Research Topics
| ROBERT DAVID SCHREIBERSummaryAffiliation: Washington University School of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
Stat1-dependent and -independent pathways in IFN-gamma-dependent signalingChilakamarti V Ramana
Lerner Research Institute, The Cleveland Clinic Foundation, OH 44195, USA
Trends Immunol 23:96-101. 2002..The diversity of gene-expression patterns mediated by Stat1-dependent and -independent mechanisms and the balance between these two pathways play an important role in the biological response to IFN-gamma...- Cytokine signaling in 2002: new surprises in the Jak/Stat pathwayJOHN J O'SHEA
Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20852, USA
Cell 109:S121-31. 2002..This review focuses on recent advances in the field and highlights some of the most active areas of Jak-Stat pathway research... 
STAT1 deficiency unexpectedly and markedly exacerbates the pathophysiological actions of IFN-alpha in the central nervous systemJianping Wang
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 99:16209-14. 2002..Finally, STAT1 or a downstream component of the JAKSTAT pathway may protect against such IFN-alpha-mediated injury in the CNS...- Blocking monoclonal antibodies specific for mouse IFN-alpha/beta receptor subunit 1 (IFNAR-1) from mice immunized by in vivo hydrodynamic transfectionKathleen C F Sheehan
Department of Pathology and Immunology, Center for Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
J Interferon Cytokine Res 26:804-19. 2006..These mAbs represent much needed tools to more clearly elucidate the biochemistry, cell biology, and physiologic function of the type I IFNs and their receptor in mediating host-protective immunity and immunopathology... 
Cancer immunoediting: integrating immunity's roles in cancer suppression and promotionRobert D Schreiber
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
Science 331:1565-70. 2011..Here, we discuss a unifying conceptual framework called "cancer immunoediting," which integrates the immune system's dual host-protective and tumor-promoting roles...- STAT1-deficient mice spontaneously develop estrogen receptor α-positive luminal mammary carcinomasSzeman Ruby Chan
Department of Pathology and Immunology, Washington University School of Medicine, 425 S, Euclid Avenue, St, Louis, MO 63110, USA
Breast Cancer Res 14:R16. 2012..Herein, we show that a subset of human breast cancers display reduced STAT1 expression and that mice lacking STAT1 surprisingly develop ERα+/PR+ mammary tumors... - Stat3 recruitment by two distinct ligand-induced, tyrosine-phosphorylated docking sites in the interleukin-10 receptor intracellular domainR M Weber-Nordt
Center for Immunology, Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 271:27954-61. 1996.... - Interferon-gamma and cancer immunoeditingGavin P Dunn
Department of Pathology and Immunology, Center for Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
Immunol Res 32:231-45. 2005..Our current work focuses on defining the molecular mechanisms that underlie cancer immunoediting and exploring the implications of this process for cancer immunotherapy... 
