J R Sanes

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Agrin promotes synaptic differentiation by counteracting an inhibitory effect of neurotransmitter
    Thomas Misgeld
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 102:11088-93. 2005
  2. ncbi request reprint Development of the vertebrate neuromuscular junction
    J R Sanes
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Annu Rev Neurosci 22:389-442. 1999
  3. ncbi request reprint Alternatively spliced isoforms of nerve- and muscle-derived agrin: their roles at the neuromuscular junction
    R W Burgess
    Department of Anatomy and Neurobiology, Washington University Medical School, St Louis, Missouri 63110, USA
    Neuron 23:33-44. 1999
  4. ncbi request reprint Watching the neuromuscular junction
    Jeff W Lichtman
    Department of Anatomy and Neurobiology, Washington University Medical School, St Louis, MO 63110, USA
    J Neurocytol 32:767-75. 2003
  5. pmc Distinct domains of MuSK mediate its abilities to induce and to associate with postsynaptic specializations
    H Zhou
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biol 146:1133-46. 1999
  6. ncbi request reprint Formation of lamina-specific synaptic connections
    J R Sanes
    Department of Anatomy and Neurobiology Washington University Medical School 660 South Euclid Avenue Campus Box 8108 St Louis Missouri 63110 USA
    Curr Opin Neurobiol 9:79-87. 1999
  7. pmc Distribution and function of laminins in the neuromuscular system of developing, adult, and mutant mice
    B L Patton
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biol 139:1507-21. 1997
  8. ncbi request reprint Maturation and maintenance of the neuromuscular synapse: genetic evidence for roles of the dystrophin--glycoprotein complex
    R M Grady
    Department of Pediatrics, Washington University Medical School, St Louis, Missouri 63110, USA
    Neuron 25:279-93. 2000
  9. ncbi request reprint Defective neuromuscular synaptogenesis in agrin-deficient mutant mice
    M Gautam
    Department of Anatomy and Neurobiology, Washington University Medical School St Louis, Missouri 63110, USA
    Cell 85:525-35. 1996
  10. ncbi request reprint Properly formed but improperly localized synaptic specializations in the absence of laminin alpha4
    B L Patton
    Department of Anatomy and Neurobiology, Washington University Medical Center, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Neurosci 4:597-604. 2001

Collaborators

Detail Information

Publications122 found, 100 shown here

  1. pmc Agrin promotes synaptic differentiation by counteracting an inhibitory effect of neurotransmitter
    Thomas Misgeld
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 102:11088-93. 2005
    ..Similar interactions between neurotransmitters and synaptic organizing molecules may operate at synapses in the central nervous system...
  2. ncbi request reprint Development of the vertebrate neuromuscular junction
    J R Sanes
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Annu Rev Neurosci 22:389-442. 1999
    ..Finally, we consider the extent to which the NMJ is a suitable model for development of neuron-neuron synapses...
  3. ncbi request reprint Alternatively spliced isoforms of nerve- and muscle-derived agrin: their roles at the neuromuscular junction
    R W Burgess
    Department of Anatomy and Neurobiology, Washington University Medical School, St Louis, Missouri 63110, USA
    Neuron 23:33-44. 1999
    ..Our results also suggest that the requirement of agrin for presynaptic differentiation is mediated indirectly by its ability to promote postsynaptic production or localization of appropriate retrograde signals...
  4. ncbi request reprint Watching the neuromuscular junction
    Jeff W Lichtman
    Department of Anatomy and Neurobiology, Washington University Medical School, St Louis, MO 63110, USA
    J Neurocytol 32:767-75. 2003
    ..The development, maturation, stability, remodeling and regeneration of neuromuscular junctions and motor units can then be assessed over intervals ranging from seconds to months...
  5. pmc Distinct domains of MuSK mediate its abilities to induce and to associate with postsynaptic specializations
    H Zhou
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biol 146:1133-46. 1999
    ..These interactions allow MuSK not only to induce a multimolecular AChR-containing complex, but also to localize that complex to a primary scaffold in the postsynaptic membrane...
  6. ncbi request reprint Formation of lamina-specific synaptic connections
    J R Sanes
    Department of Anatomy and Neurobiology Washington University Medical School 660 South Euclid Avenue Campus Box 8108 St Louis Missouri 63110 USA
    Curr Opin Neurobiol 9:79-87. 1999
    ....
  7. pmc Distribution and function of laminins in the neuromuscular system of developing, adult, and mutant mice
    B L Patton
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biol 139:1507-21. 1997
    ..The ability of laminin 11 to serve as a stop signal for growing axons explains, in part, axonal behaviors observed at developing and regenerating synapses in vivo...
