Research Topics
Genomes and Genes
| Scott F SacconeSummaryAffiliation: Washington University School of Medicine Country: USA Publications
| Collaborators
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Detail Information
Publications
Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPsScott F Saccone
Department of Psychiatry, Box 8134, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
Hum Mol Genet 16:36-49. 2007..Other genes among the top signals were KCNJ6 and GABRA4. This study represents one of the most powerful and extensive studies of nicotine dependence to date and has found novel risk loci that require confirmation by replication studies...- Genetic linkage to chromosome 22q12 for a heavy-smoking quantitative trait in two independent samplesScott F Saccone
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Am J Hum Genet 80:856-66. 2007..Fine mapping of this linkage region may reveal variants contributing to heaviness of smoking, which will lead to a better understanding of the genetic mechanisms underlying nicotine dependence... - Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genesNancy L Saccone
Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
Am J Med Genet B Neuropsychiatr Genet 150:453-66. 2009.... - A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependenceRichard A Grucza
Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Box 8134, St Louis, Missouri 63110, USA
Biol Psychiatry 64:922-9. 2008..The goal of this study was to examine the association of this variant with cocaine dependence... - Further evidence for an association between the gamma-aminobutyric acid receptor A, subunit 4 genes on chromosome 4 and Fagerström Test for Nicotine DependenceArpana Agrawal
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Addiction 104:471-7. 2009..In the present report, we extend the previous study by expanding our genotyping efforts significantly for these two genes... - Variants in nicotinic receptors and risk for nicotine dependenceLaura Jean Bierut
Department of Psychiatry, Washington University School of Medicine, Box 8134, 660 South Euclid Ave, St Louis, MO 63110, USA
Am J Psychiatry 165:1163-71. 2008.... - Genetic linkage findings for DSM-IV nicotine withdrawal in two populationsMichele L Pergadia
Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
Am J Med Genet B Neuropsychiatr Genet 150:950-9. 2009..Other studies have reported that chromosome 11 may harbor genes associated with various aspects of smoking behavior. This study adds to that literature by highlighting evidence for NW... 
Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case-control studyArpana Agrawal
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Addiction 103:1027-38. 2008....- An autosomal linkage scan for cannabis use disorders in the nicotine addiction genetics projectArpana Agrawal
Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8134, St Louis, MO 63110, USA
Arch Gen Psychiatry 65:713-21. 2008..Despite accumulating evidence that there is a genetic basis for cannabis use disorders (ie, abuse and dependence), few studies have identified genomic regions that may harbor biological risk and protective factors... - Novel genes identified in a high-density genome wide association study for nicotine dependenceLaura Jean Bierut
Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, Box 8134, St Louis, MO 63110, USA
Hum Mol Genet 16:24-35. 2007..This work anticipates the future directions of large-scale genome wide association studies with state-of-the-art methodological approaches and sharing of data with the scientific community... - A genome-wide association study of DSM-IV cannabis dependenceArpana Agrawal
Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, Saint Louis, MO 63110, USA
Addict Biol 16:514-8. 2011..While replication is required, this study represents an important first step toward clarifying the biological underpinnings of cannabis dependence... - Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5Jen C Wang
Department of Psychiatry, Washington University, 660 South Euclid, PO BOX 8134, St Louis, MO 63110, USA
Hum Mol Genet 18:3125-35. 2009.... - A 3p26-3p25 genetic linkage finding for DSM-IV major depression in heavy smoking familiesMichele L Pergadia
Department of Psychiatry, WashingtonUniversity School of Medicine, Saint Louis, MO 63110, USA
Am J Psychiatry 168:848-52. 2011..The authors tested for genetic linkage of DSM-IV-diagnosed major depressive disorder in families that were ascertained for cigarette smoking... - A genome-wide association study of alcohol dependenceLaura J Bierut
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 107:5082-7. 2010..11 and 1.16. Further dissection of the alcoholism phenotype, to disentangle the influence of comorbid substance-use disorders, will be a next step in identifying genetic variants associated with alcohol dependence... - New tools and methods for direct programmatic access to the dbSNP relational databaseScott F Saccone
Department of Psychiatry, Washington University, University of Southern California, Washington University, USA
