Scott F Saccone

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs
    Scott F Saccone
    Department of Psychiatry, Box 8134, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Hum Mol Genet 16:36-49. 2007
  2. pmc Genetic linkage to chromosome 22q12 for a heavy-smoking quantitative trait in two independent samples
    Scott F Saccone
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Hum Genet 80:856-66. 2007
  3. pmc Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes
    Nancy L Saccone
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Med Genet B Neuropsychiatr Genet 150:453-66. 2009
  4. pmc A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Box 8134, St Louis, Missouri 63110, USA
    Biol Psychiatry 64:922-9. 2008
  5. pmc Further evidence for an association between the gamma-aminobutyric acid receptor A, subunit 4 genes on chromosome 4 and Fagerström Test for Nicotine Dependence
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Addiction 104:471-7. 2009
  6. pmc Variants in nicotinic receptors and risk for nicotine dependence
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, Box 8134, 660 South Euclid Ave, St Louis, MO 63110, USA
    Am J Psychiatry 165:1163-71. 2008
  7. pmc Genetic linkage findings for DSM-IV nicotine withdrawal in two populations
    Michele L Pergadia
    Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Am J Med Genet B Neuropsychiatr Genet 150:950-9. 2009
  8. doi request reprint An autosomal linkage scan for cannabis use disorders in the nicotine addiction genetics project
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8134, St Louis, MO 63110, USA
    Arch Gen Psychiatry 65:713-21. 2008
  9. doi request reprint Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case-control study
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Addiction 103:1027-38. 2008
  10. pmc Novel genes identified in a high-density genome wide association study for nicotine dependence
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, Box 8134, St Louis, MO 63110, USA
    Hum Mol Genet 16:24-35. 2007

