Donlea
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Campus Box 8108, St Louis, Missouri, USA
    Adv Genet 68:57-81. 2009
    ..2006). In this review, we discuss the plastic mechanisms that are induced in response to social experience and how social enrichment can provide insight into the biological functions of sleep...
  14. pmc Foraging alters resilience/vulnerability to sleep disruption and starvation in Drosophila
    JEFFREY DONLEA
    Department of Anatomy and Neurobiology, Washington University in St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 109:2613-8. 2012
    ..Understanding how these tradeoffs confer resilience or vulnerability to specific environmental challenges may provide additional clues as to why an evolutionary alternative to sleep has not emerged...
  15. pmc Cross-translational studies in human and Drosophila identify markers of sleep loss
    Matthew S Thimgan
    Department of Anatomy and Physiology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 8:e61016. 2013
    ..These cross-translational data indicate that fly and human discovery experiments are mutually reinforcing and can be used interchangeably to identify candidate biomarkers of sleep loss...
  16. pmc Identification of a biomarker for sleep drive in flies and humans
    Laurent Seugnet
    Anatomy and Neurobiology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8108, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 103:19913-8. 2006
    ..These data indicate that the fly is relevant for human sleep research and represents a first step in developing an effective method for detecting sleepiness in vulnerable populations...
  17. ncbi request reprint Waking experience affects sleep need in Drosophila
    Indrani Ganguly-Fitzgerald
    Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92101, USA
    Science 313:1775-81. 2006
    ..Furthermore, this experience-dependent plasticity in sleep need is subserved by the dopaminergic and adenosine 3',5'-monophosphate signaling pathways and a particular subset of 17 long-term memory genes...

Research Grants9

  1. SELECTING BIOMARKERS FOR THE MOLECULAR DIAGNOSIS OF SLEEPINESS
    Paul Shaw; Fiscal Year: 2007
    ..Developing tools for the molecular diagnosis of sleepiness will assist with the identification and treatment of sleepiness in the general population and in critical patient populations. ..
  2. Functional Analysis of Sleep Homeostasis in Drosophila
    Paul Shaw; Fiscal Year: 2009
    ....
  3. Functional Analysis of Sleep Homeostasis in Drosophila
    Paul J Shaw; Fiscal Year: 2010
    ..Identifying pathways that are degraded during waking and restored during sleep may enhance our ability to understand neuronal processes during both health and disease. ..