Jean Schaffer

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation
    Sarah E Gale
    Center for Cardiovascular Research and Department of Internal Medicine, School of Medicine, Washington University, St Louis, Missouri 63110 1010, USA
    J Biol Chem 281:11082-9. 2006
  2. ncbi request reprint Fatty acid transport: the roads taken
    Jean E Schaffer
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Endocrinol Metab 282:E239-46. 2002
  3. ncbi request reprint Lipotoxicity: when tissues overeat
    Jean E Schaffer
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Curr Opin Lipidol 14:281-7. 2003
  4. ncbi request reprint Measurements of the cyclic variation of myocardial backscatter from two-dimensional echocardiographic images as an approach for characterizing diabetic cardiomyopathy
    Mark R Holland
    School of Medicine, Washington University, St Louis, MO 63130, USA
    J Cardiometab Syndr 1:149-52. 2006
  5. pmc Echocardiographic tissue characterization demonstrates differences in the left and right sides of the ventricular septum
    Mark R Holland
    Washington University, St Louis, MO 63130, USA
    Ultrasound Med Biol 36:1653-61. 2010
  6. ncbi request reprint Mechanisms of lipoapoptosis: implications for human heart disease
    Laura L Listenberger
    Center for Cardiovascular Research, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110 1010, USA
    Trends Cardiovasc Med 12:134-8. 2002
  7. pmc Quantitative analysis of the magnitude and time delay of cyclic variation of myocardial backscatter from asymptomatic type 2 diabetes mellitus subjects
    Allyson A Gibson
    Washington University, St Louis, MO 63130, USA
    Ultrasound Med Biol 35:1458-67. 2009
  8. ncbi request reprint Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy
    Hsiu Chiang Chiu
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 96:225-33. 2005
  9. pmc Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking
    Jessie R Zhang
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    J Clin Invest 118:2281-90. 2008
  10. ncbi request reprint Oligomerization of the murine fatty acid transport protein 1
    M Rachel Richards
    Center for Cardiovascular Research, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110 1010, USA
    J Biol Chem 278:10477-83. 2003