  8. ncbi request reprint Maturation and maintenance of the neuromuscular synapse: genetic evidence for roles of the dystrophin--glycoprotein complex
    R M Grady
    Department of Pediatrics, Washington University Medical School, St Louis, Missouri 63110, USA
    Neuron 25:279-93. 2000
    ..Together, these results demonstrate involvement of distinct protein complexes in the formation and maintenance of the synapse and implicate the DGC in the latter process...
  9. ncbi request reprint Defective neuromuscular synaptogenesis in agrin-deficient mutant mice
    M Gautam
    Department of Anatomy and Neurobiology, Washington University Medical School St Louis, Missouri 63110, USA
    Cell 85:525-35. 1996
    ....
  10. ncbi request reprint Properly formed but improperly localized synaptic specializations in the absence of laminin alpha4
    B L Patton
    Department of Anatomy and Neurobiology, Washington University Medical Center, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Neurosci 4:597-604. 2001
    ..Thus, formation and localization of synaptic specializations are regulated separately, and alpha4beta2gamma1 (called laminin-9) is critical in the latter process...
  11. ncbi request reprint Nerve terminals form but fail to mature when postsynaptic differentiation is blocked: in vivo analysis using mammalian nerve-muscle chimeras
    Q T Nguyen
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 20:6077-86. 2000
    ..Normal postsynaptic differentiation appears to be dispensable for initial stages of presynaptic differentiation but required for presynaptic maturation...
  12. ncbi request reprint Distinct phenotypes of mutant mice lacking agrin, MuSK, or rapsyn
    M Gautam
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Brain Res Dev Brain Res 114:171-8. 1999
    ..We propose that agrin works through MuSK to determine a synaptogenic region within which synaptic differentiation occurs...
  13. pmc Agrin isoforms with distinct amino termini: differential expression, localization, and function
    R W Burgess
    Department of Anatomy and Neurobiology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Cell Biol 151:41-52. 2000
    ..Thus, basal lamina-associated LN-agrin is required for neuromuscular synaptogenesis, whereas cell-associated SN-agrin may play distinct roles in the central nervous system...
  14. pmc The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform
    J H Miner
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biol 137:685-701. 1997
    ..Together, these results reveal remarkable diversity in BL composition and complexity in BL development...
  15. ncbi request reprint Rapsyn is required for MuSK signaling and recruits synaptic components to a MuSK-containing scaffold
    E D Apel
    Department of Molecular Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neuron 18:623-35. 1997
    ..This signaling requires the kinase domain of MuSK, but not its ectodomain. Thus, MuSK may interact with rapsyn in multiple ways to play both structural and signaling roles in agrin-induced differentiation...
  16. pmc Collagen IV alpha 3, alpha 4, and alpha 5 chains in rodent basal laminae: sequence, distribution, association with laminins, and developmental switches
    J H Miner
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110
    J Cell Biol 127:879-91. 1994
    ..Thus, collagen alpha 1 and alpha 2(IV) and laminin B1 appear to be fetal components of the glomerular BL, and there is a developmental switch to collagen alpha 3-alpha 5(IV) and S-laminin expression...
  17. ncbi request reprint Glial cell line-derived neurotrophic factor administration in postnatal life results in motor unit enlargement and continuous synaptic remodeling at the neuromuscular junction
    C R Keller-Peck
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    J Neurosci 21:6136-46. 2001
    ..We conclude that GDNF has a developmentally regulated effect on presynaptic branching and that sustained administration of GDNF induces a state of continuous synaptic remodeling...
  18. ncbi request reprint Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction
    E D Apel
    Department of Anatomy and Neurobiology and Department of Pediatrics, Washington University Medical School, St Louis, Missouri 63110, USA
    J Biol Chem 275:31986-95. 2000
    ..Finally, we identify a homologous gene, syne-2, that is expressed in an overlapping but distinct pattern...
  19. ncbi request reprint Roles for ephrins in positionally selective synaptogenesis between motor neurons and muscle fibers
    G Feng
    Department of Anatomy, Washington University Medical School, St Louis, Missouri 63110, USA
    Neuron 25:295-306. 2000
    ..In addition, the rostrocaudal position of at least one motor pool is altered in ephrin-A5 mutant mice, indicating that ephrins affect nerve-muscle matching by intraspinal as well as intramuscular mechanisms...
  20. ncbi request reprint Rapsyn clusters neuronal acetylcholine receptors but is inessential for formation of an interneuronal cholinergic synapse
    G Feng
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 18:4166-76. 1998
    ..Thus, rapsyn is dispensable for clustering of ganglionic neuronal nicotinic AChRs...