The IkappaB function of NF-kappaB2 p100 controls stimulated osteoclastogenesisDeborah Veis Novack
Washington University School of Medicine, 660 S Euclid Ave, Box 8301, St Louis, MO 63110, USA
J Exp Med 198:771-81. 2003..These data demonstrate a novel, biologically relevant means of regulating NF-kappaB signaling, with upstream control and kinetics distinct from the classical IkappaBalpha pathway...- The roles of IFN gamma in protection against tumor development and cancer immunoeditingHiroaki Ikeda
Department of Pathology and Immunology, Center for Immunology, School of Medicine, Washington University, 660 South Euclid Avenue, St Louis, MO 63110, USA
Cytokine Growth Factor Rev 13:95-109. 2002.... - DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytesAndrea L Bredemeyer
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Nature 456:819-23. 2008.... - Cancer immunoediting: from immunosurveillance to tumor escapeGavin P Dunn
Department of Pathology and Immunology, Center for Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA
Nat Immunol 3:991-8. 2002..In this review, we will summarize the historical and experimental basis of cancer immunoediting and discuss its dual roles in promoting host protection against cancer and facilitating tumor escape from immune destruction... - Cancer immunosurveillance, immunoediting and inflammation: independent or interdependent processes?Jack D Bui
Department of Pathology, University of California at San Diego, 9500 Gilman Drive MC 0612, La Jolla, CA 92093 0612, USA
Curr Opin Immunol 19:203-8. 2007..These apparent disparate effects of immunity on tumorigenesis provide a unique model for study of the decision-making process that dictates immune function within a tumor... - Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulationAmanda L Blasius
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
J Immunol 177:3260-5. 2006..Finally, we show that BST2 resides within an intracellular compartment corresponding to the Golgi apparatus, and may be involved in trafficking secreted cytokines in IPC... - The lymphotoxin LTalpha(1)beta(2) controls postnatal and adult spleen marginal sinus vascular structure and functionCarlene L Zindl
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
Immunity 30:408-20. 2009.... - The immunobiology of cancer immunosurveillance and immunoeditingGavin P Dunn
Department of Pathology and Immunology, Center for Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8118, St. Louis, Missouri 63110, USA
Immunity 21:137-48. 2004..The full understanding of the immunobiology of cancer immunosurveillance and immunoediting will hopefully stimulate development of more effective immunotherapeutic approaches to control and/or eliminate human cancers... - A critical function for type I interferons in cancer immunoeditingGavin P Dunn
Department of Pathology and Immunology, Center for Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Nat Immunol 6:722-9. 2005..Therefore, type I interferons are important components of the cancer immunoediting process and function in a way that does not completely overlap the functions of IFN-gamma... - Interferons, immunity and cancer immunoeditingGavin P Dunn
Washington University School of Medicine, Department of Pathology and Immunology, Box 8118, 660 South Euclid Avenue, St. Louis, Missouri 63110, USA
Nat Rev Immunol 6:836-48. 2006..More recently, type I IFNs have been found to have distinct functions in this process. In this Review, we discuss the roles of the IFNs, not only in cancer immunosurveillance but also in the broader process of cancer immunoediting... - A critical role for type I IFN in arthritis development following Borrelia burgdorferi infection of miceJennifer C Miller
Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA
J Immunol 181:8492-503. 2008..burgdorferi uses a previously unidentified receptor and a pathway traditionally associated with viruses and intracellular bacteria to initiate transcription of type I IFN and IFN-responsive genes and to initiate arthritis development... - Adaptive immunity maintains occult cancer in an equilibrium stateCatherine M Koebel
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Nature 450:903-7. 2007..These results reveal that, in addition to destroying tumour cells and sculpting tumour immunogenicity, the immune system of a naive mouse can also restrain cancer growth for extended time periods... - ABIN-3: a molecular basis for species divergence in interleukin-10-induced anti-inflammatory actionsBrian K Weaver
Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