Nucleic Acids Res 39:D901-7. 2011..isi.edu/dbsnpq. Resources such as these for programmatically querying biological databases are essential for viably integrating biological information into genetic association experiments on a genome-wide scale... - Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sampleArpana Agrawal
Washington University School of Medicine, St Louis, MO 63110, USA
Drug Alcohol Depend 93:12-20. 2008..0 on chromosome 2 (3.2, 234 cM), 10 (2.4 and 2.6 at 60 cM and 116 cM) and 13 (2.1 at 64 cM). These regions may harbor genes that contribute to the biological basis of alcohol and drug dependence... - Systematic biological prioritization after a genome-wide association study: an application to nicotine dependenceScott F Saccone
Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
Bioinformatics 24:1805-11. 2008..A challenging problem after a genome-wide association study (GWAS) is to balance the statistical evidence of genotype-phenotype correlation with a priori evidence of biological relevance... - A new statistic to evaluate imputation reliabilityPeng Lin
Department of Psychiatry, Washington University, St Louis, Missouri, United States of America
PLoS ONE 5:e9697. 2010..Traditional measures of imputation cannot effectively address these problems... - A genetic network model of cellular responses to lithium treatment and cocaine abuse in bipolar disorderRichard C McEachin
Department of Psychiatry, University of Michigan, Ann Arbor, USA
BMC Syst Biol 4:158. 2010..We initially hypothesized a gene-by-environment interaction where lithium, acting as an environmental influence, impacts signal transduction pathways leading to differential expression of genes important in the etiology of BD mania... - Genetic analysis of the maximum drinks phenotypeScott F Saccone
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
BMC Genet 6:S124. 2005..The evidence suggests that chromosome 7 may harbor an additional locus influencing the maximum drinks consumption phenotype... 
Alcoholism and related traits: a summary of Group 13 contributionsJohn P Rice
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
Genet Epidemiol 29:S96-S102. 2005..A novel linkage peak was detected using the SNP markers...- Supplementing high-density SNP microarrays for additional coverage of disease-related genes: addiction as a paradigmScott F Saccone
Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
PLoS ONE 4:e5225. 2009..This combination of biological prioritization scores and LD tagging annotation will enable addiction researchers to supplement commercial SNP microarrays to ensure comprehensive coverage of biologically relevant regions... - Power-based, phase-informed selection of single nucleotide polymorphisms for disease association screensScott F Saccone
Department of Psychiatry, Washington University, St. Louis, Missouri 63110, USA
Genet Epidemiol 30:459-70. 2006..This work is a concrete example of how empirical LD phase may be used to benefit study design... - The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-AmericansNancy L Saccone
Department of Genetics, Washington University, St Louis, Missouri 63110, UA
Cancer Res 69:6848-56. 2009..The nonsynonymous SNP rs16969968, a known risk variant in populations of European-descent, is also significantly associated with risk in African-Americans. Additional SNPs contribute to risk in distinct ways in these two populations... - In search of causal variants: refining disease association signals using cross-population contrastsNancy L Saccone
Department of Genetics, Washington University, Campus Box 8232, 4566 Scott Avenue, Saint Louis, Missouri, USA
BMC Genet 9:58. 2008..The challenge we address is to distinguish among these correlated loci to highlight potential functional variants and prioritize them for follow-up... - Modeling complex genetic and environmental influences on comorbid bipolar disorder with tobacco use disorderRichard C McEachin
Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA
BMC Med Genet 11:14. 2010..Therefore, we hypothesized a common underlying genetic etiology, interacting with nicotine exposure, influencing susceptibility to both BD and TUD... - BioQ: tracing experimental origins in public genomic databases using a novel data provenance modelScott F Saccone
Department of Psychiatry, Washington University, Saint Louis, MO 63110, USA
Bioinformatics 28:1189-91. 2012..It includes a number of human genetic variation databases such as the HapMap and 1000 Genomes projects. AVAILABILITY AND IMPLEMENTATION: BioQ is freely available to the public at http://bioq.saclab.net... - SPOT: a web-based tool for using biological databases to prioritize SNPs after a genome-wide association studyScott F Saccone
Department of Psychiatry, Washington University, St Louis, MO, USA
Nucleic Acids Res 38:W201-9. 2010..For investigators interested in incorporating biological databases into a post-GWAS SNP selection strategy, the SPOT web tool is an easily implemented and flexible solution... - Genetic analysis of maximum cigarette-use phenotypesNancy L Saccone
Department of Genetics, Washington University School of Medicine, St, Louis, Missouri, USA
BMC Genet 4:S105. 2003..Adjustments were made for the significant covariates of gender and year of birth, and sib-pair based linkage analysis was performed...