  21. ncbi request reprint Three mouse models of muscular dystrophy: the natural history of strength and fatigue in dystrophin-, dystrophin/utrophin-, and laminin alpha2-deficient mice
    A M Connolly
    Department of Neurology, Washington University School of Medicine, Box 8111 660 S Euclid, Saint Louis, MO 63110, USA
    Neuromuscul Disord 11:703-12. 2001
    ..This work demonstrates a distinct pattern of disease progression in each model and provides a foundation for assessing strategies for improving strength in each model...
  22. ncbi request reprint Kinase- and rapsyn-independent activities of the muscle-specific kinase (MuSK)
    P A Bromann
    Department of Anatomy and Neurobiology, Washington University Medical School, 660 South Euclid, St Louis, MO 63110, USA
    Neuroscience 125:417-26. 2004
    ..These results imply that rapsyn and signaling components activated by MuSK kinase may be dispensable for some early aspects of postsynaptic differentiation...
  23. ncbi request reprint Deficient development and maintenance of postsynaptic specializations in mutant mice lacking an 'adult' acetylcholine receptor subunit
    A C Missias
    Department of Molecular Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 124:5075-86. 1997
    ..This decreased density led to a profound reorganization of AChR-associated components of the postsynaptic membrane and cytoskeleton. Together, these results suggest novel roles for AChRs in assembly of the postsynaptic apparatus...
  24. ncbi request reprint Failure of postsynaptic specialization to develop at neuromuscular junctions of rapsyn-deficient mice
    M Gautam
    Department of Molecular Biology, Washington University Medical School, St Louis, Missouri 63110, USA
    Nature 377:232-6. 1995
    ..We report that rapsyn is essential for the formation of AChR clusters, but that synapse-specific transcription of AChR subunit genes can proceed in its absence...
  25. ncbi request reprint Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP
    G Feng
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neuron 28:41-51. 2000
    ..In some lines, intense labeling of small neuronal subsets provided a Golgi-like vital stain. In double transgenic mice expressing two different XFPs, it was possible to differentially label 3 neuronal subsets in a single animal...
  26. ncbi request reprint Asynchronous synapse elimination in neonatal motor units: studies using GFP transgenic mice
    C R Keller-Peck
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuron 31:381-94. 2001
    ....
  27. ncbi request reprint A synaptic localization domain in the synaptic cleft protein laminin beta 2 (s-laminin)
    P T Martin
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St.Louis, MO 63110, USA
    Science 269:413-6. 1995
    ..The synaptic targeting sequence of beta 2 contains a site previously shown to be adhesive for motor neurons...
  28. ncbi request reprint Role for alpha-dystrobrevin in the pathogenesis of dystrophin-dependent muscular dystrophies
    R M Grady
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Cell Biol 1:215-20. 1999
    ..These results indicate that both signalling and structural functions of the DGC are required for muscle stability, and implicate alpha-dystrobrevin in the former...
  29. pmc Roles for laminin in embryogenesis: exencephaly, syndactyly, and placentopathy in mice lacking the laminin alpha5 chain
    J H Miner
    Department of Medicine, Renal Division, St Louis, Missouri, USA
    J Cell Biol 143:1713-23. 1998
    ..Other laminin alpha chains accumulate in these BLs, but this compensation is apparently functionally inadequate. Our results identify new roles for laminins and BLs in diverse developmental processes...
  30. ncbi request reprint 43K protein and acetylcholine receptors colocalize during the initial stages of neuromuscular synapse formation in vivo
    P G Noakes
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110
    Dev Biol 155:275-80. 1993
    ..The precise colocalization of 43K and AChRs persisted through development. These results are consistent with 43K being involved in the nerve-induced clustering of AChRs during synapse formation...
  31. ncbi request reprint Identification and expression of mouse netrin-4
    Y Yin
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mech Dev 96:115-9. 2000
    ..In postnatal brain, it is selectively expressed in subsets of neurons, including cerebellar granule and hippocampal pyramidal cells...
  32. pmc Genetic analysis of collagen Q: roles in acetylcholinesterase and butyrylcholinesterase assembly and in synaptic structure and function
    G Feng
    Department of Anatomy and Neurobiology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Cell Biol 144:1349-60. 1999
    ..Compensation was incomplete, however, as animals lacking ColQ and synaptic AChE failed to thrive and most died before they reached maturity...
  33. ncbi request reprint Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity
    G Feng
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 282:1321-4. 1998
    ..The mutant phenotype resembled that of humans with hereditary molybdenum cofactor deficiency and hyperekplexia (a failure of inhibitory neurotransmission), suggesting that gephyrin function may be impaired in both diseases...
