L J Sandell

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi Etiology of osteoarthritis: genetics and synovial joint development
    Linda J Sandell
    Department of Orthopedic Surgery, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63108, USA
    Nat Rev Rheumatol 8:77-89. 2012
  2. ncbi Exuberant expression of chemokine genes by adult human articular chondrocytes in response to IL-1beta
    L J Sandell
    Department of Orthopaedic Surgery, Washington University School of Medicine at Barnes Jewish Hospital, St Louis, MO 63110, United States
    Osteoarthritis Cartilage 16:1560-71. 2008
  3. ncbi Cytokine regulation of cartilage-derived retinoic acid-sensitive protein (CD-RAP) in primary articular chondrocytes: suppression by IL-1, bfGF, TGFbeta and stimulation by IGF-1
    S Kondo
    Department of Orthopaedic Surgery, Washington University School of Medicine at Barnes-Jewish Hospital, St. Louis, MO 63110, USA
    J Orthop Res 19:712-9. 2001
  4. ncbi Anabolic factors in degenerative joint disease
    L J Sandell
    Washington University Medical School, Department of Orthopaedic Surgery, at Barnes Jewish Hospital, 660 S Euclid, Box 8233, St Louis, MO 63110, USA
    Curr Drug Targets 8:359-65. 2007
  5. ncbi Developmental patterns of cartilage
    L J Sandell
    Department of Orthopaedic Surgery, Barnes Jewish Hospital at Washington University School of Medicine, 216 South Kingshighway, St Louis, Missouri 63110, USA
    Front Biosci 4:D731-42. 1999
  6. ncbi Expression of type II procollagens during development of the human intervertebral disc
    A McAlinden
    Department of Orthopaedic Surgery, Washington University at Barnes-Jewish Hospital, Mail Stop 90-34-674, 216 South Kingshighway, St. Louis, MO 63110, USA
    Biochem Soc Trans 30:831-8. 2002
  7. ncbi Cartilage and bone changes during development of post-traumatic osteoarthritis in selected LGXSM recombinant inbred mice
    S Hashimoto
    Department of Orthopaedic Surgery, Washington University School of Medicine at Barnes Jewish Hospital, St Louis, MO 63110, USA
    Osteoarthritis Cartilage 20:562-71. 2012
  8. ncbi Cell biology of osteoarthritis: the chondrocyte's response to injury
    N Fukui
    Department of Orthopaedic Surgery, Washington University School of Medicine, Barnes-Jewish Hospital, Mail Stop 90-34-674, 216 South Kingshighway, St. Louis, MO 63110, USA
    Curr Rheumatol Rep 3:496-505. 2001
  9. ncbi Articular cartilage and changes in arthritis. An introduction: cell biology of osteoarthritis
    L J Sandell
    Department of Orthopaedic Surgery, Washington University School of Medicine, 216 South Kingshighway, St Louis, MO 63110, USA
    Arthritis Res 3:107-13. 2001
  10. ncbi Type IIA procollagen containing the cysteine-rich amino propeptide is deposited in the extracellular matrix of prechondrogenic tissue and binds to TGF-beta1 and BMP-2
    Y Zhu
    Washington University School of Medicine, Department of Orthopedic Surgery, St Louis, Missouri 63110, USA
    J Cell Biol 144:1069-80. 1999

