William Shannon

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Analyzing microarray data using cluster analysis
    William Shannon
    Department of Medicine, Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8005, St Louis, MO 63110, USA
    Pharmacogenomics 4:41-52. 2003
  2. ncbi request reprint Mantel statistics to correlate gene expression levels from microarrays with clinical covariates
    William D Shannon
    Department of Medicine, Washington University in St Louis School of Medicine, St Louis, Missouri 63110, USA
    Genet Epidemiol 23:87-96. 2002
  3. pmc Effect of zoledronic acid on disseminated tumour cells in women with locally advanced breast cancer: an open label, randomised, phase 2 trial
    Rebecca Aft
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Lancet Oncol 11:421-8. 2010
  4. pmc A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes
    Timothy J Ley
    Department of Medicine, Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 100:14275-80. 2003
  5. pmc Alveolar bone measurement precision for phosphor-plate images
    Charles F Hildebolt
    Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108:e96-107. 2009
  6. pmc Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia
    Daniel C Link
    Division of Oncology, Department of Medicine, Washington University, St Louis, MO 63110, USA
    Blood 110:1648-55. 2007
  7. pmc DNMT3A mutations in acute myeloid leukemia
    Timothy J Ley
    Department of Genetics, Genome Center, Washington University, St Louis, MO 63110, USA
    N Engl J Med 363:2424-33. 2010
  8. pmc Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia
    Michael H Tomasson
    Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Blood 111:4797-808. 2008
  9. pmc A high-resolution map of segmental DNA copy number variation in the mouse genome
    Timothy A Graubert
    Department of Medicine, Division of Oncology, Stem Cell Biology Section, Washington University, St Louis, Missouri, United States of America
    PLoS Genet 3:e3. 2007
  10. ncbi request reprint Sepsis gene expression profiling: murine splenic compared with hepatic responses determined by using complementary DNA microarrays
    J Perren Cobb
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Crit Care Med 30:2711-21. 2002

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Analyzing microarray data using cluster analysis
    William Shannon
    Department of Medicine, Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8005, St Louis, MO 63110, USA
    Pharmacogenomics 4:41-52. 2003
    ..The goal is to use the data itself to identify meaningful or informative subgroups. Specifically, we will focus on demonstrating the use of distance-based methods of hierarchical clustering to analyze gene expression data...
  2. ncbi request reprint Mantel statistics to correlate gene expression levels from microarrays with clinical covariates
    William D Shannon
    Department of Medicine, Washington University in St Louis School of Medicine, St Louis, Missouri 63110, USA
    Genet Epidemiol 23:87-96. 2002
    ..We also show how the Mantel statistics can be used to rank subsets of genes, found using standard clustering methods, in terms of differential expression across samples...
  3. pmc Effect of zoledronic acid on disseminated tumour cells in women with locally advanced breast cancer: an open label, randomised, phase 2 trial
    Rebecca Aft
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Lancet Oncol 11:421-8. 2010
    ..The aim of our study was to assess the effect of zoledronic acid on clearance of disseminated tumour cells (DTCs) from the bone marrow in women undergoing neoadjuvant chemotherapy for breast cancer...
  4. pmc A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes
    Timothy J Ley
    Department of Medicine, Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 100:14275-80. 2003
    ..This strategy represents a viable approach for the detection of potentially relevant, nonrandom mutations in primary human cancer cell genomes...
  5. pmc Alveolar bone measurement precision for phosphor-plate images
    Charles F Hildebolt
    Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108:e96-107. 2009
    ..The aim was to demonstrate methods for determining measurement precision and to determine the precision of alveolar bone measurements made with a vacuum-coupled positioning device and phosphor plate images...
  6. pmc Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia
    Daniel C Link
    Division of Oncology, Department of Medicine, Washington University, St Louis, MO 63110, USA
    Blood 110:1648-55. 2007
    ..These data support the hypothesis that mutations of CSF3R may provide the "activated tyrosine kinase signal" that is thought to be important for leukemogenesis...
  7. pmc DNMT3A mutations in acute myeloid leukemia
    Timothy J Ley
    Department of Genetics, Genome Center, Washington University, St Louis, MO 63110, USA
    N Engl J Med 363:2424-33. 2010
    ..The genetic alterations responsible for an adverse outcome in most patients with acute myeloid leukemia (AML) are unknown...