  34. ncbi request reprint Distribution of the ten known laminin chains in the pathways and targets of developing sensory axons
    S I Lentz
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Comp Neurol 378:547-61. 1997
    ..g., gamma 1), continue to be expressed by Schwann cells into adulthood. In contrast to peripheral nerves and ganglia, laminin chains are expressed at low levels, if at all, in the developing spinal cord gray matter...
  35. ncbi request reprint Distinct adhesive properties of ciliary and choroid neurons from the avian ciliary ganglion
    B E Porter
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    J Neurobiol 28:381-90. 1995
    ..Thus, two sets of neurons in the CG that send axons through different nerves and innervate different targets also show distinct adhesive behaviors...
  36. pmc Distinct regulatory elements control muscle-specific, fiber-type-selective, and axially graded expression of a myosin light-chain gene in transgenic mice
    M V Rao
    Department of Molecular Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell Biol 16:3909-22. 1996
    ..Together, our results provide evidence for at least nine distinct sites that exert major effects on the levels and patterns of MLC1f expression in adult muscles...
  37. ncbi request reprint N-CAM, 43K-rapsyn, and S-laminin mRNAs are concentrated at synaptic sites in muscle fibers
    L M Moscoso
    Department of Anatomy, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    Mol Cell Neurosci 6:80-9. 1995
    ..Our data suggest that selective transcription by synaptic nuclei is a general mechanism that contributes to the concentration of specific proteins in the postsynaptic apparatus at the neuromuscular junction...
  38. ncbi request reprint An LRE (leucine-arginine-glutamate)-dependent mechanism for adhesion of neurons to S-laminin
    D D Hunter
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110
    J Neurosci 11:3960-71. 1991
    ..Together, these results suggest that LRE comprises a motoneuron-selective adhesion site that is accessible in native basal laminae and that acts to inhibit neurite outgrowth...
  39. ncbi request reprint Gated migration: neurons migrate on but not onto substrates containing S-laminin
    B E Porter
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110
    Dev Biol 167:609-16. 1995
    ..Instead, s-laminin appears to block cell migration through a "gating" mechanism that acts primarily at borders...
  40. ncbi request reprint Skeletal and cardiac myopathies in mice lacking utrophin and dystrophin: a model for Duchenne muscular dystrophy
    R M Grady
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cell 90:729-38. 1997
    ..Thus, utrophin attenuates the effects of dystrophin deficiency, and the double mutant may provide a useful model for studies of pathogenesis and therapy...
  41. pmc Subtle neuromuscular defects in utrophin-deficient mice
    R M Grady
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biol 136:871-82. 1997
    ..These results point to a predominant role for other molecules in the differentiation and maintenance of the postsynaptic membrane...
  42. ncbi request reprint Aberrant differentiation of neuromuscular junctions in mice lacking s-laminin/laminin beta 2
    P G Noakes
    Department of Anatomy, Washington University Medical School, St Louis, Missouri 63110
    Nature 374:258-62. 1995
    ..By generating and characterizing mice with a targeted mutation of the s-laminin gene, we show here that s-laminin regulates formation of motor nerve terminals...
  43. ncbi request reprint Expression of multiple cadherins and catenins in the chick optic tectum
    F Miskevich
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, Missouri, 63110, USA
    Mol Cell Neurosci 12:240-55. 1998
    ..This result suggests that cadherin-based specificity involves multiple cadherin-dependent signaling pathways as well as multiple cadherins...
  44. ncbi request reprint Primary sequence of a motor neuron-selective adhesive site in the synaptic basal lamina protein S-laminin
    D D Hunter
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110
    Cell 59:905-13. 1989
    ..Together, these results define a motor neuron-selective attachment site on s-laminin...
  45. ncbi request reprint Synaptic laminin prevents glial entry into the synaptic cleft
    B L Patton
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 393:698-701. 1998
    ....
  46. ncbi request reprint Synthesis and assembly of the synaptic cleft protein S-laminin by cultured cells
    T L Green
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110
    J Biol Chem 267:2014-22. 1992
    ..Thus, the cDNA contains sufficient information to permit assembly, secretion, and post-translational modification of S-laminin...
  47. ncbi request reprint A laminin-like adhesive protein concentrated in the synaptic cleft of the neuromuscular junction
    D D Hunter
    Department of Anatomy, Washington University School of Medicine, St Louis, Missouri 63110
    Nature 338:229-34. 1989
    ..Molecular cloning reveals that s-laminin is a novel homologue of laminin, a potent promoter of neurite outgrowth...
  48. ncbi request reprint Expression of s-laminin and laminin in the developing rat central nervous system
    D D Hunter
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110
    J Comp Neurol 323:238-51. 1992
    ..Together, these results demonstrate that s-laminin is present in the developing central nervous system, and raise the possibility that this molecule may influence developmental processes...