Collaborators

Detail Information

Publications11

  1. ncbi Etiology of osteoarthritis: genetics and synovial joint development
    Linda J Sandell
    Department of Orthopedic Surgery, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63108, USA
    Nat Rev Rheumatol 8:77-89. 2012
    ....
  2. ncbi Exuberant expression of chemokine genes by adult human articular chondrocytes in response to IL-1beta
    L J Sandell
    Department of Orthopaedic Surgery, Washington University School of Medicine at Barnes Jewish Hospital, St Louis, MO 63110, United States
    Osteoarthritis Cartilage 16:1560-71. 2008
    ..To provide a more complete picture of the effect of interleukin-1 beta (IL-1beta) on adult human articular chondrocyte gene expression, in contrast to the candidate gene approach...
  3. ncbi Cytokine regulation of cartilage-derived retinoic acid-sensitive protein (CD-RAP) in primary articular chondrocytes: suppression by IL-1, bfGF, TGFbeta and stimulation by IGF-1
    S Kondo
    Department of Orthopaedic Surgery, Washington University School of Medicine at Barnes-Jewish Hospital, St. Louis, MO 63110, USA
    J Orthop Res 19:712-9. 2001
    ..These data indicate that CD-RAP expression can be regulated by cytokines known to influence chondrocyte metabolism and that IGF-1 up-regulates CD-RAP gene expression through a transcriptional mechanism...
  4. ncbi Anabolic factors in degenerative joint disease
    L J Sandell
    Washington University Medical School, Department of Orthopaedic Surgery, at Barnes Jewish Hospital, 660 S Euclid, Box 8233, St Louis, MO 63110, USA
    Curr Drug Targets 8:359-65. 2007
    ..We will also be interested in viewing the development of degenerative arthritis as a continuum from functionally normal tissue to degeneration...
  5. ncbi Developmental patterns of cartilage
    L J Sandell
    Department of Orthopaedic Surgery, Barnes Jewish Hospital at Washington University School of Medicine, 216 South Kingshighway, St Louis, Missouri 63110, USA
    Front Biosci 4:D731-42. 1999
    ..This will then be compared with the limited information currently known about the molecular aspects of osteoarthritis...
  6. ncbi Expression of type II procollagens during development of the human intervertebral disc
    A McAlinden
    Department of Orthopaedic Surgery, Washington University at Barnes-Jewish Hospital, Mail Stop 90-34-674, 216 South Kingshighway, St. Louis, MO 63110, USA
    Biochem Soc Trans 30:831-8. 2002
    ..We aim to explore this mechanism further...
  7. ncbi Cartilage and bone changes during development of post-traumatic osteoarthritis in selected LGXSM recombinant inbred mice
    S Hashimoto
    Department of Orthopaedic Surgery, Washington University School of Medicine at Barnes Jewish Hospital, St Louis, MO 63110, USA
    Osteoarthritis Cartilage 20:562-71. 2012
    ..Two recombinant inbred lines LGXSM-6 and LGXSM-33 generated from LG/J and SM/J intercross were used. Previous studies indicated that LGXSM-6 can regenerate both articular cartilage and ear hole punch while LGXSM-33 cannot...
  8. ncbi Cell biology of osteoarthritis: the chondrocyte's response to injury
    N Fukui
    Department of Orthopaedic Surgery, Washington University School of Medicine, Barnes-Jewish Hospital, Mail Stop 90-34-674, 216 South Kingshighway, St. Louis, MO 63110, USA
    Curr Rheumatol Rep 3:496-505. 2001
    ..Eventually, the newly synthesized and activated catabolic enzymes degrade the matrix components. This review presents the cellular and molecular mechanisms that account for this activity and provides some possible solutions...
  9. ncbi Articular cartilage and changes in arthritis. An introduction: cell biology of osteoarthritis
    L J Sandell
    Department of Orthopaedic Surgery, Washington University School of Medicine, 216 South Kingshighway, St Louis, MO 63110, USA
    Arthritis Res 3:107-13. 2001
    ..Proliferation plays a role in forming characteristic chondrocyte clusters near the surface, while apoptosis probably occurs primarily in the calcified cartilage...
  10. ncbi Type IIA procollagen containing the cysteine-rich amino propeptide is deposited in the extracellular matrix of prechondrogenic tissue and binds to TGF-beta1 and BMP-2
    Y Zhu
    Washington University School of Medicine, Department of Orthopedic Surgery, St Louis, Missouri 63110, USA
    J Cell Biol 144:1069-80. 1999
    ..Taken together, these results suggest that the NH2-propeptide of type IIA procollagen could function in the extracellular matrix distribution of bone morphogenetic proteins in chondrogenic tissue...
  11. ncbi The 2.2-kb promoter of cartilage-derived retinoic acid-sensitive protein controls gene expression in cartilage and embryonic mammary buds of transgenic mice
    W F Xie
    Washington University School of Medicine, Department of Orthopaedic Surgery, Yalem Research Building, Room 704, 216 South Kingshighway, St Louis, MO 63110, USA
    Matrix Biol 19:501-9. 2000
    ..The finding of transient CD-RAP expression in mammary buds suggests that it may play a role in the organogenesis of mammary glands...