Collaborators

Detail Information

Publications27

  1. ncbi request reprint A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation
    Sarah E Gale
    Center for Cardiovascular Research and Department of Internal Medicine, School of Medicine, Washington University, St Louis, Missouri 63110 1010, USA
    J Biol Chem 281:11082-9. 2006
    ..These findings underscore the importance of an AGPAT2-mediated metabolic pathway in adipocyte differentiation...
  2. ncbi request reprint Fatty acid transport: the roads taken
    Jean E Schaffer
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Endocrinol Metab 282:E239-46. 2002
    ..This review will summarize results of studies of non-protein-mediated and protein-mediated LCFA transport and discuss how these different mechanisms may contribute to cellular metabolism...
  3. ncbi request reprint Lipotoxicity: when tissues overeat
    Jean E Schaffer
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Curr Opin Lipidol 14:281-7. 2003
    ..Physiologic responses to lipid overload and therapeutic approaches to decreasing lipid accumulation will be discussed, as they add to our understanding of important pathophysiologic mechanisms...
  4. ncbi request reprint Measurements of the cyclic variation of myocardial backscatter from two-dimensional echocardiographic images as an approach for characterizing diabetic cardiomyopathy
    Mark R Holland
    School of Medicine, Washington University, St Louis, MO 63130, USA
    J Cardiometab Syndr 1:149-52. 2006
  5. pmc Echocardiographic tissue characterization demonstrates differences in the left and right sides of the ventricular septum
    Mark R Holland
    Washington University, St Louis, MO 63130, USA
    Ultrasound Med Biol 36:1653-61. 2010
    ....
  6. ncbi request reprint Mechanisms of lipoapoptosis: implications for human heart disease
    Laura L Listenberger
    Center for Cardiovascular Research, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110 1010, USA
    Trends Cardiovasc Med 12:134-8. 2002
    ..Cardiomyocyte dysfunction and death from reactive intermediates generated by long-chain saturated fatty acids may contribute to the pathogenesis of human heart disease...
  7. pmc Quantitative analysis of the magnitude and time delay of cyclic variation of myocardial backscatter from asymptomatic type 2 diabetes mellitus subjects
    Allyson A Gibson
    Washington University, St Louis, MO 63130, USA
    Ultrasound Med Biol 35:1458-67. 2009
    ..Results show that analyses of the cyclic variation of backscatter in young asymptomatic type 2 diabetics may be an early indicator for the development of diabetic cardiomyopathy...
  8. ncbi request reprint Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy
    Hsiu Chiang Chiu
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 96:225-33. 2005
    ..Moreover, the MHC-FATP model supports a role for FATPs in FFA import into the heart in vivo...
  9. pmc Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking
    Jessie R Zhang
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    J Clin Invest 118:2281-90. 2008
    ..Our results demonstrate that NPC1 serves an atheroprotective role in mice through regulation of LXR-dependent cholesterol efflux and mitigation of cholesterol-induced oxidative stress in macrophages...
  10. ncbi request reprint Oligomerization of the murine fatty acid transport protein 1
    M Rachel Richards
    Center for Cardiovascular Research, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110 1010, USA
    J Biol Chem 278:10477-83. 2003
    ..Taken together, these results are consistent with a model in which FATP1 homodimeric complexes play an important role in cellular fatty acid import...
  11. ncbi request reprint Fatty acid transport protein 1 and long-chain acyl coenzyme A synthetase 1 interact in adipocytes
    M Rachel Richards
    Center for Cardiovascular Research and Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Lipid Res 47:665-72. 2006
    ..Together, our findings suggest that a constitutive interaction between FATP1 and ACSL1 contributes to the efficient cellular uptake of LCFAs in adipocytes through vectorial acylation...
  12. pmc A critical role for eukaryotic elongation factor 1A-1 in lipotoxic cell death
    Nica M Borradaile
    Center for Cardiovascular Research, Division of Cardiology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Biol Cell 17:770-8. 2006
    ..Furthermore, our observations of oxidative stress, ER stress, and induction of eEF1A-1 expression in a mouse model of lipotoxic cardiomyopathy implicate this cellular response in the pathophysiology of metabolic disease...
  13. pmc Side chain oxygenated cholesterol regulates cellular cholesterol homeostasis through direct sterol-membrane interactions
    Sarah E Gale
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 284:1755-64. 2009
    ..These studies implicate oxysterol-membrane interactions in acute regulation of sterol homeostatic responses and provide new insights into the mechanism through which oxysterols regulate cellular cholesterol balance...
  14. doi request reprint Ca2+-independent alterations in diastolic sarcomere length and relaxation kinetics in a mouse model of lipotoxic diabetic cardiomyopathy
    Thomas P Flagg
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 104:95-103. 2009
    ....
  15. pmc As a matter of fat
    Rita T Brookheart
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Metab 10:9-12. 2009
    ..This Minireview focuses on the mechanisms by which lipid overload causes nonadipose cell death and contributes to the pathogenesis of obesity and diabetes...
  16. ncbi request reprint Lipotoxicity in the heart
    Nica M Borradaile
    Department of Internal Medicine, Washington University School of Medicine, Box 8086, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Curr Hypertens Rep 7:412-7. 2005
    ....
  17. pmc The non-coding RNA gadd7 is a regulator of lipid-induced oxidative and endoplasmic reticulum stress
    Rita T Brookheart
    Center for Cardiovascular Research, Department of Internal Medicine, The Department of Cell Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 284:7446-54. 2009
    ..Together these data are the first to implicate a non-coding RNA in a feed-forward loop with oxidative stress and its induction of the endoplasmic reticulum stress response...
  18. pmc Niemann-Pick type C1 I1061T mutant encodes a functional protein that is selected for endoplasmic reticulum-associated degradation due to protein misfolding
    Mark E Gelsthorpe
    Center for Cardiovascular Research, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Biol Chem 283:8229-36. 2008
    ....
  19. ncbi request reprint Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death
    Nica M Borradaile
    Center for Cardiovascular Research, Division of Cardiology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Lipid Res 47:2726-37. 2006
    ....
  20. pmc Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease
    S Joshua Langmade
    Center for Cardiovascular Research, Department of Internal Medicine, and Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 103:13807-12. 2006
    ..These findings suggest that treatment with pregnane X receptor ligands may be useful clinically in delaying the progressive neurodegeneration in human NPC disease...
  21. pmc Cloning of wrinkle-free, a previously uncharacterized mouse mutation, reveals crucial roles for fatty acid transport protein 4 in skin and hair development
    Casey L Moulson
    Renal Division, Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 100:5274-9. 2003
    ..However, its function in vivo had not been determined. Our results demonstrate an unexpected yet critical role for FATP4 in skin and hair development and suggest Slc27a4 to be a candidate gene for restrictive dermopathy...
  22. ncbi request reprint The sterol-sensing domain of the Niemann-Pick C1 (NPC1) protein regulates trafficking of low density lipoprotein cholesterol
    Elizabeth E Millard
    Center for Cardiovascular Research, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110 1010, USA
    J Biol Chem 280:28581-90. 2005
    ..Our finding that D787N and L657F are activating NPC1 mutations provide evidence for a conserved mechanism for the sterol-sensing domain among cholesterol homeostatic proteins...
  23. pmc Triglyceride accumulation protects against fatty acid-induced lipotoxicity
    Laura L Listenberger
    Center for Cardiovascular Research, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110 1010, USA
    Proc Natl Acad Sci U S A 100:3077-82. 2003
    ..Our findings support a model of cellular lipid metabolism in which unsaturated fatty acids serve a protective function against lipotoxicity though promotion of triglyceride accumulation...
  24. ncbi request reprint NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols
    Andrey Frolov
    Center for Cardiovascular Research, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110 1010, USA
    J Biol Chem 278:25517-25. 2003
    ..Our findings support a role for NPC1 and NPC2 in the regulation of sterol homeostasis through generation of LDL cholesterol-derived oxysterols and have important implications for the treatment of NPC disease...
  25. pmc Hyperleptinemia prevents lipotoxic cardiomyopathy in acyl CoA synthase transgenic mice
    Young Lee
    Gifford Laboratories, Touchstone Center for Diabetes Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8854, USA
    Proc Natl Acad Sci U S A 101:13624-9. 2004
    ..We conclude that obesity-level hyperleptinemia protects the heart from lipotoxicity...
  26. ncbi request reprint The steroidal analog GW707 activates the SREBP pathway through disruption of intracellular cholesterol trafficking
    Jessie Zhang
    Center for Cardiovascular Research, 91951 Les Ulis, France
    J Lipid Res 45:223-31. 2004
    ..Taken together, these findings support a mechanism in which GW707 exerts its hypolipidemic effects through disruption of late endosomal/lysosomal sterol trafficking and subsequent stimulation of LDLr activity...
  27. ncbi request reprint Alpha-lipoic acid prevents lipotoxic cardiomyopathy in acyl CoA-synthase transgenic mice
    Young Lee
    Gifford Laboratories, Touchstone Center for Diabetes Research, University of Texas, Southwestern Medical Center, Dallas, TX 75390 8854, USA
    Biochem Biophys Res Commun 344:446-52. 2006
    ..Since food restriction did not prevent lipotoxicity, we conclude that alpha-LA treatment, like hyperleptinemia, protects the heart of ACS-transgenic mice from lipotoxicity...