  49. ncbi request reprint S-laminin: mapping to mouse chromosome 9 and expression in the linked mutants tippy and ducky
    B E Porter
    Department of Anatomy and Neurobiology, Washington University Medical Center, St Louis, Missouri 63110
    Genomics 16:278-81. 1993
    ..No abnormality of the S-laminin gene or protein was detectable in either mutant...
  50. ncbi request reprint The renal glomerulus of mice lacking s-laminin/laminin beta 2: nephrosis despite molecular compensation by laminin beta 1
    P G Noakes
    Department of Anatomy, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Genet 10:400-6. 1995
    ..Laminin beta 2-deficient mice may provide a model for human congenital or idiopathic nephrotic syndromes...
  51. pmc Molecular and functional defects in kidneys of mice lacking collagen alpha 3(IV): implications for Alport syndrome
    J H Miner
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biol 135:1403-13. 1996
    ..We suggest that these alterations contribute, along with loss of collagen IV isoforms per se, to renal pathology...
  52. ncbi request reprint epsilon-Sarcoglycan, a broadly expressed homologue of the gene mutated in limb-girdle muscular dystrophy 2D
    A J Ettinger
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 272:32534-8. 1997
    ..These results raise the possibility that sarcoglycan-containing complexes mediate membrane-matrix interactions in many cell types...
  53. ncbi request reprint Developmentally regulated and spatially restricted antigens of radial glial cells
    J P Herman
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110
    Dev Dyn 197:307-18. 1993
    ..Together, these antibodies can be used to study temporal and spatial specializations of radial glia...
  54. ncbi request reprint Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, ErbB2 and ErbB3, in developing mammalian muscle
    L M Moscoso
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Dev Biol 172:158-69. 1995
    ..Finally, we show that erbB3 is not concentrated at synaptic sites in mutant mice that lack rapsyn, a cytoskeletal protein required for AChR clustering, suggesting that pathways for synaptic AChR expression and clustering interact...
  55. ncbi request reprint Organization and reorganization of neuromuscular junctions in mice lacking neural cell adhesion molecule, tenascin-C, or fibroblast growth factor-5
    L M Moscoso
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 18:1465-77. 1998
    ..Again, no significant differences among genotypes were observed. Together, these results demonstrate that N-CAM, tenascin-C, and FGF-5 are dispensable for major aspects of synaptic development and regeneration...
  56. ncbi request reprint Roles for the integrin VLA-4 and its counter receptor VCAM-1 in myogenesis
    G D Rosen
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    Cell 69:1107-19. 1992
    ..In support of the latter possibility, antibodies to VLA-4 or VCAM-1 inhibit myotube formation in culture...
  57. ncbi request reprint Expression of four immunoglobulin superfamily adhesion molecules (L1, Nr-CAM/Bravo, neurofascin/ABGP, and N-CAM) in the developing mouse spinal cord
    L M Moscoso
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Comp Neurol 352:321-34. 1995
    ..Finally, we show that each CAM has a distinct spatiotemporal pattern of expression in dorsal root ganglia...
  58. ncbi request reprint Expression of zfh-4, a new member of the zinc finger-homeodomain family, in developing brain and muscle
    W A Kostich
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Dev Dyn 202:145-52. 1995
    ..Its patterns of expression, and its homology to known DNA binding proteins, support the idea that zfh-4 may be a regulator of gene expression in developing brain and muscle...
  59. ncbi request reprint Synaptic localization and neural regulation of an N-acetylgalactosaminyl transferase in skeletal muscle
    L J Scott
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110
    J Neurosci 10:346-50. 1990
    ..These results provide a plausible metabolic basis for the localization of a synapse-specific carbohydrate and demonstrate that the expression of a glycosyltransferase is regulated by synaptic interactions...
  60. ncbi request reprint Synaptic integrins in developing, adult, and mutant muscle: selective association of alpha1, alpha7A, and alpha7B integrins with the neuromuscular junction
    P T Martin
    Department of Anatomy and Neurobiology, Washington University Medical School, St Louis, Missouri 63110, USA
    Dev Biol 174:125-39. 1996
    ..In beta2-null mutant mice, alpha7A was still present at synaptic sites, but alpha7B was absent. This result provides genetic evidence that basal lamina composition is a determinant of integrin distribution...
  61. pmc Molecular heterogeneity of basal laminae: isoforms of laminin and collagen IV at the neuromuscular junction and elsewhere
    J R Sanes
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110
    J Cell Biol 111:1685-99. 1990
    ..Of eight BLs studied, at least seven have distinct compositions, and of the nine BL components tested, at least seven have distinct distributions. These results demonstrate a hitherto undescribed degree of heterogeneity among BLs...
