Scott Saunders

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Expression of the cell surface proteoglycan glypican-5 is developmentally regulated in kidney, limb, and brain
    S Saunders
    Department of Developmental and Cell Biology and Developmental Biology Center, University of California at Irvine, 92697, USA
    Dev Biol 190:78-93. 1997
  2. ncbi request reprint GPC6, a novel member of the glypican gene family, encodes a product structurally related to GPC4 and is colocalized with GPC5 on human chromosome 13
    S Paine-Saunders
    Department of Pediatrics, Washington University Medical School, St Louis, Missouri 63110, USA
    Genomics 57:455-8. 1999
  3. ncbi request reprint glypican-3 controls cellular responses to Bmp4 in limb patterning and skeletal development
    S Paine-Saunders
    Division of Newborn Medicine, Washington University School of Medicine, St Louis, Missouri, 63110, USA
    Dev Biol 225:179-87. 2000
  4. ncbi request reprint Heparan sulfate proteoglycans retain Noggin at the cell surface: a potential mechanism for shaping bone morphogenetic protein gradients
    Stephenie Paine-Saunders
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, Missouri 63110, USA
    J Biol Chem 277:2089-96. 2002
  5. ncbi request reprint Domain-specific modification of heparan sulfate by Qsulf1 modulates the binding of the bone morphogenetic protein antagonist Noggin
    Beth L Viviano
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, Missouri 63110, USA
    J Biol Chem 279:5604-11. 2004
  6. ncbi request reprint Altered hematopoiesis in glypican-3-deficient mice results in decreased osteoclast differentiation and a delay in endochondral ossification
    Beth L Viviano
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, MO 63110, USA
    Dev Biol 282:152-62. 2005
  7. pmc Loss of glypican-3 function causes growth factor-dependent defects in cardiac and coronary vascular development
    Ann Ng
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, MO 63110, USA
    Dev Biol 335:208-15. 2009
  8. pmc Sex-specific quantitative trait loci linked to autoresuscitation failure in SWR/J mice
    B T Thach
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Heredity (Edinb) 103:469-75. 2009
  9. ncbi request reprint The rare occurrence of absent adrenals in a term infant: a case report and review of the literature
    Akshaya Vachharajani
    Department of Pediatrics, Division of Newborn Medicine, Washington University School of Medicine and St Louis Children s Hospital, St Louis, Missouri, USA
    Am J Perinatol 23:111-4. 2006
  10. ncbi request reprint Allelic variation in the serotonin transporter (5HTT) gene contributes to idiopathic pulmonary hypertension in children
    Akshaya Vachharajani
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, MO 63110, USA
    Biochem Biophys Res Commun 334:376-9. 2005

Research Grants

  1. PATHOBIOCHEMISTRY OF PROTEOGLYCANS IN DEVELOPMENT
    Scott Saunders; Fiscal Year: 2003
  2. PATHOBIOCHEMISTRY OF PROTEOGLYCANS IN DEVELOPMENT
    Scott Saunders; Fiscal Year: 2009

Collaborators

  • Patrick Y Jay
  • James Cheverud
  • ARTHUR LANDER
  • Bradley Thach
  • J T Gallagher
  • Nobue Itasaki
  • Beth L Viviano
  • Akshaya Vachharajani
  • Stephenie Paine-Saunders
  • S Paine-Saunders
  • Ann Ng
  • Beth Viviano
  • Camila Pflederer
  • Debra L Ellies
  • M R DeBaun
  • B L Viviano
  • Michelle Wong
  • George Alba
  • Jonathan M Erlich
  • Jean Francois Mouillet
  • Kathleen Bethin
  • Yoel Sadovsky
  • John McCarthy
  • Jean Philippe Rey
  • Robb Krumlauf
  • Laura Silverstein
  • Kathy Mills
  • Nijole Gasiunas
  • Aris N Economides
  • J Ess
  • W C Skarnes
  • J Zupicich