Research Grants19

  1. Cellular mechanisms that promote or prevent lipotoxicity
    Jean E Schaffer; Fiscal Year: 2010
    ....
  2. Cellular mechanisms that promotes or prevent lipotoxicity
    Jean Schaffer; Fiscal Year: 2007
    ..Moreover, these studies will provide new insights into the lipotoxic response to excess lipid accumulation in non-adipose tissues in diabetes and obesity. ..
  3. MOLECULAR BASIS OF LONG CHAIN FATTY ACID TRANSPORT
    Jean Schaffer; Fiscal Year: 2006
    ..Characterization of these mechanisms has relevance to common human diseases such as diabetes and heart failure in which abnormal lipid homeostasis contributes to pathogenesis. ..
  4. Cellular mechanisms that promote or prevent lipotoxicity
    Jean Schaffer; Fiscal Year: 2005
    ..Moreover, these studies will provide new insights into the cytotoxic response to excess lipid accumulation in non-adipose tissues observed in diseases such as diabetes, lipodystrophies, and heart failure. ..
  5. MOLECULAR BASIS OF LONG CHAIN FATTY ACID TRANSPORT
    Jean Schaffer; Fiscal Year: 2001
    ..These studies will provide insight to human disorders, which result from abnormal LCFA metabolism, and illuminate the physiologic roles of FATP and FAC in fatty acid homeostasis. ..
  6. Cellular mechanisms that promote or prevent lipotoxicity
    Jean E Schaffer; Fiscal Year: 2010
    ....