  62. ncbi request reprint Selective expression of an acetylcholine receptor-lacZ transgene in synaptic nuclei of adult muscle fibers
    J R Sanes
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110
    Development 113:1181-91. 1991
    ....
  63. ncbi request reprint Molecular cloning of a novel laminin chain, alpha 5, and widespread expression in adult mouse tissues
    J H Miner
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 270:28523-6. 1995
    ..Analysis of RNA expression showed that alpha 5 is widely expressed in adult tissues, with highest levels in lung, heart, and kidney. Our results suggest that alpha 5 may be a major laminin chain of adult basal laminae...
  64. ncbi request reprint Interspecific comparisons reveal conserved features of the Drosophila Toll protein
    M Yamagata
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110
    Gene 139:223-8. 1994
    ..Thus, we identify a set of conserved aa in the cytoplasmic domain which might be used in a signal-transduction pathway shared by invertebrates and vertebrates...
  65. pmc LL5beta: a regulator of postsynaptic differentiation identified in a screen for synaptically enriched transcripts at the neuromuscular junction
    Masashi Kishi
    Department of Anatomy and Neurobiology, Washington University Medical Center, St Louis, MO 63110, USA
    J Cell Biol 169:355-66. 2005
    ..Thus, a strategy designed to identify novel synaptic components led to identification of a protein required for assembly of the postsynaptic apparatus...
  66. pmc Syne proteins anchor muscle nuclei at the neuromuscular junction
    R Mark Grady
    Department of Anatomy and Neurobiology, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 102:4359-64. 2005
    ..We then exploited this phenotype to show that synaptic nuclear aggregates are dispensable for maturation of the NMJ...
  67. ncbi request reprint Mammalian SAD kinases are required for neuronal polarization
    Masashi Kishi
    Department of Anatomy and Neurobiology, Washington University Medical School, St Louis, MO 63110, USA
    Science 307:929-32. 2005
    ..These kinases will provide entry points for unraveling signaling mechanisms that polarize neurons...
  68. ncbi request reprint A synaptic laminin-calcium channel interaction organizes active zones in motor nerve terminals
    Hiroshi Nishimune
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 432:580-7. 2004
    ..They also suggest a model for the development of nerve terminals, and provide clues to the pathogenesis of a synaptic disease...
  69. pmc Laminins promote postsynaptic maturation by an autocrine mechanism at the neuromuscular junction
    Hiroshi Nishimune
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    J Cell Biol 182:1201-15. 2008
    ..Together with previous studies implicating laminins as organizers of presynaptic differentiation, these results show that laminins coordinate post- with presynaptic maturation...
  70. ncbi request reprint The synaptic vesicle protein CSP alpha prevents presynaptic degeneration
    Rafael Fernandez-Chacon
    Center for Basic Neuroscience, Department of Molecular Genetics and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75390, USA
    Neuron 42:237-51. 2004
    ....
  71. pmc Nerve-independent formation of a topologically complex postsynaptic apparatus
    Terrance T Kummer
    Dept of Anatomy and Neurobiology, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    J Cell Biol 164:1077-87. 2004
    ..These results reveal the sequence of steps by which a topologically complex domain forms on a cell and suggest an unexpected nerve-independent role for the postsynaptic cell in generating this topological complexity...
  72. ncbi request reprint A compensatory subpopulation of motor neurons in a mouse model of amyotrophic lateral sclerosis
    Anneliese M Schaefer
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    J Comp Neurol 490:209-19. 2005
    ..Identification of factors that protect "compensatory" motor neurons from degenerative changes may provide new targets for therapeutic intervention...
  73. ncbi request reprint Versican in the developing brain: lamina-specific expression in interneuronal subsets and role in presynaptic maturation
    Masahito Yamagata
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Neurosci 25:8457-67. 2005
    ..We propose that versican provides a lamina-specific cue for presynaptic maturation and discuss the related but distinct effects of versican depletion and VVA blockade...
  74. doi request reprint Dscam and Sidekick proteins direct lamina-specific synaptic connections in vertebrate retina
    Masahito Yamagata
    Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 451:465-9. 2008
    ..Together, our results on Dscams and Sidekicks suggest the existence of an IgSF code for laminar specificity in retina and, by implication, in other parts of the central nervous system...
  75. ncbi request reprint Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system
    Jean Livet
    Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 450:56-62. 2007
    ..The ability of the Brainbow system to label uniquely many individual cells within a population may facilitate the analysis of neuronal circuitry on a large scale...