Collaborators

Detail Information

Publications30

  1. pmc Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs
    Scott F Saccone
    Department of Psychiatry, Box 8134, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Hum Mol Genet 16:36-49. 2007
    ..Other genes among the top signals were KCNJ6 and GABRA4. This study represents one of the most powerful and extensive studies of nicotine dependence to date and has found novel risk loci that require confirmation by replication studies...
  2. pmc Genetic linkage to chromosome 22q12 for a heavy-smoking quantitative trait in two independent samples
    Scott F Saccone
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Hum Genet 80:856-66. 2007
    ..Fine mapping of this linkage region may reveal variants contributing to heaviness of smoking, which will lead to a better understanding of the genetic mechanisms underlying nicotine dependence...
  3. pmc Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes
    Nancy L Saccone
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Med Genet B Neuropsychiatr Genet 150:453-66. 2009
    ....
  4. pmc A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Box 8134, St Louis, Missouri 63110, USA
    Biol Psychiatry 64:922-9. 2008
    ..The goal of this study was to examine the association of this variant with cocaine dependence...
  5. pmc Further evidence for an association between the gamma-aminobutyric acid receptor A, subunit 4 genes on chromosome 4 and Fagerström Test for Nicotine Dependence
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Addiction 104:471-7. 2009
    ..In the present report, we extend the previous study by expanding our genotyping efforts significantly for these two genes...
  6. pmc Variants in nicotinic receptors and risk for nicotine dependence
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, Box 8134, 660 South Euclid Ave, St Louis, MO 63110, USA
    Am J Psychiatry 165:1163-71. 2008
    ....
  7. pmc Genetic linkage findings for DSM-IV nicotine withdrawal in two populations
    Michele L Pergadia
    Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Am J Med Genet B Neuropsychiatr Genet 150:950-9. 2009
    ..Other studies have reported that chromosome 11 may harbor genes associated with various aspects of smoking behavior. This study adds to that literature by highlighting evidence for NW...
  8. doi request reprint An autosomal linkage scan for cannabis use disorders in the nicotine addiction genetics project
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8134, St Louis, MO 63110, USA
    Arch Gen Psychiatry 65:713-21. 2008
    ..Despite accumulating evidence that there is a genetic basis for cannabis use disorders (ie, abuse and dependence), few studies have identified genomic regions that may harbor biological risk and protective factors...
  9. doi request reprint Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case-control study
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Addiction 103:1027-38. 2008
    ....
  10. pmc Novel genes identified in a high-density genome wide association study for nicotine dependence
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, Box 8134, St Louis, MO 63110, USA
    Hum Mol Genet 16:24-35. 2007
    ..This work anticipates the future directions of large-scale genome wide association studies with state-of-the-art methodological approaches and sharing of data with the scientific community...
  11. pmc A genome-wide association study of DSM-IV cannabis dependence
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, Saint Louis, MO 63110, USA
    Addict Biol 16:514-8. 2011
    ..While replication is required, this study represents an important first step toward clarifying the biological underpinnings of cannabis dependence...
  12. pmc A genome-wide association study of alcohol dependence
    Laura J Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:5082-7. 2010
    ..11 and 1.16. Further dissection of the alcoholism phenotype, to disentangle the influence of comorbid substance-use disorders, will be a next step in identifying genetic variants associated with alcohol dependence...
  13. pmc A 3p26-3p25 genetic linkage finding for DSM-IV major depression in heavy smoking families
    Michele L Pergadia
    Department of Psychiatry, WashingtonUniversity School of Medicine, Saint Louis, MO 63110, USA
    Am J Psychiatry 168:848-52. 2011
    ..The authors tested for genetic linkage of DSM-IV-diagnosed major depressive disorder in families that were ascertained for cigarette smoking...
  14. pmc Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5
    Jen C Wang
    Department of Psychiatry, Washington University, 660 South Euclid, PO BOX 8134, St Louis, MO 63110, USA
    Hum Mol Genet 18:3125-35. 2009
    ....
  15. pmc Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample
    Arpana Agrawal
    Washington University School of Medicine, St Louis, MO 63110, USA
    Drug Alcohol Depend 93:12-20. 2008
    ..0 on chromosome 2 (3.2, 234 cM), 10 (2.4 and 2.6 at 60 cM and 116 cM) and 13 (2.1 at 64 cM). These regions may harbor genes that contribute to the biological basis of alcohol and drug dependence...
  16. pmc New tools and methods for direct programmatic access to the dbSNP relational database
    Scott F Saccone
    Department of Psychiatry, Washington University, University of Southern California, Washington University, USA
    Nucleic Acids Res 39:D901-7. 2011
    ..isi.edu/dbsnpq. Resources such as these for programmatically querying biological databases are essential for viably integrating biological information into genetic association experiments on a genome-wide scale...
  17. pmc Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence
    Scott F Saccone
    Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Bioinformatics 24:1805-11. 2008
    ..A challenging problem after a genome-wide association study (GWAS) is to balance the statistical evidence of genotype-phenotype correlation with a priori evidence of biological relevance...
  18. pmc A genetic network model of cellular responses to lithium treatment and cocaine abuse in bipolar disorder
    Richard C McEachin
    Department of Psychiatry, University of Michigan, Ann Arbor, USA
    BMC Syst Biol 4:158. 2010
    ..We initially hypothesized a gene-by-environment interaction where lithium, acting as an environmental influence, impacts signal transduction pathways leading to differential expression of genes important in the etiology of BD mania...
  19. ncbi request reprint Alcoholism and related traits: a summary of Group 13 contributions
    John P Rice
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genet Epidemiol 29:S96-S102. 2005
    ..A novel linkage peak was detected using the SNP markers...
  20. pmc Genetic analysis of the maximum drinks phenotype
    Scott F Saccone
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    BMC Genet 6:S124. 2005
    ..The evidence suggests that chromosome 7 may harbor an additional locus influencing the maximum drinks consumption phenotype...
  21. pmc A new statistic to evaluate imputation reliability
    Peng Lin
    Department of Psychiatry, Washington University, St Louis, Missouri, United States of America
    PLoS ONE 5:e9697. 2010
    ..Traditional measures of imputation cannot effectively address these problems...
  22. pmc Supplementing high-density SNP microarrays for additional coverage of disease-related genes: addiction as a paradigm
    Scott F Saccone
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    PLoS ONE 4:e5225. 2009
    ..This combination of biological prioritization scores and LD tagging annotation will enable addiction researchers to supplement commercial SNP microarrays to ensure comprehensive coverage of biologically relevant regions...
  23. ncbi request reprint Power-based, phase-informed selection of single nucleotide polymorphisms for disease association screens
    Scott F Saccone
    Department of Psychiatry, Washington University, St Louis, Missouri 63110, USA
    Genet Epidemiol 30:459-70. 2006
    ..This work is a concrete example of how empirical LD phase may be used to benefit study design...
  24. doi request reprint Applying in silico integrative genomics to genetic studies of human disease
    Scott F Saccone
    Department of Psychiatry, Washington University, Saint Louis, Missouri, USA
    Int Rev Neurobiol 103:133-56. 2012
    ..Here, we review current methods and tools for integrating genomic data, particularly from the public domain, into genetic studies of human disease...
  25. pmc The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans
    Nancy L Saccone
    Department of Genetics, Washington University, St Louis, Missouri 63110, UA
    Cancer Res 69:6848-56. 2009
    ..The nonsynonymous SNP rs16969968, a known risk variant in populations of European-descent, is also significantly associated with risk in African-Americans. Additional SNPs contribute to risk in distinct ways in these two populations...
  26. pmc In search of causal variants: refining disease association signals using cross-population contrasts
    Nancy L Saccone
    Department of Genetics, Washington University, Campus Box 8232, 4566 Scott Avenue, Saint Louis, Missouri, USA
    BMC Genet 9:58. 2008
    ..The challenge we address is to distinguish among these correlated loci to highlight potential functional variants and prioritize them for follow-up...
  27. pmc Modeling complex genetic and environmental influences on comorbid bipolar disorder with tobacco use disorder
    Richard C McEachin
    Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA
    BMC Med Genet 11:14. 2010
    ..Therefore, we hypothesized a common underlying genetic etiology, interacting with nicotine exposure, influencing susceptibility to both BD and TUD...
  28. pmc BioQ: tracing experimental origins in public genomic databases using a novel data provenance model
    Scott F Saccone
    Department of Psychiatry, Washington University, Saint Louis, MO 63110, USA
    Bioinformatics 28:1189-91. 2012
    ..These databases, however, often lack tools for systematically determining the experimental origins of the data...
  29. pmc SPOT: a web-based tool for using biological databases to prioritize SNPs after a genome-wide association study
    Scott F Saccone
    Department of Psychiatry, Washington University, St Louis, MO, USA
    Nucleic Acids Res 38:W201-9. 2010
    ..For investigators interested in incorporating biological databases into a post-GWAS SNP selection strategy, the SPOT web tool is an easily implemented and flexible solution...
  30. pmc Genetic analysis of maximum cigarette-use phenotypes
    Nancy L Saccone
    Department of Genetics, Washington University School of Medicine, St, Louis, Missouri, USA
    BMC Genet 4:S105. 2003
    ..Adjustments were made for the significant covariates of gender and year of birth, and sib-pair based linkage analysis was performed...