Mol Cell Biol 27:4603-16. 2007..ABIN-3 is, thus, an IL-10-induced gene product capable of attenuating NF-kappaB in human macrophages yet is inoperative in mice and represents a basis for species-specific differences in IL-10 actions... - IFN-dependent down-regulation of the NKG2D ligand H60 on tumorsJack D Bui
Center for Immunology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63310, USA
J Immunol 176:905-13. 2006..This process most likely helps to specify the type of immune effector cell populations that participate in host-protective antitumor responses... - The three Es of cancer immunoeditingGavin P Dunn
Department of Pathology and Immunology, Center for Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
Annu Rev Immunol 22:329-60. 2004..quot; In this review, we summarize the history of the cancer immunosurveillance controversy and discuss its resolution and evolution into the three Es of cancer immunoediting--elimination, equilibrium, and escape... - Cancer vaccines 2004 opening address: the molecular and cellular basis of cancer immunosurveillance and immunoeditingRobert D Schreiber
Center for Immunology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
Cancer Immun 5:1. 2005 - IFN-gamma controls the generation/activation of CD4+ CD25+ regulatory T cells in antitumor immune responseHiroyoshi Nishikawa
Second Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan
J Immunol 175:4433-40. 2005..These findings support the idea that IFN-gamma regulates the generation/activation of CD4+ CD25+ regulatory T cells... - Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient miceMasaya Kobayashi
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
J Clin Invest 111:1297-308. 2003..Thus, this study clearly established a sequential innate and acquired immune mechanism for the development of Th1-dependent enterocolitis... - Breaking down the barriers to cancer immunotherapyEllen Pure
Wistar Institute and The Ludwig Institute for Cancer, Philadelphia, Pennsylvania 19104, USA
Nat Immunol 6:1207-10. 2005..Emerging insights into the mechanisms of activation and negative regulation of innate and adaptive immune cells are providing new opportunities for the development of safe and effective cancer vaccines... - Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesisJeremy B Swann
Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria 3002, Australia
Proc Natl Acad Sci U S A 105:652-6. 2008..Overall, these data not only confirm the key role that MyD88 plays in promoting tumor development but also demonstrate that inflammation-induced carcinogenesis and cancer immunoediting can indeed occur in the same mouse tumor model... - Immune-mediated dormancy: an equilibrium with cancerMichele W L Teng
Peter MacCallum Cancer Centre, Victoria, Australia
J Leukoc Biol 84:988-93. 2008..These findings form a framework for future studies aimed at validating immune-mediated cancer dormancy in humans with the hopes of devising new, immunotherapeutic strategies to treat established cancer... - Impaired response to interferon-alpha/beta and lethal viral disease in human STAT1 deficiencyStephanie Dupuis
Laboratoire de Genetique Humaine des Maladies Infectieuses, Université de Paris René Descartes INSERM UMR550, Faculte de Medecine Necker Enfants Malades, 75015 Paris, France
Nat Genet 33:388-91. 2003..Viral multiplication was not inhibited by recombinant IFN-alpha/beta in cell lines from the two individuals. Inherited impairment of the STAT1-dependent response to human IFN-alpha/beta thus results in susceptibility to viral disease... - Type I IFN contributes to NK cell homeostasis, activation, and antitumor functionJeremy B Swann
Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, 8006 Victoria, Australia
J Immunol 178:7540-9. 2007..This study demonstrates that endogenous type I IFN is a central mediator of NK cell antitumor responses... - IFN-producing cells respond to CXCR3 ligands in the presence of CXCL12 and secrete inflammatory chemokines upon activationAnne Krug
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
J Immunol 169:6079-83. 2002..Upon pathogen encounter, IPC positioning within the lymph node may be further directed by CCR7 and IPC secretion of inflammatory chemokines may attract other IPC, promoting cluster formation in lymph nodes... - Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activityJennifer E Fenner
Centre for Functional Genomics and Human Disease, Monash Institute of Medical Research, Monash University, Clayton 3168, Australia
Nat Immunol 7:33-9. 2006..Thus, SOCS1 is an important in vivo inhibitor of type I interferon signaling and contributes to balancing its beneficial antiviral versus detrimental proinflammatory effects on innate immunity... - NF-kappa B-inducing kinase regulates selected gene expression in the Nod2 signaling pathwayQilin Pan