Detail Information

Publications12

  1. ncbi request reprint Expression of the cell surface proteoglycan glypican-5 is developmentally regulated in kidney, limb, and brain
    S Saunders
    Department of Developmental and Cell Biology and Developmental Biology Center, University of California at Irvine, 92697, USA
    Dev Biol 190:78-93. 1997
    ....
  2. ncbi request reprint GPC6, a novel member of the glypican gene family, encodes a product structurally related to GPC4 and is colocalized with GPC5 on human chromosome 13
    S Paine-Saunders
    Department of Pediatrics, Washington University Medical School, St Louis, Missouri 63110, USA
    Genomics 57:455-8. 1999
    ..Radiation hybrid analysis mapped the GPC6 gene to human chromosome 13 very near the GPC5 gene, a member of the glypican family bearing strong similarity to GPC3...
  3. ncbi request reprint glypican-3 controls cellular responses to Bmp4 in limb patterning and skeletal development
    S Paine-Saunders
    Division of Newborn Medicine, Washington University School of Medicine, St Louis, Missouri, 63110, USA
    Dev Biol 225:179-87. 2000
    ..This previously unknown link between glypican-3 and BMP4 function provides evidence of a role for glypicans in vertebrate limb patterning and skeletal development and suggests a mechanism for the skeletal defects seen in SGBS...
  4. ncbi request reprint Heparan sulfate proteoglycans retain Noggin at the cell surface: a potential mechanism for shaping bone morphogenetic protein gradients
    Stephenie Paine-Saunders
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, Missouri 63110, USA
    J Biol Chem 277:2089-96. 2002
    ..Our results imply that interactions between Noggin and heparan sulfate proteoglycans in vivo regulate diffusion and therefore the formation of gradients of BMP activity...
  5. ncbi request reprint Domain-specific modification of heparan sulfate by Qsulf1 modulates the binding of the bone morphogenetic protein antagonist Noggin
    Beth L Viviano
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, Missouri 63110, USA
    J Biol Chem 279:5604-11. 2004
    ....
  6. ncbi request reprint Altered hematopoiesis in glypican-3-deficient mice results in decreased osteoclast differentiation and a delay in endochondral ossification
    Beth L Viviano
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, MO 63110, USA
    Dev Biol 282:152-62. 2005
    ..This is the first report of a requirement for heparan sulfate, and specifically Gpc3, in the lineage-specific differentiation of these cell types in vivo...
  7. pmc Loss of glypican-3 function causes growth factor-dependent defects in cardiac and coronary vascular development
    Ann Ng
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, MO 63110, USA
    Dev Biol 335:208-15. 2009
    ..This work has broad significance to understanding the genetic basis of coronary development and potentially to molecular mechanisms relevant to revascularization following ischemic injury to the heart...
  8. pmc Sex-specific quantitative trait loci linked to autoresuscitation failure in SWR/J mice
    B T Thach
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Heredity (Edinb) 103:469-75. 2009
    ..These results establish a genetic basis for AR failure phenotype in mice, with relevance to Sudden Infant Death Syndrome...
  9. ncbi request reprint The rare occurrence of absent adrenals in a term infant: a case report and review of the literature
    Akshaya Vachharajani
    Department of Pediatrics, Division of Newborn Medicine, Washington University School of Medicine and St Louis Children s Hospital, St Louis, Missouri, USA
    Am J Perinatol 23:111-4. 2006
    ..The known role of SF-1 and its mutations in adrenal gland development are discussed...
  10. ncbi request reprint Allelic variation in the serotonin transporter (5HTT) gene contributes to idiopathic pulmonary hypertension in children
    Akshaya Vachharajani
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, MO 63110, USA
    Biochem Biophys Res Commun 334:376-9. 2005
    ..We found that homozygosity for the long variant of 5HTT was highly associated with idiopathic pulmonary hypertension in children, suggesting perhaps a more important role for 5HTT gene function in the pathogenesis of early onset disease...
  11. ncbi request reprint Simpson Golabi Behmel syndrome: progress toward understanding the molecular basis for overgrowth, malformation, and cancer predisposition
    M R DeBaun
    Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    Mol Genet Metab 72:279-86. 2001
    ..Using an integrated approach employing epidemiology, molecular genetic characterization of specific GPC3 mutations, and the use of model organisms should rapidly expand the understanding of this complex disorder...
  12. ncbi request reprint Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity
    Debra L Ellies
    Stowers Institute for Medical Research, Kansa City, Missouri 64110, USA
    J Bone Miner Res 21:1738-49. 2006
    ..Our data suggest that functional interactions between Sost or Wise and LRP5/LRP6 have the potential to regulate bone deposition by modulating the Wnt pathway...

Research Grants8

  1. PATHOBIOCHEMISTRY OF PROTEOGLYCANS IN DEVELOPMENT
    Scott Saunders; Fiscal Year: 2003
    ..These short-term objectives will further our long-term objectives which are to identify the ligands and biochemical pathways through which glypicans act in both normal and abnormal human morphogenesis. ..
  2. PATHOBIOCHEMISTRY OF PROTEOGLYCANS IN DEVELOPMENT
    Scott Saunders; Fiscal Year: 2009
    ..abstract_text> ..