  76. pmc The requirement for Phr1 in CNS axon tract formation reveals the corticostriatal boundary as a choice point for cortical axons
    A Joseph Bloom
    Department of Molecular Biology and Pharmacology, Washington University, Saint Louis, Missouri 63110, USA
    Genes Dev 21:2593-606. 2007
    ..Thus, in the mammalian nervous system Phr1 is required for formation of major CNS axon tracts via a mechanism that is both cell-nonautonomous and independent of DLK...
  77. ncbi request reprint Synaptotagmin I and II are present in distinct subsets of central synapses
    Michael A Fox
    Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA
    J Comp Neurol 503:280-96. 2007
    ..The cell-, temporal-, and species-specific expression of synaptotagmin isoforms suggests that each may have distinct functions in neurotransmitter release...
  78. ncbi request reprint Labeled lines in the retinotectal system: markers for retinorecipient sublaminae and the retinal ganglion cell subsets that innervate them
    Masahito Yamagata
    Department of Anatomy and Neurobiology, Washington University Medical School, St Louis, MO 63110, USA
    Mol Cell Neurosci 33:296-310. 2006
    ..Our results define laminar-specified circuits from retina to brain and support a model in which RGCs transmit information from multiple sources to single central laminae, where it can be integrated...
  79. ncbi request reprint Cerebellar synaptic defects and abnormal motor behavior in mice lacking alpha- and beta-dystrobrevin
    R Mark Grady
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 26:2841-51. 2006
    ..We suggest that motor deficits in muscular dystrophy patients, which are their cardinal symptoms, may reflect not only peripheral derangements but also CNS defects...
  80. ncbi request reprint Molecular control of spinal accessory motor neuron/axon development in the mouse spinal cord
    Allison K Dillon
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 25:10119-30. 2005
    ..Furthermore, in the absence of the transcription factor Nkx2.9, SACMN axons fail to exit the CNS. Together, these findings suggest molecular mechanisms that are likely to regulate key steps in SACMN development...
  81. ncbi request reprint Disruption and recovery of patterned retinal activity in the absence of acetylcholine
    Rebecca C Stacy
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 25:9347-57. 2005
    ..The rapid recovery of rhythmic spontaneous activity in the presence of cholinergic antagonists and the eventual emergence of waves in ChAT knock-out regions suggest that homeostatic mechanisms regulate retinal output during development...
  82. ncbi request reprint Dual functional activity of semaphorin 3B is required for positioning the anterior commissure
    Julien Falk
    NMDA, UMR CNRS 6156, Institut de Biologie du Developpement de Marseille, Parc Scientifique de Luminy, 13288 Marseille Cedex 9, France
    Neuron 48:63-75. 2005
    ....
  83. ncbi request reprint PSD93 regulates synaptic stability at neuronal cholinergic synapses
    Michael J Parker
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 24:378-88. 2004
    ..In addition, these results suggest that the mechanism of postsynaptic scaffolding is conserved between neuronal cholinergic and glutamatergic synapses...
  84. ncbi request reprint Roles of neurotransmitter in synapse formation: development of neuromuscular junctions lacking choline acetyltransferase
    Thomas Misgeld
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuron 36:635-48. 2002
    ..At subsequent stages, neurotransmission delays some steps in synaptic maturation but accelerates others. Thus, neurotransmission affects synaptogenesis from early stages and coordinates rather than drives synaptic maturation...
  85. ncbi request reprint Sidekicks: synaptic adhesion molecules that promote lamina-specific connectivity in the retina
    Masahito Yamagata
    Department of Anatomy and Neurobiology, School of Medicine, Washington University, Saint Louis, MO 63110, USA
    Cell 110:649-60. 2002
    ..Ectopic expression of Sdk in Sdk-negative cells redirects their processes to a Sdk-positive sublamina. These results implicate Sdks as determinants of lamina-specific synaptic connectivity...
  86. ncbi request reprint Neurotransmitter receptor dynamics studied in vivo by reversible photo-unbinding of fluorescent ligands
    Mohammed Akaaboune
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Neuron 34:865-76. 2002
    ..These results demonstrate remarkable molecular dynamism underlying macroscopic stability of the postsynaptic membrane, and establish alpha-dystrobrevin as a key control point for regulation of mobility and turnover...
  87. ncbi request reprint Gamma protocadherins are required for survival of spinal interneurons
    Xiaozhong Wang
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Neuron 36:843-54. 2002
    ..In cultures from mutant spinal cord, neurons differentiate and form synapses but then die. Thus, Pcdh-gamma genes are dispensable for at least some aspects of connectivity but required for survival of specific neuronal types...