Department of Immunology, IMM 12, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
Infect Immun 74:2121-7. 2006..Specifically, we have linked NIK to the induction of the B-cell chemoattractant known as BLC and suggest that this chemokine may play a role in processes initiated by Nod2 activation that lead to improved host defense... - Comparative analysis of regulatory and effector T cells in progressively growing versus rejecting tumors of similar originsJack D Bui
Center for Immunology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
Cancer Res 66:7301-9. 2006.... - Novel STAT1 alleles in otherwise healthy patients with mycobacterial diseaseAriane Chapgier
Laboratory of Human Genetics of Infectious Diseases, University of Paris Rene Descartes, INSERM U550, Necker Medical School, Paris, France
PLoS Genet 2:e131. 2006..These STAT1 alleles define two forms of dominant STAT1 deficiency, depending on whether the mutations impair STAT1 phosphorylation or DNA binding... - Gains of glycosylation comprise an unexpectedly large group of pathogenic mutationsGuillaume Vogt
Laboratory of Human Genetics of Infectious Diseases, University of Paris René Descartes INSERM U550, Necker Medical School, 156 rue de Vaugirard, 75015 Paris, France
Nat Genet 37:692-700. 2005..Thus, an unexpectedly high proportion of mutations that cause human genetic disease might lead to the creation of new N-glycosylation sites. Their pathogenic effects may be a direct consequence of the addition of N-linked carbohydrate... - Perforin and granzymes have distinct roles in defensive immunity and immunopathologySerani L H van Dommelen
Immunology and Virology Program, Centre for Ophthalmology and Visual Science, The University of Western Australia, Western Australia, Australia
Immunity 25:835-48. 2006.... - A novel c-Jun-dependent signal transduction pathway necessary for the transcriptional activation of interferon gamma response genesDaniel J Gough
Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, and University of Melbourne, Parkville 3054, Victoria, Australia
J Biol Chem 282:938-46. 2007..This represents a novel signal transduction pathway induced by IFNgamma that proceeds in parallel with conventional JAK/STAT signaling to activate ISGs... - Definition of target antigens for naturally occurring CD4(+) CD25(+) regulatory T cellsHiroyoshi Nishikawa
Second Department of Internal Medicine, Mie University School of Medicine, Mie 514 8507, Japan
J Exp Med 201:681-6. 2005..We propose that SEREX-defined self-antigens such as those used in this study represent self-antigens that elicit naturally occurring CD4(+) CD25(+) T reg cells... - Prolongation of cardiac and islet allograft survival by a blocking hamster anti-mouse CXCR3 monoclonal antibodyRavindra Uppaluri
Department of Otolaryngology, Washington University School of Medicine and John Cochran VA Medical Center, St Louis, MO, USA
Transplantation 86:137-47. 2008..However, analysis of CXCR3 expression and function has been hampered by a general lack of availability of a neutralizing anti-CXCR3 monoclonal antibody (mAb) for use in experimental models...
Research Grants
- IL-10 Receptor Signaling That Regulates Innate ImmunityRobert Schreiber; Fiscal Year: 2007..This work should identify the molecular basis for IL-10's anti-inflammatory effects and should thus provide us with novel strategies to nonspecifically enhance resistance to infectious agents by interfering with this signaling pathway. ..
- IFNgamma Receptor Signaling Dysfuction in CancerRobert Schreiber; Fiscal Year: 2007....
- The Molecular and Cellular Basis of Cancer ImmunoeditingRobert Schreiber; Fiscal Year: 2007..This work will provide the first molecular and mechanistic insights into the cancer immunoediting process and may also establish molecular guidelines to judge the extent to which a tumor has been edited. ..
- TRAINING IN CANCER BIOLOGYRobert Schreiber; Fiscal Year: 2007....
- Jaks and Stats: Development to DiseaseRobert Schreiber; Fiscal Year: 2004..abstract_text> ..
- MOLECULAR REGULATION OF MACROPHAGE CYTOCIDAL ACTIVITYRobert Schreiber; Fiscal Year: 1993..These studies should help to better define the molecular basis of macrophage activation and provide new insights into the roles of IFN gamma and activated macrophages in promoting physiologically important immune responses...
- THE ROLE OF THE INTERFERONS IN CANCER IMMUNOEDITINGROBERT DAVID SCHREIBER; Fiscal Year: 2010..Identifying these cells and defining how they function may lead to new therapeutic strategies that use the immune system to fight cancer. ..