  8. pmc Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia
    Michael H Tomasson
    Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Blood 111:4797-808. 2008
    ..Additional studies will be required to define the roles that these somatic and germline TK gene variants play in AML pathogenesis...
  9. pmc A high-resolution map of segmental DNA copy number variation in the mouse genome
    Timothy A Graubert
    Department of Medicine, Division of Oncology, Stem Cell Biology Section, Washington University, St Louis, Missouri, United States of America
    PLoS Genet 3:e3. 2007
    ..Annotation of CNVs in the mouse genome combined with sequence-based analysis provides an important resource that will help define the genetic basis of complex traits...
  10. ncbi request reprint Sepsis gene expression profiling: murine splenic compared with hepatic responses determined by using complementary DNA microarrays
    J Perren Cobb
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Crit Care Med 30:2711-21. 2002
    ..quot;..
  11. ncbi request reprint Detecting epistatic interactions contributing to quantitative traits
    Robert Culverhouse
    Department of Medicine, Washington University in St Louis School of Medicine, St Louis, Missouri 63110, USA
    Genet Epidemiol 27:141-52. 2004
    ..Although the examples in this article involve 2-locus interactions, the RPM is computationally feasible for the analysis of more than two loci or factors...
  12. ncbi request reprint DNA microarray analysis of gene expression in human optic nerve head astrocytes in response to hydrostatic pressure
    Ping Yang
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Physiol Genomics 17:157-69. 2004
    ..These HP-responsive genes may be important in the establishment and maintenance of the ONH astrocyte phenotype under conditions of elevated IOP in glaucoma...
  13. pmc Acquired copy number alterations in adult acute myeloid leukemia genomes
    Matthew J Walter
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 106:12950-5. 2009
    ....
  14. pmc In vivo administration of hypomethylating agents mitigate graft-versus-host disease without sacrificing graft-versus-leukemia
    Jaebok Choi
    Division of Oncology, Department of Medicine, Washington University, St Louis, MO 63110, USA
    Blood 116:129-39. 2010
    ....
  15. pmc Expression profiling of murine acute promyelocytic leukemia cells reveals multiple model-dependent progression signatures
    Matthew J Walter
    Division of Oncology, Section of Stem Cell Biology, Campus Box 8007, 660 South Euclid Ave, St Louis, MO 63110 1093, USA
    Mol Cell Biol 24:10882-93. 2004
    ..The two models exhibited distinct gene expression profiles, suggesting that the dominant molecular signatures of murine acute promyelocytic leukemia can be influenced by several independent progression events...
  16. ncbi request reprint Limb dominance as a potential etiologic factor in noncontact anterior cruciate ligament tears
    Matthew J Matava
    Sports Medicine Section, Department of Orthopedic Surgery, Washington University School of Medicine, St Louis, MO, USA
    J Knee Surg 15:11-6. 2002
    ..65). Limited numbers precluded an analysis of specific limb-dominant sports activities as potential risk factors. The results of this pilot study suggest limb dominance is not a significant etiologic factor for noncontact ACL tears...
  17. pmc Identification of somatic JAK1 mutations in patients with acute myeloid leukemia
    Zhifu Xiang
    Department of Medicine, Washington University School of Medicine, St Louis, St Louis, MO 63110, USA
    Blood 111:4809-12. 2008
    ..This is the first report to demonstrate somatic JAK1 mutations in AML and suggests that JAK1 mutations may function as disease-modifying mutations in AML pathogenesis...
  18. pmc Recurring mutations found by sequencing an acute myeloid leukemia genome
    Elaine R Mardis
    Department of Genetics, Washington University, St Louis, MO 63110, USA
    N Engl J Med 361:1058-66. 2009
    ..The full complement of DNA mutations that are responsible for the pathogenesis of acute myeloid leukemia (AML) is not yet known...
  19. ncbi request reprint Variance in the expression of 5-Fluorouracil pathway genes in colorectal cancer
    Elizabeth A Kidd
    Department of Medicine, Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Cancer Res 11:2612-9. 2005
    ..These variations in gene expression could provide valuable insights for optimizing treatment selection for patients with colorectal cancer...
  20. ncbi request reprint A mouse model for developing treatment for secondary liver tumors
    Shi Rong Cai
    Departmen of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Oncol 27:113-20. 2005
    ....