  88. ncbi request reprint Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex
    Joshua T Trachtenberg
    Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Nature 420:788-94. 2002
    ..Our measurements suggest that sensory experience drives the formation and elimination of synapses and that these changes might underlie adaptive remodelling of neural circuits...
  89. ncbi request reprint PDAPP; YFP double transgenic mice: a tool to study amyloid-beta associated changes in axonal, dendritic, and synaptic structures
    Robert P Brendza
    Center for the Study of Nervous System Injury, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Comp Neurol 456:375-83. 2003
    ....
  90. ncbi request reprint The basement membrane/basal lamina of skeletal muscle
    Joshua R Sanes
    Department of Anatomy and Neurobiology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Biol Chem 278:12601-4. 2003
  91. pmc Tyrosine-phosphorylated and nonphosphorylated isoforms of alpha-dystrobrevin: roles in skeletal muscle and its neuromuscular and myotendinous junctions
    R Mark Grady
    Dept of Pediatrics, Washington University School of Medicine, Pediatric Research Bldg, St Louis, MO 63110, USA
    J Cell Biol 160:741-52. 2003
    ..More generally, alphaDB may play multiple roles in muscle by means of differential distribution of isoforms with distinct signaling or structural properties...
  92. ncbi request reprint Inhibiting axon degeneration and synapse loss attenuates apoptosis and disease progression in a mouse model of motoneuron disease
    Anna Ferri
    Department of APSIC, Division of Pharmacology, Faculty of Medicine, University of Geneva, 1211 Geneva 4, Switzerland
    Curr Biol 13:669-73. 2003
    ..These results suggest new pathogenic mechanisms and therapeutic avenues for motoneuron diseases...
  93. ncbi request reprint Dystroglycan is selectively associated with inhibitory GABAergic synapses but is dispensable for their differentiation
    Sabine Levi
    Washington University, Department of Anatomy and Neurobiology, St Louis, Missouri 63110, USA
    J Neurosci 22:4274-85. 2002
    ..Thus the DGC is not essential for GABAergic synaptogenesis but is likely to function in modulating inhibitory synapses or conferring specialized properties on a subset of them...
  94. ncbi request reprint Pre-existing pathways promote precise projection patterns
    Quyen T Nguyen
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nat Neurosci 5:861-7. 2002
    ..These results suggest that nonspecific guidance cues can be sufficient to generate specific synaptic circuitry...
  95. ncbi request reprint Genetic evidence that relative synaptic efficacy biases the outcome of synaptic competition
    Mario Buffelli
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 South Euclid, St Louis, Missouri 63110, USA
    Nature 424:430-4. 2003
    ..Here we use a genetic method to selectively inhibit neurotransmission from one of two inputs to a single target cell. We show that more powerful inputs are strongly favoured competitors during synapse elimination...
  96. ncbi request reprint Increased vulnerability to kainate-induced seizures in utrophin-knockout mice
    Irene Knuesel
    Institute of Pharmacology and Toxicology, University of Zurich, Switzerland
    Eur J Neurosci 15:1474-84. 2002
    ..These findings suggest that utrophin contributes to protect CNS neurons against pathological insults, in particular, stimuli leading to massive neuronal hypertrophy...
  97. ncbi request reprint An intrinsic distinction in neuromuscular junction assembly and maintenance in different skeletal muscles
    San Pun
    Friedrich Miescher Institute, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Neuron 34:357-70. 2002
    ..Our results show that postsynaptic differentiation processes intrinsic to FaSyn and DeSyn muscles influence the formation of NMJs during development and their maintenance in the adult...
  98. ncbi request reprint Assembly of the postsynaptic membrane at the neuromuscular junction: paradigm lost
    Terrance T Kummer
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Curr Opin Neurobiol 16:74-82. 2006
    ..These recent studies challenge the widely-held paradigms, although not the results that led to them, and suggest a new model for neuromuscular synaptogenesis...
  99. ncbi request reprint Synaptic adhesion molecules
    Masahito Yamagata
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 South Euclid, St Louis, MO 63110, USA
    Curr Opin Cell Biol 15:621-32. 2003
    ..g. SYG-1 and sidekicks), formation and alignment of synaptic specializations (e.g. SynCAM, neuroligin and neurexin), and regulation of synaptic structure and function (e.g. cadherins and syndecan)...
  100. ncbi request reprint Translational neuroscience during the Second World War
    Jeff W Lichtman
    Harvard University, USA
    J Exp Biol 209:3485-7. 2006
  101. pmc A technicolour approach to the connectome
    Jeff W Lichtman
    Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA
    Nat Rev Neurosci 9:417-22. 2008
    ..Here we review recent advances in this area, along with some of the opportunities that these advances present and the obstacles that remain...